ATE178070T1 - Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. - Google Patents
Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren.Info
- Publication number
- ATE178070T1 ATE178070T1 AT93309868T AT93309868T ATE178070T1 AT E178070 T1 ATE178070 T1 AT E178070T1 AT 93309868 T AT93309868 T AT 93309868T AT 93309868 T AT93309868 T AT 93309868T AT E178070 T1 ATE178070 T1 AT E178070T1
- Authority
- AT
- Austria
- Prior art keywords
- growth hormone
- release
- humans
- promote
- spiropiperidine
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 6
- 108010051696 Growth Hormone Proteins 0.000 title abstract 6
- 239000000122 growth hormone Substances 0.000 title abstract 6
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 208000020221 Short stature Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000013622 meat product Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 150000003413 spiro compounds Chemical class 0.000 abstract 1
- -1 spiro piperidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Feed For Specific Animals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98932292A | 1992-12-11 | 1992-12-11 | |
| US08/146,848 US5578593A (en) | 1992-12-11 | 1993-11-03 | Spiro piperidines and homologs promote release of growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178070T1 true ATE178070T1 (de) | 1999-04-15 |
Family
ID=26844355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93309868T ATE178070T1 (de) | 1992-12-11 | 1993-12-08 | Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0662481B1 (de) |
| JP (1) | JP2509147B2 (de) |
| CN (1) | CN1040432C (de) |
| AT (1) | ATE178070T1 (de) |
| AU (1) | AU673017B2 (de) |
| CA (1) | CA2110672A1 (de) |
| DE (1) | DE69324148T2 (de) |
| DZ (1) | DZ1735A1 (de) |
| ES (1) | ES2129072T3 (de) |
| HR (1) | HRP931484A2 (de) |
| IL (1) | IL107836A (de) |
| MX (1) | MX9307851A (de) |
| PH (1) | PH31168A (de) |
| SI (1) | SI9300647A (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| JP2000511885A (ja) * | 1996-05-07 | 2000-09-12 | メルク エンド カンパニー インコーポレーテッド | 成長ホルモン分泌促進薬による睡眠の強化 |
| WO1998016527A1 (en) * | 1996-10-15 | 1998-04-23 | Fujisawa Pharmaceutical Co., Ltd. | Benzoxepine derivatives which promote release of growth hormone |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| CO5160260A1 (es) * | 1999-02-19 | 2002-05-30 | Lilly Co Eli | Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido |
| US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
| ES2219368T3 (es) * | 1999-07-13 | 2004-12-01 | MERCK & CO., INC. | Amidoespiropiperidinas que promueven la liberacion de la hormona de crecimiento. |
| US7125840B2 (en) | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
| EP1497316B1 (de) | 2002-04-09 | 2006-07-05 | Eli Lilly And Company | Wachstumhormonsekretionsförderer |
| DE10317878A1 (de) * | 2003-04-17 | 2004-11-11 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von alpha-methylierten Cystein und Serin-Derivaten |
| WO2006046595A1 (ja) * | 2004-10-28 | 2006-05-04 | Sankyo Company, Limited | 光学活性４，４－二置換オキサゾリジン誘導体とその製造方法 |
| CN101081835B (zh) * | 2006-05-30 | 2011-09-21 | 上海药明康德新药开发有限公司 | 一种螺[苯并环-3-酮-1-(4′-哌啶)]模板化合物的合成方法 |
| AU2008205642B2 (en) * | 2007-01-12 | 2013-06-06 | Msd K.K. | Spirochromanon derivatives |
| JP5585822B2 (ja) * | 2010-05-11 | 2014-09-10 | 東レ・ファインケミカル株式会社 | 光学活性ニペコチン酸誘導体の製造方法 |
| US20240190875A1 (en) * | 2021-04-25 | 2024-06-13 | Changchun Genescience Pharmaceutical Co., Ltd. | Spiroindoline derivative, and preparation method and medical use thereof |
| JP2025534100A (ja) * | 2022-10-21 | 2025-10-09 | 長春金賽薬業有限責任公司 | インドリンスピロ環系化合物の結晶形、非晶質物質及び両者の製造方法と使用 |
| CN119998306A (zh) * | 2022-10-21 | 2025-05-13 | 长春金赛药业有限责任公司 | 吲哚啉螺环类化合物的溶剂化物及其晶型、制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332704D0 (en) * | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
-
1993
- 1993-12-02 IL IL107836A patent/IL107836A/en active IP Right Grant
- 1993-12-03 CA CA002110672A patent/CA2110672A1/en not_active Abandoned
- 1993-12-08 DZ DZ930130A patent/DZ1735A1/fr active
- 1993-12-08 ES ES93309868T patent/ES2129072T3/es not_active Expired - Lifetime
- 1993-12-08 DE DE69324148T patent/DE69324148T2/de not_active Expired - Fee Related
- 1993-12-08 EP EP93309868A patent/EP0662481B1/de not_active Expired - Lifetime
- 1993-12-08 AT AT93309868T patent/ATE178070T1/de not_active IP Right Cessation
- 1993-12-10 SI SI9300647A patent/SI9300647A/sl unknown
- 1993-12-10 JP JP5341449A patent/JP2509147B2/ja not_active Expired - Lifetime
- 1993-12-10 PH PH47421A patent/PH31168A/en unknown
- 1993-12-10 HR HR931484A patent/HRP931484A2/hr not_active Application Discontinuation
- 1993-12-10 AU AU52321/93A patent/AU673017B2/en not_active Ceased
- 1993-12-10 MX MX9307851A patent/MX9307851A/es not_active IP Right Cessation
- 1993-12-11 CN CN93112857A patent/CN1040432C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SI9300647A (en) | 1994-09-30 |
| DE69324148T2 (de) | 1999-10-28 |
| PH31168A (en) | 1998-03-20 |
| IL107836A0 (en) | 1994-04-12 |
| AU5232193A (en) | 1994-06-23 |
| ES2129072T3 (es) | 1999-06-01 |
| EP0662481B1 (de) | 1999-03-24 |
| AU673017B2 (en) | 1996-10-24 |
| CA2110672A1 (en) | 1994-06-12 |
| DZ1735A1 (fr) | 2002-02-17 |
| MX9307851A (es) | 1994-06-30 |
| DE69324148D1 (de) | 1999-04-29 |
| JP2509147B2 (ja) | 1996-06-19 |
| CN1040432C (zh) | 1998-10-28 |
| JPH0797367A (ja) | 1995-04-11 |
| CN1092767A (zh) | 1994-09-28 |
| IL107836A (en) | 1998-01-04 |
| EP0662481A1 (de) | 1995-07-12 |
| HRP931484A2 (en) | 1996-04-30 |
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| Publication | Publication Date | Title |
|---|---|---|
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| MY131439A (en) | Spiro piperidines and homologs promote release of growth hormone | |
| ATE178070T1 (de) | Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. | |
| IL101206A0 (en) | Benzo-fused lactams,their preparation and pharmaceutical compositions containing them | |
| DE69331197D1 (de) | Die freisetzung von wachstumshormon stimulierende benzoverknüpfte lactame | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |