ES2126636T3 - Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria. - Google Patents

Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.

Info

Publication number
ES2126636T3
ES2126636T3 ES93401239T ES93401239T ES2126636T3 ES 2126636 T3 ES2126636 T3 ES 2126636T3 ES 93401239 T ES93401239 T ES 93401239T ES 93401239 T ES93401239 T ES 93401239T ES 2126636 T3 ES2126636 T3 ES 2126636T3
Authority
ES
Spain
Prior art keywords
derivatives
bencimidazole
aggregant
diabetic
platelet activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93401239T
Other languages
English (en)
Inventor
Vera Alekseevna Anisimova
Margarita Valentinov Levchenko
Tatyana Borisovna Korochina
Alexander Alexeyevich Spasov
Sergei Gennadyevich Kovalev
Galina Petrovna Dudchenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206036A external-priority patent/FR2691462B1/fr
Priority claimed from FR9209488A external-priority patent/FR2694293B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2126636T3 publication Critical patent/ES2126636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE FORMULA GENERAL (I): DONDE A, B, C D, N, R1, R2, R3, R4, X, Y, Z SON TALES COMO SE DEFINEN EN LA DESCRIPCION. MEDICAMENTOS.
ES93401239T 1992-05-19 1993-05-14 Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria. Expired - Lifetime ES2126636T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9206036A FR2691462B1 (fr) 1992-05-19 1992-05-19 Nouveaux derives du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR9209488A FR2694293B1 (fr) 1992-07-31 1992-07-31 Nouveau dérivé du benzimidazole, son procédé de préparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
ES2126636T3 true ES2126636T3 (es) 1999-04-01

Family

ID=26229468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93401239T Expired - Lifetime ES2126636T3 (es) 1992-05-19 1993-05-14 Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.

Country Status (10)

Country Link
US (2) US5623073A (es)
EP (1) EP0571253B1 (es)
JP (1) JP2506263B2 (es)
AT (1) ATE172975T1 (es)
AU (1) AU656466B2 (es)
CA (1) CA2096475A1 (es)
DE (1) DE69321875T2 (es)
DK (1) DK0571253T3 (es)
ES (1) ES2126636T3 (es)
NZ (1) NZ247643A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CA2362337C (en) 1993-06-25 2005-08-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
AUPN236595A0 (en) 1995-04-11 1995-05-11 Rescare Limited Monitoring of apneic arousals
FR2765223B1 (fr) * 1997-06-25 1999-08-27 Adir Nouveaux derives tricycliques du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6730791B2 (en) 1998-07-02 2004-05-04 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6888004B2 (en) * 2001-01-26 2005-05-03 Bristol-Myers Squibb Company Imidazolyl derivatives as corticotropin releasing factor inhibitors
EP1753422B1 (en) * 2004-05-14 2008-05-28 The Cleveland Clinic Foundation Small molecule inhibitors for mrp1 and other multidrug transporters
KR101449057B1 (ko) 2006-03-17 2014-10-10 암비트 바이오사이언시즈 코포레이션 질환 치료용 이미다졸로티아졸 화합물
BRPI0816904B8 (pt) 2007-09-19 2021-12-07 Ambit Biosciences Corp Forma cristalna b da forma sólida do sal de bis-hcl, composição farmacêutica, e, uso de uma forma sólida
RU2386634C2 (ru) * 2007-12-27 2010-04-20 Вера Алексеевна Анисимова Средство гемореологическое, снижающее инсулинорезистентность и восстанавливающее толерантность организма к глюкозе, и фармацевтическая композиция на его основе
WO2009120874A2 (en) * 2008-03-27 2009-10-01 Burnham Institute For Medical Research INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-кB ACTIVATION
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
RU2391345C2 (ru) * 2008-07-23 2010-06-10 Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Южный Федеральный Университет" ДИГИДРОХЛОРИД 1-(3-МОРФОЛИНОПРОПИЛ)-2-ФЕНИЛИМИДАЗО[1,2-a]-БЕНЗИМИДАЗОЛА, ПРОЯВЛЯЮЩИЙ СВОЙСТВА АНТАГОНИСТА ПУРИНОВЫХ P2Y1-РЕЦЕПТОРОВ, АНТИАГРЕГАНТНУЮ И АНТИТРОМБОТИЧЕСКУЮ АКТИВНОСТЬ
CN103874702B (zh) * 2011-07-15 2015-12-09 杨森制药公司 作为γ分泌酶调节剂的经取代的吲哚衍生物
CA2995847C (en) * 2015-08-28 2024-05-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CN108250202B (zh) * 2018-01-15 2019-10-25 陕西师范大学 2,3-二取代苯并咪唑并[1,2-a]嘧啶类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732243A (en) * 1970-06-23 1973-05-08 Sankyo Co 2-(p-bromophenyl)-9-dimethyl-amino-propyl-9h-imidazo(1,2-a)benzimidazole
GB1476949A (en) * 1974-11-20 1977-06-16 Wyeth John & Brother Ltd Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
US5008282A (en) * 1988-12-28 1991-04-16 Kotobuki Seiyaku Co. Ltd. Cyclic guanidine derivatives, anti-ulceratives and methods of manufacturing the same

Also Published As

Publication number Publication date
DK0571253T3 (da) 1999-07-19
EP0571253A1 (fr) 1993-11-24
US5623073A (en) 1997-04-22
JP2506263B2 (ja) 1996-06-12
US5639756A (en) 1997-06-17
DE69321875T2 (de) 1999-06-17
EP0571253B1 (fr) 1998-11-04
AU3860893A (en) 1993-11-25
NZ247643A (en) 1995-07-26
CA2096475A1 (fr) 1993-11-20
DE69321875D1 (de) 1998-12-10
ATE172975T1 (de) 1998-11-15
JPH0687859A (ja) 1994-03-29
AU656466B2 (en) 1995-02-02

Similar Documents

Publication Publication Date Title
DE68901494D1 (de) Zusammensetzungen mit verzoegerten wirkstoffabgaben.
ATE172975T1 (de) Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung
FI914928A0 (fi) Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
FI921087A0 (fi) Nya estrar av tienylkarboxylsyror och aminoalkoholer, deras kvaterniseringsprodukter och framstaellning och anvaendning av naemnda foereningar.
IL89921A0 (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
FI943084A0 (fi) Uusia sulfonyyliaminopyrimidiinejä
ATE107499T1 (de) Haarkräftigungsmittel.
DE69122805D1 (de) Antivirusmittel
FI930429A0 (fi) Nya 1,4-dihyropyridinderivat
ES2127181T3 (es) 11-beta-aril-gona-4,9-dien-3-onas.
NZ240575A (en) N-benzoylproline derivatives and pharmaceutical compositions
IT9019754A0 (it) Composizioni farmaceutiche,dietetiche o veterinarie ad attivita' eumetabolica
KR910700089A (ko) 히드로클로로플루오로프로판의 공비 조성물 또는 공비형 조성물
IT1219712B (it) Perossiacidi eterociclici con eteroatomo "n" ammidico
FR2673055B1 (fr) Module d'amplification bibande.
EP0466662A3 (en) 6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same
DK142287D0 (da) Optisk aktive 1,4-dihydropyridinderivater
DK0552631T3 (da) Alfa-Aryl-alfa-hydroxy-beta-imidazolinyl-propionsyreamider
ATE40132T1 (de) 1,4-dihydropyridin-derivate und diese enthaltende pharmazeutische praeparate.
ES2116399T3 (es) Derivados tiazolicos de alcoxiacrilatos con una actividad fungicida.
IT8622051A1 (it) Composizioni farmaceutiche ad attivita' cicatrizzante
FI932013A0 (fi) Nya enantiomerer haerledda fraon (s)-2-amino-2-(3,4-diklorbensyl)-1-propanol
ITMI910759A0 (it) Composizione farmaceutica ad attivita' antivirale
DK0779075T3 (da) Anvendelse af 3-alpha-hydroxy-5-alpha-androsta-16-en som lægemidler
ITMI930768A0 (it) Dichiarazione ai sensi art. 4 del d.m. del 3 aprile 1981 (n. 2)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 571253

Country of ref document: ES