ES2132174T3 - Reactivo liquido de tromboplastina. - Google Patents

Reactivo liquido de tromboplastina.

Info

Publication number
ES2132174T3
ES2132174T3 ES93202175T ES93202175T ES2132174T3 ES 2132174 T3 ES2132174 T3 ES 2132174T3 ES 93202175 T ES93202175 T ES 93202175T ES 93202175 T ES93202175 T ES 93202175T ES 2132174 T3 ES2132174 T3 ES 2132174T3
Authority
ES
Spain
Prior art keywords
thromboplastine
liquid reagent
reagent
resting
months
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93202175T
Other languages
English (en)
Other versions
ES2132174T5 (es
Inventor
Juan Louis Torres
James Reth Butler
Rajesh Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25449889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2132174(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2132174T3 publication Critical patent/ES2132174T3/es
Publication of ES2132174T5 publication Critical patent/ES2132174T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION ES UN REACTIVO TROMBOPLASTINA LIQUIDA ESTABLE USADO PARA MEDIR EL RENDIMIENTO DEL SISTEMA DE COAGULACION, CON UN ENVEJECIMIENTO EN REPOSO DE MAS DE 16 MESES, Y UN METODO PARA PRODUCIR ESTE REACTIVO.
ES93202175T 1992-08-03 1993-07-22 Reactivo liquido de tromboplastina. Expired - Lifetime ES2132174T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US924211 1992-08-03
US07/924,211 US5358853A (en) 1992-08-03 1992-08-03 Liquid thromboplastin reagent

Publications (2)

Publication Number Publication Date
ES2132174T3 true ES2132174T3 (es) 1999-08-16
ES2132174T5 ES2132174T5 (es) 2005-04-16

Family

ID=25449889

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93202175T Expired - Lifetime ES2132174T5 (es) 1992-08-03 1993-07-22 Reactivo liquido de tromboplastina.

Country Status (13)

Country Link
US (2) US5358853A (es)
EP (1) EP0585987B2 (es)
JP (1) JP3330685B2 (es)
KR (1) KR100265531B1 (es)
AT (1) ATE179759T1 (es)
AU (1) AU665432B2 (es)
CA (1) CA2100617C (es)
DE (2) DE69324745D1 (es)
DK (1) DK0585987T4 (es)
ES (1) ES2132174T5 (es)
FI (1) FI109152B (es)
GR (1) GR3030728T3 (es)
ZA (1) ZA935180B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
AU7129598A (en) * 1997-04-23 1998-11-13 Instrumentation Laboratory S.P.A. Recombinant rabbit tissue factor based prothrombin time reagent
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6391609B1 (en) 1998-10-07 2002-05-21 Sigma-Aldrich Co. Thromboplastin reagents and methods for preparing and using such reagents
US6207661B1 (en) 1999-02-22 2001-03-27 Baxter International Inc. Premixed formulation of piperacillin sodium and tazobactam sodium injection
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
CA2600907C (en) * 2005-03-04 2016-06-28 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
CA2649538C (en) * 2006-04-21 2014-06-03 Yatin Gokarn Buffering agents for biopharmaceutical formulations
JP4999613B2 (ja) * 2007-08-31 2012-08-15 シスメックス株式会社 血液凝固測定用試薬及び血液凝固時間測定方法
US8821861B2 (en) * 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
DE102007062323A1 (de) 2007-12-21 2009-06-25 Siemens Healthcare Diagnostics Products Gmbh Langzeitstabiles Thromboplastin-Reagenz
CA2762611C (en) 2009-05-20 2017-03-28 Sekisui Medical Co., Ltd. Blood coagulation time prolonging agent
JP5589103B2 (ja) * 2013-01-23 2014-09-10 株式会社Ｌｓｉメディエンス 二価金属イオン含有の体外診断用試薬組成物および二価金属イオン由来金属化合物の沈殿防止方法
JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
JP2014197019A (ja) * 2014-06-30 2014-10-16 積水メディカル株式会社 血液凝固反応における血液凝固時間延長剤
US10877052B2 (en) 2016-02-12 2020-12-29 Instrumentation Laboratory Company Two component “mix and use” liquid thromboplastin reagent, methods of making, and methods of use thereof
EP3489692A1 (de) 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Prothrombinzeit-reagenz enthaltend einen eisenchelator
EP3859327A4 (en) * 2018-09-25 2022-09-07 Sekisui Medical Co., Ltd. METHOD OF MEASUREMENT OF BLOOD COAGING TIME
CN113005176A (zh) * 2019-12-20 2021-06-22 深圳市帝迈生物技术有限公司 稳定剂、凝血酶原时间检测试剂及其制备方法、试剂盒
CN111638374B (zh) * 2020-06-08 2022-10-18 深圳市国赛生物技术有限公司 一种用于测定凝血酶原时间的体外诊断试剂盒

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516216A (en) * 1947-06-24 1950-07-25 Sharp & Dohme Inc Thromboplastin as testing agent
US2847347A (en) * 1954-05-27 1958-08-12 Ortho Pharmacentical Corp Preparation of improved thromboplastin
US2847350A (en) * 1954-05-27 1958-08-12 Ortho Pharma Corp Preparation of highly active thromboplastin
US2842480A (en) * 1954-05-27 1958-07-08 Ortho Pharma Corp Preparation of thromboplastin
US2921000A (en) * 1956-05-22 1960-01-12 Ortho Pharma Corp Thromboplastin
US3522148A (en) * 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
DE3113350A1 (de) * 1981-04-02 1982-10-21 Boehringer Mannheim Gmbh, 6800 Mannheim Reagens zur optischen bestimmung des blutgerinnungsverhaltens
DE3150596A1 (de) * 1981-12-21 1983-06-30 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von gewebsthromboplastin
US4755461A (en) * 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5270451A (en) * 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
JP3348228B2 (ja) * 1988-11-23 2002-11-20 デイド ベーリング インコーポレーテッド トロンボプラスチン試薬を製造するための改良された抽出方法
US5091304A (en) * 1989-08-21 1992-02-25 International Technidyne Corporation Whole blood activated partial thromboplastin time test and associated apparatus
DE3929329A1 (de) * 1989-09-04 1991-03-07 Behringwerke Ag Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.

Also Published As

Publication number Publication date
GR3030728T3 (en) 1999-11-30
FI109152B (fi) 2002-05-31
DE69324745D1 (de) 1999-06-10
EP0585987B1 (en) 1999-05-06
US5358853A (en) 1994-10-25
JPH06201702A (ja) 1994-07-22
KR100265531B1 (ko) 2000-09-15
ES2132174T5 (es) 2005-04-16
ZA935180B (en) 1994-05-25
FI933441A0 (fi) 1993-08-02
DE69324745T4 (de) 2006-01-05
ATE179759T1 (de) 1999-05-15
DK0585987T3 (da) 1999-11-08
KR940005288A (ko) 1994-03-21
CA2100617A1 (en) 1994-02-04
US5508170A (en) 1996-04-16
AU665432B2 (en) 1996-01-04
JP3330685B2 (ja) 2002-09-30
CA2100617C (en) 2003-06-24
DE69324745T2 (de) 1999-10-14
EP0585987A1 (en) 1994-03-09
EP0585987B2 (en) 2004-09-08
DK0585987T4 (da) 2005-01-17
AU4215893A (en) 1994-02-10
FI933441L (fi) 1994-02-04

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