ATE309000T1 - Verkapselte zellen die virenpartikeln produzieren - Google Patents

Verkapselte zellen die virenpartikeln produzieren

Info

Publication number
ATE309000T1
ATE309000T1 AT96923905T AT96923905T ATE309000T1 AT E309000 T1 ATE309000 T1 AT E309000T1 AT 96923905 T AT96923905 T AT 96923905T AT 96923905 T AT96923905 T AT 96923905T AT E309000 T1 ATE309000 T1 AT E309000T1
Authority
AT
Austria
Prior art keywords
encapsulated cells
virus particles
produce virus
cells
genes
Prior art date
Application number
AT96923905T
Other languages
English (en)
Inventor
Robert Michael Saller
Walter H Guenzburg
Brian Salmons
Original Assignee
Bavarian Nordic As
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8097001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE309000(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bavarian Nordic As, Gsf Forschungszentrum Umwelt filed Critical Bavarian Nordic As
Application granted granted Critical
Publication of ATE309000T1 publication Critical patent/ATE309000T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT96923905T 1995-06-27 1996-06-24 Verkapselte zellen die virenpartikeln produzieren ATE309000T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK74095 1995-06-27
PCT/EP1996/002748 WO1997001357A1 (en) 1995-06-27 1996-06-24 Encapsulated cells producing viral particles

Publications (1)

Publication Number Publication Date
ATE309000T1 true ATE309000T1 (de) 2005-11-15

Family

ID=8097001

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923905T ATE309000T1 (de) 1995-06-27 1996-06-24 Verkapselte zellen die virenpartikeln produzieren

Country Status (21)

Country Link
US (1) US6776985B1 (de)
EP (1) EP0835137B1 (de)
JP (2) JP4119952B2 (de)
KR (1) KR100484883B1 (de)
CN (1) CN1187095C (de)
AT (1) ATE309000T1 (de)
AU (1) AU708273B2 (de)
CA (1) CA2222559A1 (de)
CZ (1) CZ286979B6 (de)
DE (1) DE69633180D1 (de)
DK (1) DK0835137T3 (de)
ES (1) ES2253754T3 (de)
IL (1) IL122119A (de)
NO (1) NO321427B1 (de)
NZ (1) NZ312671A (de)
PL (1) PL185338B1 (de)
PT (1) PT835137E (de)
RU (1) RU2187301C2 (de)
SI (1) SI0835137T1 (de)
UA (1) UA65525C2 (de)
WO (1) WO1997001357A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3908274B2 (ja) 1995-03-09 2007-04-25 ゲーエスエフ−フォルシュンクスツェントラム・フュア・ウムベルト・ウント・ゲズントハイト・ゲーエムベーハー 遺伝子治療用の抗菌ペプチドをコードする治療用遺伝子を有するベクター
ATE309000T1 (de) 1995-06-27 2005-11-15 Bavarian Nordic As Verkapselte zellen die virenpartikeln produzieren
US6540995B1 (en) 1996-03-27 2003-04-01 Bavarian Nordic Research Institute Gmbh Encapsulated cells producing cytochrome P450
RU2185821C2 (ru) 1996-03-27 2002-07-27 Бавариан Нордик Рисерч Инститьют А/С Трансдуцирующие цитохром р450 ретровирусные векторы
WO1999056660A1 (en) 1998-05-05 1999-11-11 Koninklijke Philips Electronics N.V. Toothbrush comprising a brush member having a bristle field and an interdental bristle field
AU2005229434B2 (en) 2004-03-30 2010-09-30 Nsgene A/S Therapeutic use of a growth factor, NsG33
JP2008540347A (ja) 2005-05-03 2008-11-20 フェテリネールメディツィニシュ ウニベルジテート ウィーン 浸透性カプセル
CN101903049B (zh) 2007-12-20 2014-08-13 伊西康公司 包囊的肾组织
KR101250925B1 (ko) * 2011-10-28 2013-04-04 한화케미칼 주식회사 캡슐 세포용 구조체
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
FR3044016A1 (fr) * 2015-11-24 2017-05-26 Glaxosmithkline Ip Dev Ltd Lignees cellulaires stables pour la production retrovirale
KR102067352B1 (ko) * 2015-11-24 2020-01-16 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 레트로바이러스 생산을 위한 일시적인 형질감염 방법
US11427809B2 (en) 2016-05-25 2022-08-30 Lonza Houston, Inc. Methods for isolating adeno-associated virus using a polydialkylammonium salt
RU2688383C2 (ru) * 2017-07-10 2019-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" Способ синтеза белка в культуре бактериальных клеток
CA3220737A1 (en) * 2021-05-21 2022-11-24 Bionaut Labs Ltd. System and method for localized therapeutic treatment
CN115820683B (zh) * 2022-09-28 2024-04-05 西南大学 家蚕Cyp9a20基因及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
DD160393A3 (de) * 1980-11-14 1983-07-27 Horst Dautzenberg Mikrokapseln und verfahren zu ihrer herstellung
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
EP0199362A3 (de) * 1985-04-26 1987-10-07 Massachusetts Institute Of Technology System und Vorrichtung zur verzögerten und stossweisen Freisetzung biologisch aktiver Substanzen
CA1310924C (en) * 1986-04-24 1992-12-01 Francis P. Mccormick Infective drug delivery system
WO1989011539A1 (en) 1988-05-17 1989-11-30 Sloan-Kettering Institute For Cancer Research Retroviral vector
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
DE4021050A1 (de) * 1990-06-29 1992-01-02 Akad Wissenschaften Ddr Verfahren zur herstellung von mikrokapseln
CA2051288C (en) * 1990-09-14 2002-02-05 Robert L. Martuza Viral targeted destruction of neoplastic cells
WO1992010564A1 (en) * 1990-12-13 1992-06-25 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
WO1994029437A1 (en) 1993-06-07 1994-12-22 University Of Medicine & Dentistry Of New Jersey Highly-efficient, self-inactivating, recombination-free, u3-free retroviral vectors
US5688773A (en) 1994-08-17 1997-11-18 The General Hospital Corporation Method of selectively destroying neoplastic cells
CA2198210C (en) 1994-09-02 2006-07-11 Gsf - Forschungszentrum Fur Umwelt Und Gesundheit Gmbh Non self-inactivating, expression targeted retroviral vectors
ATE309000T1 (de) 1995-06-27 2005-11-15 Bavarian Nordic As Verkapselte zellen die virenpartikeln produzieren
DK0848757T3 (da) 1995-09-06 2002-07-01 Austrian Nordic Biotherapeutic Anvendelse af WAP eller MMTV regulatoriske sekvenser for målrettet ekspression af sammenkædede heterologe gener i humane mammae celler, inklusiv humane mammae carcinoma celler
RU2185821C2 (ru) 1996-03-27 2002-07-27 Бавариан Нордик Рисерч Инститьют А/С Трансдуцирующие цитохром р450 ретровирусные векторы

Also Published As

Publication number Publication date
PL185338B1 (pl) 2003-04-30
EP0835137B1 (de) 2005-11-09
AU6415496A (en) 1997-01-30
IL122119A (en) 2004-06-01
ES2253754T3 (es) 2006-06-01
KR19990028491A (ko) 1999-04-15
NZ312671A (en) 1999-10-28
DK0835137T3 (da) 2006-03-06
KR100484883B1 (ko) 2005-09-02
CZ419597A3 (cs) 1998-03-18
CZ286979B6 (en) 2000-08-16
RU2187301C2 (ru) 2002-08-20
HK1010139A1 (en) 1999-06-17
JPH11508768A (ja) 1999-08-03
AU708273B2 (en) 1999-07-29
CN1187095C (zh) 2005-02-02
DE69633180D1 (de) 2004-09-23
PT835137E (pt) 2004-12-31
NO321427B1 (no) 2006-05-08
JP2008101011A (ja) 2008-05-01
EP0835137A1 (de) 1998-04-15
NO975813L (no) 1998-02-23
JP4848348B2 (ja) 2011-12-28
UA65525C2 (en) 2004-04-15
JP4119952B2 (ja) 2008-07-16
US6776985B1 (en) 2004-08-17
IL122119A0 (en) 1998-04-05
SI0835137T1 (sl) 2006-04-30
CA2222559A1 (en) 1997-01-16
PL324289A1 (en) 1998-05-11
NO975813D0 (no) 1997-12-10
WO1997001357A1 (en) 1997-01-16
CN1189104A (zh) 1998-07-29

Similar Documents

Publication Publication Date Title
DE69633180D1 (de) Verkapselte zellen die virenpartikeln produzieren
CA2092195A1 (en) Retroviral packaging cell line
CA2154023A1 (en) Recombinant infectious non-segmented negative strand rna virus
UA40661C2 (uk) Вектор для введення бажаного гена у рослину (варіанти), спосіб одержання трансгенної рослини, спосіб введення, принаймні, двох бажаних генів у рослину
EP1103564A4 (de) Krebsantigene, basierend auf dem tumorunterdrückenden genprodukt wt1
EP0743958A4 (de) Nicht-viraler vektor
WO1998044097A3 (en) Method for enhancing expression of a foreign or endogenous gene product in plants
EP0845032A4 (de) Isolierte nukleinsäuremoleküle, peptide die mit hla-a2 moleküle (mhc) komplexe bilden, sowie deren verwendungen
WO1991002805A3 (en) Recombinant retroviruses delivering vector constructs to target cells
GB9813540D0 (en) Chemical compounds
HUT76511A (en) Benzoyl derivatives, preparation and use thereot
DE69830663D1 (de) Nicht-primaten lentivirale vektoren und verpackungssysteme
HUP0000318A2 (hu) Tumorvakcina és eljárás előállítására
MXPA05005545A (es) Peptidos que se dirigen a celulas tomurales y endoteliales, composiciones y usos de los mismos.
RU2005129273A (ru) Противораковый агент, содержащий белок lk8 в качестве активного ингредиента
PL336640A1 (en) Substituted 3,3-diamino-2- propenonitriles, their production and application
EP1149917A3 (de) Hepatitis B Vektoren für Gentherapie
EP1070122A4 (de) Induktion apoptischer oder zytotoxischer genexpression durch adenovirus-vermittelten gen-kotransfer
DK0843731T3 (da) Adenovirusvektorer til genterapi
DE50200711D1 (de) Substanzen zur therapie von erkrankungen, die durch hochproliferierende zellen verursacht werden
ES2068811T5 (es) Plantas resistentes a virus que tienen una proteina de cubierta viral.
MY104975A (en) Protease, reverse transcriptase and endonuclease of retrovirus, and method for producing these enzymes.
WO1996033282A3 (en) High efficiency ex vivo transduction of cells by high titer recombinant retroviral preparations
CA2331440A1 (en) Amphotropic retrovirus packaging cell line, process for its production and use thereof
GR3030190T3 (en) Benzoyl derivatives and synthesis thereof

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0835137

Country of ref document: EP

REN Ceased due to non-payment of the annual fee