ATE220071T1 - Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren - Google Patents

Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren

Info

Publication number: ATE220071T1
Authority: AT; Austria
Prior art keywords: growth hormone; release; humans; promote; growth
Prior art date: 1992-12-11

Application number

AT93309867T

Other languages

English (en)

Inventor

Meng-Hsin Chen

Arthur A Patchett

David B R Johnston

James R Tata

Ravi P Nargund

Lihu Yang

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-11

Filing date

1993-12-08

Publication date

2002-07-15

1993-11-03 Priority claimed from US08/147,226 external-priority patent/US5536716A/en

1993-12-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-07-15 Application granted granted Critical

2002-07-15 Publication of ATE220071T1 publication Critical patent/ATE220071T1/de

Links

239000000122 growth hormone Substances 0.000 title abstract 6
JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
102000018997 Growth Hormone Human genes 0.000 abstract 5
108010051696 Growth Hormone Proteins 0.000 abstract 5
241001465754 Metazoa Species 0.000 abstract 2
208000020221 Short stature Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000001195 anabolic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1
235000013305 food Nutrition 0.000 abstract 1
235000013622 meat product Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
150000003413 spiro compounds Chemical class 0.000 abstract 1
-1 spiro piperidines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Crystallography & Structural Chemistry (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Fodder In General (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Feed For Specific Animals (AREA)

AT93309867T 1992-12-11 1993-12-08 Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren ATE220071T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98932292A	1992-12-11	1992-12-11
US08/147,226 US5536716A (en)	1992-12-11	1993-11-03	Spiro piperidines and homologs which promote release of growth hormone

Publications (1)

Publication Number	Publication Date
ATE220071T1 true ATE220071T1 (de)	2002-07-15

Family

ID=26844709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93309867T ATE220071T1 (de)	1992-12-11	1993-12-08	Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren

Country Status (27)

Country	Link
US (1)	US5652235A (de)
EP (1)	EP0615977B1 (de)
JP (1)	JP2509530B2 (de)
CN (1)	CN1034733C (de)
AT (1)	ATE220071T1 (de)
AU (1)	AU673552B2 (de)
BG (1)	BG61979B1 (de)
CA (1)	CA2110670C (de)
CZ (1)	CZ151495A3 (de)
DE (1)	DE69332075T2 (de)
DK (1)	DK0615977T3 (de)
DZ (1)	DZ1736A1 (de)
ES (1)	ES2177538T3 (de)
FI (1)	FI952863A0 (de)
HR (1)	HRP931486B1 (de)
HU (2)	HUT72076A (de)
IL (1)	IL107837A0 (de)
MX (1)	MX9307850A (de)
NO (1)	NO952295L (de)
NZ (1)	NZ258412A (de)
PL (1)	PL176993B1 (de)
PT (1)	PT615977E (de)
RO (1)	RO115804B1 (de)
RU (1)	RU2168512C2 (de)
SI (1)	SI9300646A (de)
SK (1)	SK282166B6 (de)
WO (1)	WO1994013696A1 (de)

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1993
- 1993-11-15 SK SK759-95A patent/SK282166B6/sk unknown
- 1993-11-15 CZ CZ951514A patent/CZ151495A3/cs unknown
- 1993-11-15 NZ NZ258412A patent/NZ258412A/en unknown
- 1993-11-15 RO RO95-01106A patent/RO115804B1/ro unknown
- 1993-11-15 WO PCT/US1993/011038 patent/WO1994013696A1/en not_active Ceased
- 1993-11-15 PL PL93309331A patent/PL176993B1/pl unknown
- 1993-11-15 RU RU95113349/04A patent/RU2168512C2/ru active
- 1993-11-15 HU HU9501683A patent/HUT72076A/hu unknown
- 1993-12-02 IL IL10783793A patent/IL107837A0/xx active IP Right Grant
- 1993-12-03 CA CA002110670A patent/CA2110670C/en not_active Expired - Lifetime
- 1993-12-08 DE DE69332075T patent/DE69332075T2/de not_active Expired - Lifetime
- 1993-12-08 EP EP93309867A patent/EP0615977B1/de not_active Expired - Lifetime
- 1993-12-08 DK DK93309867T patent/DK0615977T3/da active
- 1993-12-08 AT AT93309867T patent/ATE220071T1/de active
- 1993-12-08 PT PT93309867T patent/PT615977E/pt unknown
- 1993-12-08 ES ES93309867T patent/ES2177538T3/es not_active Expired - Lifetime
- 1993-12-08 DZ DZ930131A patent/DZ1736A1/fr active
- 1993-12-10 AU AU52320/93A patent/AU673552B2/en not_active Expired
- 1993-12-10 MX MX9307850A patent/MX9307850A/es not_active IP Right Cessation
- 1993-12-10 SI SI9300646A patent/SI9300646A/sl unknown
- 1993-12-10 HR HR931486A patent/HRP931486B1/xx not_active IP Right Cessation
- 1993-12-10 JP JP5341522A patent/JP2509530B2/ja not_active Expired - Lifetime
- 1993-12-11 CN CN93112858A patent/CN1034733C/zh not_active Expired - Lifetime
1995
- 1995-06-07 BG BG99710A patent/BG61979B1/bg unknown
- 1995-06-09 FI FI952863A patent/FI952863A0/fi unknown
- 1995-06-09 NO NO952295A patent/NO952295L/no not_active Application Discontinuation
- 1995-06-21 HU HU95P/P00324P patent/HU211301A9/hu unknown
1996
- 1996-04-30 US US08/641,311 patent/US5652235A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RO115804B1 (ro)	2000-06-30
RU2168512C2 (ru)	2001-06-10
EP0615977B1 (de)	2002-07-03
PL309331A1 (en)	1995-10-02
AU673552B2 (en)	1996-11-14
JPH06263737A (ja)	1994-09-20
WO1994013696A1 (en)	1994-06-23
BG61979B1 (bg)	1998-11-30
PL176993B1 (pl)	1999-08-31
HU9501683D0 (en)	1995-08-28
HRP931486A2 (hr)	1995-02-28
HU211301A9 (en)	1995-11-28
CN1092071A (zh)	1994-09-14
SK282166B6 (sk)	2001-11-06
FI952863A7 (fi)	1995-06-09
PT615977E (pt)	2002-10-31
US5652235A (en)	1997-07-29
SI9300646A (en)	1994-09-30
IL107837A0 (en)	1994-04-12
DZ1736A1 (fr)	2002-02-17
CN1034733C (zh)	1997-04-30
NO952295D0 (no)	1995-06-09
CA2110670A1 (en)	1994-06-12
DE69332075D1 (de)	2002-08-08
NZ258412A (en)	1997-01-29
HRP931486B1 (en)	2003-08-31
NO952295L (no)	1995-08-10
ES2177538T3 (es)	2002-12-16
MX9307850A (es)	1994-06-30
EP0615977A1 (de)	1994-09-21
DE69332075T2 (de)	2003-01-16
CZ151495A3 (en)	1995-12-13
AU5232093A (en)	1994-06-23
CA2110670C (en)	2001-04-17
DK0615977T3 (da)	2002-07-22
FI952863A0 (fi)	1995-06-09
SK75995A3 (en)	1995-11-08
BG99710A (bg)	1996-01-31
HUT72076A (en)	1996-03-28
JP2509530B2 (ja)	1996-06-19

Legal Events

Date	Code	Title	Description
2002-11-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69332075D1 (de)	2002-08-08	Spiropiperidine and ihre Homologen, die die Ausschüttung von Wachstumshormonen stimulieren
MY131439A (en)	2007-08-30	Spiro piperidines and homologs promote release of growth hormone
ATE178070T1 (de)	1999-04-15	Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren.
IL101206A (en)	1997-02-18	Benzo-fused lactams their preparation and pharmaceutical compositions containing them
DK1179984T3 (da)	2005-12-27	Metode til fremstilling af en sammensætning til forbedring af immunforsvaret hos kæledyr under anvendelse af en kombination af antioxidanter
RU95107663A (ru)	1996-11-20	Бензо-конденсированные лактамы, ускоряющие высвобождение соматотропного гормона, способы их получения, способы лечения, композиции
GR3006124T3 (de)	1993-06-21
ATE266658T1 (de)	2004-05-15	Amido-spiropiperidine promovieren die freisetzung von wachstumshormonen
ITMI910705V0 (it)	1991-07-31	Manufatti per l'alimentazione stimolatori dell'assunzione del cibo