ATE172877T1 - Filme auf copolymerenbasis, deren verwendungen in transdermalen systemen und deren herstellungsverfahren - Google Patents

Filme auf copolymerenbasis, deren verwendungen in transdermalen systemen und deren herstellungsverfahren

Info

Publication number: ATE172877T1
Authority: AT; Austria
Prior art keywords: pct; acid; methacrylate; transdermal systems; sec
Prior art date: 1992-12-21

Application number

AT94902838T

Other languages

English (en)

Inventor

Michel Istin

Jean-Marc Grognet

Charles Darnez

Original Assignee

Bio Holding

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-21

Filing date

1993-12-20

Publication date

1998-11-15

1993-12-20 Application filed by Bio Holding filed Critical Bio Holding

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172877T1 publication Critical patent/ATE172877T1/de

Links

VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 abstract 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 abstract 1
MKPHQUIFIPKXJL-UHFFFAOYSA-N 1,2-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(O)C(O)OC(=O)C(C)=C MKPHQUIFIPKXJL-UHFFFAOYSA-N 0.000 abstract 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 abstract 1
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
CNCOEDDPFOAUMB-UHFFFAOYSA-N N-Methylolacrylamide Chemical compound OCNC(=O)C=C CNCOEDDPFOAUMB-UHFFFAOYSA-N 0.000 abstract 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
239000001530 fumaric acid Substances 0.000 abstract 1
229920001600 hydrophobic polymer Polymers 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
239000011976 maleic acid Substances 0.000 abstract 1
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 abstract 1
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical compound CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 abstract 1
AYEFIAVHMUFQPZ-UHFFFAOYSA-N propane-1,2-diol;prop-2-enoic acid Chemical compound CC(O)CO.OC(=O)C=C AYEFIAVHMUFQPZ-UHFFFAOYSA-N 0.000 abstract 1
NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical class OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94902838T 1992-12-21 1993-12-20 Filme auf copolymerenbasis, deren verwendungen in transdermalen systemen und deren herstellungsverfahren ATE172877T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9215377A FR2699406B1 (fr)	1992-12-21	1992-12-21	Films à base de copolymères, leurs applications dans des systèmes transdermiques et leurs procédés de préparation.

Publications (1)

Publication Number	Publication Date
ATE172877T1 true ATE172877T1 (de)	1998-11-15

Family

ID=9436836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94902838T ATE172877T1 (de)	1992-12-21	1993-12-20	Filme auf copolymerenbasis, deren verwendungen in transdermalen systemen und deren herstellungsverfahren

Country Status (12)

Country	Link
US (1)	US5556635A (de)
EP (1)	EP0625901B1 (de)
JP (1)	JPH07508291A (de)
KR (1)	KR100314123B1 (de)
AT (1)	ATE172877T1 (de)
CA (1)	CA2130332A1 (de)
DE (1)	DE69321945T2 (de)
DK (1)	DK0625901T3 (de)
ES (1)	ES2126739T3 (de)
FR (1)	FR2699406B1 (de)
MX (1)	MX9400223A (de)
WO (1)	WO1994014425A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5919478A (en) *	1993-06-25	1999-07-06	Alza Corporation	Incorporating poly-N-vinyl amide in a transdermal system
FR2745720B1 (fr) *	1996-03-08	1998-05-07	Soc D Pharmacologie Et D Immun	Dispositif de diffusion d'un produit volatil dans l'atmosphere
ES2196208T3 (es) *	1996-03-09	2003-12-16	Nitto Denko Corp	Preparacion percutanea adhesiva.
DE69734060T2 (de)	1996-05-24	2006-06-29	Angiotech Pharmaceuticals, Inc., Vancouver	Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
JP4477152B2 (ja) *	1997-05-16	2010-06-09	株式会社共和	ストーマ用又は瘡傷用の皮膚保護材
DE19812688A1 (de) *	1998-03-23	1999-09-30	Basf Ag	Verfahren zur Herstellung von festen Dosierungsformen
FR2803204B1 (fr) *	1999-12-30	2002-05-03	Ethymed Lab	Dispositif de diffusion d'un produit volatil et procede de preparation
AU3104301A (en)	2000-01-20	2001-07-31	Noven Pharmaceuticals, Inc.	Compositions and methods to effect the release profile in the transdermal administration of active agents
DE10025970C2 (de) *	2000-05-25	2002-04-25	Lohmann Therapie Syst Lts	Estrogenhaltiges Pflaster mit einem Wirkstoffreservoir auf der Basis von Ethylcellulose und einem Ethylen-Vinylacetat-Vinylpyrrolidon-Copolymer und seine Verwendung
DE10025971B4 (de) *	2000-05-25	2004-09-02	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System in Plasterform mit verminderter Tendenz zur Wirkstoffkristallisation und seine Verwendung
JP2004520088A (ja) *	2000-08-15	2004-07-08	サーモディックス，インコーポレイティド	薬剤混和マトリックス
US6479076B2 (en) *	2001-01-12	2002-11-12	Izhak Blank	Nicotine delivery compositions
US7497623B2 (en)	2002-02-27	2009-03-03	Pactiv Corporation	Packages with active agents
US20060291756A1 (en) *	2002-02-27	2006-12-28	Thomas Toby R	Web materials with active agent for use in forming reclosable packages
US20060110080A1 (en) *	2002-02-27	2006-05-25	Thomas Toby R	Packages and structures with selective dosing of active agent
CN104397869B (zh)	2003-11-07	2016-06-08	美国无烟烟草有限责任公司	烟草组合物
US8627828B2 (en)	2003-11-07	2014-01-14	U.S. Smokeless Tobacco Company Llc	Tobacco compositions
JP5000932B2 (ja) *	2005-06-21	2012-08-15	日東電工株式会社	ニコチン含有経皮吸収製剤
WO2011130455A1 (en)	2010-04-13	2011-10-20	Najib Babul	Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
US20110253769A1 (en) *	2010-04-18	2011-10-20	Gevaram Quality Envelopes Ltd.	Tamper-resistant envelope
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US8633178B2 (en)	2011-11-23	2014-01-21	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
EP3145489A1 (de)	2014-05-22	2017-03-29	TherapeuticsMD, Inc.	Natürliche kombinierte hormonersatzformulierungen und therapien
EP3034528B1 (de)	2014-12-19	2017-06-21	Evonik Degussa GmbH	Covernetzersysteme für Verkapselungsfolien umfassend Harnstoffverbindungen
EP3034531A1 (de) *	2014-12-19	2016-06-22	Evonik Degussa GmbH	Dispersion zum einfachen Einsatz in der Herstellung von Verkapselungsfolien
ES2632783T3 (es)	2014-12-19	2017-09-15	Evonik Degussa Gmbh	Sistemas de redes de cubierta para láminas de encapsulación que comprenden compuestos de bis-(alquenilamidas)
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
WO2017173044A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd Inc.	Steroid hormone compositions in medium chain oils
WO2017173071A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2250793B1 (de) *	1973-11-09	1978-12-29	Commissariat Energie Atomique
FR2513243B1 (de) *	1981-09-24	1983-11-18	Commissariat Energie Atomique
US4994267A (en) *	1988-03-04	1991-02-19	Noven Pharmaceuticals, Inc.	Transdermal acrylic multipolymer drug delivery system
MX9202350A (es) *	1991-05-20	1992-11-01	Alza Corp	Composiciones de incrementador de penetracion a la piel que usan monolinoleato de glicerol.

1992
- 1992-12-21 FR FR9215377A patent/FR2699406B1/fr not_active Expired - Fee Related
1993
- 1993-12-20 US US08/284,669 patent/US5556635A/en not_active Expired - Fee Related
- 1993-12-20 CA CA002130332A patent/CA2130332A1/fr not_active Abandoned
- 1993-12-20 ES ES94902838T patent/ES2126739T3/es not_active Expired - Lifetime
- 1993-12-20 AT AT94902838T patent/ATE172877T1/de not_active IP Right Cessation
- 1993-12-20 DE DE69321945T patent/DE69321945T2/de not_active Expired - Fee Related
- 1993-12-20 EP EP94902838A patent/EP0625901B1/de not_active Expired - Lifetime
- 1993-12-20 KR KR1019940702918A patent/KR100314123B1/ko not_active Expired - Fee Related
- 1993-12-20 WO PCT/FR1993/001272 patent/WO1994014425A1/fr not_active Ceased
- 1993-12-20 DK DK94902838T patent/DK0625901T3/da active
- 1993-12-20 JP JP6514869A patent/JPH07508291A/ja not_active Ceased
1994
- 1994-01-03 MX MX9400223A patent/MX9400223A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
MX9400223A (es)	1994-07-29
JPH07508291A (ja)	1995-09-14
US5556635A (en)	1996-09-17
EP0625901A1 (de)	1994-11-30
FR2699406A1 (fr)	1994-06-24
DE69321945D1 (de)	1998-12-10
ES2126739T3 (es)	1999-04-01
CA2130332A1 (fr)	1994-07-07
EP0625901B1 (de)	1998-11-04
DK0625901T3 (da)	1999-07-19
FR2699406B1 (fr)	1995-03-10
WO1994014425A1 (fr)	1994-07-07
KR100314123B1 (ko)	2002-04-24
DE69321945T2 (de)	1999-04-01
KR950700729A (ko)	1995-02-20

Legal Events

Date	Code	Title	Description
2003-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE172877T1 (de)	1998-11-15	Filme auf copolymerenbasis, deren verwendungen in transdermalen systemen und deren herstellungsverfahren
DE60028256D1 (de)	2006-06-29	Druckempfindliche klebstoffe und sternblockpolymere und acrylpolymere enthaltende gegenstände
DE69628776D1 (de)	2003-07-31	Mit Arzneistoffpenetrationsbeschleuniger verträglicher druckempfindlicher Haftkleber
ES8801325A1 (es)	1987-12-16	Un metodo de preparar un adhesivo de copolimero de acrilato para adherir un substrato a la piel.
Vlček et al.	1999	Anionic polymerization of (meth) acrylate esters in the presence of stabilizers of active centres
ES2005408A6 (es)	1989-03-01	Pintura de latex acuosa alcalina y metodo de controlar la reologia de dicha pintura.
BR9609900A (pt)	1999-05-25	Processos para usar polímeros e para selar bordas lâminas de vidro de segurança laminado e lâmina de vidro de segurança laminado
MY103224A (en)	1993-05-29	2-(2''-hydroxpphenyl)-5(6)-(acryloyloxyalkoxy)- benzotrialzole and ultraviolet absorbing polymers therefrom
ES2116606T3 (es)	1998-07-16	Recubrimientos de superficie polimericos.
GB1163452A (en)	1969-09-04	Non-Adherent Dressing
MY120460A (en)	2005-10-31	Ultra high solids vinyl acetate-ethylene and vinyl acetate homopolymer emulsions.
CA2375654A1 (en)	2000-12-28	Wet-stick adhesives, articles, and methods
JP2003503539A5 (de)	2006-08-10
WO2002060417A8 (de)	2002-12-05	Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen
ATE280791T1 (de)	2004-11-15	Vinylacetat-homopolymeremulsionen und ethylen- vinylacetat-copolymeremulsionen mit ultrahohem feststoffgehalt
EP0373626A3 (de)	1991-01-16	Träger zur Zellkultur
ATE205240T1 (de)	2001-09-15	Hydrophiles klebemittel
JPH08283678A (ja)	1996-10-29	表面保護用粘着フィルム及びその製造方法
GB1431940A (en)	1976-04-14	Copolymers
DE59607352D1 (de)	2001-08-30	Polymeremulsionen mit bimodaler Molekulargewichtsverteilung
GB1157063A (en)	1969-07-02	Acrylonitrile Graft Polymers
EP0458481A3 (de)	1991-12-18	Polymerfilm
AU6052699A (en)	2000-04-26	Process for manufacturing homopolymers and copolymers of dimethylaminoethyl(meth)acrylate
ES2144887T3 (es)	2000-06-16	Agentes espesantes basados en polimeros que contienen grupos carboxilo y grupos carboxilamida.
JPS5718713A (en)	1982-01-30	Preparation of high polymeric emulsion containing glycidyl group