ATE180470T1 - Nipecotinsäurederivate als antithrombische verbindungen - Google Patents

Nipecotinsäurederivate als antithrombische verbindungen

Info

Publication number
ATE180470T1
ATE180470T1 AT95914023T AT95914023T ATE180470T1 AT E180470 T1 ATE180470 T1 AT E180470T1 AT 95914023 T AT95914023 T AT 95914023T AT 95914023 T AT95914023 T AT 95914023T AT E180470 T1 ATE180470 T1 AT E180470T1
Authority
AT
Austria
Prior art keywords
compounds
antithrombic
acid derivatives
nipecotic acid
nipecotic
Prior art date
Application number
AT95914023T
Other languages
English (en)
Inventor
Mary Pat Beavers
Patricia Andrade-Gordon
William J Hoekstra
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE180470T1 publication Critical patent/ATE180470T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95914023T 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen ATE180470T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27

Publications (1)

Publication Number Publication Date
ATE180470T1 true ATE180470T1 (de) 1999-06-15

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95914023T ATE180470T1 (de) 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen

Country Status (20)

Country Link
US (1) US5770575A (de)
EP (1) EP0746545B1 (de)
JP (1) JPH09510453A (de)
KR (1) KR100328287B1 (de)
CN (1) CN1083834C (de)
AT (1) ATE180470T1 (de)
AU (1) AU703397B2 (de)
CA (1) CA2163027A1 (de)
DE (1) DE69509875T2 (de)
DK (1) DK0746545T3 (de)
ES (1) ES2131313T3 (de)
FI (1) FI113763B (de)
GR (1) GR3030566T3 (de)
HU (1) HUT74871A (de)
MX (1) MX9504800A (de)
NO (1) NO304885B1 (de)
NZ (1) NZ283209A (de)
RU (1) RU2135470C1 (de)
TW (1) TW318179B (de)
WO (1) WO1995025091A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69429328T2 (de) * 1993-09-22 2002-06-13 Fujisawa Pharmaceutical Co., Ltd. N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten
AU4954296A (en) * 1995-03-17 1996-10-08 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iia antagonists and fibrinogen-blood platelets binding inhibitors
KR19990087694A (ko) * 1996-03-13 1999-12-27 후지야마 아키라 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌
ES2320316T3 (es) * 1996-05-01 2009-05-21 Ortho-Mcneil Pharmaceutical, Inc. Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utiles en el tratamiento de trastornos tromboticos.
SI0923555T1 (en) * 1996-05-01 2005-10-31 Ortho-Mcneil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
AU1415099A (en) * 1997-11-18 1999-06-07 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
YU74601A (sh) * 1999-03-22 2004-05-12 Ortho-Mcneil Pharmaceutical Inc., U.S. POSTUPAK ZA DOBIJANJE (S-(R*,S*)]-p-[[[1-OkSO-3-(4-PIPERIDINIL)PROPIL]-3-PIPERIDINIL]KARBONIL]AMINO]-3-PIPERIDINPROPIONSKE KISELINE I NJENIH DERIVATA
AUPQ570100A0 (en) 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
CA2558064A1 (en) 2004-02-25 2005-09-01 Astellas Pharma Inc. Contrast medium for thrombus formation
RU2349304C1 (ru) * 2007-08-10 2009-03-20 Закрытое Акционерное Общество "Канонфарма Продакшн" Таблетированная лекарственная форма клопидогрела или его фармацевтически приемлемой соли, способ ее получения и применение
EP3184149A1 (de) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Lösliches glycoprotein v zur behandlung von thrombose-erkrankungen
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (de) * 1990-07-05 1993-03-01 Hoffmann La Roche
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
JPH07503944A (ja) * 1991-11-22 1995-04-27 イエダ　リサーチ　アンド　デベロツプメント　カンパニー　リミテツド Ａｒｇ−ｇｌｙ−ａｓｐ配列の非ペプチド代替物およびそれらからなる医薬組成物
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
EP0945504A3 (de) * 1992-12-11 1999-12-08 The University Of Florida Stoffe und verfahren zur Schädlingskontrolle
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
CN1083834C (zh) 2002-05-01
KR100328287B1 (ko) 2002-10-11
WO1995025091A3 (en) 1995-10-12
FI113763B (fi) 2004-06-15
NZ283209A (en) 1998-04-27
GR3030566T3 (en) 1999-10-29
US5770575A (en) 1998-06-23
FI955498A0 (fi) 1995-11-15
MX9504800A (es) 1997-05-31
TW318179B (en) 1997-10-21
CA2163027A1 (en) 1995-09-21
DK0746545T3 (da) 1999-11-08
ES2131313T3 (es) 1999-07-16
AU703397B2 (en) 1999-03-25
HUT74871A (en) 1997-02-28
AU2119195A (en) 1995-10-03
EP0746545B1 (de) 1999-05-26
NO954609L (no) 1996-01-05
DE69509875T2 (de) 1999-12-09
JPH09510453A (ja) 1997-10-21
NO954609D0 (no) 1995-11-15
FI955498L (fi) 1996-01-15
DE69509875D1 (de) 1999-07-01
EP0746545A1 (de) 1996-12-11
WO1995025091A2 (en) 1995-09-21
RU2135470C1 (ru) 1999-08-27
NO304885B1 (no) 1999-03-01
HU9503270D0 (en) 1996-05-28
CN1128022A (zh) 1996-07-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee