ATE172743T1 - Nachweis von kollagenabbau -i(in vivo) - Google Patents

Nachweis von kollagenabbau -i(in vivo)

Info

Publication number
ATE172743T1
ATE172743T1 AT92912527T AT92912527T ATE172743T1 AT E172743 T1 ATE172743 T1 AT E172743T1 AT 92912527 T AT92912527 T AT 92912527T AT 92912527 T AT92912527 T AT 92912527T AT E172743 T1 ATE172743 T1 AT E172743T1
Authority
AT
Austria
Prior art keywords
vivo
detection
collagen degradation
binding partner
immunological binding
Prior art date
Application number
AT92912527T
Other languages
English (en)
Inventor
David R Eyre
Original Assignee
Washington Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Washington Res Found filed Critical Washington Res Found
Application granted granted Critical
Publication of ATE172743T1 publication Critical patent/ATE172743T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92912527T 1991-05-31 1992-05-15 Nachweis von kollagenabbau -i(in vivo) ATE172743T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/708,529 US5320970A (en) 1987-11-06 1991-05-31 Detection of collagen degradation in vivo

Publications (1)

Publication Number Publication Date
ATE172743T1 true ATE172743T1 (de) 1998-11-15

Family

ID=24846153

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912527T ATE172743T1 (de) 1991-05-31 1992-05-15 Nachweis von kollagenabbau -i(in vivo)

Country Status (10)

Country Link
US (4) US5320970A (de)
EP (3) EP0884055A1 (de)
JP (1) JPH06508138A (de)
KR (1) KR100249101B1 (de)
AT (1) ATE172743T1 (de)
AU (1) AU665953B2 (de)
CA (1) CA2110263A1 (de)
DE (1) DE69227456T2 (de)
IE (1) IE921772A1 (de)
WO (1) WO1992021698A1 (de)

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US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
CA2152667C (en) * 1992-12-28 2003-02-11 David J. Baylink Bone resorption assay
US6110689A (en) 1994-01-21 2000-08-29 Osteometer A/S Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
GB9506050D0 (en) * 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
ATE199185T1 (de) * 1994-10-17 2001-02-15 Osteometer Biotech As Einschätzung der fragmentierungsmuster von kollagen in körperflüssigkeiten und diagnose von mit dem kollagenmetabolismus zusammenhängenden störungen
EP0718309B1 (de) * 1994-12-23 1999-04-07 Roche Diagnostics GmbH Antigene und Antikörper zum Nachweis von Kollagen I
US5750647A (en) * 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
US5608249A (en) 1995-11-16 1997-03-04 Micron Technology, Inc. Reduced area storage node junction
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
ES2160985T3 (es) * 1996-12-09 2001-11-16 Osteometer Biotech As Ensayos de tipo sandwich para fragmentos de colageno.
US5989925A (en) 1997-06-27 1999-11-23 Serex, Inc. Antibody to and assay for peptide linked-pyridinoline as indicator of bone resorption level
ES2214722T3 (es) * 1997-07-31 2004-09-16 Metra Biosystems, Inc. Metodo de ensayo de peptidos de colageno.
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
US6030792A (en) * 1997-11-13 2000-02-29 Pfizer Inc Assays for measurement of protein fragments in biological media
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6348320B1 (en) 1998-06-19 2002-02-19 Washington Research Foundation Cartilage resorption assays measuring type II collagen fragments
DE69926888T2 (de) 1998-06-19 2006-03-30 Washington Research Foundation, Seattle Knorpelresorptionsassays
US6916903B2 (en) * 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6642007B1 (en) 1998-11-02 2003-11-04 Pfizer Inc. Assays for measurement of type II collagen fragments in urine
ES2333845T3 (es) * 1999-01-06 2010-03-02 University Of Southern California Metodo y composicion para la inhibicion de la angiogenesis.
US20050281821A1 (en) * 1999-01-06 2005-12-22 Flavia Pernasetti Method and composition for angiogenesis inhibition
US6716593B1 (en) * 1999-01-07 2004-04-06 Quidel Corporation Pyridinium crosslinks assay
CA2379373A1 (en) * 1999-07-13 2001-01-18 University Of Southern California Novel method and composition for inhibition of angiogenesis using antagonists based on mmp-9 and .beta.1 integrins
JP2004510981A (ja) 2000-10-03 2004-04-08 ロウェット、リサーチ、インスティテュート ピロール含有生体化合物の測定方法およびピロール含有生体化合物
US7390885B2 (en) * 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7365167B2 (en) * 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7488792B2 (en) * 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20060030538A1 (en) * 2004-07-21 2006-02-09 Medtronic, Inc. Methods for reducing or preventing localized fibrosis using SiRNA
WO2006020231A2 (en) * 2004-07-21 2006-02-23 Medtronic, Inc. Medical devices and methods for reducing localized fibrosis
US7763418B2 (en) * 2005-07-05 2010-07-27 Cytoskeleton, Inc. Detection of Rho proteins
US20070048325A1 (en) * 2005-08-24 2007-03-01 Dennis Van Epps Combination therapies for inhibiting integrin-extracellular matrix interactions
CN101365499A (zh) 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
US20080124813A1 (en) * 2006-11-17 2008-05-29 Phoenix Pharmaceuticals, Inc. Bead-based radioimmunoassay
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
CA3062443C (en) * 2007-06-15 2022-03-15 Warsaw Orthopedic, Inc. Method of treating tissue
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
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Also Published As

Publication number Publication date
AU2140992A (en) 1993-01-08
US5472884A (en) 1995-12-05
EP0884055A1 (de) 1998-12-16
EP0587719B1 (de) 1998-10-28
US5320970A (en) 1994-06-14
JPH06508138A (ja) 1994-09-14
EP0587719A4 (de) 1994-11-02
EP0587719A1 (de) 1994-03-23
DE69227456T2 (de) 1999-06-24
DE69227456D1 (de) 1998-12-03
US5688652A (en) 1997-11-18
AU665953B2 (en) 1996-01-25
EP0884328A1 (de) 1998-12-16
KR100249101B1 (ko) 2000-03-15
IE921772A1 (en) 1992-12-02
US5912131A (en) 1999-06-15
CA2110263A1 (en) 1992-12-10
WO1992021698A1 (en) 1992-12-10

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