ATE178319T1 - Indol-7-carboxamide derivate als analgetika - Google Patents

Indol-7-carboxamide derivate als analgetika

Info

Publication number
ATE178319T1
ATE178319T1 AT93118753T AT93118753T ATE178319T1 AT E178319 T1 ATE178319 T1 AT E178319T1 AT 93118753 T AT93118753 T AT 93118753T AT 93118753 T AT93118753 T AT 93118753T AT E178319 T1 ATE178319 T1 AT E178319T1
Authority
AT
Austria
Prior art keywords
loweralkyl
arylloweralkyl
chem
formula
carboxamide derivatives
Prior art date
Application number
AT93118753T
Other languages
English (en)
Inventor
Gregory Shutske
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ATE178319T1 publication Critical patent/ATE178319T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93118753T 1992-11-24 1993-11-22 Indol-7-carboxamide derivate als analgetika ATE178319T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/980,869 US5330986A (en) 1992-11-24 1992-11-24 Indole-7-carboxamide derivatives

Publications (1)

Publication Number Publication Date
ATE178319T1 true ATE178319T1 (de) 1999-04-15

Family

ID=25527913

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93118753T ATE178319T1 (de) 1992-11-24 1993-11-22 Indol-7-carboxamide derivate als analgetika

Country Status (8)

Country Link
US (1) US5330986A (de)
EP (1) EP0599240B1 (de)
JP (1) JP3161892B2 (de)
AT (1) ATE178319T1 (de)
DE (1) DE69324212T2 (de)
DK (1) DK0599240T3 (de)
ES (1) ES2129483T3 (de)
GR (1) GR3030364T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006715A1 (en) * 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
TW200616967A (en) * 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
TW200626142A (en) * 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
JP2009513677A (ja) * 2005-10-25 2009-04-02 スミスクライン・ビーチャム・コーポレイション 化合物
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
EP2646020B1 (de) * 2010-12-01 2016-09-21 Glaxosmithkline LLC Indole
CN107176927B (zh) * 2016-03-12 2020-02-18 福建金乐医药科技有限公司 组蛋白去甲基化酶lsd1抑制剂
US10988481B2 (en) 2016-05-19 2021-04-27 Virginia Commonwealth University Potent and selective mu opioid receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582371D1 (de) * 1984-07-06 1991-05-08 Otsuka Pharma Co Ltd Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents

Also Published As

Publication number Publication date
JPH06211788A (ja) 1994-08-02
DK0599240T3 (da) 1999-10-11
EP0599240A1 (de) 1994-06-01
DE69324212D1 (de) 1999-05-06
GR3030364T3 (en) 1999-09-30
EP0599240B1 (de) 1999-03-31
ES2129483T3 (es) 1999-06-16
JP3161892B2 (ja) 2001-04-25
DE69324212T2 (de) 1999-09-16
US5330986A (en) 1994-07-19

Similar Documents

Publication Publication Date Title
FI904327A0 (fi) N-substituerad-4-pyrimidinaminer och -pyrimidindiaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ATE247654T1 (de) Neue heterozyklische verbindungen
ATE172201T1 (de) Morphinan-derivate und medizinische verwendung
DZ1467A1 (fr) Dérivés d'acides amines.
DE69324212D1 (de) Indol-7-carboxamide Derivate als Analgetika
DE69312243D1 (de) Phenoxy- oder Phenoxyalkyl-Piperidine als antivirale Mittel
NO934792D0 (no) Xantinderivater
DE69418789D1 (de) 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
DK0586806T3 (da) Anvendelse af 2-(N-(2-aminoethyl)-amino)-eddike-syrederivater til behandling af sygdomme, der er betinget af den ikke-enzym
DE69111816D1 (de) Indolederivate und ihre verwendung als serotonin-antagoniste.
PT1021405E (pt) Derivados de azetidinona para o tratamento de infeccoes de hcmv
DE69830045D1 (de) Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika
FI903818A0 (fi) 1-(pyridinylamino)-2-pyrrolidoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ATE230391T1 (de) Pyrrolidin derivate, anti-ulcus und antibakterielle arzneimittel
DE69230498D1 (de) 2-Pyrazinylethylamin-Derivate und ihre Verwendung als Arzneimittel.
DE69008069D1 (de) Antipsychotische Verbindungen.
ATE169015T1 (de) Aminobenzoesäure derivate
ATE222583T1 (de) Derivate substituierter amidinonaphthylester
EP0911336A4 (de)
ATE207879T1 (de) Alkynylaminosäure derivate und ihre verwendung als pharmazeutische verbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee