ATE122655T1 - Verfahren zur herstellung von ioversol. - Google Patents

Verfahren zur herstellung von ioversol.

Info

Publication number: ATE122655T1
Authority: AT; Austria
Prior art keywords: hexaacetate; trichloroethane; distilled; bis; mixture
Prior art date: 1990-01-31

Application number

AT91902830T

Other languages

English (en)

Inventor

Mills Kneller

Youlin Lin

William Z Mccarthy

Rebecca A Wallace

David H White

Richard T Dean

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-31

Filing date

1990-12-19

Publication date

1995-06-15

1990-12-19 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1995-06-15 Application granted granted Critical

1995-06-15 Publication of ATE122655T1 publication Critical patent/ATE122655T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 title 1
229960004537 ioversol Drugs 0.000 title 1
UBOXGVDOUJQMTN-UHFFFAOYSA-N 1,1,2-trichloroethane Chemical compound ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT91902830T 1990-01-31 1990-12-19 Verfahren zur herstellung von ioversol. ATE122655T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/472,691 US4997983A (en)	1990-01-31	1990-01-31	Process for production of ioversol

Publications (1)

Publication Number	Publication Date
ATE122655T1 true ATE122655T1 (de)	1995-06-15

Family

ID=23876557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91902830T ATE122655T1 (de)	1990-01-31	1990-12-19	Verfahren zur herstellung von ioversol.

Country Status (9)

Country	Link
US (1)	US4997983A (de)
EP (1)	EP0513063B1 (de)
JP (1)	JPH05504137A (de)
AT (1)	ATE122655T1 (de)
AU (1)	AU654122B2 (de)
CA (1)	CA2074946A1 (de)
DE (1)	DE69019537D1 (de)
DK (1)	DK0513063T3 (de)
WO (1)	WO1991011431A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5256393A (en) *	1991-04-16	1993-10-26	Mallinckrodt Medical, Inc.	Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
US5160437A (en) *	1991-12-03	1992-11-03	Mallinckrodt Medical, Inc.	Purification of crude Ioversol using reverse osmosis
WO1993023365A1 (en) *	1992-05-15	1993-11-25	Mallinckrodt Medical, Inc.	Improved synthesis of ioversol
US5396003A (en) *	1993-05-27	1995-03-07	Mallinckrodt Medical Pmc	Recovery and purification of 1,1,2-trichloroethane for reuse in the production of ioversol
US6596904B1 (en) *	1996-01-29	2003-07-22	Mallinc Krodt Inc	Process for producing ioversol
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
FR3084668A1 (fr)	2018-08-02	2020-02-07	Guerbet	Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN115160174A (zh) *	2022-07-09	2022-10-11	浙江海洲制药有限公司	一种碘佛醇的合成方法
CN116041201A (zh) *	2022-12-30	2023-05-02	黑龙江迪诺医药有限公司	碘佛醇中间体的制备方法
CN118993930A (zh) *	2024-10-24	2024-11-22	南昌大学	一种碘佛醇水解物连续流合成工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4021481A (en) *	1969-06-27	1977-05-03	Nyegaard & Co. A/S	Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
DE2031724C3 (de) *	1969-06-27	1979-06-28	Nyegaard & Co. A/S., Oslo	N-substituierte Trijodbenz- bzw. Jodmethansulfon-am'ide, Verfahren zu deren Herstellung und radiologische Zusammensetzungen
CH608189A5 (de) *	1974-12-13	1978-12-29	Savac Ag
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
DE2909439A1 (de) *	1979-03-08	1980-09-18	Schering Ag	Neue nichtionische roentgenkontrastmittel
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
AU612510B2 (en) *	1988-03-01	1991-07-11	Mallinckrodt, Inc.	Nonionic x-ray contrast agents, compositions and methods

1990
- 1990-01-31 US US07/472,691 patent/US4997983A/en not_active Expired - Fee Related
- 1990-12-19 WO PCT/US1990/007550 patent/WO1991011431A1/en not_active Ceased
- 1990-12-19 AU AU70785/91A patent/AU654122B2/en not_active Ceased
- 1990-12-19 JP JP3503288A patent/JPH05504137A/ja active Pending
- 1990-12-19 EP EP91902830A patent/EP0513063B1/de not_active Expired - Lifetime
- 1990-12-19 DK DK91902830.8T patent/DK0513063T3/da active
- 1990-12-19 AT AT91902830T patent/ATE122655T1/de not_active IP Right Cessation
- 1990-12-19 DE DE69019537T patent/DE69019537D1/de not_active Expired - Lifetime
- 1990-12-19 CA CA002074946A patent/CA2074946A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US4997983A (en)	1991-03-05
EP0513063B1 (de)	1995-05-17
JPH05504137A (ja)	1993-07-01
WO1991011431A1 (en)	1991-08-08
AU7078591A (en)	1991-08-21
CA2074946A1 (en)	1991-08-01
DK0513063T3 (da)	1995-07-10
AU654122B2 (en)	1994-10-27
EP0513063A1 (de)	1992-11-19
DE69019537D1 (de)	1995-06-22

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Legal Events

Date	Code	Title	Description
1995-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties