ATE173017T1 - Neues biologisches verfahren zur herstellung von 7-adca - Google Patents

Neues biologisches verfahren zur herstellung von 7-adca

Info

Publication number: ATE173017T1
Authority: AT; Austria
Prior art keywords: adipoyl; adca; strain; activity; apa
Prior art date: 1991-09-11

Application number

AT92308286T

Other languages

English (en)

Inventor

Michael J Conder

Lorilee Crawford

Phyllis C Mcada

John A Rambosek

Original Assignee

Gist Brocades Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-11

Filing date

1992-09-11

Publication date

1998-11-15

1992-09-11 Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE173017T1 publication Critical patent/ATE173017T1/de

Links

NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 title 1
230000031018 biological processes and functions Effects 0.000 title 1
241000228150 Penicillium chrysogenum Species 0.000 abstract 6
108020004414 DNA Proteins 0.000 abstract 3
101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 abstract 3
MIFYHUACUWQUKT-UHFFFAOYSA-N Isopenicillin N Natural products OC(=O)C1C(C)(C)SC2C(NC(=O)CCCC(N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-UHFFFAOYSA-N 0.000 abstract 3
MIFYHUACUWQUKT-QSKNDCFUSA-N isopenicillin n Chemical compound OC(=O)[C@@H]1C(C)(C)S[C@H]2[C@H](NC(=O)CCC[C@H](N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-QSKNDCFUSA-N 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108020004511 Recombinant DNA Proteins 0.000 abstract 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
239000001963 growth medium Substances 0.000 abstract 2
125000003651 hexanedioyl group Chemical group C(CCCCC(=O)*)(=O)* 0.000 abstract 2
101710095468 Cyclase Proteins 0.000 abstract 1
241000187433 Streptomyces clavuligerus Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 abstract 1
235000011037 adipic acid Nutrition 0.000 abstract 1
239000001361 adipic acid Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT92308286T 1991-09-11 1992-09-11 Neues biologisches verfahren zur herstellung von 7-adca ATE173017T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75787991A	1991-09-11	1991-09-11
US07/933,469 US5318896A (en)	1991-09-11	1992-08-28	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Publications (1)

Publication Number	Publication Date
ATE173017T1 true ATE173017T1 (de)	1998-11-15

Family

ID=27116462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308286T ATE173017T1 (de)	1991-09-11	1992-09-11	Neues biologisches verfahren zur herstellung von 7-adca

Country Status (25)

Country	Link
US (1)	US5318896A (de)
EP (2)	EP0843013A3 (de)
JP (2)	JP3027847B2 (de)
KR (2)	KR940702544A (de)
CN (2)	CN1066488C (de)
AT (1)	ATE173017T1 (de)
AU (1)	AU657787B2 (de)
BG (1)	BG62177B1 (de)
CA (1)	CA2077921C (de)
CZ (1)	CZ287357B6 (de)
DE (1)	DE69227494T2 (de)
DK (1)	DK0532341T3 (de)
ES (1)	ES2126588T3 (de)
FI (1)	FI108148B (de)
HU (1)	HU217171B (de)
IL (1)	IL103076A (de)
MX (1)	MX9205175A (de)
NO (1)	NO316742B1 (de)
NZ (1)	NZ244236A (de)
RO (1)	RO115886B1 (de)
RU (1)	RU2178808C2 (de)
SK (1)	SK282387B6 (de)
TW (1)	TW270149B (de)
UA (1)	UA41292C2 (de)
WO (1)	WO1993005158A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3789880T2 (de) *	1986-01-31	1994-09-08	Beecham Group Plc	Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
US6709859B1 (en)	1986-01-31	2004-03-23	Beecham Group P.L.C.	Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
KR100227711B1 (ko) *	1991-10-15	1999-12-01	한스 발터 라벤	7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
CZ285622B6 (cs) *	1993-07-30	1999-10-13	Gist-Brocades B. V.	Způsob výroby a izolace 7-aminodesacetoxycafalosporanové kyseliny, rekombinantní DNA vektor a hostitelská buňka
DE69434023D1 (de) *	1993-07-30	2004-10-28	Dsm Ip Assets Bv	Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA
RU2139349C1 (ru) *	1993-07-30	1999-10-10	Гист-Брокейдс Б.В.	Способ эффективного производства 7-адцк через 2-(карбоксиэтилтио) ацетил-7-адцк и 3-(карбоксиметилтио)пропионил-7-адцк
RU2139350C1 (ru) *	1993-07-30	1999-10-10	Гист-Брокейдс Б.В.	Способ эффективного производства 7-адцк через 3-(карбоксиэтилтио)пропионил-7-адцк
US5731165A (en) *	1995-06-02	1998-03-24	Gist-Brocades, B.V.	Process for the production of 7-ADCA via expandase activity on penicillin G
EP0863989A2 (de) *	1995-11-27	1998-09-16	Gist-Brocades B.V.	Verbessertes verfahren zur herstellung von halb-synthetischen cephalosporinen mittels einer auf penicilin g wirkenden expandaseaktivität
WO1997038107A1 (en) *	1996-04-04	1997-10-16	Gist-Brocades B.V.	An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
WO1998000382A1 (en)	1996-07-02	1998-01-08	Toray Industries, Inc.	Processes for the preparation of optically active ketones
WO1998002567A2 (en)	1996-07-16	1998-01-22	Gist-Brocades B.V.	PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
EP2345734A3 (de) *	1997-02-20	2012-03-21	DSM IP Assets B.V.	Fermentative Herstellung von Wertstoffen in industriellem Umfang durch Verwendung von chemisch definierten Media
ZA983383B (en) *	1997-04-22	1998-10-27	Gist Brocades Bv	Process for the fermentative production of cephalosporin
JP2000512860A (ja) *	1997-04-22	2000-10-03	ギストブロカデスベスローテンフェンノートシャップ	β―ラクタム抗生物質を調製する方法
ATE278032T1 (de) *	1997-04-22	2004-10-15	Dsm Ip Assets Bv	Verfahren zur fermentativen herstellung von deacylierten cephalosporinen
ZA983395B (en) *	1997-04-22	1999-01-27	Gist Brocades Bv	Process for the fermentative production of deacylated cephalosporins
ZA983396B (en) *	1997-04-22	1998-10-27	Gist Brocades Bv	A method for controlling the solubility of a beta-lactam nucleus
JP2002500015A (ja) *	1997-12-24	2002-01-08	アイシスイノヴェイションリミテッド	改変型デアセトキシセファロスポリンｃシンターゼ（ｄａｏｃｓ）およびｘ線構造
CN1138781C (zh) *	1998-03-27	2004-02-18	Dsm公司	从发酵液中回收头孢菌素类化合物的方法
US6383773B2 (en) *	1998-04-23	2002-05-07	Massachusetts Institute Of Technology	Penicillin conversion
CN101353660A (zh) *	1998-05-19	2009-01-28	Dsm公司	体内生产头孢菌素的改良
ES2165276B1 (es) *	1999-06-18	2003-03-01	Antibioticos Sau	Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
AU776184B2 (en)	2000-05-13	2004-09-02	Smithkline Beecham Plc	Process for the purification of a salt of clavulanic acid
WO2007073947A2 (en)	2005-12-28	2007-07-05	Dsm Ip Assets B.V.	Mutant type ii beta- lactam acylases
EP1987041B1 (de) *	2006-02-23	2013-05-22	DSM Sinochem Pharmaceuticals Netherlands B.V.	Verbesserte herstellung von cephalosporin
EP2123772A1 (de)	2008-04-29	2009-11-25	DSM IP Assets B.V.	Beta-Lactamantibiotikum produzierende Stämme
EP2310488B1 (de) *	2008-08-05	2012-09-19	DSM Sinochem Pharmaceuticals Netherlands B.V.	Adipoyl-7-adca produzierende stämme
WO2010015627A2 (en)	2008-08-05	2010-02-11	Dsm Ip Assets B.V.	Adipoyl-7-adca producing strains
WO2010015625A1 (en) *	2008-08-05	2010-02-11	Dsm Ip Assets B.V.	Adipoyl-7-adca producing strains
EP2414530A1 (de)	2009-04-03	2012-02-08	DSM Sinochem Pharmaceuticals Netherlands B.V.	Fermentationsverfahren
WO2011161004A1 (en)	2010-06-22	2011-12-29	Dsm Ip Assets B.V.	Air bubble fermentation process
WO2012032040A1 (en)	2010-09-07	2012-03-15	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Process for the production of cephalosporins
WO2012117038A1 (en)	2011-03-03	2012-09-07	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Degradation of penicillin compounds
WO2015091455A1 (en)	2013-12-17	2015-06-25	Dpx Holdings B.V.	Bioreactor
CN113699209B (zh) *	2021-08-30	2023-05-02	浙江昂利康制药股份有限公司	一种7-adca回收方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1270852A (fr) *	1960-09-20	1961-09-01	Bayer Ag	Procédé d'acylation enzymatique d'acide 6-aminopénicillanique
DE3789880T2 (de) *	1986-01-31	1994-09-08	Beecham Group Plc	Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
IL81555A0 (en) *	1986-11-17	1987-09-16	Baldwin Jack Edward	Enzymatic process for 3-substituted cephalosporins
ES2058141T3 (es) *	1987-01-17	1994-11-01	Hoechst Ag	Utilizacion de gamma-glutamil-transpeptidasa.
US5070020A (en) *	1988-05-09	1991-12-03	Eli Lilly And Company	Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5108918A (en) *	1988-08-11	1992-04-28	Gist-Brocades	Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
IL95766A (en) *	1989-09-27	1996-12-05	Lilly Co Eli	Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity
KR0171897B1 (ko) *	1989-12-27	1999-02-01	후지사와 도모끼찌로	7-아미노세펨 화합물 또는 그 염류의 제조 방법
KR100227711B1 (ko) *	1991-10-15	1999-12-01	한스 발터 라벤	7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

1992
- 1992-08-28 US US07/933,469 patent/US5318896A/en not_active Expired - Lifetime
- 1992-09-07 NZ NZ244236A patent/NZ244236A/en not_active IP Right Cessation
- 1992-09-07 IL IL10307692A patent/IL103076A/en not_active IP Right Cessation
- 1992-09-10 CN CN92112278A patent/CN1066488C/zh not_active Expired - Lifetime
- 1992-09-10 CA CA002077921A patent/CA2077921C/en not_active Expired - Fee Related
- 1992-09-10 MX MX9205175A patent/MX9205175A/es unknown
- 1992-09-11 UA UA94005434A patent/UA41292C2/uk unknown
- 1992-09-11 EP EP97203374A patent/EP0843013A3/de not_active Withdrawn
- 1992-09-11 AU AU23542/92A patent/AU657787B2/en not_active Ceased
- 1992-09-11 ES ES92308286T patent/ES2126588T3/es not_active Expired - Lifetime
- 1992-09-11 EP EP92308286A patent/EP0532341B1/de not_active Expired - Lifetime
- 1992-09-11 KR KR1019940700777A patent/KR940702544A/ko active Granted
- 1992-09-11 SK SK288-94A patent/SK282387B6/sk unknown
- 1992-09-11 KR KR1019940700777A patent/KR0132440B1/ko not_active Expired - Fee Related
- 1992-09-11 RO RO94-00380A patent/RO115886B1/ro unknown
- 1992-09-11 WO PCT/US1992/007711 patent/WO1993005158A1/en not_active Ceased
- 1992-09-11 RU RU94017674/13A patent/RU2178808C2/ru not_active IP Right Cessation
- 1992-09-11 AT AT92308286T patent/ATE173017T1/de not_active IP Right Cessation
- 1992-09-11 HU HU9400715A patent/HU217171B/hu not_active IP Right Cessation
- 1992-09-11 DE DE69227494T patent/DE69227494T2/de not_active Expired - Fee Related
- 1992-09-11 DK DK92308286T patent/DK0532341T3/da active
- 1992-09-11 CZ CZ1994532A patent/CZ287357B6/cs not_active IP Right Cessation
- 1992-09-11 JP JP5505516A patent/JP3027847B2/ja not_active Expired - Fee Related
- 1992-09-19 TW TW081107399A patent/TW270149B/zh active
1994
- 1994-03-09 BG BG98643A patent/BG62177B1/bg unknown
- 1994-03-10 NO NO19940848A patent/NO316742B1/no unknown
- 1994-03-10 FI FI941135A patent/FI108148B/fi active
1999
- 1999-08-26 JP JP11239731A patent/JP3072101B2/ja not_active Expired - Fee Related
2000
- 2000-08-31 CN CN00126889A patent/CN1332247A/zh active Pending

