ATE179704T1 - Benzoxazinderivate, verfahren diese zu erhalten und ihre verwendung als medikamente - Google Patents

Benzoxazinderivate, verfahren diese zu erhalten und ihre verwendung als medikamente

Info

Publication number
ATE179704T1
ATE179704T1 AT95906357T AT95906357T ATE179704T1 AT E179704 T1 ATE179704 T1 AT E179704T1 AT 95906357 T AT95906357 T AT 95906357T AT 95906357 T AT95906357 T AT 95906357T AT E179704 T1 ATE179704 T1 AT E179704T1
Authority
AT
Austria
Prior art keywords
group
formula
representing
pct
hydrogen atom
Prior art date
Application number
AT95906357T
Other languages
English (en)
Inventor
Maurice-Bernard Fleury
Jean-Marc Maurette
Martine Largeron
Original Assignee
Pharmascience Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmascience Lab filed Critical Pharmascience Lab
Application granted granted Critical
Publication of ATE179704T1 publication Critical patent/ATE179704T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/05—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/07—Oxygen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/09—Nitrogen containing compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Metallurgy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95906357T 1993-12-29 1994-12-29 Benzoxazinderivate, verfahren diese zu erhalten und ihre verwendung als medikamente ATE179704T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9315836A FR2714381B1 (fr) 1993-12-29 1993-12-29 Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments .

Publications (1)

Publication Number Publication Date
ATE179704T1 true ATE179704T1 (de) 1999-05-15

Family

ID=9454544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906357T ATE179704T1 (de) 1993-12-29 1994-12-29 Benzoxazinderivate, verfahren diese zu erhalten und ihre verwendung als medikamente

Country Status (11)

Country Link
US (1) US5804580A (de)
EP (1) EP0737187B1 (de)
JP (1) JPH09507483A (de)
AT (1) ATE179704T1 (de)
AU (1) AU1510495A (de)
DE (1) DE69418347T2 (de)
DK (1) DK0737187T3 (de)
ES (1) ES2131805T3 (de)
FR (1) FR2714381B1 (de)
GR (1) GR3030567T3 (de)
WO (1) WO1995018114A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
FR2779144B1 (fr) * 1998-05-29 2000-06-30 Adir Nouveaux composes 8-amino-1,4-benzoxaziniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GR1007084B (el) * 2008-08-07 2010-11-26 Ευτυχια Κοϊνη 1,4- βενζοξαζινικα αναλογα
CN102552233B (zh) * 2011-12-26 2014-05-14 暨南大学 3,4-二羟基苯甲酸甲酯在制备防治神经退行性疾病药物中的应用
CN113106473B (zh) * 2021-04-14 2022-02-18 南京工业大学 一种通过连续电化学微反应器装置制备1,3-苯并噁嗪衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377202A2 (fr) * 1977-01-12 1978-08-11 Pharmascience Lab Compositions pharmaceutiques contenant de l'hexahydroxy-2,3,4,3',4',5'-benzophenone
US4263322A (en) * 1979-03-01 1981-04-21 Riet Bartholomeus Van T Hydroxy benzohydroxamic acids and benzamides
FR2504917B1 (fr) * 1981-05-04 1987-09-25 Delalande Sa Nouveau systeme oxydant selectif et son application a la preparation de derives aromatiques ortho-dihydroxyles ou ortho-dialcoxyles
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
US5124325A (en) * 1989-06-13 1992-06-23 Kyorin Pharmaceutical Co., Ltd. Therapeutic agents of metabolic bone disease
US5208247A (en) * 1991-08-01 1993-05-04 American Cyanamid Company Pyridinium compounds which are useful as antagonists of platelet activating factor

Also Published As

Publication number Publication date
JPH09507483A (ja) 1997-07-29
FR2714381B1 (fr) 1996-02-02
FR2714381A1 (fr) 1995-06-30
WO1995018114A1 (fr) 1995-07-06
GR3030567T3 (en) 1999-10-29
AU1510495A (en) 1995-07-17
ES2131805T3 (es) 1999-08-01
EP0737187B1 (de) 1999-05-06
EP0737187A1 (de) 1996-10-16
DK0737187T3 (da) 1999-11-15
DE69418347D1 (de) 1999-06-10
DE69418347T2 (de) 1999-11-18
US5804580A (en) 1998-09-08

Similar Documents

Publication Publication Date Title
ATE209186T1 (de) Überbrückte azabicyclische derivate als substanz p antagonisten
ES8306707A1 (es) "procedimiento para la preparacion de nuevos derivados de la aminometil-5-aril-3-oxazolidinona-2-"
ATE171445T1 (de) Perhydroisoindolderivate als substanz p antagonisten
ZA931073B (en) Hypolipidaemic compounds
ATE152445T1 (de) 3,5-dioxo-(2h,4h)-1,2,4-triazine als 5ht1a ligande
ATE203015T1 (de) Pyrazol-derivate, verfahren für ihre herstellung und sie enthaltende zusammensetzungen
NO975758L (no) Heterosykliske frie metylradikaler som bildeforbedrende milder
DK0696281T3 (da) Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater
CA2423007A1 (en) Spiro derivatives and adhesion molecule inhibitors containing the same as effective ingredients
DE69418347D1 (de) Benzoxazinderivate, verfahren diese zu erhalten und ihre verwendung als medikamente
SE8903226L (sv) Kemiska foereningar
IL108387A (en) Optically active beta-aminoalkoxyborane complex and its use in organic synthesis
DK0532566T3 (da) Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken
CS180191A3 (en) Novel derivatives of oxazole, process for their preparation and pharmaceuticals containing them
DE59207425D1 (de) Imidazolylmethyl-Pyridine
NO154391C (no) E 2-amino-naftalen-derivater.
DE69211101D1 (de) Alpha-Methylen-2-Vinyl-Phenylessigsäurederivate, Verfahren zu deren Herstellung und ihre Anwendung als Pestizide
DE69725167D1 (de) N-benzolsulfonyl-l-prolin derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung
ATE148463T1 (de) N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel
DK0678088T3 (da) N-acylpyrrolidiner og lægemidler til behandling og forebyggelse af cholecystokinin- og gastrinrelaterede sygdomme
DE69412085D1 (de) Neues verfahren zur herstellung von beta-alkoxyacrylsäure
MX9302833A (es) Piridinas substituidas, proceso para su preparacion y composicion farmaceutica que las comprende.
DE69818051D1 (de) N-benzenesulfonyl-l-prolin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung
DK0478559T3 (da) Forbedret fremgangsmåde til fremstilling af kentonforbindelser
ES511642A0 (es) "metodo de preparar sulfohalogenuros".

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee