ATE172975T1 - Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung - Google Patents

Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung

Info

Publication number
ATE172975T1
ATE172975T1 AT93401239T AT93401239T ATE172975T1 AT E172975 T1 ATE172975 T1 AT E172975T1 AT 93401239 T AT93401239 T AT 93401239T AT 93401239 T AT93401239 T AT 93401239T AT E172975 T1 ATE172975 T1 AT E172975T1
Authority
AT
Austria
Prior art keywords
derivatives
clugging
benzimidezole
platele
antidiabetic
Prior art date
Application number
AT93401239T
Other languages
English (en)
Inventor
Vera Alekseevna Anisimova
Margarita Valentinov Levchenko
Tatyana Borisovna Korochina
Alexander Alexeyevich Spasov
Sergei Gennadyevich Kovalev
Galina Petrovna Dudchenko
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206036A external-priority patent/FR2691462B1/fr
Priority claimed from FR9209488A external-priority patent/FR2694293B1/fr
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE172975T1 publication Critical patent/ATE172975T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93401239T 1992-05-19 1993-05-14 Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung ATE172975T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9206036A FR2691462B1 (fr) 1992-05-19 1992-05-19 Nouveaux derives du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR9209488A FR2694293B1 (fr) 1992-07-31 1992-07-31 Nouveau dérivé du benzimidazole, son procédé de préparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
ATE172975T1 true ATE172975T1 (de) 1998-11-15

Family

ID=26229468

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93401239T ATE172975T1 (de) 1992-05-19 1993-05-14 Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung

Country Status (10)

Country Link
US (2) US5623073A (de)
EP (1) EP0571253B1 (de)
JP (1) JP2506263B2 (de)
AT (1) ATE172975T1 (de)
AU (1) AU656466B2 (de)
CA (1) CA2096475A1 (de)
DE (1) DE69321875T2 (de)
DK (1) DK0571253T3 (de)
ES (1) ES2126636T3 (de)
NZ (1) NZ247643A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0705245T3 (da) 1993-06-25 2003-04-14 Merrell Pharma Inc Nye mellemprodukter til fremstilling af antihistaminiske 4-diphenylmethyl/diphenylmethoxy-piperidinforbindelser
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
AUPN236595A0 (en) 1995-04-11 1995-05-11 Rescare Limited Monitoring of apneic arousals
FR2765223B1 (fr) * 1997-06-25 1999-08-27 Adir Nouveaux derives tricycliques du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6730791B2 (en) 1998-07-02 2004-05-04 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
KR20040034594A (ko) * 2001-01-26 2004-04-28 브리스톨-마이어스스퀴브컴파니 코르티코트로핀 방출 인자 억제제로서의 이미다졸릴 유도체
US8318724B2 (en) * 2004-05-14 2012-11-27 The Cleveland Clinic Foundation Small molecule inhibitors of MRP1 and other multidrug transporters
KR101449057B1 (ko) 2006-03-17 2014-10-10 암비트 바이오사이언시즈 코포레이션 질환 치료용 이미다졸로티아졸 화합물
EP2201018B1 (de) * 2007-09-19 2016-03-16 Ambit Biosciences Corporation Feste formen, die n-(5-tert.-butylisoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}harnstoff umfassen zusammensetzungen davon und anwendungen damit
RU2386634C2 (ru) * 2007-12-27 2010-04-20 Вера Алексеевна Анисимова Средство гемореологическое, снижающее инсулинорезистентность и восстанавливающее толерантность организма к глюкозе, и фармацевтическая композиция на его основе
US20090247520A1 (en) * 2008-03-27 2009-10-01 The Burnham Institute For Medical Research INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
RU2391345C2 (ru) * 2008-07-23 2010-06-10 Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Южный Федеральный Университет" ДИГИДРОХЛОРИД 1-(3-МОРФОЛИНОПРОПИЛ)-2-ФЕНИЛИМИДАЗО[1,2-a]-БЕНЗИМИДАЗОЛА, ПРОЯВЛЯЮЩИЙ СВОЙСТВА АНТАГОНИСТА ПУРИНОВЫХ P2Y1-РЕЦЕПТОРОВ, АНТИАГРЕГАНТНУЮ И АНТИТРОМБОТИЧЕСКУЮ АКТИВНОСТЬ
TWI567079B (zh) * 2011-07-15 2017-01-21 健生醫藥公司 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物
MX382156B (es) * 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.
CN108250202B (zh) * 2018-01-15 2019-10-25 陕西师范大学 2,3-二取代苯并咪唑并[1,2-a]嘧啶类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732243A (en) * 1970-06-23 1973-05-08 Sankyo Co 2-(p-bromophenyl)-9-dimethyl-amino-propyl-9h-imidazo(1,2-a)benzimidazole
GB1476949A (en) * 1974-11-20 1977-06-16 Wyeth John & Brother Ltd Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
US5008282A (en) * 1988-12-28 1991-04-16 Kotobuki Seiyaku Co. Ltd. Cyclic guanidine derivatives, anti-ulceratives and methods of manufacturing the same

Also Published As

Publication number Publication date
DE69321875T2 (de) 1999-06-17
JPH0687859A (ja) 1994-03-29
US5623073A (en) 1997-04-22
DK0571253T3 (da) 1999-07-19
JP2506263B2 (ja) 1996-06-12
NZ247643A (en) 1995-07-26
AU3860893A (en) 1993-11-25
AU656466B2 (en) 1995-02-02
US5639756A (en) 1997-06-17
DE69321875D1 (de) 1998-12-10
EP0571253A1 (de) 1993-11-24
ES2126636T3 (es) 1999-04-01
EP0571253B1 (de) 1998-11-04
CA2096475A1 (fr) 1993-11-20

Similar Documents

Publication Publication Date Title
ATE172975T1 (de) Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung
NO900356D0 (no) Blandinger med forsinket frigjoering.
FI943084A0 (fi) Uusia sulfonyyliaminopyrimidiinejä
FI914928A0 (fi) Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
FI921087A0 (fi) Nya estrar av tienylkarboxylsyror och aminoalkoholer, deras kvaterniseringsprodukter och framstaellning och anvaendning av naemnda foereningar.
NO176443C (no) Halogenerte hydrokarbonlösningsmidler og anvendelse derav
ATE107499T1 (de) Haarkräftigungsmittel.
ATE114316T1 (de) Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel.
NO180166C (no) Pyrrolidin- og tiazolidinderivater samt medikamenter inneholdende forbindelsene
NZ240575A (en) N-benzoylproline derivatives and pharmaceutical compositions
FI932105A0 (fi) Sulfonylbensylsubstituerade benso- och pyridopyridoner
ES2127181T3 (es) 11-beta-aril-gona-4,9-dien-3-onas.
DE69115526D1 (de) 2,4-Pyrimidindionderivate und diese enthaltende Arzneimittel
KR910700089A (ko) 히드로클로로플루오로프로판의 공비 조성물 또는 공비형 조성물
IT1270975B (it) Composti piperidin-triazinici atti all'impiego come stabilizzanti allaluce, al calore e alla ossidazione per materiali organici
SE8403376D0 (sv) Spirosuccinimide, ihre herstellung und verwendung
ATE92469T1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
FI924477A0 (fi) Foerfarande foer diastereoselektiv reduktiv pinakolkoppling av homochirala a-aminoaldehyder
DE59404557D1 (de) Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
ES2123728T3 (es) Derivados de pirrolo-pirazina de actividad 5-ht3.
IT1263892B (it) Composti piperidin-triazinici atti all'impiego come stabilizzanti per materiali organici
DK0552631T3 (da) Alfa-Aryl-alfa-hydroxy-beta-imidazolinyl-propionsyreamider
ES2093051T3 (es) Purinil- y pirimidil-tetrahidrofuranos.
FI932013A0 (fi) Nya enantiomerer haerledda fraon (s)-2-amino-2-(3,4-diklorbensyl)-1-propanol
DK0779075T3 (da) Anvendelse af 3-alpha-hydroxy-5-alpha-androsta-16-en som lægemidler