ATE173258T1 - Kondensierte pyridin derivate als hemmer von effekten freier radikaler - Google Patents

Kondensierte pyridin derivate als hemmer von effekten freier radikaler

Info

Publication number: ATE173258T1
Authority: AT; Austria
Prior art keywords: alkyl; nz1z2; alkoxy; phenyl; inhibiters
Prior art date: 1992-08-27

Application number

AT93402095T

Other languages

English (en)

Inventor

Andre Bachy

Laurent Fraisse

Peter Keane

Etienne Mendes

Jean-Claude Vernieres

Jacques Simiand

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-27

Filing date

1993-08-25

Publication date

1998-11-15

1993-08-25 Application filed by Sanofi Sa filed Critical Sanofi Sa

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE173258T1 publication Critical patent/ATE173258T1/de

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
150000003254 radicals Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
-1 benzyloxy, benzyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrrole Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Toys (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

AT93402095T 1992-08-27 1993-08-25 Kondensierte pyridin derivate als hemmer von effekten freier radikaler ATE173258T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9210329A FR2695126B1 (fr)	1992-08-27	1992-08-27	Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (1)

Publication Number	Publication Date
ATE173258T1 true ATE173258T1 (de)	1998-11-15

Family

ID=9433050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93402095T ATE173258T1 (de)	1992-08-27	1993-08-25	Kondensierte pyridin derivate als hemmer von effekten freier radikaler

Country Status (17)

Country	Link
US (2)	US5360799A (de)
EP (1)	EP0587473B1 (de)
JP (1)	JPH06184145A (de)
KR (1)	KR100267802B1 (de)
AT (1)	ATE173258T1 (de)
AU (1)	AU659027B2 (de)
CA (1)	CA2104883A1 (de)
DE (1)	DE69322033T2 (de)
DK (1)	DK0587473T3 (de)
ES (1)	ES2125315T3 (de)
FI (1)	FI103889B1 (de)
FR (1)	FR2695126B1 (de)
GR (1)	GR3029283T3 (de)
HU (1)	HU217623B (de)
MX (1)	MX9305181A (de)
NO (1)	NO300845B1 (de)
NZ (1)	NZ248498A (de)

Families Citing this family (34)

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Publication number	Priority date	Publication date	Assignee	Title
CA2492922A1 (en) *	2002-07-19	2004-01-29	Pharmacia Corporation	Substituted thiophene carboxamide compounds for the treatment of inflammation
GB0522715D0 (en)	2005-11-08	2005-12-14	Helperby Therapeutics Ltd	New use
CN103214484B (zh)	2005-12-13	2016-07-06	因塞特控股公司	作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶
AU2008249745B2 (en) *	2007-05-09	2012-01-12	Pfizer Inc.	Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
ES2483728T3 (es) *	2007-06-08	2014-08-07	Dart Neuroscience (Cayman) Ltd	Derivados terapéuticos de pirazolonafatiridina
AR068063A1 (es)	2007-08-27	2009-11-04	Basf Plant Science Gmbh	Co mpuestos de pirazol para controlar plagas de invertebrados
AR070479A1 (es) *	2008-02-26	2010-04-07	Takeda Pharmaceutical	Derivado heterociclico fusionado y su uso
WO2010034737A1 (en)	2008-09-24	2010-04-01	Basf Se	Pyrazole compounds for controlling invertebrate pests
EP2432472B1 (de)	2009-05-22	2019-10-02	Incyte Holdings Corporation	3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- oder heptannitril als jak-inhibitoren
MY156727A (en)	2009-05-22	2016-03-15	Incyte Corp	N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
ES2472918T3 (es)	2009-07-06	2014-07-03	Basf Se	Compuestos de piridazina para controlar plagas de invertebrados
BR112012001597A2 (pt)	2009-07-24	2015-09-01	Basf Se	Método para controlar e/ou combater pestes de invertebrados, método para a proteção do material de propagação de planta e/ou das plantas que crescem do mesmo, material de propagação de planta e método para tratar ou proteger um animal de infestação ou infecção por parasitas
TW201113285A (en)	2009-09-01	2011-04-16	Incyte Corp	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (de)	2010-03-10	2020-05-06	Incyte Holdings Corporation	Piperidin-4-yl azetidin-derivate als jak1-inhibitoren
CA2818542A1 (en)	2010-11-19	2012-05-24	Incyte Corporation	Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
MY165963A (en)	2011-06-20	2018-05-18	Incyte Holdings Corp	Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
JP6359546B2 (ja)	2012-11-01	2018-07-18	インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅＨｏｌｄｉｎｇｓＣｏｒｐｏｒａｔｉｏｎ	Ｊａｋ阻害薬としての三環式縮合チオフェン誘導体
TWI761825B (zh)	2012-11-15	2022-04-21	美商英塞特控股公司	盧梭利替尼之緩釋性劑型
MX384910B (es)	2013-03-06	2025-03-14	Incyte Holdings Corp	Procesos e intermedios para hacer un inhibidor de jak.
SG11201600815WA (en)	2013-08-07	2016-03-30	Incyte Corp	Sustained release dosage forms for a jak1 inhibitor
BR112016025427A2 (pt)	2014-04-30	2017-08-15	Incyte Corp	processos de preparação de um inibidor de jak1 e formas do mesmo
WO2015184305A1 (en)	2014-05-30	2015-12-03	Incyte Corporation	TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3377490A1 (de)	2015-11-16	2018-09-26	Fundacion para la Investigacion Medica Aplicada	Neuartige verbindungen als inhibitoren von dna-methyltransferasen
CN113768934A (zh)	2018-03-30	2021-12-10	因赛特公司	使用jak抑制剂治疗化脓性汗腺炎
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
KR20240101561A (ko)	2021-10-14	2024-07-02	인사이트 코포레이션	Kras의 저해제로서의 퀴놀린 화합물
US11897883B1 (en)	2023-09-01	2024-02-13	King Faisal University	Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en)	2023-09-06	2024-02-06	King Faisal University	Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en)	2023-09-15	2024-01-09	King Faisal University	1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en)	2023-12-14	2024-04-09	King Faisal University	Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors
WO2026076207A1 (en) *	2024-10-04	2026-04-09	Incyte Corporation	Tricyclic heteroaryl compounds as inhibitors of tyk2 and/or jak1

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US3887570A (en) *	1973-09-28	1975-06-03	Squibb & Sons Inc	Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

1992
- 1992-08-27 FR FR9210329A patent/FR2695126B1/fr not_active Expired - Fee Related
1993
- 1993-08-19 US US08/109,073 patent/US5360799A/en not_active Expired - Fee Related
- 1993-08-20 AU AU44747/93A patent/AU659027B2/en not_active Ceased
- 1993-08-25 ES ES93402095T patent/ES2125315T3/es not_active Expired - Lifetime
- 1993-08-25 DK DK93402095T patent/DK0587473T3/da active
- 1993-08-25 DE DE69322033T patent/DE69322033T2/de not_active Expired - Fee Related
- 1993-08-25 AT AT93402095T patent/ATE173258T1/de not_active IP Right Cessation
- 1993-08-25 NZ NZ248498A patent/NZ248498A/en unknown
- 1993-08-25 EP EP93402095A patent/EP0587473B1/de not_active Expired - Lifetime
- 1993-08-26 CA CA002104883A patent/CA2104883A1/fr not_active Abandoned
- 1993-08-26 NO NO933051A patent/NO300845B1/no not_active IP Right Cessation
- 1993-08-26 JP JP5211451A patent/JPH06184145A/ja active Pending
- 1993-08-26 FI FI933756A patent/FI103889B1/fi active
- 1993-08-26 HU HU9302425A patent/HU217623B/hu not_active IP Right Cessation
- 1993-08-26 MX MX9305181A patent/MX9305181A/es not_active IP Right Cessation
- 1993-08-27 KR KR1019930017022A patent/KR100267802B1/ko not_active Expired - Fee Related
1994
- 1994-07-12 US US08/273,943 patent/US5468750A/en not_active Expired - Fee Related
1999
- 1999-02-03 GR GR990400363T patent/GR3029283T3/el unknown

Also Published As

Publication number	Publication date
EP0587473B1 (de)	1998-11-11
FI933756L (fi)	1994-02-28
NZ248498A (en)	1994-09-27
KR940003958A (ko)	1994-03-14
AU659027B2 (en)	1995-05-04
FI103889B (fi)	1999-10-15
AU4474793A (en)	1994-03-03
DE69322033T2 (de)	1999-06-17
NO300845B1 (no)	1997-08-04
HU217623B (hu)	2000-03-28
US5360799A (en)	1994-11-01
DE69322033D1 (de)	1998-12-17
MX9305181A (es)	1994-06-30
FI933756A0 (fi)	1993-08-26
US5468750A (en)	1995-11-21
ES2125315T3 (es)	1999-03-01
FR2695126B1 (fr)	1994-11-10
CA2104883A1 (fr)	1994-02-28
HU9302425D0 (en)	1993-11-29
FI103889B1 (fi)	1999-10-15
NO933051D0 (no)	1993-08-26
HUT64957A (en)	1994-03-28
DK0587473T3 (da)	1999-07-26
NO933051L (no)	1994-02-28
GR3029283T3 (en)	1999-05-28
FR2695126A1 (fr)	1994-03-04
EP0587473A1 (de)	1994-03-16
KR100267802B1 (ko)	2000-11-01
JPH06184145A (ja)	1994-07-05

Legal Events

Date	Code	Title	Description
1999-09-15	UEP	Publication of translation of european patent specification
2002-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69322033D1 (de)	1998-12-17	Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler
ATE345122T1 (de)	2006-12-15	Stabile emulsionszubereitungen
DK1256569T3 (da)	2010-10-11	Phenacylamin-derivater, fremstilling deraf samt skadedyrsmiddel indeholdende disse derivater
ATE178894T1 (de)	1999-04-15	Herbizide 2,6-substituierte pyridine
NO923126D0 (no)	1992-08-11	Preparat og metode for behandling av canser
DE69414019D1 (de)	1998-11-26	Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren
KR930009997A (ko)	1993-06-21	히드록시피리돈카르복스아미드, 그의 제조 방법 및 용도
KR910019994A (ko)	1991-12-19	시클로헥센온 옥심 에테르, 이들의 제조방법, 이들의 제조를 위한 중간체 및 이들의 제초제로서의 용도
ATE124403T1 (de)	1995-07-15	Barbitursäurederivate mit insektizider wirkung.
ATE71486T1 (de)	1992-02-15	Herbizide mittel.
YU165791A (sh)	1994-05-10	Postupak za pripremanje derivata 8-hlorohinolona
ATE80396T1 (de)	1992-09-15	Alpha-hydroxy-azolylethyloxirane und diese enthaltende fungizide.
DE3277815D1 (en)	1988-01-21	Herbicidal compositions containing heterocyclic pentalenes
ATE148462T1 (de)	1997-02-15	Isoxazole derivate als lichtschutzmittel
MY104164A (en)	1994-02-28	Heterocyclic compounds.
DK44779A (da)	1979-02-02	2-chlorsulfinylazetidin-4-on-forbindelser til anvendelse som mellemprodukter ved fremstilling af 3-exomethylencephamsulfoxider
KR870000011A (ko)	1987-02-16	디클로로퀴놀린 유도체를 기초로한 제초 조성물