ES2010786A6 - Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune. - Google Patents

Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune.

Info

Publication number
ES2010786A6
ES2010786A6 ES8802722A ES8802722A ES2010786A6 ES 2010786 A6 ES2010786 A6 ES 2010786A6 ES 8802722 A ES8802722 A ES 8802722A ES 8802722 A ES8802722 A ES 8802722A ES 2010786 A6 ES2010786 A6 ES 2010786A6
Authority
ES
Spain
Prior art keywords
nucleotides
immune system
antimetastatic
acilo
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802722A
Other languages
English (en)
Inventor
Roland Kenith Robins
Howard Brinker Cottam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/136,020 external-priority patent/US4880784A/en
Application filed by Brigham Young University filed Critical Brigham Young University
Publication of ES2010786A6 publication Critical patent/ES2010786A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

METODO PARA PREPARAR NUCLEOSIDOS Y NUCLEOTIDOS MEJORADORES DEL SISTEMA ANTIVIRAL, ANTITUMORAL, ANTIMETASTASICO E INMUNE QUE RESPONDEN A LA ESTRUCTURA: DONDE R4-R7 SON H, OH U O-ACILO C1-C18, R3 ES H, ACILO, C1-C18 U OP(OH2)2-, O R5 Y R7 SON H U OH, R6 ES H Y R3 Y R4 JUNTOS SON OPO(OH)-, X ES =O O =S, Y ES -OH, -SH, -NH2 O HALOGENO, Y Z ES H, -NH2, -OH O HALOGENO, SIENDO EL HALOGENO CL O BR. CONSISTE EN FORMAR UN DERIVADO SILILO DE UNA TIAZOLO[4,5-D]PIRIMIDINA 2,5,7-SUSTITUIDA, HACER REACCIONAR DICHO DERIVADO SILILO CON 1-SUSTITUIDO-BLOQUEADO-D-PENTOFURANOSA, EN PRESENCIA DE UN CATALIZADOR, FORMANDO UN NUCLEOSIDO BLOQUEADO, Y DESBLOQUEAR DICHO NUCLEOSIDO. LOS PRODUCTOS OBTENIDOS SON UTILES PARA TRATAR ENFERMEDADES VIRALES Y TUMORES EN MAMIFEROS.
ES8802722A 1987-12-21 1988-09-03 Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune. Expired ES2010786A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/136,020 US4880784A (en) 1987-12-21 1987-12-21 Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US07/236,366 US5041426A (en) 1987-12-21 1988-08-25 Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides

Publications (1)

Publication Number Publication Date
ES2010786A6 true ES2010786A6 (es) 1989-12-01

Family

ID=26833912

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802722A Expired ES2010786A6 (es) 1987-12-21 1988-09-03 Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune.

Country Status (11)

Country Link
US (1) US5041426A (es)
EP (2) EP0636372B1 (es)
JP (1) JP2590248B2 (es)
KR (1) KR970002611B1 (es)
AR (1) AR246104A1 (es)
AT (2) ATE173929T1 (es)
CA (1) CA1319931C (es)
DE (2) DE3856279T2 (es)
DK (1) DK406389A (es)
ES (1) ES2010786A6 (es)
WO (1) WO1989005649A1 (es)

Families Citing this family (35)

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US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
CA1335572C (en) * 1988-05-23 1995-05-16 Yoon Sang Cho-Chung Derivatives of cyclic amp as treatment for cancer
IL129126A0 (en) * 1996-10-16 2000-02-17 Icn Pharmaceuticals Monocyclic l-nucleosides analogs and uses thereof
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
ATE271063T1 (de) * 1996-10-16 2004-07-15 Icn Pharmaceuticals Purin-l-nukleoside, deren analoga und verwendungen
EP1103559A1 (en) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmune nucleosides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
EA008380B1 (ru) * 2001-11-27 2007-04-27 Анадис Фармасьютикалз, Инк. 3-β-D-РИБОФУРАНОЗИЛТИАЗОЛО[4,5-d]ПИРИМИДИННУКЛЕОЗИДЫ И ИХ ПРИМЕНЕНИЯ
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
CN1845745B (zh) * 2003-09-05 2011-11-02 安那迪斯药品股份有限公司 Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途
EP1667694B1 (en) * 2003-09-05 2010-04-28 Anadys Pharmaceuticals, Inc. Tlr7 ligands for the treatment of hepatitis c
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
US20080070852A1 (en) * 2004-06-07 2008-03-20 Averett Devron R 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof
CN101212968B (zh) * 2004-12-17 2011-11-16 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
CN102504001B (zh) * 2004-12-17 2015-02-25 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
SG152296A1 (en) 2005-11-21 2009-05-29 Anadys Pharmaceuticals Inc Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2- one
AU2007249668B2 (en) 2006-04-11 2011-04-07 Novartis Ag HCV/HIV inhibitors and their uses
MX2008016518A (es) 2006-06-22 2009-01-19 Anadys Pharmaceuticals Inc Profarmacos de 5-amino-3-(3'-desoxi-beta-d-ribofuranosil)-tiazolo[ 4,5-d]pirimidin-2,7-dion.
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
KR100880298B1 (ko) 2006-12-06 2009-01-28 애나디스 파마슈티칼스, 인코포레이티드 ３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
PT2609923T (pt) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
EA201390532A1 (ru) 2010-10-08 2013-09-30 Новартис Аг Композиции сульфамидых ингибиторов ns3, содержащие витамин е
JPWO2012102366A1 (ja) * 2011-01-28 2014-06-30 日本たばこ産業株式会社 新規ピペラジン化合物の製造方法
PT3166607T (pt) 2014-07-11 2022-12-07 Gilead Sciences Inc Moduladores de receptores de tipo toll para o tratamento do vih
CA2960436C (en) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
CA2963717C (en) * 2014-12-08 2023-10-10 F. Hoffmann-La Roche Ag 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
CN107427514B (zh) 2015-03-16 2021-07-13 豪夫迈·罗氏有限公司 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
WO2016180691A1 (en) 2015-05-08 2016-11-17 F. Hoffmann-La Roche Ag Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
WO2016180743A1 (en) 2015-05-12 2016-11-17 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
WO2017001307A1 (en) 2015-06-30 2017-01-05 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
EP3568400B1 (en) 2017-01-06 2025-11-19 F. Hoffmann-La Roche AG Process for the preparation of 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
US4746651A (en) * 1983-11-01 1988-05-24 Scripps Clinic And Research Foundation Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives

Also Published As

Publication number Publication date
ATE173929T1 (de) 1998-12-15
EP0348446B1 (en) 1995-08-09
EP0348446A1 (en) 1990-01-03
DE3854297T2 (de) 1996-03-28
EP0636372B1 (en) 1998-12-02
US5041426A (en) 1991-08-20
CA1319931C (en) 1993-07-06
DE3856279D1 (de) 1999-01-14
EP0636372A1 (en) 1995-02-01
WO1989005649A1 (en) 1989-06-29
AR246104A1 (es) 1994-03-30
DK406389A (da) 1989-10-04
ATE126060T1 (de) 1995-08-15
JPH03504122A (ja) 1991-09-12
DE3856279T2 (de) 1999-05-20
KR970002611B1 (en) 1997-03-06
JP2590248B2 (ja) 1997-03-12
DK406389D0 (da) 1989-08-18
KR900700106A (ko) 1990-08-11
EP0348446A4 (en) 1991-09-25
DE3854297D1 (de) 1995-09-14

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-09-03

PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20080904