ATE176912T1 - 2-piperazinon-verbindungen und deren verwendung - Google Patents
2-piperazinon-verbindungen und deren verwendungInfo
- Publication number
- ATE176912T1 ATE176912T1 AT94304241T AT94304241T ATE176912T1 AT E176912 T1 ATE176912 T1 AT E176912T1 AT 94304241 T AT94304241 T AT 94304241T AT 94304241 T AT94304241 T AT 94304241T AT E176912 T1 ATE176912 T1 AT E176912T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- formula
- hydrogen atom
- halogen atom
- adhesion
- Prior art date
Links
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical class O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 p-hydroxyphenyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14613693 | 1993-06-17 | ||
| JP25414293 | 1993-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176912T1 true ATE176912T1 (de) | 1999-03-15 |
Family
ID=26477044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94304241T ATE176912T1 (de) | 1993-06-17 | 1994-06-13 | 2-piperazinon-verbindungen und deren verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5550131A (de) |
| EP (1) | EP0643072B1 (de) |
| KR (1) | KR950000683A (de) |
| CN (1) | CN1098409A (de) |
| AT (1) | ATE176912T1 (de) |
| AU (1) | AU6477194A (de) |
| CA (1) | CA2126026A1 (de) |
| DE (1) | DE69416629T2 (de) |
| FI (1) | FI942881A7 (de) |
| HU (1) | HUT70045A (de) |
| NO (1) | NO942274L (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2216162A1 (en) * | 1995-04-26 | 1996-10-31 | Takeda Chemical Industries, Ltd. | Piperazinones useful as inhibitors of platelet aggregation |
| EP0750913A3 (de) * | 1995-06-30 | 1997-11-05 | Takeda Chemical Industries, Ltd. | Disaccharide enthaltende gefriergetrocknete Zubereitung für pharmazeutische Verwendung |
| IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
| US6100423A (en) * | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| US5919777A (en) * | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| AU6120298A (en) | 1997-03-07 | 1998-09-22 | Takeda Chemical Industries Ltd. | 2-peperazinone-1-acetic acid derivatives and their use |
| WO1998042342A1 (en) * | 1997-03-24 | 1998-10-01 | Merck & Co., Inc. | Thrombin inhibitors |
| AU6896298A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6369063B1 (en) | 1997-04-14 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| WO1998046628A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| AU742178B2 (en) * | 1998-05-26 | 2001-12-20 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
| CN1253442C (zh) * | 1999-07-26 | 2006-04-26 | 参天制药株式会社 | 新型噻嗪和吡嗪衍生物 |
| KR100360122B1 (ko) * | 2000-09-14 | 2002-11-07 | 대한민국(서울대학교 총장) | 제충 및 제초 기능을 갖는 폴리에틸렌 멀칭필름 |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| AU2002331064B2 (en) | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA39849C2 (uk) * | 1991-03-26 | 2001-07-16 | Ф.Хоффманн-Ля Рош Аг | ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ |
| AU646966B2 (en) * | 1991-08-23 | 1994-03-10 | Takeda Chemical Industries Ltd. | 2-piperazinone compounds, their production and use |
-
1994
- 1994-06-09 HU HU9401726A patent/HUT70045A/hu unknown
- 1994-06-13 EP EP94304241A patent/EP0643072B1/de not_active Expired - Lifetime
- 1994-06-13 AT AT94304241T patent/ATE176912T1/de not_active IP Right Cessation
- 1994-06-13 DE DE69416629T patent/DE69416629T2/de not_active Expired - Fee Related
- 1994-06-16 AU AU64771/94A patent/AU6477194A/en not_active Abandoned
- 1994-06-16 NO NO942274A patent/NO942274L/no unknown
- 1994-06-16 CA CA002126026A patent/CA2126026A1/en not_active Abandoned
- 1994-06-16 FI FI942881A patent/FI942881A7/fi not_active Application Discontinuation
- 1994-06-17 CN CN94106799A patent/CN1098409A/zh active Pending
- 1994-06-17 US US08/262,315 patent/US5550131A/en not_active Expired - Fee Related
- 1994-06-17 KR KR1019940013860A patent/KR950000683A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0643072B1 (de) | 1999-02-24 |
| EP0643072A1 (de) | 1995-03-15 |
| HU9401726D0 (en) | 1994-09-28 |
| HUT70045A (en) | 1995-09-28 |
| CN1098409A (zh) | 1995-02-08 |
| US5550131A (en) | 1996-08-27 |
| FI942881A7 (fi) | 1994-12-18 |
| AU6477194A (en) | 1994-12-22 |
| NO942274L (no) | 1994-12-19 |
| FI942881A0 (fi) | 1994-06-16 |
| DE69416629T2 (de) | 1999-07-22 |
| NO942274D0 (no) | 1994-06-16 |
| KR950000683A (ko) | 1995-01-03 |
| DE69416629D1 (de) | 1999-04-01 |
| CA2126026A1 (en) | 1994-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |