ATE173929T1 - 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung - Google Patents

7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung

Info

Publication number: ATE173929T1
Authority: AT; Austria
Prior art keywords: antimetastatic; tumoral; thia; immuno; antiviral
Prior art date: 1987-12-21

Application number

AT94112331T

Other languages

English (en)

Inventor

Roland Kenith Robins

Howard Brinkerhoff Cottam

Original Assignee

Icn Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-09-02

Publication date

1998-12-15

1987-12-21 Priority claimed from US07/136,020 external-priority patent/US4880784A/en

1988-09-02 Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173929T1 publication Critical patent/ATE173929T1/de

Links

IZJRBCBYBVGNSZ-UFMOHRQQSA-N 5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dihydro-[1,3]thiazolo[4,5-d]pyrimidin-7-one Chemical class C1SC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O IZJRBCBYBVGNSZ-UFMOHRQQSA-N 0.000 title 1
230000002001 anti-metastasis Effects 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
230000003308 immunostimulating effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94112331T 1987-12-21 1988-09-02 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung ATE173929T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/136,020 US4880784A (en)	1987-12-21	1987-12-21	Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US07/236,366 US5041426A (en)	1987-12-21	1988-08-25	Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides

Publications (1)

Publication Number	Publication Date
ATE173929T1 true ATE173929T1 (de)	1998-12-15

Family

ID=26833912

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94112331T ATE173929T1 (de)	1987-12-21	1988-09-02	7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung
AT88908566T ATE126060T1 (de)	1987-12-21	1988-09-02	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT88908566T ATE126060T1 (de)	1987-12-21	1988-09-02	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.

Country Status (11)

Country	Link
US (1)	US5041426A (de)
EP (2)	EP0348446B1 (de)
JP (1)	JP2590248B2 (de)
KR (1)	KR970002611B1 (de)
AR (1)	AR246104A1 (de)
AT (2)	ATE173929T1 (de)
CA (1)	CA1319931C (de)
DE (2)	DE3856279T2 (de)
DK (1)	DK406389A (de)
ES (1)	ES2010786A6 (de)
WO (1)	WO1989005649A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US5166141A (en) *	1983-11-01	1992-11-24	Scripps Clinic And Research Foundation	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
JPH04501254A (ja) *	1988-05-23	1992-03-05	アメリカ合衆国	癌治療剤としてのサイクリックａｍｐ誘導体
BR9714349A (pt) *	1996-10-16	2000-11-14	Icn Pharmaceuticals	L-nucleosìdeos purina, seus análogos e utilizacões dos mesmos
ATE238328T1 (de) *	1996-10-16	2003-05-15	Ribapharm Inc	Monozyklische l-nukleoside, analoga und ihre anwendungen
US6509320B1 (en) *	1996-10-16	2003-01-21	Icn Pharmaceuticals, Inc.	Purine L-nucleosides, analogs and uses thereof
EP1103559A1 (de) *	1997-01-17	2001-05-30	ICN Pharmaceuticals, Inc.	Autoimmun-Nukleoside
US7638496B2 (en)	2000-02-15	2009-12-29	Valeant Pharmaceuticals North America	Nucleoside analogs with carboxamidine modified monocyclic base
US6645990B2 (en) *	2000-08-15	2003-11-11	Amgen Inc.	Thiazolyl urea compounds and methods of uses
AP2004003069A0 (en)	2001-11-27	2004-06-30	Anadys Pharmaceuticals Inc	3-beta-d-ribofuranosynthiazolo [4-5-d] pyridimine nucleosides and uses thereof.
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
CN1845745B (zh) *	2003-09-05	2011-11-02	安那迪斯药品股份有限公司	Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途
JP2007504232A (ja) *	2003-09-05	2007-03-01	アナディスファーマシューティカルズインク	Ｃ型肝炎ウイルス感染治療用のｔｌｒ７リガンド及びそのプロドラッグの投与
GB0500020D0 (en)	2005-01-04	2005-02-09	Novartis Ag	Organic compounds
CA2566541C (en) *	2004-06-07	2012-10-09	Anadys Pharmaceuticals, Inc.	3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
US7560544B2 (en) *	2004-12-17	2009-07-14	Anadys Pharmaceuticals, Inc.	3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
CN101212968B (zh) *	2004-12-17	2011-11-16	安那迪斯药品股份有限公司	3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
DE602006015700D1 (de) *	2005-11-21	2010-09-02	Anadys Pharmaceuticals Inc	Neues verfahren zur herstellung von 5-amino-3h-thiazoloä4,5-düpyrimidin-2-on
EP2007789B1 (de)	2006-04-11	2015-05-20	Novartis AG	Spirozyklische HCV/HIV-Hemmer und ihre Verwendung
KR101461604B1 (ko) *	2006-06-22	2014-11-18	애나디스 파마슈티칼스, 인코포레이티드	5-아미노-3-(3''-데옥시-β-Ｄ-리보퓨라노실)-티아졸로［4,5-ｄ］파이리미딘-2,7-다이온의 프로드럭
WO2008011406A2 (en)	2006-07-18	2008-01-24	Anadys Pharmaceuticals, Inc.	Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
KR100880298B1 (ko)	2006-12-06	2009-01-28	애나디스 파마슈티칼스, 인코포레이티드	３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
RS53347B (sr)	2008-12-09	2014-10-31	Gilead Sciences, Inc.	Modulatori toll-sličnih receptora
US8512690B2 (en)	2009-04-10	2013-08-20	Novartis Ag	Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en)	2009-04-10	2011-07-28	Trixi Brandl	Organic compounds and their uses
SG184324A1 (en)	2010-03-31	2012-11-29	Gilead Pharmasset Llc	Nucleoside phosphoramidates
JP5909495B2 (ja)	2010-10-08	2016-04-26	ノバルティスアーゲー	スルファミドｎｓ３阻害剤のビタミンｅ製剤
WO2012102366A1 (ja) *	2011-01-28	2012-08-02	日本たばこ産業株式会社	新規ピペラジン化合物の製造方法
JP6522732B2 (ja)	2014-07-11	2019-05-29	ギリアードサイエンシーズ，インコーポレイテッド	Ｈｉｖを治療するためのトール様受容体の調節因子
SG11201701520TA (en)	2014-09-16	2017-04-27	Gilead Sciences Inc	Solid forms of a toll-like receptor modulator
SG11201704512PA (en) *	2014-12-08	2017-07-28	Hoffmann La Roche	3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
CA2979490C (en)	2015-03-16	2023-07-18	F. Hoffmann-La Roche Ag	Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
CN107743491B (zh)	2015-05-08	2020-08-21	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
JP6806709B2 (ja)	2015-05-12	2021-01-06	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ウイルス感染症の治療と予防のための新規置換アミノチアゾロピリミジンジオン
WO2017001307A1 (en)	2015-06-30	2017-01-05	F. Hoffmann-La Roche Ag	Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
CA3048768A1 (en)	2017-01-06	2018-07-12	F. Hoffmann-La Roche Ag	Process for the preparation of 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
TWI810456B (zh)	2019-05-22	2023-08-01	美商基利科學股份有限公司	Tlr7調節化合物及hiv疫苗之組合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4746651A (en) *	1983-11-01	1988-05-24	Scripps Clinic And Research Foundation	Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives
US5166141A (en) *	1983-11-01	1992-11-24	Scripps Clinic And Research Foundation	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals

1988
- 1988-08-25 US US07/236,366 patent/US5041426A/en not_active Expired - Lifetime
- 1988-09-02 AT AT94112331T patent/ATE173929T1/de not_active IP Right Cessation
- 1988-09-02 AR AR88311844A patent/AR246104A1/es active
- 1988-09-02 CA CA000576416A patent/CA1319931C/en not_active Expired - Lifetime
- 1988-09-02 EP EP88908566A patent/EP0348446B1/de not_active Expired - Lifetime
- 1988-09-02 AT AT88908566T patent/ATE126060T1/de not_active IP Right Cessation
- 1988-09-02 WO PCT/US1988/002982 patent/WO1989005649A1/en not_active Ceased
- 1988-09-02 DE DE3856279T patent/DE3856279T2/de not_active Expired - Lifetime
- 1988-09-02 DE DE3854297T patent/DE3854297T2/de not_active Expired - Lifetime
- 1988-09-02 EP EP94112331A patent/EP0636372B1/de not_active Expired - Lifetime
- 1988-09-02 JP JP63507805A patent/JP2590248B2/ja not_active Expired - Lifetime
- 1988-09-03 ES ES8802722A patent/ES2010786A6/es not_active Expired
1989
- 1989-08-18 DK DK406389A patent/DK406389A/da unknown
- 1989-08-21 KR KR89701557A patent/KR970002611B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2010786A6 (es)	1989-12-01
EP0348446A1 (de)	1990-01-03
KR970002611B1 (en)	1997-03-06
DE3856279T2 (de)	1999-05-20
EP0348446B1 (de)	1995-08-09
DE3854297D1 (de)	1995-09-14
EP0636372B1 (de)	1998-12-02
EP0636372A1 (de)	1995-02-01
US5041426A (en)	1991-08-20
WO1989005649A1 (en)	1989-06-29
CA1319931C (en)	1993-07-06
DE3854297T2 (de)	1996-03-28
KR900700106A (ko)	1990-08-11
DK406389D0 (da)	1989-08-18
JP2590248B2 (ja)	1997-03-12
ATE126060T1 (de)	1995-08-15
EP0348446A4 (en)	1991-09-25
JPH03504122A (ja)	1991-09-12
AR246104A1 (es)	1994-03-30
DK406389A (da)	1989-10-04
DE3856279D1 (de)	1999-01-14

Legal Events

Date	Code	Title
1999-06-15	UEP	Publication of translation of european patent specification
2005-11-15	EEIH	Change in the person of patent owner
2008-12-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE173929T1 (de)	1998-12-15	7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung
NO870477D0 (no)	1987-02-06	5-amino-4-hydroksy-valerylderivater substituert med svovelholdige grupper.
DE68925161D1 (de)	1996-02-01	Alkylavermectin-Derivate
FI930070A7 (fi)	1993-01-08	Hiv-inhiberande benzenacetamidderivat
DK491389A (da)	1990-04-07	Substituerede 9h-purinderivater
DK187288A (da)	1988-10-11	Tertiaere arylethylaminderivater med opiatantagonistisk virkning
IT1219542B (it)	1990-05-18	Derivati pepticidi,loro preparazione e loro impiego come medicamenti
DK19789D0 (da)	1989-01-17	Dehydrocholcalciferolderivater
MX9100225A (es)	1992-02-28	Derivados del carbostiril
DE3868866D1 (de)	1992-04-09	Ergolinderivate mit antiparkinsonwirkung.
DE68927657D1 (de)	1997-02-27	Butynylaminderivate
IT1219676B (it)	1990-05-24	Derivati della tiourea,loro preparazione e loro impiego come medicamenti
DK486089D0 (da)	1989-10-03	Pyranobenzoxadiazolderivater
FI895282A7 (fi)	1990-05-09	Tetraliinijohdannaisia
IT8721977A0 (it)	1987-09-21	Derivati ammidinici
FI923458A7 (fi)	1992-07-31	4,5-sykloalkano-3-bentsatsepin-7-olijohdannaiset ja niiden käyttö
DE68926320D1 (de)	1996-05-30	Pyrazoloacridonderivate mit Antitumoraktivität
DK160389A (da)	1989-10-05	Aryldionderivater
DE3782362D1 (de)	1992-12-03	Cyanacetamid-derivate mit fungizider wirkung.
FI892041A7 (fi)	1989-10-30	Triazinderivat.
IT1228882B (it)	1991-07-09	Derivati 4 demetossi antraciclinici
DK324489D0 (da)	1989-06-29	Substituerede azacyclohexylderivater
AT389415B (de)	1989-12-11	Pfluganordnung
DK322489A (da)	1989-12-31	1-normonylderivater
PT91643A (pt)	1990-03-30	Ligacao de derivacao