ATE178908T1 - Lys(b28) insuline. analoge des menschlichen insulins - Google Patents

Lys(b28) insuline. analoge des menschlichen insulins

Info

Publication number: ATE178908T1
Authority: AT; Austria
Prior art keywords: human insulin; sup; lys; analogues; insuline
Prior art date: 1988-12-23

Application number

AT97121214T

Other languages

English (en)

Inventor

Per Balschmidt

Jens Vejlgaard Brange

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1989-12-21

Publication date

1999-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26067619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE178908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-12-23 Priority claimed from DK721588A external-priority patent/DK721588D0/da

1989-09-28 Priority claimed from DK477789A external-priority patent/DK477789D0/da

1989-12-21 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE178908T1 publication Critical patent/ATE178908T1/de

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fats And Perfumes (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT97121214T 1988-12-23 1989-12-21 Lys(b28) insuline. analoge des menschlichen insulins ATE178908T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK721588A DK721588D0 (da)	1988-12-23	1988-12-23	Humaninsulinanaloger
DK477789A DK477789D0 (da)	1989-09-28	1989-09-28	Nye polypeptider

Publications (1)

Publication Number	Publication Date
ATE178908T1 true ATE178908T1 (de)	1999-04-15

Family

ID=26067619

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT97121214T ATE178908T1 (de)	1988-12-23	1989-12-21	Lys(b28) insuline. analoge des menschlichen insulins
AT97121213T ATE175974T1 (de)	1988-12-23	1989-12-21	Lys(b28) insuline. analogen des menschlichen insulins
AT89313460T ATE170875T1 (de)	1988-12-23	1989-12-21	Analoge vom menschlichen insulin

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT97121213T ATE175974T1 (de)	1988-12-23	1989-12-21	Lys(b28) insuline. analogen des menschlichen insulins
AT89313460T ATE170875T1 (de)	1988-12-23	1989-12-21	Analoge vom menschlichen insulin

Country Status (17)

Country	Link
US (1)	US5164366A (de)
EP (3)	EP0375437B1 (de)
JP (1)	JPH04502465A (de)
KR (1)	KR910700262A (de)
CN (1)	CN1043719A (de)
AT (3)	ATE178908T1 (de)
AU (1)	AU641631B2 (de)
CA (1)	CA2006578A1 (de)
DE (4)	DE68928917T2 (de)
ES (1)	ES2134669T3 (de)
FI (1)	FI913037A0 (de)
HU (1)	HUT56857A (de)
IL (1)	IL92853A0 (de)
NO (1)	NO301483B1 (de)
NZ (1)	NZ231936A (de)
WO (1)	WO1990007522A1 (de)
YU (1)	YU243689A (de)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
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1989
- 1989-12-15 HU HU90984A patent/HUT56857A/hu unknown
- 1989-12-15 WO PCT/DK1989/000296 patent/WO1990007522A1/en not_active Ceased
- 1989-12-15 KR KR1019900701869A patent/KR910700262A/ko not_active Ceased
- 1989-12-15 FI FI913037A patent/FI913037A0/fi not_active Application Discontinuation
- 1989-12-15 AU AU48344/90A patent/AU641631B2/en not_active Ceased
- 1989-12-15 JP JP2501698A patent/JPH04502465A/ja active Pending
- 1989-12-20 US US07/453,445 patent/US5164366A/en not_active Expired - Fee Related
- 1989-12-21 AT AT97121214T patent/ATE178908T1/de not_active IP Right Cessation
- 1989-12-21 AT AT97121213T patent/ATE175974T1/de active
- 1989-12-21 DE DE68928917T patent/DE68928917T2/de not_active Expired - Fee Related
- 1989-12-21 DE DE68928810T patent/DE68928810T2/de not_active Expired - Fee Related
- 1989-12-21 DE DE68928971T patent/DE68928971T2/de not_active Expired - Fee Related
- 1989-12-21 DE DE0861851T patent/DE861851T1/de active Pending
- 1989-12-21 NZ NZ231936A patent/NZ231936A/en unknown
- 1989-12-21 EP EP89313460A patent/EP0375437B1/de not_active Expired - Lifetime
- 1989-12-21 ES ES97121214T patent/ES2134669T3/es not_active Expired - Lifetime
- 1989-12-21 EP EP97121214A patent/EP0861851B1/de not_active Expired - Lifetime
- 1989-12-21 EP EP97121213A patent/EP0837072B1/de not_active Expired - Lifetime
- 1989-12-21 AT AT89313460T patent/ATE170875T1/de active
- 1989-12-22 IL IL92853A patent/IL92853A0/xx unknown
- 1989-12-22 YU YU02436/89A patent/YU243689A/xx unknown
- 1989-12-22 CA CA002006578A patent/CA2006578A1/en not_active Abandoned
- 1989-12-23 CN CN89109575A patent/CN1043719A/zh active Pending
1991
- 1991-06-21 NO NO912438A patent/NO301483B1/no unknown

Also Published As

Publication number	Publication date
DE68928971D1 (de)	1999-05-27
DE68928971T2 (de)	1999-12-02
ES2134669T3 (es)	1999-10-01
CN1043719A (zh)	1990-07-11
FI913037A7 (fi)	1991-06-20
ATE175974T1 (de)	1999-02-15
YU243689A (en)	1991-10-31
WO1990007522A1 (en)	1990-07-12
NO912438D0 (no)	1991-06-21
DE68928917D1 (de)	1999-03-04
HUT56857A (en)	1991-10-28
ATE170875T1 (de)	1998-09-15
EP0837072B1 (de)	1999-01-20
EP0375437A3 (de)	1991-09-11
US5164366A (en)	1992-11-17
NO301483B1 (no)	1997-11-03
AU641631B2 (en)	1993-09-30
DE68928810T2 (de)	1999-03-18
FI913037A0 (fi)	1991-06-20
DE861851T1 (de)	1999-04-22
DE68928810D1 (de)	1998-10-15
EP0375437B1 (de)	1998-09-09
EP0837072A2 (de)	1998-04-22
EP0861851A1 (de)	1998-09-02
NZ231936A (en)	1992-04-28
JPH04502465A (ja)	1992-05-07
EP0375437A2 (de)	1990-06-27
AU4834490A (en)	1990-08-01
EP0837072A3 (de)	1998-08-19
IL92853A0 (en)	1990-09-17
NO912438L (no)	1991-08-21
EP0861851B1 (de)	1999-04-14
CA2006578A1 (en)	1990-06-23
DE68928917T2 (de)	1999-08-05
KR910700262A (ko)	1991-03-14

Legal Events

Date	Code	Title	Description
1999-12-15	UEP	Publication of translation of european patent specification
2003-09-15	REN	Ceased due to non-payment of the annual fee

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