ATE173456T1 - Verfahren zur herstellung von zwischenprodukten zur synthese von antifungale mittel - Google Patents
Verfahren zur herstellung von zwischenprodukten zur synthese von antifungale mittelInfo
- Publication number
- ATE173456T1 ATE173456T1 AT95905849T AT95905849T ATE173456T1 AT E173456 T1 ATE173456 T1 AT E173456T1 AT 95905849 T AT95905849 T AT 95905849T AT 95905849 T AT95905849 T AT 95905849T AT E173456 T1 ATE173456 T1 AT E173456T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- antifungal agents
- intermediate products
- producing intermediate
- producing
- Prior art date
Links
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 239000003429 antifungal agent Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- -1 allylic halides Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- KDCQXNHIUCCTHE-UHFFFAOYSA-N oxolane;1h-pyrrole Chemical class C1CCOC1.C=1C=CNC=1 KDCQXNHIUCCTHE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
- C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/64—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by simultaneous introduction of -OH groups and halogens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/166,332 US5349099A (en) | 1993-12-13 | 1993-12-13 | Process for preparing intermediates for the synthesis of antifungal agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE173456T1 true ATE173456T1 (de) | 1998-12-15 |
Family
ID=22602818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95905849T ATE173456T1 (de) | 1993-12-13 | 1994-12-09 | Verfahren zur herstellung von zwischenprodukten zur synthese von antifungale mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5349099A (de) |
| EP (1) | EP0734369B1 (de) |
| JP (1) | JPH09507215A (de) |
| AT (1) | ATE173456T1 (de) |
| AU (1) | AU1430495A (de) |
| CA (1) | CA2178807A1 (de) |
| DE (1) | DE69414724T2 (de) |
| ES (1) | ES2123949T3 (de) |
| SG (1) | SG45428A1 (de) |
| WO (1) | WO1995016658A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5442093A (en) * | 1994-05-09 | 1995-08-15 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US6835860B2 (en) | 2002-02-01 | 2004-12-28 | Merck & Co., Inc. | Iodohydroxylation of olefins |
| AU2011254657B2 (en) * | 2010-05-19 | 2016-02-04 | Sandoz Ag | Preparation of posaconazole intermediates |
| EP2571847B1 (de) | 2010-05-19 | 2016-09-21 | Sandoz AG | Verfahren zur herstellung chiraler hydrazide |
| JP5955837B2 (ja) * | 2010-05-19 | 2016-07-20 | サンド・アクチエンゲゼルシヤフト | ポサコナゾール及びポサコナゾール中間体の精製 |
| CN102906087B (zh) | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性三唑酮的方法 |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| CN105622413B (zh) * | 2016-01-14 | 2017-11-24 | 宁波新凯生物科技有限公司 | 2‑[2‑(2，4‑二氟苯基)烯丙基]‑1，3‑丙二酸二乙酯的合成方法 |
| CN105622412B (zh) * | 2016-01-14 | 2017-11-24 | 宁波新凯生物科技有限公司 | 一种合成2‑[2‑(2，4‑二氟苯基)烯丙基]‑1，3‑丙二酸二乙酯的方法 |
| CN105732311B (zh) * | 2016-03-30 | 2017-12-22 | 宁波新凯生物科技有限公司 | 一种合成2‑[2‑(2，4‑二氟苯基)‑2‑丙烯‑1‑基]‑1，3‑丙二醇的方法 |
| CN105777486B (zh) * | 2016-03-30 | 2018-09-11 | 浙江大学宁波理工学院 | 一种2-[2-(2，4-二氟苯基)-2-丙烯-1-基]-1，3-丙二醇的合成方法 |
| CN105777539B (zh) * | 2016-03-30 | 2018-04-10 | 浙江大学宁波理工学院 | 一种2‑[2‑（2，4‑二氟苯基）烯丙基]‑1，3‑丙二酸二乙酯的合成方法 |
| CN114671737B (zh) * | 2022-04-18 | 2023-10-24 | 张家口市格瑞高新技术有限公司 | 一种泊沙康唑主环中间体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087473A (en) * | 1976-11-03 | 1978-05-02 | The Dow Chemical Company | Preferential aliphatic halogenation of ar-substituted alkylbenzenes |
| DE3852477T2 (de) * | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| FI97382C (fi) * | 1988-03-04 | 1996-12-10 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi |
| US4935564A (en) * | 1988-07-28 | 1990-06-19 | Dow Corning Corporation | Process for preparing alkyl halides |
| US5039676A (en) * | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
-
1993
- 1993-12-13 US US08/166,332 patent/US5349099A/en not_active Expired - Lifetime
-
1994
- 1994-12-09 DE DE69414724T patent/DE69414724T2/de not_active Expired - Lifetime
- 1994-12-09 AT AT95905849T patent/ATE173456T1/de not_active IP Right Cessation
- 1994-12-09 WO PCT/US1994/013778 patent/WO1995016658A1/en not_active Ceased
- 1994-12-09 JP JP7516792A patent/JPH09507215A/ja active Pending
- 1994-12-09 AU AU14304/95A patent/AU1430495A/en not_active Abandoned
- 1994-12-09 ES ES95905849T patent/ES2123949T3/es not_active Expired - Lifetime
- 1994-12-09 SG SG1996007448A patent/SG45428A1/en unknown
- 1994-12-09 EP EP95905849A patent/EP0734369B1/de not_active Expired - Lifetime
- 1994-12-09 CA CA002178807A patent/CA2178807A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69414724T2 (de) | 1999-05-27 |
| DE69414724D1 (de) | 1998-12-24 |
| AU1430495A (en) | 1995-07-03 |
| CA2178807A1 (en) | 1995-06-22 |
| US5349099A (en) | 1994-09-20 |
| WO1995016658A1 (en) | 1995-06-22 |
| JPH09507215A (ja) | 1997-07-22 |
| ES2123949T3 (es) | 1999-01-16 |
| EP0734369A1 (de) | 1996-10-02 |
| EP0734369B1 (de) | 1998-11-18 |
| SG45428A1 (en) | 1998-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |