ATE173929T1 - 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung - Google Patents

7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung

Info

Publication number: ATE173929T1
Authority: AT; Austria
Prior art keywords: antimetastatic; tumoral; thia; immuno; antiviral
Prior art date: 1987-12-21

Application number

AT94112331T

Other languages

English (en)

Inventor

Roland Kenith Robins

Howard Brinkerhoff Cottam

Original Assignee

Icn Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-09-02

Publication date

1998-12-15

1987-12-21 Priority claimed from US07/136,020 external-priority patent/US4880784A/en

1988-09-02 Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173929T1 publication Critical patent/ATE173929T1/de

Links

IZJRBCBYBVGNSZ-UFMOHRQQSA-N 5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dihydro-[1,3]thiazolo[4,5-d]pyrimidin-7-one Chemical class C1SC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O IZJRBCBYBVGNSZ-UFMOHRQQSA-N 0.000 title 1
230000002001 anti-metastasis Effects 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
230000003308 immunostimulating effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94112331T 1987-12-21 1988-09-02 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung ATE173929T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/136,020 US4880784A (en)	1987-12-21	1987-12-21	Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US07/236,366 US5041426A (en)	1987-12-21	1988-08-25	Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides

Publications (1)

Publication Number	Publication Date
ATE173929T1 true ATE173929T1 (de)	1998-12-15

Family

ID=26833912

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94112331T ATE173929T1 (de)	1987-12-21	1988-09-02	7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung
AT88908566T ATE126060T1 (de)	1987-12-21	1988-09-02	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT88908566T ATE126060T1 (de)	1987-12-21	1988-09-02	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.

Country Status (11)

Country	Link
US (1)	US5041426A (de)
EP (2)	EP0348446B1 (de)
JP (1)	JP2590248B2 (de)
KR (1)	KR970002611B1 (de)
AR (1)	AR246104A1 (de)
AT (2)	ATE173929T1 (de)
CA (1)	CA1319931C (de)
DE (2)	DE3856279T2 (de)
DK (1)	DK406389A (de)
ES (1)	ES2010786A6 (de)
WO (1)	WO1989005649A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US5166141A (en) *	1983-11-01	1992-11-24	Scripps Clinic And Research Foundation	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
JPH04501254A (ja) *	1988-05-23	1992-03-05	アメリカ合衆国	癌治療剤としてのサイクリックａｍｐ誘導体
SK284054B6 (sk) *	1996-10-16	2004-08-03	Icn Pharmaceuticals, Inc.	Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie
AU727177B2 (en) *	1996-10-16	2000-12-07	Icn Pharmaceuticals, Inc.	Purine L-nucleosides, analogs and uses thereof
US6509320B1 (en) *	1996-10-16	2003-01-21	Icn Pharmaceuticals, Inc.	Purine L-nucleosides, analogs and uses thereof
EP1103559A1 (de) *	1997-01-17	2001-05-30	ICN Pharmaceuticals, Inc.	Autoimmun-Nukleoside
US7638496B2 (en)	2000-02-15	2009-12-29	Valeant Pharmaceuticals North America	Nucleoside analogs with carboxamidine modified monocyclic base
US6645990B2 (en) *	2000-08-15	2003-11-11	Amgen Inc.	Thiazolyl urea compounds and methods of uses
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
WO2003045968A1 (en) *	2001-11-27	2003-06-05	Anadys Pharmaceuticals, Inc.	3-β-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
EP1667694B1 (de)	2003-09-05	2010-04-28	Anadys Pharmaceuticals, Inc.	Tlr7-liganden zur behandlung von hepatitis c
CN1845745B (zh) *	2003-09-05	2011-11-02	安那迪斯药品股份有限公司	Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途
GB0500020D0 (en)	2005-01-04	2005-02-09	Novartis Ag	Organic compounds
AU2004320625B2 (en) *	2004-06-07	2009-08-27	Anadys Pharmaceuticals, Inc.	3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
ES2459368T3 (es) *	2004-12-17	2014-05-09	Anadys Pharmaceuticals, Inc.	Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
CN101212968B (zh) *	2004-12-17	2011-11-16	安那迪斯药品股份有限公司	3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
CA2630463C (en) *	2005-11-21	2015-01-06	Anadys Pharmaceuticals, Inc.	Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
EP2518079A3 (de)	2006-04-11	2012-12-12	Novartis AG	HCV/HIV-Hemmer und Benutzung davon
CA2655904C (en) *	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
EP2040712B1 (de) *	2006-07-18	2011-03-02	Anadys Pharmaceuticals, Inc.	Carbonat- und carbamat-prodrugs von thiazolo [4,5-d]-pyrimidinen
KR100880298B1 (ko)	2006-12-06	2009-01-28	애나디스 파마슈티칼스, 인코포레이티드	３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
UY32306A (es)	2008-12-09	2010-07-30	Gilead Sciences Inc	Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos
US20110182850A1 (en)	2009-04-10	2011-07-28	Trixi Brandl	Organic compounds and their uses
US8512690B2 (en)	2009-04-10	2013-08-20	Novartis Ag	Derivatised proline containing peptide compounds as protease inhibitors
AP2012006535A0 (en)	2010-03-31	2012-10-31	Gilead Pharmasset Llc	Stereoselective synthesis of phosphorous containing actives
CN103179966B (zh)	2010-10-08	2017-03-15	诺瓦提斯公司	磺酰胺ns3抑制剂的维生素e制剂
JPWO2012102366A1 (ja) *	2011-01-28	2014-06-30	日本たばこ産業株式会社	新規ピペラジン化合物の製造方法
SI3166607T1 (sl)	2014-07-11	2023-01-31	Gilead Sciences, Inc.	Modulatorji toličnih receptorjev za zdravljenje HIV-a
CN110305133A (zh)	2014-09-16	2019-10-08	吉利德科学公司	Toll样受体调节剂的固体形式
HUE053704T2 (hu) *	2014-12-08	2021-07-28	Hoffmann La Roche	3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
CN107427514B (zh)	2015-03-16	2021-07-13	豪夫迈·罗氏有限公司	使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
EP3294745B1 (de)	2015-05-08	2020-01-01	H. Hoffnabb-La Roche Ag	Neuartige oxathiolan-carbonsäuren und derivate zur behandlung und prophylaxe von virusinfektionen
CN107592864B (zh)	2015-05-12	2021-04-16	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
CN107820498B (zh)	2015-06-30	2020-06-19	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的取代的氨基噻唑并嘧啶二酮
WO2018127525A1 (en)	2017-01-06	2018-07-12	F. Hoffmann-La Roche Ag	PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS
CN113924114A (zh)	2019-05-22	2022-01-11	吉利德科学公司	Tlr7调节化合物和hiv疫苗的组合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5166141A (en) *	1983-11-01	1992-11-24	Scripps Clinic And Research Foundation	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
US4746651A (en) *	1983-11-01	1988-05-24	Scripps Clinic And Research Foundation	Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives

1988
- 1988-08-25 US US07/236,366 patent/US5041426A/en not_active Expired - Lifetime
- 1988-09-02 DE DE3856279T patent/DE3856279T2/de not_active Expired - Lifetime
- 1988-09-02 CA CA000576416A patent/CA1319931C/en not_active Expired - Lifetime
- 1988-09-02 JP JP63507805A patent/JP2590248B2/ja not_active Expired - Lifetime
- 1988-09-02 DE DE3854297T patent/DE3854297T2/de not_active Expired - Lifetime
- 1988-09-02 AT AT94112331T patent/ATE173929T1/de not_active IP Right Cessation
- 1988-09-02 AR AR88311844A patent/AR246104A1/es active
- 1988-09-02 AT AT88908566T patent/ATE126060T1/de not_active IP Right Cessation
- 1988-09-02 WO PCT/US1988/002982 patent/WO1989005649A1/en not_active Ceased
- 1988-09-02 EP EP88908566A patent/EP0348446B1/de not_active Expired - Lifetime
- 1988-09-02 EP EP94112331A patent/EP0636372B1/de not_active Expired - Lifetime
- 1988-09-03 ES ES8802722A patent/ES2010786A6/es not_active Expired
1989
- 1989-08-18 DK DK406389A patent/DK406389A/da unknown
- 1989-08-21 KR KR89701557A patent/KR970002611B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5041426A (en)	1991-08-20
DK406389A (da)	1989-10-04
DE3854297D1 (de)	1995-09-14
WO1989005649A1 (en)	1989-06-29
KR970002611B1 (en)	1997-03-06
DE3856279D1 (de)	1999-01-14
AR246104A1 (es)	1994-03-30
EP0636372A1 (de)	1995-02-01
JP2590248B2 (ja)	1997-03-12
EP0348446B1 (de)	1995-08-09
ES2010786A6 (es)	1989-12-01
DK406389D0 (da)	1989-08-18
KR900700106A (ko)	1990-08-11
JPH03504122A (ja)	1991-09-12
EP0636372B1 (de)	1998-12-02
EP0348446A4 (en)	1991-09-25
CA1319931C (en)	1993-07-06
DE3856279T2 (de)	1999-05-20
EP0348446A1 (de)	1990-01-03
DE3854297T2 (de)	1996-03-28
ATE126060T1 (de)	1995-08-15

Legal Events

Date	Code	Title
1999-06-15	UEP	Publication of translation of european patent specification
2005-11-15	EEIH	Change in the person of patent owner
2008-12-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3856279D1 (de)	1999-01-14	7-Thia-Guanosin-Derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender Wirkung
DE68927948D1 (de)	1997-05-15	Trehalosderivate
NO870477D0 (no)	1987-02-06	5-amino-4-hydroksy-valerylderivater substituert med svovelholdige grupper.
DE68925161D1 (de)	1996-02-01	Alkylavermectin-Derivate
FI930070A7 (fi)	1993-01-08	Hiv-inhiberande benzenacetamidderivat
DK491389D0 (da)	1989-10-05	Substituerede 9h-purinderivater
IT1219542B (it)	1990-05-18	Derivati pepticidi,loro preparazione e loro impiego come medicamenti
DK19789D0 (da)	1989-01-17	Dehydrocholcalciferolderivater
MX9100225A (es)	1992-02-28	Derivados del carbostiril
DE68927657D1 (de)	1997-02-27	Butynylaminderivate
DK486089D0 (da)	1989-10-03	Pyranobenzoxadiazolderivater
IT1231238B (it)	1991-11-26	Derivati ammidinici
FI895282A7 (fi)	1990-05-09	Tetraliinijohdannaisia
DE68907013D1 (de)	1993-07-15	Guaninderivate mit antiviraler wirkung und deren pharmazeutisch vertraegliche salze.
FI923458A7 (fi)	1992-07-31	4,5-sykloalkano-3-bentsatsepin-7-olijohdannaiset ja niiden käyttö
DE68926320D1 (de)	1996-05-30	Pyrazoloacridonderivate mit Antitumoraktivität
DE3880561D1 (de)	1993-06-03	Actinoninderivate mit physiologischen aktivitaeten.
DK160389A (da)	1989-10-05	Aryldionderivater
DE3782362D1 (de)	1992-12-03	Cyanacetamid-derivate mit fungizider wirkung.
IT1228882B (it)	1991-07-09	Derivati 4 demetossi antraciclinici
DK324489D0 (da)	1989-06-29	Substituerede azacyclohexylderivater
AT389415B (de)	1989-12-11	Pfluganordnung
DK322489A (da)	1989-12-31	1-normonylderivater
PT91643A (pt)	1990-03-30	Ligacao de derivacao
DK81588A (da)	1989-08-18	Gametocide n-phosphonomethylglycinderivater