ATE175723T1 - Elektrochemische denatusierung von doppelsträngiger nukleinsäure - Google Patents
Elektrochemische denatusierung von doppelsträngiger nukleinsäureInfo
- Publication number
- ATE175723T1 ATE175723T1 AT95910680T AT95910680T ATE175723T1 AT E175723 T1 ATE175723 T1 AT E175723T1 AT 95910680 T AT95910680 T AT 95910680T AT 95910680 T AT95910680 T AT 95910680T AT E175723 T1 ATE175723 T1 AT E175723T1
- Authority
- AT
- Austria
- Prior art keywords
- electrochemical
- nucleic acid
- double stranded
- stranded nucleic
- denatusation
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 238000004925 denaturation Methods 0.000 abstract 2
- 230000036425 denaturation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 230000000737 periodic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9405016A GB9405016D0 (en) | 1994-03-15 | 1994-03-15 | Electrical manipulation of nucleic acids |
| GBGB9502284.4A GB9502284D0 (en) | 1995-02-06 | 1995-02-06 | Electrochemical denaturation of double-stranded nucleic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE175723T1 true ATE175723T1 (de) | 1999-01-15 |
Family
ID=26304504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95910680T ATE175723T1 (de) | 1994-03-15 | 1995-03-14 | Elektrochemische denatusierung von doppelsträngiger nukleinsäure |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6033850A (de) |
| EP (1) | EP0750680B1 (de) |
| JP (1) | JPH09510107A (de) |
| CN (1) | CN1059238C (de) |
| AT (1) | ATE175723T1 (de) |
| DE (1) | DE69507289T2 (de) |
| TW (1) | TW533236B (de) |
| WO (1) | WO1995025177A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197508B1 (en) | 1990-09-12 | 2001-03-06 | Affymetrix, Inc. | Electrochemical denaturation and annealing of nucleic acid |
| ATE175723T1 (de) * | 1994-03-15 | 1999-01-15 | Scient Generics Ltd | Elektrochemische denatusierung von doppelsträngiger nukleinsäure |
| US6207369B1 (en) * | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| DE69534386T2 (de) | 1995-08-25 | 2006-04-20 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Freigabe von intrazellulärem material |
| US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
| US6953663B1 (en) | 1995-11-29 | 2005-10-11 | Affymetrix, Inc. | Polymorphism detection |
| US6355436B1 (en) | 1996-05-17 | 2002-03-12 | L'ecole Centrale De Lyon | Method for analyzing biological substances in a conductive liquid medium |
| US6308847B1 (en) | 1996-05-20 | 2001-10-30 | Fresenius Kabi Aktiebolag | Medical containers |
| GB9613980D0 (en) * | 1996-07-02 | 1996-09-04 | Scient Generics Ltd | Denaturation of double-stranded nucleic acid |
| GB9614544D0 (en) * | 1996-07-11 | 1996-09-04 | Scient Generics Ltd | Denaturation of double-stranded nucleic acid |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| GB9706654D0 (en) * | 1997-04-02 | 1997-05-21 | Scient Generics Ltd | Disassociation of interacting molecules |
| WO1998045474A1 (en) * | 1997-04-04 | 1998-10-15 | Innogenetics N.V. | Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions |
| US5993611A (en) * | 1997-09-24 | 1999-11-30 | Sarnoff Corporation | Capacitive denaturation of nucleic acid |
| US7179638B2 (en) | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
| US6713309B1 (en) | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
| US6884578B2 (en) | 2000-03-31 | 2005-04-26 | Affymetrix, Inc. | Genes differentially expressed in secretory versus proliferative endometrium |
| US7108969B1 (en) | 2000-09-08 | 2006-09-19 | Affymetrix, Inc. | Methods for detecting and diagnosing oral cancer |
| EP2333543B1 (de) | 2000-09-26 | 2018-01-10 | Health Research, Incorporated | Analyse der hiv-1 co-rezeptorsverwendung zur klinischen auswertung von hiv-infizierten patienten |
| US6670131B2 (en) | 2000-11-30 | 2003-12-30 | Kabushiki Kaisha Toshiba | Nucleic acid detection method and apparatus, and vessel for detecting nucleic acid |
| AU785425B2 (en) | 2001-03-30 | 2007-05-17 | Genetic Technologies Limited | Methods of genomic analysis |
| US7063946B2 (en) * | 2001-09-10 | 2006-06-20 | Meso Scale Technologies, Llc. | Methods, reagents, kits and apparatus for protein function analysis |
| US20050069926A1 (en) * | 2003-08-01 | 2005-03-31 | Affymetrix, Inc. | Helicase-amplified reverse transcription |
| KR101506727B1 (ko) * | 2004-05-13 | 2015-04-03 | 나노바이오심 인크. | 나노-ｐｃｒ: 핵산 증폭 및 검출을 위한 방법 및 장치 |
| KR101381331B1 (ko) | 2005-05-09 | 2014-04-04 | 테라노스, 인코포레이티드 | 현장진료 유체 시스템 및 그 용도 |
| US20070037169A1 (en) * | 2005-08-09 | 2007-02-15 | Combimatrix Corporation | Selective Dehybridization using Electrochemically-Generated Reagent on an Electrode Microarray |
| EP2025762A3 (de) | 2006-01-17 | 2009-09-30 | Health Research Inc. | Heteroduplex-Trackingassay |
| US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
| US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
| EP2016415B1 (de) | 2006-04-21 | 2013-08-14 | Nanobiosym, Inc. | Einzelmolekülplattform für wirkstoffentdeckung: verfahren für wirkstoffentdeckung, einschliesslich der entdeckung von krebsmitteln und viruziden |
| BRPI0813718A2 (pt) | 2007-07-13 | 2014-12-30 | Univ Leland Stanford Junior | Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados |
| US8088593B2 (en) | 2007-10-02 | 2012-01-03 | Theranos, Inc. | Modular point-of-care devices, systems, and uses thereof |
| WO2010068702A2 (en) * | 2008-12-10 | 2010-06-17 | Illumina, Inc. | Methods and compositions for hybridizing nucleic acids |
| WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| CN106323875B (zh) | 2011-01-21 | 2019-07-09 | 西拉诺斯知识产权有限责任公司 | 样品使用最大化的系统和方法 |
| US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
| US8380541B1 (en) | 2011-09-25 | 2013-02-19 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
| US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
| US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
| US8435738B2 (en) | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
| US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
| US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
| US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
| MX344792B (es) | 2011-09-25 | 2017-01-06 | Theranos Inc | Sistemas y métodos para múltiples análisis. |
| US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
| US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
| US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| AU2013315800A1 (en) | 2012-09-11 | 2015-03-12 | Theranos Ip Company, Llc | Information management systems and methods using a biological signature |
| SG11201506421PA (en) | 2013-02-18 | 2015-09-29 | Theranos Inc | Systems and methods for collecting and transmitting assay results |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| US11545241B1 (en) | 2013-09-07 | 2023-01-03 | Labrador Diagnostics Llc | Systems and methods for analyte testing and data management |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| KR20240025725A (ko) | 2013-12-11 | 2024-02-27 | 아큐라젠 홀딩스 리미티드 | 희귀 서열 변이를 검출하기 위한 조성물 및 방법 |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| EP3143158A1 (de) | 2014-05-14 | 2017-03-22 | Stratos Genomics, Inc. | Translokationssteuerung zur messung einer nanopore |
| EP3283512A4 (de) | 2015-04-17 | 2018-10-03 | Distributed Bio Inc | Verfahren zur massenhumanisierung von nichthumanen antikörpern |
| MX2018004284A (es) | 2015-10-09 | 2018-05-16 | Accuragen Holdings Ltd | Metodos y composiciones para el enriquecimiento de productos de amplificacion. |
| EP3383994A4 (de) | 2015-12-03 | 2019-08-28 | Accuragen Holdings Limited | Verfahren und zusammensetzungen zum formen von ligationsprodukten |
| CN109511265B (zh) | 2016-05-16 | 2023-07-14 | 安可济控股有限公司 | 通过链鉴定改进测序的方法 |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| WO2019241290A1 (en) | 2018-06-12 | 2019-12-19 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| US11179808B1 (en) * | 2018-07-11 | 2021-11-23 | Rosemount Aerospace Inc. | System and method of additive manufacturing |
| CN113671167B (zh) * | 2020-05-14 | 2024-08-02 | 北京元芯碳基集成电路研究院 | 生物电子器件及其制备方法和可控转化方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8417301D0 (en) * | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5032570A (en) * | 1987-08-04 | 1991-07-16 | Hitachi Metals, Ltd. | Method for producing ceramic superconducting material using intermediate products |
| US5824477A (en) | 1990-09-12 | 1998-10-20 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| AU8517391A (en) * | 1990-09-12 | 1992-03-30 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| US5527670A (en) * | 1990-09-12 | 1996-06-18 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| JP3509859B2 (ja) | 1991-11-07 | 2004-03-22 | ナノトロニクス，インコーポレイテッド | 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション |
| US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
| GB9201481D0 (en) * | 1992-01-23 | 1992-03-11 | Scient Generics Ltd | Treatment of nucleic acid material |
| US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
| US6129828A (en) | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
| ATE175723T1 (de) * | 1994-03-15 | 1999-01-15 | Scient Generics Ltd | Elektrochemische denatusierung von doppelsträngiger nukleinsäure |
| FR2722294B1 (fr) | 1994-07-07 | 1996-10-04 | Lyon Ecole Centrale | Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede |
| US6013165A (en) | 1998-05-22 | 2000-01-11 | Lynx Therapeutics, Inc. | Electrophoresis apparatus and method |
-
1995
- 1995-03-14 AT AT95910680T patent/ATE175723T1/de not_active IP Right Cessation
- 1995-03-14 EP EP95910680A patent/EP0750680B1/de not_active Expired - Lifetime
- 1995-03-14 WO PCT/GB1995/000542 patent/WO1995025177A1/en not_active Ceased
- 1995-03-14 US US08/704,657 patent/US6033850A/en not_active Expired - Lifetime
- 1995-03-14 DE DE69507289T patent/DE69507289T2/de not_active Expired - Lifetime
- 1995-03-14 JP JP7523910A patent/JPH09510107A/ja not_active Ceased
- 1995-03-14 CN CN95192089A patent/CN1059238C/zh not_active Expired - Fee Related
- 1995-07-01 TW TW084106845A patent/TW533236B/zh not_active IP Right Cessation
-
2000
- 2000-03-06 US US09/519,149 patent/US6291185B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6291185B1 (en) | 2001-09-18 |
| DE69507289D1 (de) | 1999-02-25 |
| JPH09510107A (ja) | 1997-10-14 |
| DE69507289T2 (de) | 1999-07-08 |
| WO1995025177A1 (en) | 1995-09-21 |
| EP0750680B1 (de) | 1999-01-13 |
| US6033850A (en) | 2000-03-07 |
| TW533236B (en) | 2003-05-21 |
| CN1143979A (zh) | 1997-02-26 |
| EP0750680A1 (de) | 1997-01-02 |
| CN1059238C (zh) | 2000-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |