ATE178614T1 - Zyklische verbindungen zur verwendung als inhibitoren des glycoprotein iib/iiia - Google Patents

Zyklische verbindungen zur verwendung als inhibitoren des glycoprotein iib/iiia

Info

Publication number
ATE178614T1
ATE178614T1 AT92921273T AT92921273T ATE178614T1 AT E178614 T1 ATE178614 T1 AT E178614T1 AT 92921273 T AT92921273 T AT 92921273T AT 92921273 T AT92921273 T AT 92921273T AT E178614 T1 ATE178614 T1 AT E178614T1
Authority
AT
Austria
Prior art keywords
cyclic compounds
iiia
glycoprotein iib
inhibitors
compounds
Prior art date
Application number
AT92921273T
Other languages
English (en)
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of ATE178614T1 publication Critical patent/ATE178614T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT92921273T 1991-09-30 1992-09-30 Zyklische verbindungen zur verwendung als inhibitoren des glycoprotein iib/iiia ATE178614T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76784891A 1991-09-30 1991-09-30
US94928592A 1992-09-09 1992-09-09

Publications (1)

Publication Number Publication Date
ATE178614T1 true ATE178614T1 (de) 1999-04-15

Family

ID=27117970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921273T ATE178614T1 (de) 1991-09-30 1992-09-30 Zyklische verbindungen zur verwendung als inhibitoren des glycoprotein iib/iiia

Country Status (15)

Country Link
EP (1) EP0625164B1 (de)
JP (1) JPH07502023A (de)
AT (1) ATE178614T1 (de)
AU (1) AU672178B2 (de)
CA (1) CA2120362A1 (de)
DE (1) DE69228881T2 (de)
DK (1) DK0625164T3 (de)
ES (1) ES2131533T3 (de)
FI (1) FI941457L (de)
GR (1) GR3029931T3 (de)
HU (1) HUT68094A (de)
IL (1) IL103252A (de)
MX (1) MX9205574A (de)
NZ (1) NZ244528A (de)
WO (1) WO1993007170A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
CA2148945A1 (en) * 1992-11-18 1994-05-26 Gregory James Wells Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
EP0691987A1 (de) * 1993-03-29 1996-01-17 The Du Pont Merck Pharmaceutical Company Zyklische verbindungen als inhibitoren des platelet-glykoproteins iib/iiia
AU682857B2 (en) * 1993-03-29 1997-10-23 Du Pont Pharmaceuticals Company Novel processes and intermediate compounds for the preparation of platelet clycoprotein IIb/IIIa inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AU6663794A (en) * 1993-05-13 1994-12-12 Du Pont Merck Pharmaceutical Company, The Processes and intermediate compounds useful for the preparation of platelet glycoprotein iib/iiia inhibitors
AU1975695A (en) * 1994-03-04 1995-09-18 Du Pont Merck Pharmaceutical Company, The Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex
DE4415310A1 (de) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
US5879659A (en) * 1996-03-13 1999-03-09 Dupont Pharmaceuticals Company Ternary radiopharmaceutical complexes
JP2004525109A (ja) 2001-02-15 2004-08-19 キング・ファーマシューティカルズ・インコーポレイティッド 安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (de) 2007-03-28 2016-10-19 President and Fellows of Harvard College Geheftete Polypeptide
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
AU3040589A (en) 1988-02-22 1989-09-06 Upjohn Company, The Homoarginine-based peptides as platelet aggregation inhibitors
ZW6189A1 (en) 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
FR2631626B1 (fr) 1988-05-20 1990-08-10 Centre Nat Rech Scient Nouveaux pentapeptides et leurs applications en tant que medicaments, notamment antithrombotiques
JP2945680B2 (ja) 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
US5084466A (en) 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
US5120859A (en) 1989-09-22 1992-06-09 Genentech, Inc. Chimeric amino acid analogues
US4952562A (en) 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
NZ235564A (en) 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
NZ235563A (en) 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides

Also Published As

Publication number Publication date
EP0625164B1 (de) 1999-04-07
IL103252A (en) 1997-03-18
MX9205574A (es) 1993-03-01
JPH07502023A (ja) 1995-03-02
CA2120362A1 (en) 1993-04-15
DK0625164T3 (da) 1999-10-18
EP0625164A1 (de) 1994-11-23
DE69228881T2 (de) 1999-10-14
DE69228881D1 (de) 1999-05-12
WO1993007170A1 (en) 1993-04-15
AU672178B2 (en) 1996-09-26
FI941457A7 (fi) 1994-03-29
AU2756192A (en) 1993-05-03
IL103252A0 (en) 1993-02-21
HUT68094A (en) 1995-05-29
HU9400912D0 (en) 1994-06-28
ES2131533T3 (es) 1999-08-01
NZ244528A (en) 1995-02-24
FI941457A0 (fi) 1994-03-29
GR3029931T3 (en) 1999-07-30
FI941457L (fi) 1994-03-29

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee