ATE174591T1 - Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps - Google Patents

Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps

Info

Publication number: ATE174591T1
Authority: AT; Austria
Prior art keywords: ligands; pct; dopamine receptor; receptor subtype; tricyclic heteroaromatic
Prior art date: 1993-09-15

Application number

AT94925561T

Other languages

English (en)

Inventor

William Barnaby Davey

Paul David Leeson

Michael Rowley

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-15

Filing date

1994-09-06

Publication date

1999-01-15

1993-09-15 Priority claimed from GB939319110A external-priority patent/GB9319110D0/en

1993-09-16 Priority claimed from GB939319151A external-priority patent/GB9319151D0/en

1994-09-06 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1999-01-15 Application granted granted Critical

1999-01-15 Publication of ATE174591T1 publication Critical patent/ATE174591T1/de

Links

102000015554 Dopamine receptor Human genes 0.000 title abstract 2
108050004812 Dopamine receptor Proteins 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
150000002390 heteroarenes Chemical class 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT94925561T 1993-09-15 1994-09-06 Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps ATE174591T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939319110A GB9319110D0 (en)	1993-09-15	1993-09-15	Therapeutic agents
GB939319151A GB9319151D0 (en)	1993-09-16	1993-09-16	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE174591T1 true ATE174591T1 (de)	1999-01-15

Family

ID=26303522

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94925561T ATE174591T1 (de)	1993-09-15	1994-09-06	Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps

Country Status (9)

Country	Link
US (1)	US6080745A (de)
EP (1)	EP0724572B1 (de)
JP (1)	JPH09502449A (de)
AT (1)	ATE174591T1 (de)
AU (1)	AU681695B2 (de)
CA (1)	CA2168739A1 (de)
DE (1)	DE69415341T2 (de)
ES (1)	ES2126773T3 (de)
WO (1)	WO1995007893A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
US6187774B1 (en) *	1996-03-04	2001-02-13	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and pharmaceutical applications thereof
WO1999055335A1 (en) *	1998-04-30	1999-11-04	Basf Aktiengesellschaft	Substituted tricyclic pyrazole derivatives with protein kinase activity
WO1999064425A1 (en) *	1998-06-09	1999-12-16	Neurogen Corporation	Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
AU2003234567A1 (en)	2002-05-15	2003-12-02	Janssen Pharmaceutica N.V.	N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors
AR040967A1 (es) *	2002-08-12	2005-04-27	Janssen Pharmaceutica Nv	Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CN100522972C (zh) *	2002-08-15	2009-08-05	詹森药业有限公司	稠合杂环异噁唑啉衍生物和它们作为抗抑郁剂的用途
AU2003275430A1 (en) *	2003-10-03	2005-05-19	Ortho-Mcneil Pharmaceutical, Inc.	Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist
ITMI20041033A1 (it) *	2004-05-24	2004-08-24	Neuroscienze S C A R L	Composti farmaceutici
PE20080520A1 (es) *	2006-07-11	2008-06-13	Janssen Pharmaceutica Nv	Derivados de benzofuro- y benzotienopirimidina como moduladores del receptor de histamina h4
US7985745B2 (en)	2006-10-02	2011-07-26	Abbott Laboratories	Method for pain treatment
US8735411B2 (en)	2006-10-02	2014-05-27	Abbvie Inc.	Macrocyclic benzofused pyrimidine derivatives
CN102686571B (zh)	2009-10-29	2015-11-25	百时美施贵宝公司	三环杂环化合物
CN108602780A (zh) *	2016-01-29	2018-09-28	明治制果药业株式会社	新的化合物及其药理学上可接受的盐

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01250380A (ja) *	1987-12-26	1989-10-05	Tokyo Tanabe Co Ltd	光学活性ベンゾキノリジン誘導体、その製造方法およびそれを有効成分とする抗菌剤
NZ232091A (en) *	1989-01-16	1990-12-21	Bellon Labor Sa Roger	7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
US5041443A (en) *	1989-02-21	1991-08-20	Dainippon Pharmaceutical Co., Ltd.	Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
ES2076253T3 (es) *	1989-05-19	1995-11-01	Hoechst Roussel Pharma	N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
FR2671350A1 (fr) *	1991-01-08	1992-07-10	Adir	Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
JPH08502958A (ja) *	1992-10-23	1996-04-02	メルクシヤープエンドドームリミテツド	ドーパミンレセプターサブタイプリガンド

1994
- 1994-09-06 WO PCT/GB1994/001936 patent/WO1995007893A1/en not_active Ceased
- 1994-09-06 JP JP7509036A patent/JPH09502449A/ja active Pending
- 1994-09-06 AU AU75426/94A patent/AU681695B2/en not_active Ceased
- 1994-09-06 DE DE69415341T patent/DE69415341T2/de not_active Expired - Fee Related
- 1994-09-06 EP EP94925561A patent/EP0724572B1/de not_active Expired - Lifetime
- 1994-09-06 AT AT94925561T patent/ATE174591T1/de not_active IP Right Cessation
- 1994-09-06 US US08/617,895 patent/US6080745A/en not_active Expired - Fee Related
- 1994-09-06 ES ES94925561T patent/ES2126773T3/es not_active Expired - Lifetime
- 1994-09-06 CA CA002168739A patent/CA2168739A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0724572B1 (de)	1998-12-16
CA2168739A1 (en)	1995-03-23
JPH09502449A (ja)	1997-03-11
DE69415341D1 (de)	1999-01-28
ES2126773T3 (es)	1999-04-01
WO1995007893A1 (en)	1995-03-23
AU7542694A (en)	1995-04-03
US6080745A (en)	2000-06-27
AU681695B2 (en)	1997-09-04
DE69415341T2 (de)	1999-07-15
EP0724572A1 (de)	1996-08-07

Legal Events

Date	Code	Title	Description
1999-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ES2121193T3 (es)	1998-11-16	Derivados de bencimidazoles.
DE69415341D1 (de)	1999-01-28	Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps
DE69420637D1 (de)	1999-10-21	Tricyclische Derivate und ihre Anwendung als Krebsmittel
DE69325662D1 (de)	1999-08-19	Dopamin rezeptor subtyp liganden
TNSN97192A1 (fr)	2005-03-15	Derives de pyrimidine bicycliques condenses, procede pour leur preparation et compositions pharmaceutiques les contenant.
NZ519241A (en)	2004-12-24	Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it
ATE200667T1 (de)	2001-05-15	Quinazoline derivate und ihre anwendung als krebsmittel
ATE160774T1 (de)	1997-12-15	Antipsychotische benzimidazolderivate
ATE160773T1 (de)	1997-12-15	Kondensierte tricyclische heteroaromatische verbindungen als dopamin-rezeptor-subtyp-liganden
ES2110225T3 (es)	1998-02-01	Derivados antisicoticos de indazol.
WO1994020459A3 (en)	1994-10-13	Pyrrolo-pyridine derivatives as dopamine receptor ligands
GB9305641D0 (en)	1993-05-05	Therapeutic agents
ES2145289T3 (es)	2000-07-01	Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina.
DE69713273D1 (de)	2002-07-18	Verwendung von 3,4-Diphenylchromanen zur Herstellung eines Arzneimittels zur Behandlung bzw. Vorbeugung des Prostatakarzinoms
TR199902094T2 (xx)	1999-12-21	3-Heteroareil-4(3H)-kinazolinonlar�n atropizomerleri.
PL319636A1 (en)	1997-08-18	Derivatives of 2,7-substituted octahydro-1h-pyrido[1,2-a]pyrasine
AU655958B2 (en)	1995-01-19	Use of quisqualate-receptor antagonists for treating Parkinson's disease
NZ334553A (en)	2000-11-24	N-(2-Benzothiazolyl) piperidine-1 ethanamine derivatives and pharmaceutical use
DE69407607D1 (de)	1998-02-05	Imidanolon- und oxanolonderivate als dopaminantagonisten
FI911533A7 (fi)	1991-10-01	Bentsoksatsiini-johdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö sairauksien hoitamiseen tai ennalta ehkäisemiseksi
DK0766695T3 (da)	1999-02-15	Pyrrolidinderivater til behandling af CCK- og gastrinrelaterede sygdomme
TW362097B (en)	1999-06-21	3-Phenyl-1, 4-dialkyl-1,2,4-triazolium salts and their use as antidepressants
MX9705390A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis de desordenes degenerativos cerebrales.
MX9705378A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis de la obesidad.
MX9705379A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis vasodilatadora.