ATE214695T1 - Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen - Google Patents
Racemisierungsverfahren bei der herstellung von levobupivacaine und analogenInfo
- Publication number
- ATE214695T1 ATE214695T1 AT95932092T AT95932092T ATE214695T1 AT E214695 T1 ATE214695 T1 AT E214695T1 AT 95932092 T AT95932092 T AT 95932092T AT 95932092 T AT95932092 T AT 95932092T AT E214695 T1 ATE214695 T1 AT E214695T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- compound
- date
- levobupivacaine
- analogues
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title 1
- 229960004288 levobupivacaine Drugs 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- -1 piperidine-2-carboxanilide compound Chemical class 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94306962 | 1994-09-23 | ||
| GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
| PCT/GB1995/002247 WO1996009290A1 (en) | 1994-09-23 | 1995-09-22 | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE214695T1 true ATE214695T1 (de) | 2002-04-15 |
Family
ID=26137306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95932092T ATE214695T1 (de) | 1994-09-23 | 1995-09-22 | Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5786484A (de) |
| EP (1) | EP0782569B1 (de) |
| JP (1) | JP3898220B2 (de) |
| KR (1) | KR100393133B1 (de) |
| CN (1) | CN1104416C (de) |
| AT (1) | ATE214695T1 (de) |
| AU (1) | AU695479B2 (de) |
| CA (1) | CA2200490C (de) |
| DE (1) | DE69525950T2 (de) |
| DK (1) | DK0782569T3 (de) |
| ES (1) | ES2173194T3 (de) |
| FI (1) | FI117436B (de) |
| HU (1) | HU216291B (de) |
| MX (1) | MX9702210A (de) |
| NO (1) | NO308074B1 (de) |
| PL (1) | PL183204B1 (de) |
| PT (1) | PT782569E (de) |
| WO (1) | WO1996009290A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
| US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| EP1295873A4 (de) * | 2000-06-14 | 2004-05-19 | Verfahren zur herstellung racemischer piperidinderivate und zur herstellung optisch aktiver piperidinderivate | |
| DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
| US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
| BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP2218448B1 (de) | 2002-12-13 | 2015-09-23 | Durect Corporation | Orale Darreichungsform mit flüssigen hochviskose Trägersystemen |
| DK2767292T3 (en) | 2004-09-17 | 2016-12-19 | Durect Corp | RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| EP2067471B1 (de) * | 2007-12-06 | 2018-02-14 | Durect Corporation | Orale arzneimitteldosierformen |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| CA2905131A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
| CN109475505A (zh) | 2016-07-06 | 2019-03-15 | 度瑞公司 | 具有药物组成物、屏障层及药物层的口服剂型 |
| WO2019222565A1 (en) | 2018-05-18 | 2019-11-21 | Kura Oncology, Inc. | Synthesis of tipifarnib |
| WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/en not_active Ceased
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
- 1995-09-22 CA CA002200490A patent/CA2200490C/en not_active Expired - Lifetime
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active Expired - Lifetime
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 EP EP95932092A patent/EP0782569B1/de not_active Expired - Lifetime
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
-
1997
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100393133B1 (ko) | 2003-11-17 |
| FI117436B (fi) | 2006-10-13 |
| EP0782569B1 (de) | 2002-03-20 |
| ES2173194T3 (es) | 2002-10-16 |
| DE69525950D1 (de) | 2002-04-25 |
| US5786484A (en) | 1998-07-28 |
| JPH10505855A (ja) | 1998-06-09 |
| PT782569E (pt) | 2002-09-30 |
| CA2200490A1 (en) | 1996-03-28 |
| FI971202A0 (fi) | 1997-03-21 |
| CN1159184A (zh) | 1997-09-10 |
| MX9702210A (es) | 1998-05-31 |
| CN1104416C (zh) | 2003-04-02 |
| DE69525950T2 (de) | 2002-09-19 |
| AU695479B2 (en) | 1998-08-13 |
| NO971358L (no) | 1997-03-21 |
| EP0782569A1 (de) | 1997-07-09 |
| DK0782569T3 (da) | 2002-07-22 |
| WO1996009290A1 (en) | 1996-03-28 |
| AU3527995A (en) | 1996-04-09 |
| PL319368A1 (en) | 1997-08-04 |
| HU216291B (hu) | 1999-06-28 |
| FI971202L (fi) | 1997-03-21 |
| JP3898220B2 (ja) | 2007-03-28 |
| NO971358D0 (no) | 1997-03-21 |
| CA2200490C (en) | 2007-01-09 |
| NO308074B1 (no) | 2000-07-17 |
| HUT77055A (hu) | 1998-03-02 |
| PL183204B1 (pl) | 2002-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |