ATE173017T1 - Neues biologisches verfahren zur herstellung von 7-adca - Google Patents

Neues biologisches verfahren zur herstellung von 7-adca

Info

Publication number: ATE173017T1
Authority: AT; Austria
Prior art keywords: adipoyl; adca; strain; activity; apa
Prior art date: 1991-09-11

Application number

AT92308286T

Other languages

English (en)

Inventor

Michael J Conder

Lorilee Crawford

Phyllis C Mcada

John A Rambosek

Original Assignee

Gist Brocades Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-11

Filing date

1992-09-11

Publication date

1998-11-15

1992-09-11 Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE173017T1 publication Critical patent/ATE173017T1/de

Links

NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 title 1
230000031018 biological processes and functions Effects 0.000 title 1
241000228150 Penicillium chrysogenum Species 0.000 abstract 6
108020004414 DNA Proteins 0.000 abstract 3
101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 abstract 3
MIFYHUACUWQUKT-UHFFFAOYSA-N Isopenicillin N Natural products OC(=O)C1C(C)(C)SC2C(NC(=O)CCCC(N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-UHFFFAOYSA-N 0.000 abstract 3
MIFYHUACUWQUKT-QSKNDCFUSA-N isopenicillin n Chemical compound OC(=O)[C@@H]1C(C)(C)S[C@H]2[C@H](NC(=O)CCC[C@H](N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-QSKNDCFUSA-N 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108020004511 Recombinant DNA Proteins 0.000 abstract 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
239000001963 growth medium Substances 0.000 abstract 2
125000003651 hexanedioyl group Chemical group C(CCCCC(=O)*)(=O)* 0.000 abstract 2
101710095468 Cyclase Proteins 0.000 abstract 1
241000187433 Streptomyces clavuligerus Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 abstract 1
235000011037 adipic acid Nutrition 0.000 abstract 1
239000001361 adipic acid Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)

AT92308286T 1991-09-11 1992-09-11 Neues biologisches verfahren zur herstellung von 7-adca ATE173017T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75787991A	1991-09-11	1991-09-11
US07/933,469 US5318896A (en)	1991-09-11	1992-08-28	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Publications (1)

Publication Number	Publication Date
ATE173017T1 true ATE173017T1 (de)	1998-11-15

Family

ID=27116462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308286T ATE173017T1 (de)	1991-09-11	1992-09-11	Neues biologisches verfahren zur herstellung von 7-adca

Country Status (25)

Country	Link
US (1)	US5318896A (de)
EP (2)	EP0843013A3 (de)
JP (2)	JP3027847B2 (de)
KR (2)	KR940702544A (de)
CN (2)	CN1066488C (de)
AT (1)	ATE173017T1 (de)
AU (1)	AU657787B2 (de)
BG (1)	BG62177B1 (de)
CA (1)	CA2077921C (de)
CZ (1)	CZ287357B6 (de)
DE (1)	DE69227494T2 (de)
DK (1)	DK0532341T3 (de)
ES (1)	ES2126588T3 (de)
FI (1)	FI108148B (de)
HU (1)	HU217171B (de)
IL (1)	IL103076A (de)
MX (1)	MX9205175A (de)
NO (1)	NO316742B1 (de)
NZ (1)	NZ244236A (de)
RO (1)	RO115886B1 (de)
RU (1)	RU2178808C2 (de)
SK (1)	SK282387B6 (de)
TW (1)	TW270149B (de)
UA (1)	UA41292C2 (de)
WO (1)	WO1993005158A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6709859B1 (en)	1986-01-31	2004-03-23	Beecham Group P.L.C.	Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) *	1986-01-31	1994-09-08	Beecham Group Plc	Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
SK280569B6 (sk) *	1991-10-15	2000-03-13	Gist-Brocades B.V.	Biologický spôsob výroby kyseliny7-aminodeacetylce
PT711348E (pt) *	1993-07-30	2003-08-29	Dsm Nv	Processo para a eficiente producao de 7-adca por via de 3-(carboxietiltio)propionil-7-adca
RU2139350C1 (ru) *	1993-07-30	1999-10-10	Гист-Брокейдс Б.В.	Способ эффективного производства 7-адцк через 3-(карбоксиэтилтио)пропионил-7-адцк
KR100336174B1 (ko) *	1993-07-30	2002-11-01	디에스엠 기스트 베.파우.	2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
RU2139349C1 (ru) *	1993-07-30	1999-10-10	Гист-Брокейдс Б.В.	Способ эффективного производства 7-адцк через 2-(карбоксиэтилтио) ацетил-7-адцк и 3-(карбоксиметилтио)пропионил-7-адцк
US5731165A (en) *	1995-06-02	1998-03-24	Gist-Brocades, B.V.	Process for the production of 7-ADCA via expandase activity on penicillin G
EP0863989A2 (de) *	1995-11-27	1998-09-16	Gist-Brocades B.V.	Verbessertes verfahren zur herstellung von halb-synthetischen cephalosporinen mittels einer auf penicilin g wirkenden expandaseaktivität
WO1997038107A1 (en) *	1996-04-04	1997-10-16	Gist-Brocades B.V.	An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
US6320069B1 (en)	1996-07-02	2001-11-20	Toray Industries, Inc.	Production of optically active ketone
AU4201897A (en)	1996-07-16	1998-02-09	Gist-Brocades B.V.	Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
PL335227A1 (en) *	1997-02-20	2000-04-10	Dsm Nv	Industrial-scale production of valuable compounds by fermentation in a chemically defined medium
BR9804858A (pt) *	1997-04-22	1999-08-24	Gist Brocades Bv	M-todo de prepara-Æo de antibiÄtico b-lactam
WO1998048037A1 (en) *	1997-04-22	1998-10-29	Dsm N.V.	A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS
AU7648898A (en) *	1997-04-22	1998-11-13	Gist-Brocades B.V.	Process for the fermentative production of deacylated cephalosporins
SI0915988T1 (en) *	1997-04-22	2003-06-30	Dsm N.V.	Process for the fermentative production of deacylated cephalosporins
US6319684B1 (en)	1997-04-22	2001-11-20	Dms N.V.	Process for the fermentative production of cephalosporin
AU1772099A (en) *	1997-12-24	1999-07-19	Isis Innovation Limited	Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure
ES2186347T3 (es) *	1998-03-27	2003-05-01	Dsm Nv	Nuevo procedimiento de produccion por fermentacion de cefalosporina.
US6383773B2 (en) *	1998-04-23	2002-05-07	Massachusetts Institute Of Technology	Penicillin conversion
PL344863A1 (en) *	1998-05-19	2001-11-19	Dsm Nv	Improved in vivo
ES2165276B1 (es) *	1999-06-18	2003-03-01	Antibioticos Sau	Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
BRPI0110774B8 (pt)	2000-05-13	2021-05-25	Smithkline Beecham Plc	processo para purificação de um sal de ácido clavulânico
BRPI0621278A2 (pt)	2005-12-28	2011-12-06	Dsm Ip Assests Bv	acilases mutantes
ES2423454T3 (es) *	2006-02-23	2013-09-20	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Producción mejorada de cefalosporina
EP2123772A1 (de)	2008-04-29	2009-11-25	DSM IP Assets B.V.	Beta-Lactamantibiotikum produzierende Stämme
CN102119213A (zh) *	2008-08-05	2011-07-06	帝斯曼知识产权资产管理有限公司	生产己二酰基-7-adca的菌株
CN102131921A (zh)	2008-08-05	2011-07-20	帝斯曼知识产权资产管理有限公司	生产己二酰基-7-adca的菌株
CN102131917A (zh) *	2008-08-05	2011-07-20	帝斯曼知识产权资产管理有限公司	生产己二酰基-7-adca的菌株
WO2010115838A1 (en)	2009-04-03	2010-10-14	Dsm Ip Assets B.V.	Fermentation process
HUE035540T2 (en)	2010-06-22	2018-05-02	Dsm Sinochem Pharm Nl Bv	Air bubble fermentation process
EP2614066B1 (de)	2010-09-07	2017-11-29	DSM Sinochem Pharmaceuticals Netherlands B.V.	Verfahren zur herstellung von cephalosporinen
EA023822B1 (ru)	2011-03-03	2016-07-29	Дсм Синокем Фармасьютикалз Нидерландз Б.В.	Разложение соединений пенициллина
WO2015091455A1 (en)	2013-12-17	2015-06-25	Dpx Holdings B.V.	Bioreactor
CN113699209B (zh) *	2021-08-30	2023-05-02	浙江昂利康制药股份有限公司	一种7-adca回收方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1270852A (fr) *	1960-09-20	1961-09-01	Bayer Ag	Procédé d'acylation enzymatique d'acide 6-aminopénicillanique
DE3789880T2 (de) *	1986-01-31	1994-09-08	Beecham Group Plc	Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
HUT43644A (en) *	1986-11-17	1987-11-30	Univ Oxford	Process for producing 3-substituted-cephalosporines
DE3881531D1 (de) *	1987-01-17	1993-07-15	Hoechst Ag	Verwendung von gamma-glutamyl-transpeptidase.
US5070020A (en) *	1988-05-09	1991-12-03	Eli Lilly And Company	Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5108918A (en) *	1988-08-11	1992-04-28	Gist-Brocades	Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
IL95766A (en) *	1989-09-27	1996-12-05	Lilly Co Eli	Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity
KR0171897B1 (ko) *	1989-12-27	1999-02-01	후지사와 도모끼찌로	7-아미노세펨 화합물 또는 그 염류의 제조 방법
SK280569B6 (sk) *	1991-10-15	2000-03-13	Gist-Brocades B.V.	Biologický spôsob výroby kyseliny7-aminodeacetylce

1992
- 1992-08-28 US US07/933,469 patent/US5318896A/en not_active Expired - Lifetime
- 1992-09-07 IL IL10307692A patent/IL103076A/en not_active IP Right Cessation
- 1992-09-07 NZ NZ244236A patent/NZ244236A/en not_active IP Right Cessation
- 1992-09-10 CA CA002077921A patent/CA2077921C/en not_active Expired - Fee Related
- 1992-09-10 MX MX9205175A patent/MX9205175A/es unknown
- 1992-09-10 CN CN92112278A patent/CN1066488C/zh not_active Expired - Lifetime
- 1992-09-11 DK DK92308286T patent/DK0532341T3/da active
- 1992-09-11 RU RU94017674/13A patent/RU2178808C2/ru not_active IP Right Cessation
- 1992-09-11 CZ CZ1994532A patent/CZ287357B6/cs not_active IP Right Cessation
- 1992-09-11 UA UA94005434A patent/UA41292C2/uk unknown
- 1992-09-11 RO RO94-00380A patent/RO115886B1/ro unknown
- 1992-09-11 KR KR1019940700777A patent/KR940702544A/ko active Granted
- 1992-09-11 ES ES92308286T patent/ES2126588T3/es not_active Expired - Lifetime
- 1992-09-11 EP EP97203374A patent/EP0843013A3/de not_active Withdrawn
- 1992-09-11 HU HU9400715A patent/HU217171B/hu not_active IP Right Cessation
- 1992-09-11 WO PCT/US1992/007711 patent/WO1993005158A1/en not_active Ceased
- 1992-09-11 AU AU23542/92A patent/AU657787B2/en not_active Ceased
- 1992-09-11 AT AT92308286T patent/ATE173017T1/de not_active IP Right Cessation
- 1992-09-11 DE DE69227494T patent/DE69227494T2/de not_active Expired - Fee Related
- 1992-09-11 KR KR1019940700777A patent/KR0132440B1/ko not_active Expired - Fee Related
- 1992-09-11 SK SK288-94A patent/SK282387B6/sk unknown
- 1992-09-11 JP JP5505516A patent/JP3027847B2/ja not_active Expired - Fee Related
- 1992-09-11 EP EP92308286A patent/EP0532341B1/de not_active Expired - Lifetime
- 1992-09-19 TW TW081107399A patent/TW270149B/zh active
1994
- 1994-03-09 BG BG98643A patent/BG62177B1/bg unknown
- 1994-03-10 NO NO19940848A patent/NO316742B1/no unknown
- 1994-03-10 FI FI941135A patent/FI108148B/fi active
1999
- 1999-08-26 JP JP11239731A patent/JP3072101B2/ja not_active Expired - Fee Related
2000
- 2000-08-31 CN CN00126889A patent/CN1332247A/zh active Pending

Also Published As

Publication number	Publication date
CA2077921C (en)	1998-11-24
BG62177B1 (bg)	1999-04-30
JPH07501931A (ja)	1995-03-02
FI941135L (fi)	1994-03-10
NO940848L (no)	1994-03-10
JP3072101B2 (ja)	2000-07-31
CA2077921A1 (en)	1993-03-12
DE69227494D1 (de)	1998-12-10
NZ244236A (en)	1994-03-25
KR0132440B1 (ko)	1998-04-14
HUT69801A (en)	1995-09-28
WO1993005158A1 (en)	1993-03-18
SK282387B6 (sk)	2002-01-07
MX9205175A (es)	1994-02-28
IL103076A (en)	1996-10-31
ES2126588T3 (es)	1999-04-01
EP0532341B1 (de)	1998-11-04
FI108148B (fi)	2001-11-30
BG98643A (bg)	1995-03-31
CN1332247A (zh)	2002-01-23
KR940702544A (ko)	1994-08-20
HU9400715D0 (en)	1994-06-28
NO316742B1 (no)	2004-04-26
DE69227494T2 (de)	1999-04-08
CZ287357B6 (cs)	2000-11-15
US5318896A (en)	1994-06-07
FI941135A0 (fi)	1994-03-10
EP0843013A2 (de)	1998-05-20
JP2000060582A (ja)	2000-02-29
AU657787B2 (en)	1995-03-23
IL103076A0 (en)	1993-02-21
NO940848D0 (no)	1994-03-10
CN1075336A (zh)	1993-08-18
HU217171B (hu)	1999-12-28
CN1066488C (zh)	2001-05-30
EP0532341A1 (de)	1993-03-17
DK0532341T3 (da)	1999-07-19
AU2354292A (en)	1993-03-18
RO115886B1 (ro)	2000-07-28
SK28894A3 (en)	1994-09-07
JP3027847B2 (ja)	2000-04-04
EP0843013A3 (de)	1998-06-17
UA41292C2 (uk)	2001-09-17
CZ53294A3 (en)	1994-08-17
TW270149B (de)	1996-02-11
RU2178808C2 (ru)	2002-01-27

Legal Events

Date	Code	Title
1999-05-15	UEP	Publication of translation of european patent specification
2000-04-15	EEIH	Change in the person of patent owner
2011-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69227494D1 (de)	1998-12-10	Neues biologisches Verfahren zur Herstellung von 7-ADCA
RU2002130702A (ru)	2004-05-20	Новый биологический способ получения 7-ацк и 7-адац
DE69031710D1 (de)	1997-12-18	Verfahren zur herstellung eines proteins mittels eines durch mehrfachkopieintegrierung eines expressionsvektors transformierten pilzes
DE69233459D1 (de)	2005-01-20	Herstellung von gamma-linolensäure durch eine delta-6 desaturase
KR960704048A (ko)	1996-08-31	3-(카르복시에틸티오) 프로피오닐-7-adca를 경유하여 7-adca를 제조하는 효율적인 방법(process for the efficient production of 7-adca via 3(carboxyethylth io)-propionyl-7-adca)
EP0828850B1 (de)	2001-11-21	Verfahren zur herstellung von 7-adca durch umsetzung penicillins g mittels expandase
ATE137803T1 (de)	1996-05-15	Verfahren zur herstellung von 7-aminocephem- verbindungen oder deren salzen
DE68926893D1 (de)	1996-09-05	Verfahren zur Herstellung von clavulanic Säure
ATE92532T1 (de)	1993-08-15	Verfahren zur herstellung von polysacchariden.
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