ATE180767T1 - Verfahren zur herstellung von n-acylierten aminophenolen - Google Patents
Verfahren zur herstellung von n-acylierten aminophenolenInfo
- Publication number
- ATE180767T1 ATE180767T1 AT94106545T AT94106545T ATE180767T1 AT E180767 T1 ATE180767 T1 AT E180767T1 AT 94106545 T AT94106545 T AT 94106545T AT 94106545 T AT94106545 T AT 94106545T AT E180767 T1 ATE180767 T1 AT E180767T1
- Authority
- AT
- Austria
- Prior art keywords
- aminophenol
- producing
- reactor
- aminophenols
- acylated
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 2
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 acyl anhydride Chemical class 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000012263 liquid product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005489 paracetamol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5655593A | 1993-04-30 | 1993-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180767T1 true ATE180767T1 (de) | 1999-06-15 |
Family
ID=22005175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94106545T ATE180767T1 (de) | 1993-04-30 | 1994-04-27 | Verfahren zur herstellung von n-acylierten aminophenolen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5648535A (de) |
| EP (1) | EP0622354B1 (de) |
| JP (1) | JPH072746A (de) |
| CN (1) | CN1054370C (de) |
| AT (1) | ATE180767T1 (de) |
| DE (1) | DE69418768T2 (de) |
| ES (1) | ES2131604T3 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2687203A1 (en) * | 2007-05-22 | 2008-11-27 | Shell Internationale Research Maatschappij B.V. | Process for converting levulinic acid into pentanoic acid |
| US9102589B2 (en) | 2010-07-30 | 2015-08-11 | Granules India Limited | Reactive distillation process for preparation of acetaminophen |
| CN105753730A (zh) * | 2016-04-06 | 2016-07-13 | 宜兴市新宇化工有限公司 | 2-氨基-4-氯-5-硝基苯酚的制备方法 |
| FR3109580B1 (fr) * | 2020-04-27 | 2023-03-10 | Ipsomedic | Procédé de synthèse du paracétamol en continu |
| WO2021235335A1 (ja) * | 2020-05-18 | 2021-11-25 | 株式会社エーピーアイ コーポレーション | アセトアミノフェンの製造方法 |
| CN112479914B (zh) * | 2020-11-24 | 2023-05-09 | 蚌埠丰原医药科技发展有限公司 | 一种连续生产对乙酰氨基酚的装置和方法 |
| WO2023090315A1 (ja) * | 2021-11-16 | 2023-05-25 | 株式会社エーピーアイ コーポレーション | アセトアミノフェンの製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3076030A (en) * | 1960-11-03 | 1963-01-29 | Abbott Lab | Process for the preparation of acetylaminophenols |
| US3341587A (en) * | 1964-10-15 | 1967-09-12 | Nepera Chemical Co Inc | Process for the preparation of n-acetyl-p-aminophenol (apap) |
| US3383416A (en) * | 1965-07-08 | 1968-05-14 | Roland G. Benner | Process for preparing aminophenol |
| US3917695A (en) * | 1973-02-20 | 1975-11-04 | Mallinckrodt Inc | Preparation of N-acetyl-p-aminophenol |
| US4264525A (en) * | 1979-07-02 | 1981-04-28 | Penick Corporation | Stepwise reduction of p-nitrophenol |
| US4670589A (en) * | 1982-11-04 | 1987-06-02 | Monsanto Company | Preparation of N-acetyl-p-aminophenol |
| DE4215592A1 (de) * | 1992-05-12 | 1993-11-18 | Bayer Ag | Verfahren zur Herstellung von N-acylierten p-Aminophenolen |
-
1994
- 1994-04-27 AT AT94106545T patent/ATE180767T1/de not_active IP Right Cessation
- 1994-04-27 EP EP94106545A patent/EP0622354B1/de not_active Expired - Lifetime
- 1994-04-27 DE DE69418768T patent/DE69418768T2/de not_active Expired - Fee Related
- 1994-04-27 ES ES94106545T patent/ES2131604T3/es not_active Expired - Lifetime
- 1994-04-28 CN CN94105390A patent/CN1054370C/zh not_active Expired - Fee Related
- 1994-04-28 JP JP6091831A patent/JPH072746A/ja active Pending
-
1995
- 1995-05-26 US US08/451,338 patent/US5648535A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0622354A2 (de) | 1994-11-02 |
| EP0622354A3 (de) | 1996-06-12 |
| US5648535A (en) | 1997-07-15 |
| JPH072746A (ja) | 1995-01-06 |
| CN1054370C (zh) | 2000-07-12 |
| DE69418768T2 (de) | 1999-10-21 |
| ES2131604T3 (es) | 1999-08-01 |
| CN1108241A (zh) | 1995-09-13 |
| EP0622354B1 (de) | 1999-06-02 |
| DE69418768D1 (de) | 1999-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |