ATE84150T1 - Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker. - Google Patents

Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker.

Info

Publication number
ATE84150T1
ATE84150T1 AT88850314T AT88850314T ATE84150T1 AT E84150 T1 ATE84150 T1 AT E84150T1 AT 88850314 T AT88850314 T AT 88850314T AT 88850314 T AT88850314 T AT 88850314T AT E84150 T1 ATE84150 T1 AT E84150T1
Authority
AT
Austria
Prior art keywords
lanthanide
homogeneous
chelate
bios
marker
Prior art date
Application number
AT88850314T
Other languages
English (en)
Inventor
Ilkka Hemmilae
Timo Loevgren
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Application granted granted Critical
Publication of ATE84150T1 publication Critical patent/ATE84150T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT88850314T 1987-09-24 1988-09-20 Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker. ATE84150T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8703682A SE8703682L (sv) 1987-09-24 1987-09-24 Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
EP88850314A EP0324323B1 (de) 1987-09-24 1988-09-20 Homogene biospezifische Bestimmungsmethode mit Lanthanidchelaten-Marker

Publications (1)

Publication Number Publication Date
ATE84150T1 true ATE84150T1 (de) 1993-01-15

Family

ID=20369657

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88850314T ATE84150T1 (de) 1987-09-24 1988-09-20 Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker.

Country Status (6)

Country Link
US (1) US5637509A (de)
EP (1) EP0324323B1 (de)
JP (1) JPH01127957A (de)
AT (1) ATE84150T1 (de)
DE (1) DE3877179T2 (de)
SE (1) SE8703682L (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801702D0 (sv) * 1988-05-05 1988-05-05 Pharmacia Ab Sett vid bestemning av enzymatisk aktivitet
GB8927503D0 (en) * 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
WO1991010908A1 (en) * 1990-01-17 1991-07-25 Wallac Oy Oligosaccharide derivates linked to lanthanide chelates and to a reactive group
ATE156522T1 (de) * 1991-02-14 1997-08-15 Dade Microscan Inc Neue oligonukleotide konjugiert zu lanthanide- chelaten
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
DE4210970C2 (de) * 1992-04-02 1996-10-17 Markus Dipl Chem Sauer Verfahren zur simultanen optischen qualitativen und quantitativen Erfassung von verschiedenen mit Fluorochromen oder Fluorogenen markierten Molekülen eines Gemisches mittels Laserspektroskopie
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6399397B1 (en) 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0730472B1 (de) * 1993-11-16 2006-08-02 Bracco International B.V. Immobilisiertes markierungsverfahren
US5792330A (en) * 1995-05-31 1998-08-11 Board Of Regents, The University Of Texas System Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
JP2001520377A (ja) 1997-10-15 2001-10-30 アクレイラ バイオサイエンシズ，インコーポレイティド 積層状マイクロ構造式装置および積層状マイクロ構造式装置製造方法
US6770460B1 (en) * 1998-01-29 2004-08-03 Wallac Oy Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
DK1154991T3 (da) * 1999-02-18 2004-11-22 Univ California Salicylamid-lanthanidkomplekser til anvendelse som luminescerende markörer
AU768957B2 (en) * 1999-02-18 2004-01-08 Regents Of The University Of California, The Phthalamide-lanthanide complexes for use as luminescent markers
US6838292B1 (en) 1999-04-19 2005-01-04 Alion Science And Technology Corporation Detection of biological warfare agents
US20020072625A1 (en) * 1999-12-10 2002-06-13 Johnson David Kenneth Materials and methods for measuring chelate: anti-chelate binding by fluorescence polarization immunoassay
WO2003003063A2 (en) * 2001-06-28 2003-01-09 Ia, Inc. Fiber-optic sensor array
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7211440B2 (en) 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7485453B2 (en) 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
GB0210535D0 (en) * 2002-05-08 2002-06-19 Novartis Ag Organic compounds
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7169550B2 (en) 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7906276B2 (en) * 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
AU2005269819A1 (en) * 2004-07-23 2006-02-09 Amgen Inc. Generic probes for the detection of phosphorylated sequences
US7671218B2 (en) * 2004-08-13 2010-03-02 Elitech Holdings B.V. Phosphonate fluorescent dyes and conjugates
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
JP4320342B2 (ja) * 2004-08-17 2009-08-26 独立行政法人科学技術振興機構 希土類蛍光錯体を用いた標識方法と分析検出法
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7858384B2 (en) * 2005-04-29 2010-12-28 Kimberly-Clark Worldwide, Inc. Flow control technique for assay devices
US7803319B2 (en) * 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
DE102005020384A1 (de) * 2005-05-02 2006-11-09 Therainvention Gmbh Spektroskopisches Verfahren zum Nachweis von Analyten
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7618810B2 (en) * 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US7645583B2 (en) * 2005-12-14 2010-01-12 Kimberly-Clark Worldwide, Inc. Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin
US7745158B2 (en) * 2005-12-14 2010-06-29 Kimberly-Clark Worldwide, Inc. Detection of secreted aspartyl proteases from Candida species
US8758989B2 (en) * 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
FI20090306A0 (fi) 2009-08-25 2009-08-25 Qret Technologies Oy Erotusvapaa määritysmenetelmä
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
CA2867414C (en) 2012-03-16 2021-06-01 Stat-Diagnostica & Innovation, S.L. A test cartridge with integrated transfer module
EP2841943B1 (de) 2012-04-24 2023-09-27 Kemira Oyj Verfahren zur charakterisierung und/oder bestimmung von proben
TR201809361T4 (tr) 2013-11-19 2018-07-23 Kemira Oyj Analiz yöntemi.
EP3071968B1 (de) 2013-11-19 2020-04-22 Kemira Oyj Analyseverfahren
WO2017139679A1 (en) 2016-02-12 2017-08-17 The Regents Of The University Of California Systems and compositions for diagnosing pathogenic fungal infection and methods of using the same
JP7215999B2 (ja) 2016-12-21 2023-01-31 エフ．ホフマン－ラ ロシュ アーゲー 抗体またはリガンドの結合および機能を決定するためのアッセイ法
WO2018187385A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Compositions and methods of diagnosing pancreatic cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1111762A (en) * 1977-12-28 1981-11-03 David S. Frank Fluorescent rare earth chelate in polymeric latex particles
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
SE425439B (sv) * 1981-04-30 1982-09-27 Wallac Oy Immunologisk analys med lantanidkelatkomplex som markor
US4637988A (en) * 1981-07-01 1987-01-20 Eastman Kodak Company Fluorescent labels for immunoassay
US4837169A (en) * 1981-07-01 1989-06-06 Eastman Kodak Company Polypyridine Fluorescent labels for immunoassay
US4468469A (en) * 1981-11-04 1984-08-28 Miles Laboratories, Inc. Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays
US4454232A (en) * 1982-06-07 1984-06-12 Bio-Rad Laboratories, Inc. Estriol assay
SE454115B (sv) * 1982-09-13 1988-03-28 Wallac Oy Homogenfasanalys med lantanidkelat som merksubstans
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
GB8420521D0 (en) * 1984-08-13 1984-09-19 Hsc Res Dev Corp Fluorescent label
GB8421318D0 (en) * 1984-08-22 1984-09-26 Ekins R P Potentiating antibodies/other macro-molecules
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
US4734378A (en) * 1985-06-26 1988-03-29 Abbott Laboratories Precipitation of interfering proteins in fluorescence polarization immunoassay for digoxin
US4751190A (en) * 1985-07-22 1988-06-14 Abbott Laboratories Fluorescence polarization immunoassay and reagents for use therein
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
WO1987007955A1 (en) * 1986-06-17 1987-12-30 Baxter Travenol Laboratories, Inc. Homogeneous fluoroassay methods employing fluorescent background rejection and water-soluble rare earth metal chelate fluorophores

Also Published As

Publication number Publication date
DE3877179T2 (de) 1993-04-29
EP0324323A1 (de) 1989-07-19
JPH01127957A (ja) 1989-05-19
SE8703682L (sv) 1989-03-25
DE3877179D1 (de) 1993-02-11
EP0324323B1 (de) 1992-12-30
US5637509A (en) 1997-06-10
SE8703682D0 (sv) 1987-09-24

Similar Documents

Publication Publication Date Title
ATE84150T1 (de) Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker.
CA2322858A1 (en) Detection of analytes by fluorescent lanthanide chelates
Laulhere et al. Iron release and uptake by plant ferritin: effects of pH, reduction and chelation
Ohnishi et al. A simplified method of quantitating protein using the biuret and phenol reagents
RU2002131153A (ru) Композиции стабилизированного тетразолий-феназинового реагента и способы их применения
DE69616243D1 (de) Testvorrichtung mit einem stabilen Kopplungsfarbstoff zur Bestimmung von Analyten
ATE365226T1 (de) Kupplungsfarbstoff zur spektrophotometrischen bestimmung von analyten
DE69233674D1 (de) Homogenes Testsystem zur Bestimmung eines Analytes
RU2002131152A (ru) Композиции стабилизированного тетразолиевого реагента и способы их применения
EP0290269A3 (de) Immunoassayverfahren und Reagenzien und Herstellungsverfahren der letzteren
Yeung Chemical analysis of single human erythrocytes
DE3856567D1 (de) Lumineszente Rhenium-Komplexe und Verfahren zur Herstellung
EP0586574A4 (de) Verfahren und reagenzien zur ausführung von ioneneinfang-digoxin-assays.
DE3842657A1 (de) Verfahren und mittel zur bestimmung von maleimidgruppen
Bramanti et al. Application of mercury cold vapor atomic fluorescence spectrometry to the characterization of mercury-accessible− SH groups in native proteins
Song et al. A study of the chemiluminescence behavior of myoglobin with luminol and its analytical applications
NO903748L (no) Fremgangsmaate ved enzymatisk bestemmelse av analyttkonsentrasjoner.
EP0477402A1 (de) Agenz zur Bestimmung von Mangan und Verfahren in Verbindung damit
EP0296795B1 (de) Analytisches Verfahren und Element für eine Ferroion-Probe
IL124093A (en) Cyanide containing hemoglobin reagent composition and method for the determination of hemoglobin in blood
KR960018583A (ko) 면역 분석법
SU1755137A1 (ru) Способ определени пирокатехина
JPH0584099A (ja) アスコルビン酸耐性組成物および液体試薬溶液中の成分を検出する試験装置
JPH09107991A (ja) 化学ルミネセンス型分析方法並びにそのための試薬及びキット
SU1262372A1 (ru) Способ определени меди /п/

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties