ATE175965T1 - Amorphe form von aztreonam - Google Patents

Amorphe form von aztreonam

Info

Publication number: ATE175965T1
Authority: AT; Austria
Prior art keywords: amorphous form; aztreonam; methylethoxy; ami; imino
Prior art date: 1987-07-01

Application number

AT88110480T

Other languages

English (en)

Inventor

Sailesh Amilal Varia

George Eugene Reier

James Douglas Pipkin

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-01

Filing date

1988-06-30

Publication date

1999-02-15

1988-06-30 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE175965T1 publication Critical patent/ATE175965T1/de

Links

WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 title 1
WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 title 1
229960003644 aztreonam Drugs 0.000 title 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Materials For Medical Uses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88110480T 1987-07-01 1988-06-30 Amorphe form von aztreonam ATE175965T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6839287A	1987-07-01	1987-07-01

Publications (1)

Publication Number	Publication Date
ATE175965T1 true ATE175965T1 (de)	1999-02-15

Family

ID=22082279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88110480T ATE175965T1 (de)	1987-07-01	1988-06-30	Amorphe form von aztreonam

Country Status (9)

Country	Link
EP (1)	EP0297580B1 (de)
JP (1)	JP2701869B2 (de)
KR (1)	KR890002141A (de)
CN (1)	CN1028234C (de)
AT (1)	ATE175965T1 (de)
CA (1)	CA1339136C (de)
DE (1)	DE3856297T2 (de)
ES (1)	ES2127178T3 (de)
GR (1)	GR3029873T3 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN191492B (de) *	1999-05-25	2003-12-06	Ranbaxy Lab Ltd
KR100600550B1 (ko)	2000-10-20	2006-07-13	에자이 가부시키가이샤	질소 함유 방향환 유도체
US7138419B2 (en)	2000-12-27	2006-11-21	Corus Pharma, Inc.	Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate
US7214364B2 (en)	2000-12-27	2007-05-08	Corus Pharma, Inc.	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
DK2301524T3 (da)	2000-12-27	2013-07-15	Gilead Sciences Inc	Inhalerbar aztreonam uden arginin til behandling og forebyggelse af bakterielle lungeinfektioner
MXPA05001486A (es)	2002-08-05	2006-05-25	Teva Gyogyszergyar Reszvenytar	Preparacion de aztreonam.
WO2004052333A1 (en) *	2002-12-11	2004-06-24	Pari Gmbh	Pharmaceutical compositions for the pulmonary delivery of aztreonam
EP1604665B1 (de)	2003-03-10	2011-05-11	Eisai R&D Management Co., Ltd.	C-kit kinase-hemmer
US7452991B2 (en)	2003-05-15	2008-11-18	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Aztreonam β polymorph with very low residual solvent content
BRPI0411691A (pt) *	2003-07-02	2006-12-26	Teva Gyogyszergyar Reszvenytar	l-lisina de aztreonam e seus métodos de preparação
HUE025742T2 (hu)	2003-12-25	2016-04-28	Eisai R&D Man Co Ltd	4-(3-klór-4-(ciklopropilamino-karbonil)aminofenoxi)-7-metoxi-6-kinolin-karboxamid vagy szolvátja sójának kristálya és eljárás elõállításukra
US8969379B2 (en)	2004-09-17	2015-03-03	Eisai R&D Management Co., Ltd.	Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
WO2006122253A1 (en)	2005-05-09	2006-11-16	Sicor, Inc.	Process for making aztreonam
KR100951607B1 (ko) *	2005-06-23	2010-04-09	에자이 알앤드디 매니지먼트 가부시키가이샤	4-(3-클로로-4-(시클로프로필아미노카르보닐)아미노페녹시)-7-메톡시-6-퀴놀린카르복사미드의 비정질 염 및 그 제조방법
US7550483B2 (en)	2005-06-23	2009-06-23	Eisai R&D Management Co., Ltd.	Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same
JP4989476B2 (ja)	2005-08-02	2012-08-01	エーザイ・アール・アンド・ディー・マネジメント株式会社	血管新生阻害物質の効果を検定する方法
CN104706637A (zh)	2006-05-18	2015-06-17	卫材R&D管理有限公司	针对甲状腺癌的抗肿瘤剂
JP5368096B2 (ja)	2006-08-28	2013-12-18	エーザイ・アール・アンド・ディー・マネジメント株式会社	未分化型胃癌に対する抗腫瘍剤
WO2008093855A1 (ja)	2007-01-29	2008-08-07	Eisai R & D Management Co., Ltd.	未分化型胃癌治療用組成物
CA2704000C (en)	2007-11-09	2016-12-13	Eisai R&D Management Co., Ltd.	Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101579336B (zh) *	2009-07-07	2010-06-23	重庆市庆余堂制药有限公司	一种注射用氨曲南及其生产方法
CA2771403C (en)	2009-08-19	2015-02-24	Eisai R&D Management Co. Ltd.	Quinoline derivative-containing pharmaceutical composition
CN102958523B (zh)	2010-06-25	2014-11-19	卫材R&D管理有限公司	使用具有激酶抑制作用的组合的抗肿瘤剂
CN101912356B (zh) *	2010-08-02	2012-01-11	王明	一种氨曲南/精氨酸药物组合物脂微球注射剂
AU2012246490B2 (en)	2011-04-18	2016-08-04	Eisai R&D Management Co., Ltd.	Therapeutic agent for tumor
JP6038128B2 (ja)	2011-06-03	2016-12-07	エーザイ・アール・アンド・ディー・マネジメント株式会社	レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
JPWO2014098176A1 (ja) *	2012-12-21	2017-01-12	エーザイ・アール・アンド・ディー・マネジメント株式会社	キノリン誘導体のアモルファス及びその製造方法
CA2912219C (en)	2013-05-14	2021-11-16	Eisai R&D Management Co., Ltd.	Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
EP3187491A4 (de)	2014-08-28	2018-08-01	Eisai R&D Management Co., Ltd.	Hochreines chinolinderivat und verfahren zur herstellung davon
US20180028662A1 (en)	2015-02-25	2018-02-01	Eisai R&D Management Co., Ltd.	Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (ko)	2015-03-04	2024-05-13	머크 샤프 앤드 돔 코포레이션	암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CA2988707C (en)	2015-06-16	2023-10-10	Eisai R&D Management Co., Ltd.	Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
CN108135894B (zh)	2015-08-20	2021-02-19	卫材R&D管理有限公司	肿瘤治疗剂
CN110072528B (zh)	2017-02-08	2022-04-26	卫材R&D管理有限公司	治疗肿瘤的药物组合物
WO2018212202A1 (en)	2017-05-16	2018-11-22	Eisai R&D Management Co., Ltd.	Treatment of hepatocellular carcinoma

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1181075A (en) *	1981-07-13	1985-01-15	David M. Floyd	CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile

1988
- 1988-06-28 CA CA000570624A patent/CA1339136C/en not_active Expired - Fee Related
- 1988-06-29 CN CN88104073A patent/CN1028234C/zh not_active Expired - Fee Related
- 1988-06-29 JP JP63162369A patent/JP2701869B2/ja not_active Expired - Lifetime
- 1988-06-30 AT AT88110480T patent/ATE175965T1/de not_active IP Right Cessation
- 1988-06-30 DE DE3856297T patent/DE3856297T2/de not_active Expired - Fee Related
- 1988-06-30 KR KR1019880007972A patent/KR890002141A/ko not_active Ceased
- 1988-06-30 EP EP88110480A patent/EP0297580B1/de not_active Expired - Lifetime
- 1988-06-30 ES ES88110480T patent/ES2127178T3/es not_active Expired - Lifetime
1999
- 1999-04-05 GR GR990400962T patent/GR3029873T3/el unknown

Also Published As

Publication number	Publication date
DE3856297D1 (de)	1999-03-04
ES2127178T3 (es)	1999-04-16
JP2701869B2 (ja)	1998-01-21
CN1030238A (zh)	1989-01-11
KR890002141A (ko)	1989-04-08
EP0297580A1 (de)	1989-01-04
EP0297580B1 (de)	1999-01-20
JPS6422874A (en)	1989-01-25
CN1028234C (zh)	1995-04-19
GR3029873T3 (en)	1999-07-30
DE3856297T2 (de)	1999-06-02
CA1339136C (en)	1997-07-29

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Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2001-03-15	REN	Ceased due to non-payment of the annual fee