ATE180057T1 - Elektrochemilumineszente testverfahren - Google Patents
Elektrochemilumineszente testverfahrenInfo
- Publication number
- ATE180057T1 ATE180057T1 AT89913023T AT89913023T ATE180057T1 AT E180057 T1 ATE180057 T1 AT E180057T1 AT 89913023 T AT89913023 T AT 89913023T AT 89913023 T AT89913023 T AT 89913023T AT E180057 T1 ATE180057 T1 AT E180057T1
- Authority
- AT
- Austria
- Prior art keywords
- analyte
- interest
- sample
- test methods
- luminesce
- Prior art date
Links
- 238000010998 test method Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 6
- 239000000126 substance Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004020 luminiscence type Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Control Of El Displays (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26688288A | 1988-11-03 | 1988-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180057T1 true ATE180057T1 (de) | 1999-05-15 |
Family
ID=23016372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89913023T ATE180057T1 (de) | 1988-11-03 | 1989-10-31 | Elektrochemilumineszente testverfahren |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0757252A3 (de) |
| JP (1) | JP2992974B2 (de) |
| KR (1) | KR0143993B1 (de) |
| AT (1) | ATE180057T1 (de) |
| AU (1) | AU637775B2 (de) |
| CA (1) | CA2002101C (de) |
| DE (1) | DE68928994T2 (de) |
| IL (1) | IL92164A (de) |
| SG (1) | SG60022A1 (de) |
| WO (1) | WO1990005301A1 (de) |
| ZA (1) | ZA898290B (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705402A (en) * | 1988-11-03 | 1998-01-06 | Igen International, Inc. | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| US6274325B1 (en) | 1990-06-25 | 2001-08-14 | Boehringer Mannheim Gmbh | Method for carrying out a homogeneous-immunoassay based on agglutination |
| IL100867A (en) * | 1991-02-06 | 1995-12-08 | Igen Inc | Method and apparatus for improved luminescence assays |
| JPH0534345A (ja) * | 1991-02-19 | 1993-02-09 | Tdk Corp | 化学発光を利用する抗原・抗体の測定方法 |
| ATE184320T1 (de) * | 1991-07-10 | 1999-09-15 | Igen Int Inc | Verfahren für verbesserte lumineszenz-assays unter verwendung von teilchenkonzentration und chemilumineszenznachweis |
| DE69228817T2 (de) * | 1991-07-26 | 1999-09-23 | Dade Chemistry Systems Inc., Deerfield | Signalerkennungspruefung in der anwesenheit von einem suspendierten festen träger |
| ZA929351B (en) * | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| US5541113A (en) * | 1993-09-22 | 1996-07-30 | Beckman Instruments, Inc. | Method for detecting an analyte using an electrochemical luminescent transition metal label |
| CN1114106C (zh) * | 1994-07-25 | 2003-07-09 | 罗切诊断学有限公司 | 金属螯合物标记的肽及其制备方法 |
| US5660991A (en) * | 1994-10-28 | 1997-08-26 | Lakowicz; Joseph R. | Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research |
| US5744367A (en) * | 1994-11-10 | 1998-04-28 | Igen International, Inc. | Magnetic particle based electrochemiluminescent detection apparatus and method |
| AU4756296A (en) * | 1995-01-06 | 1996-07-24 | Igen, Inc. | Electrogenerated chemiluminescence through enhanced particle luminescence |
| JPH11502617A (ja) * | 1995-03-10 | 1999-03-02 | メソ スケール テクノロジーズ,エルエルシー | 多重アレイの多重特異的な電気化学発光試験 |
| US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6319670B1 (en) * | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| WO1996036870A1 (en) * | 1995-05-18 | 1996-11-21 | Igen, Inc. | Method for derivitizing electrodes and assay methods using such derivitized electrodes |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| EP0957360B1 (de) | 1998-05-06 | 2002-07-31 | Roche Diagnostics GmbH | Entstörung durch Rheumafaktoren |
| US6420109B1 (en) | 1998-09-11 | 2002-07-16 | Genelabs Technologies, Inc. | Nucleic acid ligand interaction assays |
| US6136268A (en) * | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
| AU2002341621A1 (en) * | 2001-09-10 | 2003-03-24 | Meso Scale Technologies, Llc | Methods, reagents, kits and apparatus for protein function analysis |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| JP4902674B2 (ja) | 2006-03-09 | 2012-03-21 | エフ.ホフマン−ラ ロシュ アーゲー | 抗薬物抗体アッセイ法 |
| JP4964957B2 (ja) | 2006-09-12 | 2012-07-04 | エフ.ホフマン−ラ ロシュ アーゲー | 抗薬物抗体アッセイ |
| ATE530907T1 (de) | 2007-02-27 | 2011-11-15 | Hoffmann La Roche | Verfahren zur beurteilung der hemmungsaktivität von antikörpern gegen insulinartigen wachstumsfaktor-1-rezeptor |
| CA2709127C (en) | 2007-12-15 | 2013-11-12 | F. Hoffmann-La Roche Ag | Distinguishing assay |
| US8264347B2 (en) | 2008-06-24 | 2012-09-11 | Trelleborg Sealing Solutions Us, Inc. | Seal system in situ lifetime measurement |
| US8614297B2 (en) | 2008-12-22 | 2013-12-24 | Hoffmann-La Roche Inc. | Anti-idiotype antibody against an antibody against the amyloid β peptide |
| JP5805190B2 (ja) | 2010-08-19 | 2015-11-04 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ |
| WO2012143380A1 (en) | 2011-04-20 | 2012-10-26 | F. Hoffmann-La Roche Ag | Microwaves for immunohistochemical analysis |
| CN103649125A (zh) | 2011-06-22 | 2014-03-19 | 霍夫曼-拉罗奇有限公司 | 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞 |
| CA2853917A1 (en) | 2011-12-19 | 2013-06-27 | F. Hoffmann-La Roche Ag | Method for the detection of free binding partner of a multispecific binder |
| WO2013113663A1 (en) | 2012-02-01 | 2013-08-08 | F. Hoffmann-La Roche Ag | Method for the detection of a binding partner of a multispecific binder |
| KR102084805B1 (ko) | 2012-03-08 | 2020-03-04 | 에프. 호프만-라 로슈 아게 | 순환 면역 복합체의 특성화를 위한 다중 크로마토그래피-면역분석 방법 |
| ES2627482T3 (es) | 2012-07-13 | 2017-07-28 | F. Hoffmann-La Roche Ag | Procedimiento para la detección de una proteína de unión multiespecífica |
| WO2014096015A1 (en) | 2012-12-21 | 2014-06-26 | F. Hoffmann-La Roche Ag | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| BR112015032960B1 (pt) | 2013-07-04 | 2021-01-05 | F. Hoffmann-La Roche Ag | imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro |
| KR102425339B1 (ko) | 2014-12-08 | 2022-07-25 | 에프. 호프만-라 로슈 아게 | 비타민 d 의 측정을 위한 방법 |
| JP6979941B2 (ja) | 2015-08-20 | 2021-12-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Peg化分析物特異的結合剤を用いた粒子に基づくイムノアッセイ |
| WO2017072210A1 (en) | 2015-10-29 | 2017-05-04 | F. Hoffmann-La Roche Ag | Anti-variant fc-region antibodies and methods of use |
| CA3004199C (en) | 2015-11-30 | 2024-05-07 | F. Hoffmann-La Roche Ag | Immunoassay for the determination of fc-region modified antibodies |
| BR112018017336A2 (pt) | 2016-03-07 | 2018-12-26 | Hoffmann La Roche | método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão |
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| WO2020229378A1 (en) | 2019-05-13 | 2020-11-19 | F. Hoffmann-La Roche Ag | Interference-suppressed pharmacokinetic immunoassay |
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| JP2025524027A (ja) | 2022-07-22 | 2025-07-25 | エフ. ホフマン-ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための(血液)バイオマーカーとしてのメテオリン様タンパク質(metrnl) |
| EP4558830A1 (de) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Leukotrien-a4-hydrolase (lta4h) als (blut) biomarker zur diagnose des polyzystischen ovarialsyndroms |
| AU2023329315A1 (en) | 2022-08-24 | 2025-01-16 | Amgen Inc. | Anti-drug antibody assays |
| CN121532654A (zh) | 2023-07-20 | 2026-02-13 | 豪夫迈·罗氏有限公司 | 针对抗体组合物的筛选方法 |
| CN121752901A (zh) | 2023-07-28 | 2026-03-27 | 豪夫迈·罗氏有限公司 | 作为子宫内膜异位症的生物标志物的血清EphA1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280815A (en) * | 1979-06-18 | 1981-07-28 | Technicon Instruments Corporation | Electrochemiluminescent immunoassay and apparatus therefor |
| US4652533A (en) * | 1983-04-28 | 1987-03-24 | Pandex Laboratories, Inc. | Method of solid phase immunoassay incorporating a luminescent label |
| US4687747A (en) * | 1984-07-02 | 1987-08-18 | Mallinckrodt, Inc. | Phenanthridinium ester as a labelling compound in luminometric immunoassay |
| DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
| JPH0737464B2 (ja) * | 1986-04-30 | 1995-04-26 | イゲン,インコーポレーテッド | エレクトロ化学ルミネセンスアツセイ |
| SE458968B (sv) * | 1987-06-16 | 1989-05-22 | Wallac Oy | Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser |
| CA2002083C (en) * | 1988-11-03 | 2001-01-09 | Haresh P. Shah | Enhanced electrochemiluminescence |
-
1989
- 1989-10-31 ZA ZA898290A patent/ZA898290B/xx unknown
- 1989-10-31 IL IL9216489A patent/IL92164A/en active IP Right Grant
- 1989-10-31 AU AU46357/89A patent/AU637775B2/en not_active Ceased
- 1989-10-31 SG SG1996011161A patent/SG60022A1/en unknown
- 1989-10-31 AT AT89913023T patent/ATE180057T1/de not_active IP Right Cessation
- 1989-10-31 WO PCT/US1989/004919 patent/WO1990005301A1/en not_active Ceased
- 1989-10-31 JP JP2500352A patent/JP2992974B2/ja not_active Expired - Lifetime
- 1989-10-31 EP EP96202510A patent/EP0757252A3/de not_active Ceased
- 1989-10-31 KR KR1019900701404A patent/KR0143993B1/ko not_active Expired - Fee Related
- 1989-10-31 DE DE68928994T patent/DE68928994T2/de not_active Expired - Lifetime
- 1989-10-31 EP EP89913023A patent/EP0446245B1/de not_active Expired - Lifetime
- 1989-11-02 CA CA002002101A patent/CA2002101C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU4635789A (en) | 1990-05-28 |
| JP2992974B2 (ja) | 1999-12-20 |
| DE68928994D1 (de) | 1999-06-17 |
| SG60022A1 (en) | 1999-02-22 |
| EP0757252A3 (de) | 1997-04-16 |
| EP0446245A1 (de) | 1991-09-18 |
| IL92164A0 (en) | 1990-07-12 |
| DE68928994T2 (de) | 1999-12-16 |
| JPH04502209A (ja) | 1992-04-16 |
| WO1990005301A1 (en) | 1990-05-17 |
| CA2002101A1 (en) | 1990-05-03 |
| EP0757252A2 (de) | 1997-02-05 |
| AU637775B2 (en) | 1993-06-10 |
| IL92164A (en) | 1996-01-19 |
| EP0446245B1 (de) | 1999-05-12 |
| EP0446245A4 (en) | 1991-11-13 |
| CA2002101C (en) | 2002-05-28 |
| KR0143993B1 (ko) | 1998-07-15 |
| ZA898290B (en) | 1991-06-26 |
| KR900702368A (ko) | 1990-12-06 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |