ATE180483T1 - Imidazo(1,2-a>indeno (1,2-e> pyrazinone antagonisten der ampa und nmda rezeptoren - Google Patents

Imidazo(1,2-a>indeno (1,2-e> pyrazinone antagonisten der ampa und nmda rezeptoren

Info

Publication number: ATE180483T1
Authority: AT; Austria
Prior art keywords: pct; ampa; receptor; antagonists; pyrazinone
Prior art date: 1994-03-28

Application number

AT95914403T

Other languages

English (en)

Inventor

Jean-Claude Aloup

Francois Audiau

Michel Barreau

Dominique Damour

Arielle Genevois-Borella

Patrick Jimonet

Serge Mignani

Yves Ribeill

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-28

Filing date

1995-03-23

Publication date

1999-06-15

1995-03-23 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1999-06-15 Application granted granted Critical

1999-06-15 Publication of ATE180483T1 publication Critical patent/ATE180483T1/de

Links

102000003678 AMPA Receptors Human genes 0.000 title abstract 2
108090000078 AMPA Receptors Proteins 0.000 title abstract 2
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title abstract 2
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title abstract 2
MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical compound OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002464 receptor antagonist Substances 0.000 abstract 2
229940044551 receptor antagonist Drugs 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000036963 noncompetitive effect Effects 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Otolaryngology (AREA)
Oncology (AREA)
Virology (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

AT95914403T 1994-03-28 1995-03-23 Imidazo(1,2-a>indeno (1,2-e> pyrazinone antagonisten der ampa und nmda rezeptoren ATE180483T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9403581A FR2717812B1 (fr)	1994-03-28	1994-03-28	Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.

Publications (1)

Publication Number	Publication Date
ATE180483T1 true ATE180483T1 (de)	1999-06-15

Family

ID=9461466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95914403T ATE180483T1 (de)	1994-03-28	1995-03-23	Imidazo(1,2-a>indeno (1,2-e> pyrazinone antagonisten der ampa und nmda rezeptoren

Country Status (13)

Country	Link
US (1)	US5789406A (de)
EP (1)	EP0752991B1 (de)
JP (1)	JPH09510726A (de)
AT (1)	ATE180483T1 (de)
AU (1)	AU2141295A (de)
DE (1)	DE69509888T2 (de)
DK (1)	DK0752991T3 (de)
ES (1)	ES2134459T3 (de)
FR (1)	FR2717812B1 (de)
GR (1)	GR3030273T3 (de)
IL (1)	IL113147A0 (de)
WO (1)	WO1995026349A1 (de)
ZA (1)	ZA952531B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2743366B1 (fr) *	1996-01-10	1998-02-06	Rhone Poulenc Rorer Sa	Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant
DE50207103D1 (en) *	2001-03-14	2006-07-20	Gruenenthal Gmbh	Substituierte pyrazolo- und thiazolopyrimidine als analgetika
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7320992B2 (en) *	2003-08-25	2008-01-22	Amgen Inc.	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (de)	2007-04-18	2014-12-24	Probiodrug AG	Thioharnstoffderivate als glutaminylcyclaseinhibitoren
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (de)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazolderivate als glutaminylcyclase-hemmer
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668678A (en) *	1980-05-09	1987-05-26	Usv Pharmaceutical Corporation	Triazoloquinoxalin-1,4-diones
US4507300A (en) *	1980-05-09	1985-03-26	Usv Pharmaceutical Corporation	Pyridotriazolopyrazine-diones for treating allergy
US4400382A (en) *	1980-05-09	1983-08-23	Usv Pharmaceutical Corporation	Thiazoloquinoxalin-1,4-diones for treating allergy
US4354027A (en) *	1980-05-19	1982-10-12	Usv Pharmaceutical Corporation	Triazoloquinoxalin-4-ones
US5191197A (en) *	1988-05-11	1993-03-02	Symbol Technologies, Inc.	Arm mounted scanner actuatable by hand movement
US5196421A (en) *	1991-06-05	1993-03-23	Eli Lilly And Company	Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
DK162491D0 (da) *	1991-09-20	1991-09-20	Novo Nordisk As	Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
EP0647137B1 (de) *	1992-06-22	2008-08-13	The Regents Of The University Of California	Glycinrezeptorantagonisten und ihre verwendung
FR2696466B1 (fr) *	1992-10-02	1994-11-25	Rhone Poulenc Rorer Sa	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) *	1993-02-02	1993-02-02	Novo Nordisk As	Heterocykliske forbindelser og deres fremstilling og anvendelse
FR2707643B1 (fr) *	1993-07-16	1995-08-11	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.
FR2707645B1 (fr) *	1993-07-16	1995-08-11	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant.

1994
- 1994-03-28 FR FR9403581A patent/FR2717812B1/fr not_active Expired - Fee Related
1995
- 1995-03-23 US US08/714,163 patent/US5789406A/en not_active Expired - Fee Related
- 1995-03-23 AT AT95914403T patent/ATE180483T1/de not_active IP Right Cessation
- 1995-03-23 JP JP7524994A patent/JPH09510726A/ja active Pending
- 1995-03-23 EP EP95914403A patent/EP0752991B1/de not_active Expired - Lifetime
- 1995-03-23 DE DE69509888T patent/DE69509888T2/de not_active Expired - Fee Related
- 1995-03-23 WO PCT/FR1995/000357 patent/WO1995026349A1/fr not_active Ceased
- 1995-03-23 AU AU21412/95A patent/AU2141295A/en not_active Abandoned
- 1995-03-23 DK DK95914403T patent/DK0752991T3/da active
- 1995-03-23 ES ES95914403T patent/ES2134459T3/es not_active Expired - Lifetime
- 1995-03-27 IL IL11314795A patent/IL113147A0/xx unknown
- 1995-03-28 ZA ZA952531A patent/ZA952531B/xx unknown
1999
- 1999-05-27 GR GR980402937T patent/GR3030273T3/el unknown

Also Published As

Publication number	Publication date
JPH09510726A (ja)	1997-10-28
DK0752991T3 (da)	1999-11-08
GR3030273T3 (en)	1999-08-31
DE69509888D1 (de)	1999-07-01
AU2141295A (en)	1995-10-17
EP0752991A1 (de)	1997-01-15
EP0752991B1 (de)	1999-05-26
ES2134459T3 (es)	1999-10-01
US5789406A (en)	1998-08-04
WO1995026349A1 (fr)	1995-10-05
IL113147A0 (en)	1995-06-29
FR2717812A1 (fr)	1995-09-29
FR2717812B1 (fr)	1996-05-10
ZA952531B (en)	1996-01-11
DE69509888T2 (de)	1999-09-30

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2001-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE180483T1 (de)	1999-06-15	Imidazo(1,2-a>indeno (1,2-e> pyrazinone antagonisten der ampa und nmda rezeptoren
ATE180476T1 (de)	1999-06-15	5h-indeno(1,2-b>pyrazin-2,3-dion-derivate antagonisten der ampa und nmda rezeptoren
DE69804966D1 (de)	2002-05-23	Neue verbindungen
DK0752992T3 (da)	2001-07-30	Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater og farmaceutiske præparater indeholdende disse derivater
DE69508421D1 (de)	1999-04-22	SPIRO[HETEROZYCLISCHE-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN]-4'-ONE, IHRE HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL
DE69525738D1 (de)	2002-04-11	Heterocyclische verbindungen und ihre herstellung und verwendung
ATE188214T1 (de)	2000-01-15	Pyrrolyl-tetrahydrobenzochinoxalindione, ihre herstellung und verwendung als glutamatrezeptor- antagonisten