ATE172971T1 - Heterocyclische neurokinin-antagonisten - Google Patents

Heterocyclische neurokinin-antagonisten

Info

Publication number: ATE172971T1
Authority: AT; Austria
Prior art keywords: heterocyclic; neurokinin antagonists; neurokinin; antagonists; implicated
Prior art date: 1993-08-17

Application number

AT94923781T

Other languages

English (en)

Inventor

Scott Carson Miller

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-17

Filing date

1994-08-15

Publication date

1998-11-15

1994-08-15 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172971T1 publication Critical patent/ATE172971T1/de

Links

239000005557 antagonist Substances 0.000 title 1
108010040722 Neurokinin-2 Receptors Proteins 0.000 abstract 1
102100037342 Substance-K receptor Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94923781T 1993-08-17 1994-08-15 Heterocyclische neurokinin-antagonisten ATE172971T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939317104A GB9317104D0 (en)	1993-08-17	1993-08-17	Therapeutic heterocycles

Publications (1)

Publication Number	Publication Date
ATE172971T1 true ATE172971T1 (de)	1998-11-15

Family

ID=10740632

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94923781T ATE172971T1 (de)	1993-08-17	1994-08-15	Heterocyclische neurokinin-antagonisten

Country Status (24)

Country	Link
US (6)	US5567700A (de)
EP (1)	EP0714392B1 (de)
JP (1)	JP3502386B2 (de)
KR (1)	KR100359631B1 (de)
CN (1)	CN1077573C (de)
AT (1)	ATE172971T1 (de)
AU (1)	AU677091B2 (de)
CA (1)	CA2166800C (de)
CZ (1)	CZ285299B6 (de)
DE (1)	DE69414398T2 (de)
DK (1)	DK0714392T3 (de)
ES (1)	ES2123810T3 (de)
FI (1)	FI111253B (de)
GB (2)	GB9317104D0 (de)
HU (1)	HU219586B (de)
IL (1)	IL110672A (de)
MY (1)	MY112102A (de)
NO (1)	NO305657B1 (de)
NZ (1)	NZ269575A (de)
PL (1)	PL178426B1 (de)
RU (1)	RU2153498C2 (de)
SK (1)	SK281232B6 (de)
WO (1)	WO1995005377A1 (de)
ZA (1)	ZA946142B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5583134A (en) *	1992-09-30	1996-12-10	Sanofi	1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
GB9321557D0 (en) *	1992-11-03	1993-12-08	Zeneca Ltd	Carboxamide derivatives
GB9317104D0 (en) *	1993-08-17	1993-09-29	Zeneca Ltd	Therapeutic heterocycles
GB9322643D0 (en) *	1993-11-03	1993-12-22	Zeneca Ltd	Lactam derivatives
US5589489A (en) *	1993-12-15	1996-12-31	Zeneca Limited	Cyclic amide derivatives for treating asthma
GB9408872D0 (en) *	1994-05-03	1994-06-22	Zeneca Ltd	Heterocyclic compounds
TW432061B (en) *	1994-08-09	2001-05-01	Pfizer Res & Dev	Lactams
EP0709375B1 (de) *	1994-10-25	2005-05-18	AstraZeneca AB	Therapeutisch wirksame Heterocyclen
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
GB9421709D0 (en) *	1994-10-27	1994-12-14	Zeneca Ltd	Therapeutic compounds
GB9508786D0 (en)	1995-04-29	1995-06-21	Zeneca Ltd	Substituted heterocycles
US5688960A (en) *	1995-05-02	1997-11-18	Schering Corporation	Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
US5696267A (en) *	1995-05-02	1997-12-09	Schering Corporation	Substituted oximes, hydrazones and olefins as neurokinin antagonists
GB9521781D0 (en) *	1995-10-24	1996-01-03	Merck Sharp & Dohme	Therapeutic agents
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) *	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5789422A (en) *	1996-10-28	1998-08-04	Schering Corporation	Substituted arylalkylamines as neurokinin antagonists
MY116430A (en) *	1997-11-21	2004-01-31	Schering Corp	Substituted oximes as neurokinin antagonists
GB9924141D0 (en) *	1998-10-30	1999-12-15	Zeneca Ltd	Treatment of gastric asthma
US6063926A (en) *	1998-11-18	2000-05-16	Schering Corporation	Substituted oximes as neurokinin antagonists
WO2000039114A2 (en) *	1998-12-23	2000-07-06	Schering Corporation	Substituted oximes and hydrazones as neurokinin antagonists
US6204265B1 (en)	1998-12-23	2001-03-20	Schering Corporation	Substituted oximes and hydrazones as neurokinin antagonists
GB0015246D0 (en) *	2000-06-22	2000-08-16	Astrazeneca Ab	Method for the treatment of urinary incontinence
SE0103795D0 (sv)	2001-11-02	2001-11-02	Astrazeneca Ab	Compounds and method for the treatment of överactive bladder
SE0103668D0 (sv) *	2001-11-02	2001-11-02	Astrazeneca Ab	Method for the treatment of overactive blader
PE20030762A1 (es) *	2001-12-18	2003-09-05	Schering Corp	Compuestos heterociclicos como antagonistas nk1
US20100189797A1 (en)	2002-06-10	2010-07-29	Julien Mendlewicz	Oral antidepressant formulation
TW200508221A (en)	2003-06-13	2005-03-01	Astrazeneca Ab	New azetidine compounds
GB0326407D0 (en) *	2003-11-12	2003-12-17	Glaxo Group Ltd	Chemical compounds
TWI396686B (zh) *	2004-05-21	2013-05-21	Takeda Pharmaceutical	環狀醯胺衍生物、以及其製品和用法
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
AR057828A1 (es)	2005-09-29	2007-12-19	Astrazeneca Ab	Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US8106208B2 (en) *	2006-05-18	2012-01-31	Albireo Ab	Benzamide compounds that act as NK receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
UA41251C2 (uk) *	1990-01-04	2001-09-17	Пфайзер, Інк.	Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) *	1991-05-03	1993-08-27	Sanofi Elf	Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676781B1 (fr) *	1991-05-23	1995-03-31	Peugeot	Dispositif de refroidissement de l'air de suralimentation d'un moteur a combustion interne d'un vehicule.
FR2688219B1 (fr) *	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) *	1992-11-03	1993-12-08	Zeneca Ltd	Carboxamide derivatives
GB9317104D0 (en) *	1993-08-17	1993-09-29	Zeneca Ltd	Therapeutic heterocycles
GB9325074D0 (en) *	1993-12-07	1994-02-02	Zeneca Ltd	Bicyclic heterocycles

1993
- 1993-08-17 GB GB939317104A patent/GB9317104D0/en active Pending
1994
- 1994-08-15 DK DK94923781T patent/DK0714392T3/da active
- 1994-08-15 DE DE69414398T patent/DE69414398T2/de not_active Expired - Fee Related
- 1994-08-15 GB GB9416442A patent/GB9416442D0/en active Pending
- 1994-08-15 KR KR1019960700676A patent/KR100359631B1/ko not_active Expired - Fee Related
- 1994-08-15 CZ CZ96434A patent/CZ285299B6/cs not_active IP Right Cessation
- 1994-08-15 EP EP94923781A patent/EP0714392B1/de not_active Expired - Lifetime
- 1994-08-15 JP JP50682295A patent/JP3502386B2/ja not_active Expired - Fee Related
- 1994-08-15 ZA ZA946142A patent/ZA946142B/xx unknown
- 1994-08-15 AT AT94923781T patent/ATE172971T1/de not_active IP Right Cessation
- 1994-08-15 AU AU73880/94A patent/AU677091B2/en not_active Ceased
- 1994-08-15 HU HU9503826A patent/HU219586B/hu not_active IP Right Cessation
- 1994-08-15 WO PCT/GB1994/001777 patent/WO1995005377A1/en not_active Ceased
- 1994-08-15 RU RU96105910/04A patent/RU2153498C2/ru not_active IP Right Cessation
- 1994-08-15 PL PL94313075A patent/PL178426B1/pl not_active IP Right Cessation
- 1994-08-15 SK SK210-96A patent/SK281232B6/sk not_active IP Right Cessation
- 1994-08-15 CA CA002166800A patent/CA2166800C/en not_active Expired - Fee Related
- 1994-08-15 NZ NZ269575A patent/NZ269575A/en not_active IP Right Cessation
- 1994-08-15 US US08/290,642 patent/US5567700A/en not_active Expired - Lifetime
- 1994-08-15 ES ES94923781T patent/ES2123810T3/es not_active Expired - Lifetime
- 1994-08-15 CN CN94193155A patent/CN1077573C/zh not_active Expired - Fee Related
- 1994-08-16 MY MYPI94002143A patent/MY112102A/en unknown
- 1994-08-16 IL IL11067294A patent/IL110672A/xx not_active IP Right Cessation
1996
- 1996-02-16 FI FI960727A patent/FI111253B/fi active
- 1996-02-16 NO NO960630A patent/NO305657B1/no not_active IP Right Cessation
- 1996-08-05 US US08/689,199 patent/US5861392A/en not_active Expired - Fee Related
1998
- 1998-06-29 US US09/106,606 patent/US5990130A/en not_active Expired - Fee Related
1999
- 1999-06-18 US US09/336,087 patent/US6124279A/en not_active Expired - Fee Related
2000
- 2000-09-22 US US09/668,257 patent/US6444809B1/en not_active Expired - Fee Related
2002
- 2002-08-30 US US10/233,160 patent/US7053213B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ269575A (en)	1997-11-24
US6124279A (en)	2000-09-26
GB9317104D0 (en)	1993-09-29
US20030187255A1 (en)	2003-10-02
FI960727L (fi)	1996-02-16
IL110672A (en)	1999-06-20
PL178426B1 (pl)	2000-04-28
WO1995005377A1 (en)	1995-02-23
ES2123810T3 (es)	1999-01-16
SK21096A3 (en)	1997-02-05
US6444809B1 (en)	2002-09-03
HU219586B (hu)	2001-05-28
CA2166800C (en)	2006-06-06
DE69414398T2 (de)	1999-05-06
CZ43496A3 (en)	1996-05-15
NO960630L (no)	1996-02-16
FI960727A0 (fi)	1996-02-16
ZA946142B (en)	1995-02-17
NO305657B1 (no)	1999-07-05
AU677091B2 (en)	1997-04-10
CN1129449A (zh)	1996-08-21
MY112102A (en)	2001-04-30
US5861392A (en)	1999-01-19
US5567700A (en)	1996-10-22
US7053213B2 (en)	2006-05-30
HUT75113A (en)	1997-04-28
JP3502386B2 (ja)	2004-03-02
CA2166800A1 (en)	1995-02-23
EP0714392A1 (de)	1996-06-05
EP0714392B1 (de)	1998-11-04
US5990130A (en)	1999-11-23
GB9416442D0 (en)	1994-10-05
PL313075A1 (en)	1996-05-27
IL110672A0 (en)	1994-11-11
NO960630D0 (no)	1996-02-16
CZ285299B6 (cs)	1999-06-16
SK281232B6 (sk)	2001-01-18
HU9503826D0 (en)	1996-02-28
FI111253B (fi)	2003-06-30
CN1077573C (zh)	2002-01-09
AU7388094A (en)	1995-03-14
DE69414398D1 (de)	1998-12-10
DK0714392T3 (da)	2001-02-05
JPH09501439A (ja)	1997-02-10
KR100359631B1 (ko)	2003-01-24
RU2153498C2 (ru)	2000-07-27

Legal Events

Date	Code	Title	Description
1999-09-15	UEP	Publication of translation of european patent specification
2010-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE172971T1 (de)	1998-11-15	Heterocyclische neurokinin-antagonisten
MY131434A (en)	2007-08-30	Angiotensin ii antagonists
EA199900559A1 (ru)	2000-02-28	Замещенные, азотсодержащие гетероциклы в качестве ингибиторов протеинкиназы p38
HUT74992A (en)	1997-03-28	Use of serotonin antagonist indol derivatives for producing pharmaceutical compositions using for treating fibromyalgia
EA200100058A1 (ru)	2001-08-27	4-бензилпиперидиналкилсульфоксидные гетероциклические соединения и их применение в качестве подтип-избирательных антагонистов nmda-рецепторов
FI935585A0 (fi)	1993-12-13	Pyrrolopyrimidiner
CL2003002756A1 (es)	2005-02-11	Compuestos derivados de (1-carbamoil-1,1-defenilmetil)-1-[substituido)alquil]purrolidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del sindrome de intestino irritable o incontinencia.
TR200001312T2 (tr)	2000-09-21	Benzotiyazol protein tirozin kinaz önleyicileri.
DE69925024D1 (de)	2005-06-02	Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
DE122008000037I1 (de)	2008-11-06	Morpholinwirkstoffvorläufer als tachykininreceptorantagonisten
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
DE69133135D1 (de)	2002-11-21	Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
DE69904922D1 (de)	2003-02-20	Pharmazeutische zusammensetzung zur behandlung von alkoholabhängigkeit, die opioid antagonisten mit nmda-rezeptorkomplex-modulatoren enthält
TR199700956T1 (xx)	1998-02-21	Indazolkarboksamidler.
ATE369348T1 (de)	2007-08-15	Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie
EE200100520A (et)	2002-12-16	N-(2-fenüül-4-aminobutüül)-1-naftamiidid neurokiniin-1-retseptori antagonistidena
ATE169019T1 (de)	1998-08-15	Xanthinderivate als adenosin-a1 rezeptor antagonisten
YU39396A (sh)	1999-09-27	Upotreba izolovanog prirodnog proteina gojaznosti za pripremu leka i njegova farmaceutska formulacija
DK0758312T3 (da)	2000-05-01	Substituerede fusionerede og broforbundne bicykliske forbindelser som terapeutiske midler
DE69526738D1 (de)	2002-06-20	Endothelin-rezeptor-antagonisten
AR021502A1 (es)	2002-07-24	Uso de derivados de azabicicloalcanos n-sustituidos para el tratamiento de enfermedades del sistema central nervioso
TR200000916T2 (tr)	2000-07-21	İkameli piperidin türevleri.