Also Published As

Publication number	Publication date
TW270149B (de)	1996-02-11
JP2000060582A (ja)	2000-02-29
EP0532341B1 (de)	1998-11-04
MX9205175A (es)	1994-02-28
FI108148B (fi)	2001-11-30
EP0843013A3 (de)	1998-06-17
JPH07501931A (ja)	1995-03-02
DK0532341T3 (da)	1999-07-19
CA2077921A1 (en)	1993-03-12
AU657787B2 (en)	1995-03-23
BG62177B1 (bg)	1999-04-30
ES2126588T3 (es)	1999-04-01
SK282387B6 (sk)	2002-01-07
CZ53294A3 (en)	1994-08-17
HU9400715D0 (en)	1994-06-28
WO1993005158A1 (en)	1993-03-18
NO316742B1 (no)	2004-04-26
US5318896A (en)	1994-06-07
HU217171B (hu)	1999-12-28
DE69227494T2 (de)	1999-04-08
CN1066488C (zh)	2001-05-30
HUT69801A (en)	1995-09-28
JP3027847B2 (ja)	2000-04-04
KR940702544A (ko)	1994-08-20
UA41292C2 (uk)	2001-09-17
EP0532341A1 (de)	1993-03-17
BG98643A (bg)	1995-03-31
NO940848L (no)	1994-03-10
IL103076A (en)	1996-10-31
CZ287357B6 (cs)	2000-11-15
KR0132440B1 (ko)	1998-04-14
AU2354292A (en)	1993-03-18
CN1332247A (zh)	2002-01-23
NO940848D0 (no)	1994-03-10
EP0843013A2 (de)	1998-05-20
RU2178808C2 (ru)	2002-01-27
JP3072101B2 (ja)	2000-07-31
FI941135L (fi)	1994-03-10
NZ244236A (en)	1994-03-25
FI941135A0 (fi)	1994-03-10
IL103076A0 (en)	1993-02-21
CA2077921C (en)	1998-11-24
SK28894A3 (en)	1994-09-07
DE69227494D1 (de)	1998-12-10
CN1075336A (zh)	1993-08-18
RO115886B1 (ro)	2000-07-28

Legal Events

Date	Code	Title
1999-05-15	UEP	Publication of translation of european patent specification
2000-04-15	EEIH	Change in the person of patent owner
2011-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE173017T1 (de)	1998-11-15	Neues biologisches verfahren zur herstellung von 7-adca
RU2002130702A (ru)	2004-05-20	Новый биологический способ получения 7-ацк и 7-адац
DE69031710D1 (de)	1997-12-18	Verfahren zur herstellung eines proteins mittels eines durch mehrfachkopieintegrierung eines expressionsvektors transformierten pilzes
KR960704048A (ko)	1996-08-31	3-(카르복시에틸티오) 프로피오닐-7-adca를 경유하여 7-adca를 제조하는 효율적인 방법(process for the efficient production of 7-adca via 3(carboxyethylth io)-propionyl-7-adca)
EP0828850B1 (de)	2001-11-21	Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase
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