ATE177743T1 - Langkettiger carbonsäureimidester - Google Patents

Langkettiger carbonsäureimidester

Info

Publication number
ATE177743T1
ATE177743T1 AT92107035T AT92107035T ATE177743T1 AT E177743 T1 ATE177743 T1 AT E177743T1 AT 92107035 T AT92107035 T AT 92107035T AT 92107035 T AT92107035 T AT 92107035T AT E177743 T1 ATE177743 T1 AT E177743T1
Authority
AT
Austria
Prior art keywords
long chain
chain carboxylic
group
proteins
salts
Prior art date
Application number
AT92107035T
Other languages
English (en)
Inventor
Iwao Ebashi
Tetsuo Takigawa
Masayasu Inoue
Original Assignee
Kuraray Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co filed Critical Kuraray Co
Application granted granted Critical
Publication of ATE177743T1 publication Critical patent/ATE177743T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
AT92107035T 1991-04-24 1992-04-24 Langkettiger carbonsäureimidester ATE177743T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12273791 1991-04-24

Publications (1)

Publication Number Publication Date
ATE177743T1 true ATE177743T1 (de) 1999-04-15

Family

ID=14843348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92107035T ATE177743T1 (de) 1991-04-24 1992-04-24 Langkettiger carbonsäureimidester

Country Status (5)

Country Link
US (3) US5336782A (de)
EP (1) EP0511600B1 (de)
KR (1) KR950003921B1 (de)
AT (1) ATE177743T1 (de)
DE (1) DE69228627T2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336782A (en) * 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester
NZ273285A (en) * 1993-09-17 1997-10-24 Novo Nordisk As Insulin derivatives and compositions thereof
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US6680295B1 (en) * 1994-09-22 2004-01-20 The Administrators Of The Tulane Educational Fund Method and pharmaceutical composition for prevention and treatment of brain damage
JP3708151B2 (ja) * 1994-12-15 2005-10-19 協和醗酵工業株式会社 Ｐｅｇ化したヒト顆粒球コロニー刺激因子の定量法
US5869602A (en) 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US7235627B2 (en) * 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
WO1998022122A1 (en) * 1996-11-21 1998-05-28 Promega Corporation Alkyl peptide amides and applications
US6291078B1 (en) 1997-10-22 2001-09-18 Mannington Mills, Inc. Surface coverings containing aluminum oxide
US6228463B1 (en) 1997-02-20 2001-05-08 Mannington Mills, Inc. Contrasting gloss surface coverings optionally containing dispersed wear-resistant particles and methods of making the same
US6218001B1 (en) * 1997-10-22 2001-04-17 Mannington Mills, Inc. Surface coverings containing dispersed wear-resistant particles and methods of making the same
CA2361830A1 (en) 1999-03-17 2000-09-21 Novo Nordisk A/S Method for acylating peptides and novel acylating agents
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US20080063844A1 (en) * 2001-06-29 2008-03-13 Mannington Mills, Inc. Surface coverings containing aluminum oxide
CN1264607C (zh) 2001-09-28 2006-07-19 大赛璐化学工业株式会社 含有n－取代的环酰亚胺化合物的催化剂和使用该催化剂生产有机化合物的方法
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
FR2862642B1 (fr) * 2003-11-20 2006-01-27 Oreal Utilisation cosmetique de n-hydroxy imides
FR2862643B1 (fr) * 2003-11-20 2005-12-30 Oreal Utilisation cosmetique de n-hydroxy imides
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
WO2007052780A1 (en) * 2005-11-04 2007-05-10 Nippon Shokubai Co., Ltd. Composition, protein modifier, and modified protein
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2190872B1 (de) 2007-09-05 2018-03-14 Novo Nordisk A/S Glucagon-like peptid-1-derivate und ihre pharmazeutische verwendung
CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
US20120329711A1 (en) 2009-12-16 2012-12-27 Nordisk A/S Glp-1 receptor agonist compounds with a modified n-terminus
JP6231386B2 (ja) 2010-11-09 2017-11-15 ノヴォ ノルディスク アー／エス リンカーを有する二重アシル化されたｇｌｐ−１誘導体
AU2012241894B2 (en) 2011-04-12 2015-12-03 Novo Nordisk A/S Double-acylated GLP-1 derivatives
EP2836508B1 (de) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulinformulierungen
CN104411322B (zh) 2012-05-08 2017-05-24 诺和诺德股份有限公司 双酰化glp‑1衍生物
EP2846823B1 (de) 2012-05-08 2019-12-04 Novo Nordisk A/S Zweifach acylierte glp-1-derivate
WO2014078895A1 (en) * 2012-11-21 2014-05-30 The University Of Sydney Omega-3 analogues
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
CN111925321B (zh) * 2020-09-24 2020-12-29 北京纳百生物科技有限公司 一种百草枯半抗原、完全抗原、抗体、检测试纸及试剂盒

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US2041265A (en) * 1936-05-19 Actlated polypepxides
US2794796A (en) * 1957-06-04 ouucg
US2729628A (en) * 1952-10-31 1956-01-03 Godfrey E Mann Acylated proteins
US2872450A (en) * 1955-12-06 1959-02-03 Bayer Ag Thio- and dithio-carboxylic acid esters and a process for their manufacture
US2932589A (en) * 1956-03-12 1960-04-12 Glidden Co Paper coating compositions and process
US2866783A (en) * 1956-07-05 1958-12-30 Bovarnick Max Glutamic and aspartic acid polypeptide polymers as plasma volume extenders
US3685998A (en) * 1970-10-27 1972-08-22 Monsanto Co Protein cross-linked with polymerized unsaturated carboxylic acid
US3847893A (en) * 1972-03-01 1974-11-12 Bayer Ag Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine
US4234475A (en) * 1975-08-15 1980-11-18 The Gillette Company Reacting protein with organic acid
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
IT1207996B (it) * 1986-03-18 1989-06-01 Magis Farmaceutici Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
JPH01199573A (ja) * 1987-10-25 1989-08-10 Kuraray Co Ltd スーパーオキシドジスムターゼ誘導体およびその製造法
JPH0796558B2 (ja) * 1988-03-31 1995-10-18 協和醗酵工業株式会社 修飾ポリペプチド
GB2217319A (en) * 1988-04-19 1989-10-25 Synpharm Ltd Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
EP0401384B1 (de) * 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemisch modifizierte granulocytenkolonie erregender faktor
WO1990007340A1 (fr) * 1989-01-09 1990-07-12 Meiji Milk Products Co., Ltd. Agent anti-hiv
US5336782A (en) * 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester

Also Published As

Publication number Publication date
EP0511600A3 (en) 1993-01-20
DE69228627T2 (de) 1999-10-21
USRE36359E (en) 1999-10-26
KR920019743A (ko) 1992-11-19
US5336782A (en) 1994-08-09
EP0511600A2 (de) 1992-11-04
DE69228627D1 (de) 1999-04-22
EP0511600B1 (de) 1999-03-17
US5414089A (en) 1995-05-09
KR950003921B1 (ko) 1995-04-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee