ATE176458T1 - Verfahren zur enantiomerentrennung von aryloxipropanolamin-derivaten und chirale stationäre phase zur anwendung für diese methode - Google Patents

Verfahren zur enantiomerentrennung von aryloxipropanolamin-derivaten und chirale stationäre phase zur anwendung für diese methode

Info

Publication number
ATE176458T1
ATE176458T1 AT92923449T AT92923449T ATE176458T1 AT E176458 T1 ATE176458 T1 AT E176458T1 AT 92923449 T AT92923449 T AT 92923449T AT 92923449 T AT92923449 T AT 92923449T AT E176458 T1 ATE176458 T1 AT E176458T1
Authority
AT
Austria
Prior art keywords
aryloxipropanolamine
pct
derivatives
stationary phase
chiral stationary
Prior art date
Application number
AT92923449T
Other languages
English (en)
Inventor
Lutz Fischer
Ralf Muller
Klaus Mosbach
Bjoern Ekberg
Original Assignee
Lutz Fischer
Ralf Muller
Klaus Mosbach
Bjoern Ekberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lutz Fischer, Ralf Muller, Klaus Mosbach, Bjoern Ekberg filed Critical Lutz Fischer
Application granted granted Critical
Publication of ATE176458T1 publication Critical patent/ATE176458T1/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3852—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography using imprinted phases or molecular recognition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/29—Chiral phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
    • B01J20/3057—Use of a templating or imprinting material ; filling pores of a substrate or matrix followed by the removal of the substrate or matrix
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AT92923449T 1991-11-04 1992-10-30 Verfahren zur enantiomerentrennung von aryloxipropanolamin-derivaten und chirale stationäre phase zur anwendung für diese methode ATE176458T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103234A SE9103234D0 (sv) 1991-11-04 1991-11-04 Foerfarande foer separering av enantiomerer av aryloxipropanolaminderivat och kiralt fastfaskromatografimaterial foer anvaendning vid foerfarandet

Publications (1)

Publication Number Publication Date
ATE176458T1 true ATE176458T1 (de) 1999-02-15

Family

ID=20384212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92923449T ATE176458T1 (de) 1991-11-04 1992-10-30 Verfahren zur enantiomerentrennung von aryloxipropanolamin-derivaten und chirale stationäre phase zur anwendung für diese methode

Country Status (7)

Country Link
US (1) US5461175A (de)
EP (1) EP0632794B1 (de)
JP (1) JP3193048B2 (de)
AT (1) ATE176458T1 (de)
DE (1) DE69228390D1 (de)
SE (1) SE9103234D0 (de)
WO (1) WO1993009075A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9400450A0 (en) * 1994-02-10 1995-08-11 Klaus Mosbach Preparation and application of artificial anti-idiotypic antibodies obtained by molecular imprinting
US5756717A (en) * 1995-05-24 1998-05-26 Perseptive Biosystems, Inc Protein imaging
WO1996041173A1 (en) * 1995-06-07 1996-12-19 Martinex R & D Inc. Nanoparticles imprinted with recognition sites for target molecules
US5728296A (en) * 1996-03-20 1998-03-17 Bio-Rad Laboratories, Inc. Selective recognition of solutes in chromatographic media by artificially created affinity
US6048691A (en) * 1996-05-13 2000-04-11 Motorola, Inc. Method and system for performing a binding assay
AU6860996A (en) * 1996-08-22 1998-03-06 Igen, Inc. Separating enantiomers by molecular imprinting
US5942444A (en) * 1997-01-27 1999-08-24 Biocode, Inc. Marking of products to establish identity, source and fate
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6884842B2 (en) * 1997-10-14 2005-04-26 Alnis Biosciences, Inc. Molecular compounds having complementary surfaces to targets
DE19855173C2 (de) 1998-11-30 2001-03-15 Gottschall Instruction Ges Fue Verfahren zur Herstellung derivatisierter Polymere und Derivate von funktionelle Gruppen aufweisende Polymere sowie Verfahren zur Substratbindung
HK1042309B (zh) * 1998-11-30 2004-12-03 戈特沙尔博士技术色谱仪器有限公司 聚合物网状结构的制备方法
JP2000254490A (ja) * 1999-03-15 2000-09-19 Toyo Ink Mfg Co Ltd 比較的低分子の化合物を選択的に捕捉する特性を有する高分子材料、被覆剤、分離方法、分離材、機能性化合物等の検知方法および検知材料
US6310110B1 (en) 1999-07-30 2001-10-30 Michael A. Markowitz Molecularly-imprinted material made by template-directed synthesis
GB0001513D0 (en) * 2000-01-25 2000-03-15 Univ Cranfield Rational design of mips using computational approach
US6582971B1 (en) 2000-08-21 2003-06-24 Lynntech, Inc. Imprinting large molecular weight compounds in polymer composites
US20040126814A1 (en) * 2000-08-21 2004-07-01 Singh Waheguru Pal Sensor having molecularly imprinted polymers
US20030219828A1 (en) * 2000-08-21 2003-11-27 Singh Waheguru Pal Imprinting large molecular weight compounds in polymer composites
AU2002247765B2 (en) * 2001-03-28 2007-04-26 Clondiag Chip Technologies Gmbh Device for referencing fluorescence signals
JP4315337B2 (ja) * 2004-01-16 2009-08-19 オルガノ株式会社 光学分割能を有する非粒子状有機多孔質体及びその製造方法
US7705062B2 (en) * 2005-09-08 2010-04-27 The United States Of America As Represented By The Secretary Of The Navy Nanoporous organosilicas as pre-concentration materials for sensors
GB2441528B8 (en) * 2006-09-08 2010-03-31 Porvair Filtration Group Ltd Co-sintered polymer structures
CN101104698B (zh) * 2007-08-10 2010-05-19 华中科技大学 用于分离手性化合物的分子凝胶及其制备方法
FR2920337B1 (fr) * 2007-08-29 2010-03-12 Essilor Int Procede de preparation d'un article moule transparent a base d'un alliage de polymere thermoplastique et de polymere thermodurcissable
WO2015029072A2 (en) 2013-08-30 2015-03-05 Council Of Scientific And Industrial Research Racemic drug resolution using polymer supported chiral selector

Also Published As

Publication number Publication date
DE69228390D1 (de) 1999-03-18
EP0632794B1 (de) 1999-02-03
JP3193048B2 (ja) 2001-07-30
EP0632794A1 (de) 1995-01-11
JPH07500833A (ja) 1995-01-26
US5461175A (en) 1995-10-24
WO1993009075A1 (en) 1993-05-13
SE9103234D0 (sv) 1991-11-04

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