ATE179759T1 - Flüssiges thromboplastin-reagens - Google Patents

Flüssiges thromboplastin-reagens

Info

Publication number: ATE179759T1
Authority: AT; Austria
Prior art keywords: thromboplastin reagent; liquid thromboplastin; reagent; liquid; months
Prior art date: 1992-08-03

Application number

AT93202175T

Other languages

English (en)

Inventor

Juan Louis Torres

James Reth Butler

Rajesh Sharma

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-03

Filing date

1993-07-22

Publication date

1999-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25449889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE179759(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-07-22 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1999-05-15 Application granted granted Critical

1999-05-15 Publication of ATE179759T1 publication Critical patent/ATE179759T1/de

Links

239000003153 chemical reaction reagent Substances 0.000 title abstract 3
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 2
102000002262 Thromboplastin Human genes 0.000 title abstract 2
108010000499 Thromboplastin Proteins 0.000 title abstract 2
239000007788 liquid Substances 0.000 title abstract 2
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Zoology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93202175T 1992-08-03 1993-07-22 Flüssiges thromboplastin-reagens ATE179759T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/924,211 US5358853A (en)	1992-08-03	1992-08-03	Liquid thromboplastin reagent

Publications (1)

Publication Number	Publication Date
ATE179759T1 true ATE179759T1 (de)	1999-05-15

Family

ID=25449889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93202175T ATE179759T1 (de)	1992-08-03	1993-07-22	Flüssiges thromboplastin-reagens

Country Status (13)

Country	Link
US (2)	US5358853A (de)
EP (1)	EP0585987B2 (de)
JP (1)	JP3330685B2 (de)
KR (1)	KR100265531B1 (de)
AT (1)	ATE179759T1 (de)
AU (1)	AU665432B2 (de)
CA (1)	CA2100617C (de)
DE (2)	DE69324745D1 (de)
DK (1)	DK0585987T4 (de)
ES (1)	ES2132174T5 (de)
FI (1)	FI109152B (de)
GR (1)	GR3030728T3 (de)
ZA (1)	ZA935180B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6379975B1 (en)	1996-11-27	2002-04-30	T.A.C. Thrombosis And Coagulation Aktiebolag	Methods and reagents for determining protein S
AU7129598A (en) *	1997-04-23	1998-11-13	Instrumentation Laboratory S.P.A.	Recombinant rabbit tissue factor based prothrombin time reagent
DE19720853A1 (de) *	1997-05-17	1998-11-19	Dade Behring Marburg Gmbh	Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
DE19811016A1 (de) *	1998-03-13	1999-09-16	Dade Behring Marburg Gmbh	Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6391609B1 (en)	1998-10-07	2002-05-21	Sigma-Aldrich Co.	Thromboplastin reagents and methods for preparing and using such reagents
US6207661B1 (en)	1999-02-22	2001-03-27	Baxter International Inc.	Premixed formulation of piperacillin sodium and tazobactam sodium injection
US6733985B1 (en) *	1999-05-19	2004-05-11	International Technidyne Corporation	Preparation of stable liquid and dried synthetic prothrombin time reagents
US6248353B1 (en)	1999-12-10	2001-06-19	Dade Behring Inc.	Reconstitution of purified membrane proteins into preformed liposomes
US6855509B2 (en) *	2000-12-19	2005-02-15	Instrumentation Laboratory Company	Protein S functional assay and kit therefor
US7148067B2 (en) *	2004-08-31	2006-12-12	The Board Of Trustees Of The University Of Illinois	Thromboplastin reagents
US20080260858A1 (en) *	2005-02-16	2008-10-23	The Board Of Trustees Of The University Of Illnois	Universal Procoagulant
CA2600907C (en) *	2005-03-04	2016-06-28	The Board Of Trustees Of The University Of Illinois	Coagulation and fibrinolytic cascades modulator
CA2649538C (en) *	2006-04-21	2014-06-03	Yatin Gokarn	Buffering agents for biopharmaceutical formulations
JP4999613B2 (ja) *	2007-08-31	2012-08-15	シスメックス株式会社	血液凝固測定用試薬及び血液凝固時間測定方法
US8821861B2 (en) *	2007-10-05	2014-09-02	The Board Of Trustees Of The University Of Illinois	Fibrin sealant
WO2009061697A1 (en)	2007-11-09	2009-05-14	The Board Of Trustees Of The University Of Illinois	Anticoagulant antagonist and hemophilia procoagulant
DE102007062323A1 (de)	2007-12-21	2009-06-25	Siemens Healthcare Diagnostics Products Gmbh	Langzeitstabiles Thromboplastin-Reagenz
CA2762611C (en)	2009-05-20	2017-03-28	Sekisui Medical Co., Ltd.	Blood coagulation time prolonging agent
JP5589103B2 (ja) *	2013-01-23	2014-09-10	株式会社Ｌｓｉメディエンス	二価金属イオン含有の体外診断用試薬組成物および二価金属イオン由来金属化合物の沈殿防止方法
JP6250306B2 (ja) *	2013-05-28	2017-12-20	株式会社Ｌｓｉメディエンス	リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
JP2014197019A (ja) *	2014-06-30	2014-10-16	積水メディカル株式会社	血液凝固反応における血液凝固時間延長剤
US10877052B2 (en)	2016-02-12	2020-12-29	Instrumentation Laboratory Company	Two component “mix and use” liquid thromboplastin reagent, methods of making, and methods of use thereof
EP3489692A1 (de)	2017-11-28	2019-05-29	Siemens Healthcare Diagnostics Products GmbH	Prothrombinzeit-reagenz enthaltend einen eisenchelator
EP3859327A4 (de) *	2018-09-25	2022-09-07	Sekisui Medical Co., Ltd.	Verfahren zur messung der blutgerinnungszeit
CN113005176A (zh) *	2019-12-20	2021-06-22	深圳市帝迈生物技术有限公司	稳定剂、凝血酶原时间检测试剂及其制备方法、试剂盒
CN111638374B (zh) *	2020-06-08	2022-10-18	深圳市国赛生物技术有限公司	一种用于测定凝血酶原时间的体外诊断试剂盒

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2516216A (en) *	1947-06-24	1950-07-25	Sharp & Dohme Inc	Thromboplastin as testing agent
US2847347A (en) *	1954-05-27	1958-08-12	Ortho Pharmacentical Corp	Preparation of improved thromboplastin
US2847350A (en) *	1954-05-27	1958-08-12	Ortho Pharma Corp	Preparation of highly active thromboplastin
US2842480A (en) *	1954-05-27	1958-07-08	Ortho Pharma Corp	Preparation of thromboplastin
US2921000A (en) *	1956-05-22	1960-01-12	Ortho Pharma Corp	Thromboplastin
US3522148A (en) *	1965-08-13	1970-07-28	Dade Reagents Inc	Stabilized thromboplastin preparation
DE3113350A1 (de) *	1981-04-02	1982-10-21	Boehringer Mannheim Gmbh, 6800 Mannheim	Reagens zur optischen bestimmung des blutgerinnungsverhaltens
DE3150596A1 (de) *	1981-12-21	1983-06-30	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von gewebsthromboplastin
US4755461A (en) *	1986-04-17	1988-07-05	Bio/Data Corporation	Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5270451A (en) *	1988-11-23	1993-12-14	Baxter Diagnostics Inc.	Extraction method for preparing thromboplastin reagents
JP3348228B2 (ja) *	1988-11-23	2002-11-20	デイドベーリングインコーポレーテッド	トロンボプラスチン試薬を製造するための改良された抽出方法
US5091304A (en) *	1989-08-21	1992-02-25	International Technidyne Corporation	Whole blood activated partial thromboplastin time test and associated apparatus
DE3929329A1 (de) *	1989-09-04	1991-03-07	Behringwerke Ag	Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
FR2679251B1 (fr) *	1991-07-18	1993-11-12	Nord Assoc Essor Transfusion San	Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.

1992
- 1992-08-03 US US07/924,211 patent/US5358853A/en not_active Expired - Lifetime
1993
- 1993-07-15 CA CA002100617A patent/CA2100617C/en not_active Expired - Fee Related
- 1993-07-16 ZA ZA935180A patent/ZA935180B/xx unknown
- 1993-07-22 AT AT93202175T patent/ATE179759T1/de not_active IP Right Cessation
- 1993-07-22 EP EP93202175A patent/EP0585987B2/de not_active Expired - Lifetime
- 1993-07-22 DK DK93202175T patent/DK0585987T4/da active
- 1993-07-22 DE DE69324745A patent/DE69324745D1/de not_active Expired - Fee Related
- 1993-07-22 DE DE69324745T patent/DE69324745T4/de not_active Expired - Lifetime
- 1993-07-22 ES ES93202175T patent/ES2132174T5/es not_active Expired - Lifetime
- 1993-07-23 AU AU42158/93A patent/AU665432B2/en not_active Ceased
- 1993-08-02 FI FI933441A patent/FI109152B/fi not_active IP Right Cessation
- 1993-08-02 KR KR1019930014928A patent/KR100265531B1/ko not_active Expired - Fee Related
- 1993-08-03 JP JP19255593A patent/JP3330685B2/ja not_active Expired - Fee Related
1994
- 1994-06-03 US US08/253,523 patent/US5508170A/en not_active Expired - Fee Related
1999
- 1999-07-08 GR GR990401807T patent/GR3030728T3/el unknown

Also Published As

Publication number	Publication date
GR3030728T3 (en)	1999-11-30
FI109152B (fi)	2002-05-31
DE69324745D1 (de)	1999-06-10
EP0585987B1 (de)	1999-05-06
US5358853A (en)	1994-10-25
JPH06201702A (ja)	1994-07-22
KR100265531B1 (ko)	2000-09-15
ES2132174T5 (es)	2005-04-16
ZA935180B (en)	1994-05-25
FI933441A0 (fi)	1993-08-02
DE69324745T4 (de)	2006-01-05
DK0585987T3 (da)	1999-11-08
KR940005288A (ko)	1994-03-21
CA2100617A1 (en)	1994-02-04
US5508170A (en)	1996-04-16
AU665432B2 (en)	1996-01-04
JP3330685B2 (ja)	2002-09-30
CA2100617C (en)	2003-06-24
DE69324745T2 (de)	1999-10-14
EP0585987A1 (de)	1994-03-09
EP0585987B2 (de)	2004-09-08
DK0585987T4 (da)	2005-01-17
ES2132174T3 (es)	1999-08-16
AU4215893A (en)	1994-02-10
FI933441L (fi)	1994-02-04

Legal Events

Date

Code

Title

Description

2000-01-15

UEP

Publication of translation of european patent specification

2006-08-15

UEP