ATE178908T1 - LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN - Google Patents

LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN

Info

Publication number
ATE178908T1
ATE178908T1 AT97121214T AT97121214T ATE178908T1 AT E178908 T1 ATE178908 T1 AT E178908T1 AT 97121214 T AT97121214 T AT 97121214T AT 97121214 T AT97121214 T AT 97121214T AT E178908 T1 ATE178908 T1 AT E178908T1
Authority
AT
Austria
Prior art keywords
human insulin
sup
lys
analogues
insuline
Prior art date
Application number
AT97121214T
Other languages
German (de)
Inventor
Per Balschmidt
Jens Vejlgaard Brange
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26067619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE178908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK721588A external-priority patent/DK721588D0/en
Priority claimed from DK477789A external-priority patent/DK477789D0/en
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE178908T1 publication Critical patent/ATE178908T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Human insulin analogues having a positively charged amino acid residue, i.e. Lys or Arg, in position B28, i.e. in position 8 in the B-chain calculated from [Gly<sup>B20</sup>], and optionally being further modified in the C-terminal end of the B-chain from [Phe<sup>B24</sup>] to the C-terminal amino acid residue and optionally A21 and/or B3 being different from Asn as well as insulin preparations containing the human insulin analogues are provided.
AT97121214T 1988-12-23 1989-12-21 LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN ATE178908T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK721588A DK721588D0 (en) 1988-12-23 1988-12-23 HUMAN INSULIN ANALOGS
DK477789A DK477789D0 (en) 1989-09-28 1989-09-28 NEW POLYPEPTIDES

Publications (1)

Publication Number Publication Date
ATE178908T1 true ATE178908T1 (en) 1999-04-15

Family

ID=26067619

Family Applications (3)

Application Number Title Priority Date Filing Date
AT97121214T ATE178908T1 (en) 1988-12-23 1989-12-21 LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN
AT89313460T ATE170875T1 (en) 1988-12-23 1989-12-21 HUMAN INSULIN ANALOGUES
AT97121213T ATE175974T1 (en) 1988-12-23 1989-12-21 LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT89313460T ATE170875T1 (en) 1988-12-23 1989-12-21 HUMAN INSULIN ANALOGUES
AT97121213T ATE175974T1 (en) 1988-12-23 1989-12-21 LYS(B28) INSULINE. ANALOGUES OF HUMAN INSULIN

Country Status (17)

Country Link
US (1) US5164366A (en)
EP (3) EP0837072B1 (en)
JP (1) JPH04502465A (en)
KR (1) KR910700262A (en)
CN (1) CN1043719A (en)
AT (3) ATE178908T1 (en)
AU (1) AU641631B2 (en)
CA (1) CA2006578A1 (en)
DE (4) DE68928917T2 (en)
ES (1) ES2134669T3 (en)
FI (1) FI913037A7 (en)
HU (1) HUT56857A (en)
IL (1) IL92853A0 (en)
NO (1) NO301483B1 (en)
NZ (1) NZ231936A (en)
WO (1) WO1990007522A1 (en)
YU (1) YU243689A (en)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK336188D0 (en) * 1988-06-20 1988-06-20 Nordisk Gentofte propeptides
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
DK155690D0 (en) * 1990-06-28 1990-06-28 Novo Nordisk As NEW PEPTIDES
DK10191D0 (en) * 1991-01-22 1991-01-22 Novo Nordisk As HIS UNKNOWN PEPTIDES
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
DK72793D0 (en) * 1993-06-21 1993-06-21 Novo Nordisk As NEW PRODUCT
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AU3562195A (en) * 1994-10-04 1996-04-26 Novo Nordisk A/S Preparations containing aspb28 human insulin and nicotinamide
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
CN1069649C (en) * 1996-01-25 2001-08-15 中国科学院上海生物化学研究所 [Beta-9 glutamic acid, beta-10 aspartic acid] human insulin
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
DE19726167B4 (en) * 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
EA200000453A1 (en) 1997-10-24 2000-10-30 Эли Лилли Энд Компани COMPOSITIONS OF INSOLUBLE INSULIN
CA2309955A1 (en) * 1997-11-12 1999-05-20 Alza Corporation Method for decreasing self-association of polypeptides
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7022674B2 (en) * 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
CA2402191C (en) 2000-03-24 2012-03-13 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
AU2002248464A1 (en) * 2001-02-21 2002-09-12 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
CN1247616C (en) * 2002-07-19 2006-03-29 上海中科生龙达生物技术（集团）有限公司 New monomeric insulin and its medicinal composition and prepn process
US7193035B2 (en) 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
CN1836047B (en) 2003-06-17 2010-12-22 赛姆生物系统遗传公司 Method for producing insulin in plants
MXPA06001283A (en) 2003-08-05 2006-04-11 Novo Nordisk As Novel insulin derivatives.
SI2107069T1 (en) 2003-08-05 2013-04-30 Novo Nordisk A/S Novel insulin derivatives
TR201906789T4 (en) 2003-11-20 2019-05-21 Novo Nordisk As Peptide formulations containing propylene glycol that are most suitable for use in manufacturing and injection devices.
CN1902226A (en) 2003-12-03 2007-01-24 诺和诺德公司 Single-chain insulin
EP2033662B1 (en) 2004-01-21 2012-10-17 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
BRPI0513508B1 (en) 2004-07-19 2021-06-01 Biocon Limited INSULIN-OLIGOMER CONJUGATES, FORMULATIONS AND USES THEREOF
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP1846447B1 (en) 2005-02-02 2013-08-21 Novo Nordisk A/S Insulin derivatives
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
JPWO2006093222A1 (en) * 2005-03-02 2008-08-07 味の素株式会社 Insulin multimerization inhibitor
CN102660614A (en) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 Method for making mature insulin polypeptides
CA2621344C (en) 2005-09-14 2014-12-16 Sanofi-Aventis Deutschland Gmbh Cleavage of precursors of insulins by a variant of trypsin
JP4808785B2 (en) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス Insulin composition and method for producing the composition
EP1991576B1 (en) 2006-02-27 2010-09-29 Novo Nordisk A/S Insulin derivatives
JP5312054B2 (en) 2006-03-15 2013-10-09 ノボ・ノルデイスク・エー／エス Mixture of amylin and insulin
MX2008014061A (en) 2006-05-09 2008-11-14 Novo Nordisk As Insulin derivative.
EP2024390B1 (en) 2006-05-09 2015-08-19 Novo Nordisk A/S Insulin derivative
CA2652989A1 (en) * 2006-06-08 2007-12-13 Diabecore Medical Inc. Derivatized insulin oligomers
DK2074141T3 (en) 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US20110144010A1 (en) 2007-06-01 2011-06-16 Novo Nordisk A/S Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
AU2008257505B2 (en) 2007-06-01 2013-05-16 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
JP5868594B2 (en) 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ Orally administrable solid pharmaceutical composition and process thereof
MX2010005317A (en) 2007-11-20 2010-06-02 Ambrx Inc Modified insulin polypeptides and their uses.
CN102007143B (en) 2008-01-09 2015-08-26 塞诺菲-安万特德国有限公司 There is the novel insulin derivates of super delayed aging feature
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
CN102037008B (en) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 Protease-stabilized, acylated insulin analogs
DE102008051834A1 (en) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Drug, useful e.g. for treating diabetes, preferably type-I or II and for controlling fasting, postprandial and/or postabsorptive plasma glucose concentration, comprises insulin and glucagon-like peptide-1 agonist
CN102256618A (en) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 Combinations of insulin and GLP-1 agonists
DE102009038210A1 (en) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a GLP-1 agonist
DE102008053048A1 (en) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Medicament, useful e.g. for treating diabetes, controlling fasting, postprandial or postabsorptive blood glucose concentration in diabetic patients and improving glucose tolerance, comprises insulin and glucagon-like peptide-1 agonist
AU2009309623B9 (en) 2008-10-30 2014-10-02 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
PL2451437T3 (en) 2009-07-06 2017-05-31 Sanofi-Aventis Deutschland Gmbh Aqueous preparations comprising methionine
US20120232002A1 (en) 2009-07-06 2012-09-13 Sanofi-Aventis Deutschland Gmbh Slow-acting insulin preparations
WO2011003820A1 (en) 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
AU2010277559B2 (en) 2009-07-31 2016-08-11 Sanofi-Aventis Deutschland Gmbh Prodrugs comprising an insulin linker conjugate
PL2459171T3 (en) 2009-07-31 2017-11-30 Sanofi-Aventis Deutschland Gmbh Long acting insulin composition
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (en) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1-agonist, an insulin and methionine.
US20130143803A1 (en) 2010-05-10 2013-06-06 Novo Nordisk A/S Process for the Preparation of Insulin-Zinc Complexes
MA34521B1 (en) 2010-08-17 2013-09-02 Ambrx Inc MODIFIED RELAXINE POLYPEPTIDES AND USES THEREOF
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
DK2632478T3 (en) 2010-10-27 2019-10-07 Novo Nordisk As TREATMENT OF DIABETES MELITUS USING INSULIN INJECTIONS SUBMITTED AT VARIOUS INJECTION INTERVALS
CN103167878A (en) 2010-10-27 2013-06-19 诺沃—诺迪斯克有限公司 Treating diabetes melitus using insulin injections administered with varying injection intervals
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (en) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland PHARMACEUTICAL COMBINATION FOR USE IN GLUCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
RU2014127270A (en) 2011-12-15 2016-02-10 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. ANALOGUE OF HUMAN INSULIN AND ITS Acylated Derivative
CA2872083A1 (en) 2012-05-01 2013-11-07 Novo Nordisk A/S Pharmaceutical composition
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
EP2854841B1 (en) 2012-06-04 2017-02-22 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms
EP2919804B1 (en) 2012-11-13 2018-01-31 Adocia Quick-acting insulin formulation including a substituted anionic compound
WO2014093696A2 (en) 2012-12-12 2014-06-19 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
US9707275B2 (en) 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
JP2016505601A (en) 2012-12-26 2016-02-25 ウォックハート リミテッド Pharmaceutical composition
KR20140088837A (en) * 2013-01-03 2014-07-11 한미약품 주식회사 Insulinotropic peptide derivative wherein its N-terminal charge is modified
TWI780236B (en) 2013-02-04 2022-10-11 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP2016519127A (en) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス New dosing regimen
US20160271226A1 (en) 2013-09-30 2016-09-22 Wockhardt Limited Pharmaceutical composition
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
JP6723921B2 (en) 2014-01-09 2020-07-15 サノフイＳａｎｏｆｉ Glycerin-free stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
CN105960249B (en) 2014-01-09 2021-03-16 赛诺菲 Stabilized pharmaceutical formulations of insulin analogs and/or insulin derivatives
US9895423B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin aspart
AR099569A1 (en) * 2014-02-28 2016-08-03 Novo Nordisk As INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE
CN104017809A (en) * 2014-06-05 2014-09-03 山东省农业科学院生物技术研究中心 Expression gene and method for modified human Insulin protein
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
PE20171622A1 (en) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland INSULIN GLARGIN / LIXISENATIDE FIXED RATIO FORMULATION
AR102869A1 (en) 2014-12-16 2017-03-29 Lilly Co Eli QUICK ACTION INSULIN COMPOSITIONS
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
JO3749B1 (en) 2015-08-27 2021-01-31 Lilly Co Eli Fast acting insulin formulations
UY36870A (en) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd NEW INSULIN ANALOGS
CN105440125B (en) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 The preparation method of insulin detemir or its analog
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
RU2764197C1 (en) 2016-09-23 2022-01-14 Ханми Фарм. Ко., Лтд. Insulin analogues with reduced affinity to insulin receptor and their use
DK3518892T5 (en) 2016-09-29 2024-09-02 Arecor Ltd PHARMACEUTICAL FORMULATION CONTAINING AN INSULIN COMPOUND
TWI700091B (en) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 Insulin containing pharmaceutical compositions
CN110446501A (en) 2017-03-09 2019-11-12 代阿麦迪卡股份有限公司 The dosage form of tissue kallikrein 1
AR111341A1 (en) 2017-03-23 2019-07-03 Hanmi Pharm Ind Co Ltd AN INSULIN ANALOG WITH REDUCED AFFINITY FOR THE INSULIN RECEIVER AND USE OF IT
GB201707187D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707189D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707188D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
KR20190140048A (en) 2017-06-01 2019-12-18 일라이 릴리 앤드 캄파니 Fast-acting insulin composition
CN112040928A (en) 2018-04-04 2020-12-04 艾瑞克有限公司 Medical infusion pump system for delivery of insulin compounds
CA3094304A1 (en) 2018-04-04 2019-10-10 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
IL277721B2 (en) 2018-04-04 2024-03-01 Arecor Ltd Medical infusion pump for administering an insulin compound
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US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
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CN119529057A (en) 2019-12-30 2025-02-28 甘李药业股份有限公司 Long-acting GLP-1 compounds
AU2020417892A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Insulin derivative
GB202004814D0 (en) 2020-04-01 2020-05-13 Arecor Ltd Novel formulations
CN114075275A (en) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 Long-acting insulin analogue
CN118574842A (en) 2022-01-28 2024-08-30 甘李药业股份有限公司 Acylated insulin
CN115493919B (en) * 2022-11-21 2023-04-07 保定佳瑞源生物芯片有限公司 Calibrator diluent of C peptide and insulin detection kit

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1426061A (en) * 1972-12-28 1976-02-25 Ici Ltd Polypeptides
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DE3326472A1 (en) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt NEW INSULIN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR TREATING THE DIABETES MELLITUS
DK347086D0 (en) * 1986-07-21 1986-07-21 Novo Industri As NOVEL PEPTIDES
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
FI884914A0 (en) * 1987-02-25 1988-10-24 Novo Industri As NYA INSULINDERIVAT.
DK257988D0 (en) * 1988-05-11 1988-05-11 Novo Industri As NEW PEPTIDES
PT93057B (en) * 1989-02-09 1995-12-29 Lilly Co Eli PROCESS FOR THE PREPARATION OF INSULIN ANALOGS

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DE68928810T2 (en) 1999-03-18
EP0375437A2 (en) 1990-06-27
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NO301483B1 (en) 1997-11-03
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YU243689A (en) 1991-10-31
IL92853A0 (en) 1990-09-17
ATE170875T1 (en) 1998-09-15
ATE175974T1 (en) 1999-02-15
NO912438D0 (en) 1991-06-21
DE68928971D1 (en) 1999-05-27
EP0837072A2 (en) 1998-04-22
CN1043719A (en) 1990-07-11
HUT56857A (en) 1991-10-28
EP0375437B1 (en) 1998-09-09
AU641631B2 (en) 1993-09-30
JPH04502465A (en) 1992-05-07
US5164366A (en) 1992-11-17
DE861851T1 (en) 1999-04-22
EP0861851B1 (en) 1999-04-14
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FI913037A7 (en) 1991-06-20
WO1990007522A1 (en) 1990-07-12
DE68928810D1 (en) 1998-10-15
ES2134669T3 (en) 1999-10-01
EP0837072B1 (en) 1999-01-20
DE68928971T2 (en) 1999-12-02
AU4834490A (en) 1990-08-01
EP0375437A3 (en) 1991-09-11
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NO912438L (en) 1991-08-21
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CA2006578A1 (en) 1990-06-23
DE68928917D1 (en) 1999-03-04

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