ATE177648T1 - Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien - Google Patents

Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien

Info

Publication number
ATE177648T1
ATE177648T1 AT91308438T AT91308438T ATE177648T1 AT E177648 T1 ATE177648 T1 AT E177648T1 AT 91308438 T AT91308438 T AT 91308438T AT 91308438 T AT91308438 T AT 91308438T AT E177648 T1 ATE177648 T1 AT E177648T1
Authority
AT
Austria
Prior art keywords
neoplastic cells
cell lines
packaging cell
retrovirus vector
producing packaging
Prior art date
Application number
AT91308438T
Other languages
English (en)
Inventor
Robert L Martuza
Xandra O Breakfield
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27078482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE177648(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE177648T1 publication Critical patent/ATE177648T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/13011Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91308438T 1990-09-14 1991-09-16 Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien ATE177648T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58205590A 1990-09-14 1990-09-14
US74665591A 1991-08-16 1991-08-16

Publications (1)

Publication Number Publication Date
ATE177648T1 true ATE177648T1 (de) 1999-04-15

Family

ID=27078482

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91308438T ATE177648T1 (de) 1990-09-14 1991-09-16 Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien

Country Status (5)

Country Link
EP (1) EP0476953B1 (de)
JP (1) JPH05246895A (de)
AT (1) ATE177648T1 (de)
CA (1) CA2051288C (de)
DE (1) DE69130996T2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569679B1 (en) 1988-03-21 2003-05-27 Chiron Corporation Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene
US6133029A (en) 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US5662896A (en) 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5997859A (en) * 1988-03-21 1999-12-07 Chiron Corporation Method for treating a metastatic carcinoma using a conditionally lethal gene
US5716826A (en) * 1988-03-21 1998-02-10 Chiron Viagene, Inc. Recombinant retroviruses
WO1993021959A1 (en) * 1992-05-01 1993-11-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bystander effect tumoricidal therapy
GB9305759D0 (en) * 1993-03-19 1993-05-05 Medical Research Council And T Hiv therapy method and agents
CA2171109A1 (en) * 1993-10-01 1995-04-13 Zvi Ram Gene therapy of the nervous system
EP0722343A4 (de) * 1993-10-06 1999-12-29 Us Gov Health & Human Serv Die behandlung von tumoren durch genetische transformation von tumorzellen mit genen, die für selektive, negative marker und für cytokine kodieren
WO1995014091A2 (en) 1993-11-18 1995-05-26 Chiron Viagene, Inc. Compositions and methods for utilizing conditionally lethal genes
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
AU2434195A (en) * 1994-05-02 1995-11-29 University Of Washington Thymidine kinase mutants
US6638762B1 (en) 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
CA2210718A1 (en) 1995-01-17 1996-07-25 Genetic Therapy, Inc. Delivery of therapeutic agents by gene therapy
ATE309000T1 (de) 1995-06-27 2005-11-15 Bavarian Nordic As Verkapselte zellen die virenpartikeln produzieren
US6602499B1 (en) 1998-04-30 2003-08-05 The General Hospital Corporation Combination viral-based and gene-based therapy of tumors
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
ATE527347T1 (de) 2001-08-02 2011-10-15 Inst Clayton De La Rech Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen
RU2305708C2 (ru) * 2001-10-02 2007-09-10 Энститю Клейтон Де Ля Решерш Рекомбинантный лентивирусный вектор, клетка-хозяин, трансдуцированная лентивирусным вектором, способ ее трансдукции и применение

Also Published As

Publication number Publication date
EP0476953B1 (de) 1999-03-17
EP0476953A3 (en) 1992-12-16
CA2051288C (en) 2002-02-05
CA2051288A1 (en) 1992-03-15
DE69130996D1 (de) 1999-04-22
DE69130996T2 (de) 1999-07-29
EP0476953A2 (de) 1992-03-25
JPH05246895A (ja) 1993-09-24

Similar Documents

Publication Publication Date Title
ATE177648T1 (de) Gezielte zerstörung neoplastischer zellen mit hilfe von retrovirusvektor-produzierenden packungszelllinien
DK464087A (da) Haloarylnitril-nedbrydende gen, anvendelsen heraf og celler indeholdende dette
FI970983L (fi) Molekyylien siirto solujen sytoplasmaan
FI890406A0 (fi) Polymera material.
DK149790A (da) 0-(3amino-2-hydroxypropyl)-hydroximsyrehalogenider og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende en eller flere af halogeniderne og disses anvendelse
DK158659C (da) 2,4,6-triiod-isophthalsyrederivater, deres fremstilling og roentgenkontrastmidler indeholdende disse.
ES2023417B3 (es) Procedimiento para polimerizar una o mas 1-olefinas en fase gaseosa en presencia de material inorganico pulverulento.
FI862380A7 (fi) Lasersädettä kestävä materiaali.
ES278850Y (es) Expendedor de material laminar.
IT8420245A0 (it) Fune di trasporto ad organi raschianti in materia plastica.
DK35483A (da) Expressionsvectorer for catechol-2,3-oxygenase, de vundne enzymer og deres anvendelse
FI882278A0 (fi) Parannettuja kromikatalyyttikoostumuksia ja polymerointimenetelmä, jossa niitä käytetään
DE3579045D1 (de) Lagermaterial und dessen herstellungsverfahren.
FI875467A7 (fi) DNA-molekyylit, jotka ovat hyödyllisiä kasviensuojelussa.
FI880582A0 (fi) Paperinvalmistuksessa käytettävät uudet valmisteet
IT8022385A0 (it) Agenti per la gelificazione di fluoroelastomeri e prodotti con essi ottenuti.
IT7923867A0 (it) Procedimento e impianto di movimentazione di prodotti in pile.
IT1188214B (it) Stabilizzante alla luce per polimeri,particolarmente per polipropilene,polietilene,polistirolo e per polimeri contenenti cloro
DE3676901D1 (de) Wickelachse zum anbringen von umhuellungsmaterial.
TR20254A (tr) 1,3,4-tiyadiyazol-2-karboksilik asit tuerevleri,bu bilesim imaline mahsus usuller ve bunlari ihtiva eden fungisit ve nemasit maddeler
DE3688883D1 (de) Strukturmaterial und dessen herstellung.
DE58902502D1 (de) 2,6-polyalkylpiperidinsubstituierte benzimidazol-2-carbonsaeureanilide und deren verwendung zum stabilisieren von organischem material.
FI791629A7 (fi) Menetelmä pregnaanityyppisten steroidien hydroksiasetyyli- sivuketjun rakentamiseksi, uudet 21-hydroksi-20-okso17 - pregnaaniyhdisteet ja nä itä yhdisteitä sisältävät farmaseuttiset valmisteet.
ATA68181A (de) Vorrichtung zum ein- oder beidseitigen besaeumen von brettern, balken u. dgl.
DE3481049D1 (de) Staubfreier behaelter und dessen herstellung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
RZN Patent revoked