ATE177757T1 - Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17 - Google Patents

Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17

Info

Publication number: ATE177757T1
Authority: AT; Austria
Prior art keywords: pro; against human; immunogenic composition; composition against; glu
Prior art date: 1993-11-12

Application number

AT95902570T

Other languages

English (en)

Inventor

Philip C Gevas

Stephen Grimes

Stephen L Karr

Dov Michaeli

Robert Scibienski

Original Assignee

Aphton Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1994-11-10

Publication date

1999-04-15

1994-11-10 Application filed by Aphton Corp filed Critical Aphton Corp

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE177757T1 publication Critical patent/ATE177757T1/de

Links

230000002163 immunogen Effects 0.000 title abstract 3
102400000921 Gastrin Human genes 0.000 title abstract 2
101001002317 Homo sapiens Gastrin Proteins 0.000 title abstract 2
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT95902570T 1993-11-12 1994-11-10 Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17 ATE177757T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/151,219 US5468494A (en)	1993-11-12	1993-11-12	Immunogenic compositions against human gastrin 17

Publications (1)

Publication Number	Publication Date
ATE177757T1 true ATE177757T1 (de)	1999-04-15

Family

ID=22537815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95902570T ATE177757T1 (de)	1993-11-12	1994-11-10	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17

Country Status (10)

Country	Link
US (1)	US5468494A (de)
EP (1)	EP0728148B1 (de)
JP (1)	JP3694893B2 (de)
AT (1)	ATE177757T1 (de)
AU (1)	AU1179795A (de)
DE (1)	DE69417252T2 (de)
DK (1)	DK0728148T3 (de)
ES (1)	ES2130575T3 (de)
GR (1)	GR3029791T3 (de)
WO (1)	WO1995013297A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0380230T3 (da) *	1989-01-24	1995-01-16	Aphton Corp	Immunogene sammensætninger mod gastrin-peptider
US6861510B1 (en) *	1989-01-24	2005-03-01	Aphton Corporation	Immunogenic compositions against gastrin peptides
CA2261433A1 (en) *	1993-12-09	1995-06-10	Belinda Sanchez Ramirez	Composition comprising autologous epidermal growth factor
US5688506A (en) *	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
DK0889735T3 (da) *	1996-02-08	2011-08-08	Cancer Advances Inc	Immunogene metoder til behandling af gastrointestinal cancer
US20040001842A1 (en) *	1997-05-12	2004-01-01	Dov Michaeli	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
US6548066B1 (en) *	1997-05-12	2003-04-15	Aphton Corporation	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
JP2002515448A (ja) *	1998-05-15	2002-05-28	アフトン・コーポレーシヨン	食道逆流病の処置法
US20030068326A1 (en) *	1998-05-15	2003-04-10	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
KR100699574B1 (ko) *	1998-05-15	2007-03-23	리셉터 바이오로직스 인크	종양 치료를 위한 조합 치료
JP2002515458A (ja) *	1998-05-15	2002-05-28	アフトン・コーポレーシヨン	高ガストリン血症の予防および処置
WO2001045670A2 (en) *	1999-12-23	2001-06-28	Aphton Corporation	A stable immunogenic composition for frozen storage
US6783761B2 (en)	2000-05-05	2004-08-31	Aphton Corporation	Chimeric peptide immunogens
CA2441228A1 (en) *	2001-03-23	2002-10-03	Aphton Corporation	Combination treatment of pancreatic cancer
CU22999A1 (es) *	2001-12-04	2004-10-12	Centro Inmunologia Molecular	Método de tratamiento de enfermedades malignas e infecciosas crónicas
US20090191232A1 (en) *	2001-05-04	2009-07-30	Gevas Philip C	Combination therapy for the treatment of tumors
JP2004536835A (ja) *	2001-07-09	2004-12-09	アフトンコーポレーション	肝臓、肺および食道の癌性ならびに前癌性状態の治療および防止
US20040247661A1 (en) *	2002-07-03	2004-12-09	Dov Michaeli	Liposomal vaccine
CN1665487A (zh) *	2002-07-03	2005-09-07	埃弗顿有限公司	脂质体疫苗
US20050169979A1 (en) *	2002-07-03	2005-08-04	Dov Michaeli	Liposomal vaccine
US7235376B2 (en) *	2003-03-28	2007-06-26	Receptor Biologix, Inc.	Gastrin hormone immunoassays
EP2567974A3 (de)	2004-09-22	2013-05-22	Cancer Advances, Inc.,	Monoklonale Antikörper gegen Progastrin
JP5452223B2 (ja) *	2006-07-24	2014-03-26	テトラロジックファーマシューティカルズコーポレーション	Ｉａｐ阻害剤
WO2009054091A1 (ja) *	2007-10-26	2009-04-30	Advanced Life Science Institute, Inc.	ガストリン放出ペプチド前駆体に対する抗体及びその使用
US9498522B2 (en)	2008-08-07	2016-11-22	Mercia Pharma Inc.	Immunotherapeutic compositions for the treatment of alzheimer'S disease
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
CN101797382B (zh) *	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
US8674064B2 (en)	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
GB201121571D0 (en)	2011-12-15	2012-01-25	Astrimmune Ltd	Compounds and uses thereof
PT2999485T (pt) *	2013-05-21	2018-04-30	Tyg Oncology Ltd	Composição imunogénica do peptido gastrina
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer
IL271427B2 (en)	2017-06-15	2025-08-01	Cancer Advances Inc	Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
WO2022099128A1 (en) *	2020-11-06	2022-05-12	Cancer Advances Inc.	Compositions and methods for enhancing t cell penetration of tumors and cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4201770A (en) *	1973-05-07	1980-05-06	The Ohio State University	Antigenic modification of polypeptides
US4691006A (en) *	1983-03-04	1987-09-01	Ohio State University	Antigenic modification of polypeptides
US4526716A (en) *	1981-11-20	1985-07-02	The Ohio State University	Antigenic modification of polypeptides
US4384995A (en) *	1980-01-16	1983-05-24	The Ohio State University	Antigenic modification of polypeptides
US4069313A (en) *	1974-11-19	1978-01-17	Merck & Co., Inc.	Water-in-oil adjuvant composition
US4894443A (en) *	1984-02-08	1990-01-16	Cetus Corporation	Toxin conjugates
DK0380230T3 (da) *	1989-01-24	1995-01-16	Aphton Corp	Immunogene sammensætninger mod gastrin-peptider
US5023077A (en) *	1989-01-24	1991-06-11	Aphton Corporation	Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
US5120829A (en) *	1989-03-20	1992-06-09	La Jolla Cancer Research Foundation	Hydrophobic attachment site for adhesion peptides
US5256542A (en) *	1992-03-09	1993-10-26	Tanox Biosystems, Inc.	Selecting low frequency antigen-specific single B lymphocytes with correction for background noise

1993
- 1993-11-12 US US08/151,219 patent/US5468494A/en not_active Expired - Lifetime
1994
- 1994-11-10 JP JP51407395A patent/JP3694893B2/ja not_active Expired - Lifetime
- 1994-11-10 AU AU11797/95A patent/AU1179795A/en not_active Abandoned
- 1994-11-10 AT AT95902570T patent/ATE177757T1/de active
- 1994-11-10 EP EP95902570A patent/EP0728148B1/de not_active Expired - Lifetime
- 1994-11-10 DK DK95902570T patent/DK0728148T3/da active
- 1994-11-10 DE DE69417252T patent/DE69417252T2/de not_active Expired - Lifetime
- 1994-11-10 ES ES95902570T patent/ES2130575T3/es not_active Expired - Lifetime
- 1994-11-10 WO PCT/US1994/013205 patent/WO1995013297A2/en not_active Ceased
1999
- 1999-03-23 GR GR990400879T patent/GR3029791T3/el unknown

Also Published As

Publication number	Publication date
WO1995013297A3 (en)	1995-06-15
GR3029791T3 (en)	1999-06-30
JPH09505056A (ja)	1997-05-20
DE69417252D1 (de)	1999-04-22
EP0728148B1 (de)	1999-03-17
DE69417252T2 (de)	1999-07-08
ES2130575T3 (es)	1999-07-01
US5468494A (en)	1995-11-21
EP0728148A1 (de)	1996-08-28
JP3694893B2 (ja)	2005-09-14
WO1995013297A2 (en)	1995-05-18
AU1179795A (en)	1995-05-29
DK0728148T3 (da)	1999-09-27

Legal Events

Date	Code	Title	Description
1999-10-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69417252D1 (de)	1999-04-22	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
IL113812A0 (en)	1995-08-31	Copolymer-1, pharmaceutical compositions containing it and its use
GR3023233T3 (en)	1997-07-30	Inhibitors of dipeptidyl-aminopeptidase type iv
ZA975470B (en)	1997-12-22	Insulin preparations containing naci.
JO2034B1 (en)	1999-05-15	Isotopes of the hormone peptide its uses and the chemical compounds it contains
GR3026758T3 (en)	1998-07-31	Lactobacillus strains of human origin, their compositions and uses thereof
ATE280826T1 (de)	2004-11-15	Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
CA2100745A1 (en)	1993-05-20	Amylin agonist peptides and uses therefor
GB9108652D0 (en)	1991-06-12	Immunoreactive compounds
BG103664A (en)	2000-03-31	Pharmaceutical forms containing ammoxycillin and clavulanate
MY107158A (en)	1995-09-30	3-arylcarbonyl; -1h-indoles useful as therapeutic agents.
SE9101838D0 (sv)	1991-06-14	Novel peptides and their use
BG103968A (en)	2000-07-31	Pharmaceutical antiviral composition containing glycirricinic acid and at least one protein with antiviral activity
BG103677A (en)	2000-06-30	Solid mixtures based on sulphonylcarbamides and adjuvants
AU1751892A (en)	1992-11-02	Novel peptide compositions and uses therefor
MY106352A (en)	1995-05-30	Hemoregulatory peptides.
ITRM910430A1 (it)	1992-12-17	Composizioni farmaceutiche di somatostatina con assorbimento migliorato, loro preparazione e loro impiego
AU2415599A (en)	1999-07-19	Rantes mutants and therapeutic applications thereof
DE69524971D1 (de)	2002-02-14	Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen
MD970269A (en)	1999-05-31	Clavulanates
IL139604A0 (en)	2002-02-10	Novel peptides
AU8375891A (en)	1992-03-19	Antioxidant system based on a basic amino acid in combination with a tocopherol or derivative thereof and a nonthiolated polypeptide, and compositions containing the same
EP0717618A4 (de)	1997-06-04	Stabilisierte tablettenformulierung
JO1999B1 (en)	1999-05-15	Isotopes of the hormone 'LH-RH' have their uses and the chemical compounds they contain
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use