ATE173732T1 - 8-(1-aminocycloalkyl)-1,3-dialkylxanthinderivat als antagonisten von adenosinrezeptoren - Google Patents
8-(1-aminocycloalkyl)-1,3-dialkylxanthinderivat als antagonisten von adenosinrezeptorenInfo
- Publication number
- ATE173732T1 ATE173732T1 AT93100723T AT93100723T ATE173732T1 AT E173732 T1 ATE173732 T1 AT E173732T1 AT 93100723 T AT93100723 T AT 93100723T AT 93100723 T AT93100723 T AT 93100723T AT E173732 T1 ATE173732 T1 AT E173732T1
- Authority
- AT
- Austria
- Prior art keywords
- aminocycloalkyl
- dialkylxanthine
- antagonists
- derivative
- adenosine receptors
- Prior art date
Links
- 102000009346 Adenosine receptors Human genes 0.000 title 1
- 108050000203 Adenosine receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920132A IT1260444B (it) | 1992-01-24 | 1992-01-24 | Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE173732T1 true ATE173732T1 (de) | 1998-12-15 |
Family
ID=11361662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93100723T ATE173732T1 (de) | 1992-01-24 | 1993-01-19 | 8-(1-aminocycloalkyl)-1,3-dialkylxanthinderivat als antagonisten von adenosinrezeptoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5378844B1 (de) |
| EP (1) | EP0552712B1 (de) |
| CN (1) | CN1035877C (de) |
| AT (1) | ATE173732T1 (de) |
| CA (1) | CA2087922C (de) |
| DE (1) | DE69322177T2 (de) |
| DK (1) | DK0552712T3 (de) |
| ES (1) | ES2125911T3 (de) |
| GR (1) | GR3029476T3 (de) |
| IT (1) | IT1260444B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928386B2 (ja) * | 1992-07-08 | 1999-08-03 | 協和醗酵工業株式会社 | うつ病治療剤 |
| DE4316576A1 (de) * | 1993-05-18 | 1994-11-24 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin |
| AU7546794A (en) * | 1993-09-06 | 1995-03-27 | Kyowa Hakko Kogyo Co. Ltd. | Depression remedy |
| US6117870A (en) * | 1998-11-12 | 2000-09-12 | Fujirebio Kabushiki Kaisha | Cyclic amide derivatives |
| MXPA02009755A (es) | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de proteina a-beta. |
| FR2814077A1 (fr) * | 2000-09-20 | 2002-03-22 | Inst Nat Sante Rech Med | Utilisation de modulateurs de recepteurs a l'adenosine pour reguler la fonction des netrines et/ou de leurs recepteurs |
| WO2004101558A1 (en) * | 2003-05-13 | 2004-11-25 | F. Hoffmann-La Roche Ag | 2-imidazo-benzothiazoles as adenosine receptor ligands |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2879271A (en) * | 1953-07-23 | 1959-03-24 | Knoll Ag | Basic derivatives of mono- and dimethyl xanthines, and a process of making same |
| EP0011399A1 (de) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| JP2843634B2 (ja) * | 1989-03-06 | 1999-01-06 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
-
1992
- 1992-01-24 IT ITMI920132A patent/IT1260444B/it active IP Right Grant
-
1993
- 1993-01-19 AT AT93100723T patent/ATE173732T1/de not_active IP Right Cessation
- 1993-01-19 ES ES93100723T patent/ES2125911T3/es not_active Expired - Lifetime
- 1993-01-19 EP EP93100723A patent/EP0552712B1/de not_active Expired - Lifetime
- 1993-01-19 DE DE69322177T patent/DE69322177T2/de not_active Expired - Fee Related
- 1993-01-19 DK DK93100723T patent/DK0552712T3/da active
- 1993-01-22 CN CN93102055A patent/CN1035877C/zh not_active Expired - Fee Related
- 1993-01-22 US US08007757 patent/US5378844B1/en not_active Expired - Fee Related
- 1993-01-22 CA CA002087922A patent/CA2087922C/en not_active Expired - Fee Related
-
1999
- 1999-02-24 GR GR990400573T patent/GR3029476T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2087922C (en) | 2004-11-30 |
| EP0552712B1 (de) | 1998-11-25 |
| DE69322177D1 (de) | 1999-01-07 |
| CN1082047A (zh) | 1994-02-16 |
| GR3029476T3 (en) | 1999-05-28 |
| US5378844B1 (en) | 1998-12-01 |
| IT1260444B (it) | 1996-04-09 |
| CA2087922A1 (en) | 1993-07-25 |
| ES2125911T3 (es) | 1999-03-16 |
| DK0552712T3 (da) | 1999-08-09 |
| DE69322177T2 (de) | 1999-06-24 |
| ITMI920132A0 (it) | 1992-01-24 |
| ITMI920132A1 (it) | 1993-07-24 |
| US5378844A (en) | 1995-01-03 |
| CN1035877C (zh) | 1997-09-17 |
| EP0552712A1 (de) | 1993-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |