ATE180470T1 - Nipecotinsäurederivate als antithrombische verbindungen - Google Patents

Nipecotinsäurederivate als antithrombische verbindungen

Info

Publication number
ATE180470T1
ATE180470T1 AT95914023T AT95914023T ATE180470T1 AT E180470 T1 ATE180470 T1 AT E180470T1 AT 95914023 T AT95914023 T AT 95914023T AT 95914023 T AT95914023 T AT 95914023T AT E180470 T1 ATE180470 T1 AT E180470T1
Authority
AT
Austria
Prior art keywords
compounds
antithrombic
acid derivatives
nipecotic acid
nipecotic
Prior art date
Application number
AT95914023T
Other languages
English (en)
Inventor
Mary Pat Beavers
Patricia Andrade-Gordon
William J Hoekstra
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE180470T1 publication Critical patent/ATE180470T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
AT95914023T 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen ATE180470T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27

Publications (1)

Publication Number Publication Date
ATE180470T1 true ATE180470T1 (de) 1999-06-15

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95914023T ATE180470T1 (de) 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen

Country Status (20)

Country Link
US (1) US5770575A (de)
EP (1) EP0746545B1 (de)
JP (1) JPH09510453A (de)
KR (1) KR100328287B1 (de)
CN (1) CN1083834C (de)
AT (1) ATE180470T1 (de)
AU (1) AU703397B2 (de)
CA (1) CA2163027A1 (de)
DE (1) DE69509875T2 (de)
DK (1) DK0746545T3 (de)
ES (1) ES2131313T3 (de)
FI (1) FI113763B (de)
GR (1) GR3030566T3 (de)
HU (1) HUT74871A (de)
MX (1) MX9504800A (de)
NO (1) NO304885B1 (de)
NZ (1) NZ283209A (de)
RU (1) RU2135470C1 (de)
TW (1) TW318179B (de)
WO (1) WO1995025091A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2161155C2 (ru) * 1993-09-22 2000-12-27 Фудзисава Фармасьютикал Ко., Лтд Производные n-(3-пиперидинилкарбонил)-бета-аланина в качестве антагонистов фактора активации тромбоцитов (фат), способ получения, фармацевтическая композиция и способ лечения
CA2215106A1 (en) * 1995-03-17 1996-09-26 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iiia antagonists and fibrinogen-blood platelets binding inhibitors
KR19990087694A (ko) * 1996-03-13 1999-12-27 후지야마 아키라 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌
EP1184374B1 (de) * 1996-05-01 2009-01-28 Ortho-McNeil Pharmaceutical, Inc. Carboxamidderivate von Pyrrolidin, Piperidin und Hexahydropiperizin für Behandlung von Thrombosen
PT923555E (pt) * 1996-05-01 2005-09-30 Ortho Mcneil Pharm Inc Derivados carboxamida de pirrolidina, piperidina e hexa-hidroazepina para o tratamento de disturbios tromboticos
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
AU1415099A (en) * 1997-11-18 1999-06-07 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
MXPA01009615A (es) * 1999-03-22 2003-07-21 Johnson & Johnson Procedimiento para la preparacion de acido [s -(r*s*)] -°-[[[1[1- oxo-3 -(4-piperidinil) propil]3 -piperidini] carbonil] amino] -3-piridinil] carbonil] amino] -3-piridinpropanoico, y derivados del mismo.
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
EP2404899A1 (de) 2004-02-25 2012-01-11 Astellas Pharma Inc. Kontrastmittel für Thrombusentdeckung
RU2349304C1 (ru) * 2007-08-10 2009-03-20 Закрытое Акционерное Общество "Канонфарма Продакшн" Таблетированная лекарственная форма клопидогрела или его фармацевтически приемлемой соли, способ ее получения и применение
EP3184149A1 (de) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Lösliches glycoprotein v zur behandlung von thrombose-erkrankungen
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (de) * 1990-07-05 1993-03-01 Hoffmann La Roche
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
US5352667A (en) * 1991-11-22 1994-10-04 Ofer Lider Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
US5358934A (en) * 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
NO954609L (no) 1996-01-05
EP0746545A1 (de) 1996-12-11
FI955498A0 (fi) 1995-11-15
EP0746545B1 (de) 1999-05-26
FI113763B (fi) 2004-06-15
RU2135470C1 (ru) 1999-08-27
TW318179B (en) 1997-10-21
NO954609D0 (no) 1995-11-15
NZ283209A (en) 1998-04-27
KR100328287B1 (ko) 2002-10-11
HUT74871A (en) 1997-02-28
GR3030566T3 (en) 1999-10-29
US5770575A (en) 1998-06-23
DE69509875D1 (de) 1999-07-01
CN1083834C (zh) 2002-05-01
FI955498L (fi) 1996-01-15
WO1995025091A2 (en) 1995-09-21
CA2163027A1 (en) 1995-09-21
MX9504800A (es) 1997-05-31
NO304885B1 (no) 1999-03-01
ES2131313T3 (es) 1999-07-16
DE69509875T2 (de) 1999-12-09
CN1128022A (zh) 1996-07-31
DK0746545T3 (da) 1999-11-08
AU703397B2 (en) 1999-03-25
HU9503270D0 (en) 1996-05-28
WO1995025091A3 (en) 1995-10-12
AU2119195A (en) 1995-10-03
JPH09510453A (ja) 1997-10-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee