ATE177648T1 - Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien - Google Patents
Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinienInfo
- Publication number
- ATE177648T1 ATE177648T1 AT91308438T AT91308438T ATE177648T1 AT E177648 T1 ATE177648 T1 AT E177648T1 AT 91308438 T AT91308438 T AT 91308438T AT 91308438 T AT91308438 T AT 91308438T AT E177648 T1 ATE177648 T1 AT E177648T1
- Authority
- AT
- Austria
- Prior art keywords
- neoplastic cells
- cell lines
- packaging cell
- retrovirus vector
- producing packaging
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58205590A | 1990-09-14 | 1990-09-14 | |
| US74665591A | 1991-08-16 | 1991-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE177648T1 true ATE177648T1 (de) | 1999-04-15 |
Family
ID=27078482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91308438T ATE177648T1 (de) | 1990-09-14 | 1991-09-16 | Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0476953B1 (de) |
| JP (1) | JPH05246895A (de) |
| AT (1) | ATE177648T1 (de) |
| CA (1) | CA2051288C (de) |
| DE (1) | DE69130996T2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569679B1 (en) | 1988-03-21 | 2003-05-27 | Chiron Corporation | Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene |
| US6133029A (en) | 1988-03-21 | 2000-10-17 | Chiron Corporation | Replication defective viral vectors for infecting human cells |
| US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
| US5997859A (en) * | 1988-03-21 | 1999-12-07 | Chiron Corporation | Method for treating a metastatic carcinoma using a conditionally lethal gene |
| US5716826A (en) * | 1988-03-21 | 1998-02-10 | Chiron Viagene, Inc. | Recombinant retroviruses |
| WO1993021959A1 (en) * | 1992-05-01 | 1993-11-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bystander effect tumoricidal therapy |
| GB9305759D0 (en) * | 1993-03-19 | 1993-05-05 | Medical Research Council And T | Hiv therapy method and agents |
| CA2171109A1 (en) * | 1993-10-01 | 1995-04-13 | Zvi Ram | Gene therapy of the nervous system |
| EP0722343A4 (de) * | 1993-10-06 | 1999-12-29 | Us Gov Health & Human Serv | Die behandlung von tumoren durch genetische transformation von tumorzellen mit genen, die für selektive, negative marker und für cytokine kodieren |
| WO1995014091A2 (en) | 1993-11-18 | 1995-05-26 | Chiron Viagene, Inc. | Compositions and methods for utilizing conditionally lethal genes |
| US6451571B1 (en) | 1994-05-02 | 2002-09-17 | University Of Washington | Thymidine kinase mutants |
| AU2434195A (en) * | 1994-05-02 | 1995-11-29 | University Of Washington | Thymidine kinase mutants |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| CA2210718A1 (en) | 1995-01-17 | 1996-07-25 | Genetic Therapy, Inc. | Delivery of therapeutic agents by gene therapy |
| ATE309000T1 (de) | 1995-06-27 | 2005-11-15 | Bavarian Nordic As | Verkapselte zellen die virenpartikeln produzieren |
| US6602499B1 (en) | 1998-04-30 | 2003-08-05 | The General Hospital Corporation | Combination viral-based and gene-based therapy of tumors |
| US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| ATE527347T1 (de) | 2001-08-02 | 2011-10-15 | Inst Clayton De La Rech | Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen |
| RU2305708C2 (ru) * | 2001-10-02 | 2007-09-10 | Энститю Клейтон Де Ля Решерш | Рекомбинантный лентивирусный вектор, клетка-хозяин, трансдуцированная лентивирусным вектором, способ ее трансдукции и применение |
-
1991
- 1991-09-13 CA CA002051288A patent/CA2051288C/en not_active Expired - Fee Related
- 1991-09-16 DE DE69130996T patent/DE69130996T2/de not_active Expired - Fee Related
- 1991-09-16 AT AT91308438T patent/ATE177648T1/de not_active IP Right Cessation
- 1991-09-16 EP EP91308438A patent/EP0476953B1/de not_active Revoked
- 1991-09-17 JP JP3236166A patent/JPH05246895A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0476953B1 (de) | 1999-03-17 |
| EP0476953A3 (en) | 1992-12-16 |
| CA2051288C (en) | 2002-02-05 |
| CA2051288A1 (en) | 1992-03-15 |
| DE69130996D1 (de) | 1999-04-22 |
| DE69130996T2 (de) | 1999-07-29 |
| EP0476953A2 (de) | 1992-03-25 |
| JPH05246895A (ja) | 1993-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE177648T1 (de) | Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien | |
| DK464087A (da) | Haloarylnitril-nedbrydende gen, anvendelsen heraf og celler indeholdende dette | |
| FI970983L (fi) | Molekyylien siirto solujen sytoplasmaan | |
| FI890406A0 (fi) | Polymera material. | |
| DK149790A (da) | 0-(3amino-2-hydroxypropyl)-hydroximsyrehalogenider og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende en eller flere af halogeniderne og disses anvendelse | |
| DK158659C (da) | 2,4,6-triiod-isophthalsyrederivater, deres fremstilling og roentgenkontrastmidler indeholdende disse. | |
| ES2023417B3 (es) | Procedimiento para polimerizar una o mas 1-olefinas en fase gaseosa en presencia de material inorganico pulverulento. | |
| FI862380A7 (fi) | Lasersädettä kestävä materiaali. | |
| ES278850Y (es) | Expendedor de material laminar. | |
| IT8420245A0 (it) | Fune di trasporto ad organi raschianti in materia plastica. | |
| DK35483A (da) | Expressionsvectorer for catechol-2,3-oxygenase, de vundne enzymer og deres anvendelse | |
| FI882278A0 (fi) | Parannettuja kromikatalyyttikoostumuksia ja polymerointimenetelmä, jossa niitä käytetään | |
| DE3579045D1 (de) | Lagermaterial und dessen herstellungsverfahren. | |
| FI875467A7 (fi) | DNA-molekyylit, jotka ovat hyödyllisiä kasviensuojelussa. | |
| FI880582A0 (fi) | Paperinvalmistuksessa käytettävät uudet valmisteet | |
| IT8022385A0 (it) | Agenti per la gelificazione di fluoroelastomeri e prodotti con essi ottenuti. | |
| IT7923867A0 (it) | Procedimento e impianto di movimentazione di prodotti in pile. | |
| IT1188214B (it) | Stabilizzante alla luce per polimeri,particolarmente per polipropilene,polietilene,polistirolo e per polimeri contenenti cloro | |
| DE3676901D1 (de) | Wickelachse zum anbringen von umhuellungsmaterial. | |
| TR20254A (tr) | 1,3,4-tiyadiyazol-2-karboksilik asit tuerevleri,bu bilesim imaline mahsus usuller ve bunlari ihtiva eden fungisit ve nemasit maddeler | |
| DE3688883D1 (de) | Strukturmaterial und dessen herstellung. | |
| DE58902502D1 (de) | 2,6-polyalkylpiperidinsubstituierte benzimidazol-2-carbonsaeureanilide und deren verwendung zum stabilisieren von organischem material. | |
| FI791629A7 (fi) | Menetelmä pregnaanityyppisten steroidien hydroksiasetyyli- sivuketjun rakentamiseksi, uudet 21-hydroksi-20-okso17 - pregnaaniyhdisteet ja nä itä yhdisteitä sisältävät farmaseuttiset valmisteet. | |
| ATA68181A (de) | Vorrichtung zum ein- oder beidseitigen besaeumen von brettern, balken u. dgl. | |
| DE3481049D1 (de) | Staubfreier behaelter und dessen herstellung. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee | ||
| RZN | Patent revoked |