ATE180018T1 - Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen - Google Patents
Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellenInfo
- Publication number
- ATE180018T1 ATE180018T1 AT92919254T AT92919254T ATE180018T1 AT E180018 T1 ATE180018 T1 AT E180018T1 AT 92919254 T AT92919254 T AT 92919254T AT 92919254 T AT92919254 T AT 92919254T AT E180018 T1 ATE180018 T1 AT E180018T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- reporter
- block
- substrate
- haloalkyl
- Prior art date
Links
- 230000002503 metabolic effect Effects 0.000 title abstract 3
- 239000000758 substrate Substances 0.000 abstract 4
- 230000003834 intracellular effect Effects 0.000 abstract 3
- 230000003595 spectral effect Effects 0.000 abstract 3
- 239000012491 analyte Substances 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 230000014759 maintenance of location Effects 0.000 abstract 2
- 150000003568 thioethers Chemical class 0.000 abstract 2
- 150000003573 thiols Chemical class 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/20—Coumarin derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/20—Coumarin derivatives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74925691A | 1991-08-23 | 1991-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180018T1 true ATE180018T1 (de) | 1999-05-15 |
Family
ID=25012967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92919254T ATE180018T1 (de) | 1991-08-23 | 1992-08-21 | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5362628A (de) |
| EP (1) | EP0603266B1 (de) |
| AT (1) | ATE180018T1 (de) |
| DE (1) | DE69229174T2 (de) |
| WO (1) | WO1993004192A1 (de) |
Families Citing this family (84)
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| EP0649533B1 (de) * | 1992-03-30 | 2000-05-10 | Abbott Laboratories | Reagenzien und verfahren zum nachweis und zur quantifizierung von thyroxin in flüssigen proben |
| US5352803A (en) * | 1992-03-30 | 1994-10-04 | Abbott Laboratories | 5(6)-methyl substituted fluorescein derivatives |
| US5534416A (en) * | 1993-04-13 | 1996-07-09 | Molecular Probes, Inc. | Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes |
| US5510526A (en) * | 1993-06-29 | 1996-04-23 | Cargill, Incorporated | Lactic acid production, separation and/or recovery process |
| US6187951B1 (en) | 1993-06-29 | 2001-02-13 | Cargill, Incorporated | Lactic acid production, separation and/or recovery process |
| US5459268A (en) * | 1993-10-25 | 1995-10-17 | Molecular Probes, Inc. | Xanthylium dyes that are well retained in mitochondria |
| US5798276A (en) | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
| US6162931A (en) * | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| US5830912A (en) * | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5773236A (en) * | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
| US6342611B1 (en) | 1997-10-10 | 2002-01-29 | Cytovia, Inc. | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof |
| FR2781055B1 (fr) * | 1998-07-09 | 2000-10-13 | Immunotech Sa | Reactif et methode pour la permeabilisation et l'identification des erythrocytes |
| EP1100520B1 (de) * | 1998-07-21 | 2004-09-22 | Cytovia, Inc. | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
| US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| US6534300B1 (en) | 1999-09-14 | 2003-03-18 | Genzyme Glycobiology Research Institute, Inc. | Methods for producing highly phosphorylated lysosomal hydrolases |
| WO2002012545A2 (en) | 2000-08-03 | 2002-02-14 | Cytovia, Inc. | Method of identifying immunosuppressive agents |
| US20030027229A1 (en) * | 2001-06-01 | 2003-02-06 | Cytovia, Inc. | Methods of identifying potentially therapeutically selective and effective anti-cancer agents that are inducers of apoptosis |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| US20050069962A1 (en) * | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
| US6800472B2 (en) | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
| US6905856B2 (en) | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
| CN1665790A (zh) * | 2002-05-03 | 2005-09-07 | 莫莱丘莱尔探针公司 | 用于检测和分离磷酸化分子的组合物及方法 |
| US20040171034A1 (en) | 2002-05-03 | 2004-09-02 | Brian Agnew | Compositions and methods for detection and isolation of phosphorylated molecules |
| US7445894B2 (en) * | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| US20050233307A1 (en) * | 2002-09-12 | 2005-10-20 | Kyle Gee | Site-specific labeling of affinity tags in fusion proteins |
| AU2003287735A1 (en) * | 2002-11-12 | 2004-06-03 | Argose, Inc. | Non-invasive measurement of analytes |
| US20040106163A1 (en) * | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
| KR20050109934A (ko) | 2003-01-31 | 2005-11-22 | 프로메가 코포레이션 | 관능기의 단백질로의 공유 테더링 |
| US20050250214A1 (en) * | 2004-05-05 | 2005-11-10 | Gee Kyle R | Zinc binding compounds and their method of use |
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| US20050074796A1 (en) * | 2003-07-31 | 2005-04-07 | Stephen Yue | Unsymmetrical cyanine dimer compounds and their application |
| US7271265B2 (en) * | 2003-08-11 | 2007-09-18 | Invitrogen Corporation | Cyanine compounds and their application as quenching compounds |
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| US20050214807A1 (en) * | 2003-11-19 | 2005-09-29 | Iain Johnson | Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection |
| US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
| EP2610315B1 (de) | 2003-12-05 | 2016-08-31 | Life Technologies Corporation | Methinsubstituierte Cyaninfarbstoffverbindungen |
| US7446202B2 (en) | 2003-12-05 | 2008-11-04 | Molecular Probes, Inc. | Cyanine dye compounds |
| US20050123935A1 (en) * | 2003-12-09 | 2005-06-09 | Richard Haugland | Pyrenyloxysulfonic acid fluorescent agents |
| US8039642B2 (en) | 2003-12-09 | 2011-10-18 | Life Technologies Corporation | Pyrenyloxysulfonic acid fluorescent agents |
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| EP1711504A2 (de) | 2004-01-21 | 2006-10-18 | Molecular Probes Inc. | Derivate von cephalosporin und clavulansäure zum nachweis von beta-lactamase in einer probe |
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| EP1885718B1 (de) | 2005-05-11 | 2017-03-15 | Life Technologies Corporation | Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung |
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| ES2434491T3 (es) * | 2005-10-13 | 2013-12-16 | Funda��O D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | An�lisis inmunohistoqu�mico multiplex in situ |
| US7842823B2 (en) * | 2005-10-27 | 2010-11-30 | The Regents Of The University Of California | Fluorogenic probes for reactive oxygen species |
| US7521577B2 (en) * | 2006-01-12 | 2009-04-21 | Molecular Probes, Inc. | Heavy metal binding compounds and their method of use |
| WO2007087582A1 (en) | 2006-01-24 | 2007-08-02 | Invitrogen Corporation | Device and methods for quantifying analytes |
| US20080038761A1 (en) * | 2006-01-30 | 2008-02-14 | Invitrogen Corporation | Compositions and methods for detecting and quantifying toxic substances in disease states |
| US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| EP2727965B1 (de) | 2006-10-27 | 2019-03-06 | Life Technologies Corporation | FLUOROGENE pH-SENSITIVE FARBSTOFFE UND IHRE VERWENDUNG |
| US8586743B2 (en) * | 2007-01-30 | 2013-11-19 | Life Technologies Corporation | Labeling reagents and methods of their use |
| US8981100B2 (en) * | 2007-07-27 | 2015-03-17 | Life Technologies Corporation | Use of novel coumarins as glutathione and thiol labels |
| ES2396797T3 (es) * | 2007-08-17 | 2013-02-27 | University Of Washington | Procedimientos de ensayo de la actividad enzimática alfa-L-iduronidasa |
| US20090247984A1 (en) * | 2007-10-24 | 2009-10-01 | Masimo Laboratories, Inc. | Use of microneedles for small molecule metabolite reporter delivery |
| WO2009094536A1 (en) * | 2008-01-24 | 2009-07-30 | Life Technologies Corporation | Fluorogenic hydrazine-substituted compounds |
| WO2009152102A2 (en) * | 2008-06-10 | 2009-12-17 | The Regents Of The University Of California | Pro-fluorescent probes |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| PL2710375T3 (pl) | 2011-05-18 | 2019-07-31 | Baxalta GmbH | Testy aktywności zależne od modyfikacji |
| US9618453B2 (en) | 2011-10-11 | 2017-04-11 | The Hong Kong University Of Science And Technology | Aggregation induced emission of fluorescent bioprobes and methods of using the same |
| US9409928B2 (en) | 2011-10-11 | 2016-08-09 | The Hong Kong University Of Science And Technology | Aggregation induced emission active cytophilic fluorescent bioprobes for long-term cell tracking |
| JP6180423B2 (ja) | 2011-11-08 | 2017-08-16 | ユニヴァーシティ オブ ワシントン | リソソーム酵素アッセイ法および組成物 |
| US9599622B2 (en) | 2012-05-30 | 2017-03-21 | Life Technologies Corporation | Fluorogenic pH-sensitive dyes and their methods of use (II) |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| SG11201602522VA (en) | 2013-10-02 | 2016-04-28 | Medimmune Llc | Neutralizing anti-influenza a antibodies and uses thereof |
| EP3502693A1 (de) | 2014-05-16 | 2019-06-26 | Life Technologies Corporation | Zellverfolgungsreagenzien und deren verfahren zur verwendung |
| WO2015175870A1 (en) | 2014-05-16 | 2015-11-19 | Life Technologies Corporation | Carbopyronone compounds useful as diagnostic adjuvants |
| WO2016011035A2 (en) | 2014-07-15 | 2016-01-21 | Medlmmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| EP3227264B1 (de) | 2014-12-03 | 2020-10-21 | Life Technologies Corporation | Hydrazinyl- und aminooxyverbindungen und verfahren zur verwendung davon |
| EP3314257B1 (de) | 2015-06-26 | 2021-06-16 | Life Technologies Corporation | Zellverfolgungsreagenzien und deren verfahren zur verwendung |
| SG11201808528VA (en) * | 2016-03-30 | 2018-10-30 | Convatec Technologies Inc | Modified wound dressings |
| WO2017181176A1 (en) | 2016-04-15 | 2017-10-19 | Lcahn School Of Medicine At Mount Sinai | Tissue profiling using multiplexed immunohistochemical consecutive staining |
| EP3475443B1 (de) | 2016-06-23 | 2025-02-12 | Life Technologies Corporation | Verfahren und zusammensetzungen zur detektion oder messung von caspasen oder apoptosen |
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| WO2018132562A1 (en) | 2017-01-11 | 2018-07-19 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate |
| SG11202101282QA (en) | 2018-08-10 | 2021-03-30 | Life Technologies Corp | Silicon-substituted rhodamine dyes and dye conjugates |
| WO2023021311A1 (en) | 2021-08-20 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Selective measurement of human factor viii |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788200A (fr) * | 1971-09-03 | 1973-02-28 | Lonza Ag | Procede de fabrication de 4-halogenomethylcoumarines et nouveaux composes ainsi obtenus |
| US4220722A (en) * | 1978-02-10 | 1980-09-02 | Syva Company | Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby |
| US4279992A (en) * | 1978-03-13 | 1981-07-21 | Miles Laboratories, Inc. | Specific binding assay employing an enzyme-cleavable substrate as label |
| US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
| US4812409A (en) * | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
| DE3614647A1 (de) * | 1986-04-30 | 1987-11-05 | Euratom | 7-phenylessigsaeure-4-alkyl-coumarinylamide, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase |
| US5112739A (en) * | 1988-08-02 | 1992-05-12 | Polaroid Corporation | Enzyme controlled release system |
-
1992
- 1992-08-21 AT AT92919254T patent/ATE180018T1/de active
- 1992-08-21 WO PCT/US1992/007068 patent/WO1993004192A1/en not_active Ceased
- 1992-08-21 DE DE69229174T patent/DE69229174T2/de not_active Expired - Lifetime
- 1992-08-21 EP EP92919254A patent/EP0603266B1/de not_active Expired - Lifetime
-
1993
- 1993-03-05 US US08/026,633 patent/US5362628A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0603266A1 (de) | 1994-06-29 |
| EP0603266B1 (de) | 1999-05-12 |
| WO1993004192A1 (en) | 1993-03-04 |
| DE69229174D1 (de) | 1999-06-17 |
| US5362628A (en) | 1994-11-08 |
| DE69229174T2 (de) | 1999-09-16 |
| EP0603266A4 (en) | 1997-01-15 |
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