ATE181927T1 - Kovalentgebundene dimere von glykopeptid- antibiotika - Google Patents
Kovalentgebundene dimere von glykopeptid- antibiotikaInfo
- Publication number
- ATE181927T1 ATE181927T1 AT97302416T AT97302416T ATE181927T1 AT E181927 T1 ATE181927 T1 AT E181927T1 AT 97302416 T AT97302416 T AT 97302416T AT 97302416 T AT97302416 T AT 97302416T AT E181927 T1 ATE181927 T1 AT E181927T1
- Authority
- AT
- Austria
- Prior art keywords
- covalene
- dimers
- glycopeptide antibiotics
- glycopeptide
- bonded dimers
- Prior art date
Links
- 239000000539 dimer Substances 0.000 title abstract 2
- 239000003910 polypeptide antibiotic agent Substances 0.000 title 1
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 108010059993 Vancomycin Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
- 229960003165 vancomycin Drugs 0.000 abstract 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1533096P | 1996-04-12 | 1996-04-12 | |
| US3173696P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE181927T1 true ATE181927T1 (de) | 1999-07-15 |
Family
ID=26687247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97302416T ATE181927T1 (de) | 1996-04-12 | 1997-04-08 | Kovalentgebundene dimere von glykopeptid- antibiotika |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0801075B1 (de) |
| AT (1) | ATE181927T1 (de) |
| AU (1) | AU2441697A (de) |
| DE (1) | DE69700308T2 (de) |
| DK (1) | DK0801075T3 (de) |
| ES (1) | ES2136457T3 (de) |
| GR (1) | GR3031302T3 (de) |
| WO (1) | WO1997038702A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840684A (en) * | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| US5919771A (en) * | 1997-05-20 | 1999-07-06 | Eli Lilly And Company | Urea and thiourea derivatives of glycopeptides |
| US5977063A (en) * | 1997-05-20 | 1999-11-02 | Eli Lilly And Company | Alkylated hexapeptides |
| FR2778184A1 (fr) * | 1998-02-20 | 1999-11-05 | Advanced Medicine Inc | Composes a liaisons multiples antibacteriens nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US6518242B1 (en) | 1998-02-20 | 2003-02-11 | Theravance, Inc. | Derivatives of glycopeptide antibacterial agents |
| DE69908819T2 (de) | 1998-12-23 | 2004-05-06 | Theravance, Inc., South San Francisco | Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten |
| US7119061B2 (en) | 2002-11-18 | 2006-10-10 | Vicuron Pharmaceuticals, Inc. | Dalbavancin compositions for treatment of bacterial infections |
| US20060074014A1 (en) | 2002-11-18 | 2006-04-06 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
| AU2003299561A1 (en) | 2002-11-18 | 2004-06-15 | Vicuron Pharmaceuticals Inc. | Compositions and methods for treating bacterial infections with protein-dalbavancin complexes |
| CA2588285A1 (en) | 2004-11-29 | 2006-06-01 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
| JP4888863B2 (ja) * | 2004-11-29 | 2012-02-29 | 国立大学法人名古屋大学 | グリコペプチド抗生物質ダイマー誘導体 |
| JP5192384B2 (ja) | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法 |
| CA2623239C (en) | 2005-09-22 | 2016-07-12 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
| CN101959900A (zh) | 2007-12-26 | 2011-01-26 | 盐野义制药株式会社 | 糖肽类抗生素糖基化衍生物 |
| EP2260060A4 (de) | 2008-04-01 | 2013-01-16 | Univ Cornell | Organisch lösliche chitosansalze und daraus hergestellte chitosan-abgeleitete biomaterialien |
-
1997
- 1997-04-07 AU AU24416/97A patent/AU2441697A/en not_active Abandoned
- 1997-04-07 WO PCT/US1997/005659 patent/WO1997038702A1/en not_active Ceased
- 1997-04-08 ES ES97302416T patent/ES2136457T3/es not_active Expired - Lifetime
- 1997-04-08 DK DK97302416T patent/DK0801075T3/da active
- 1997-04-08 AT AT97302416T patent/ATE181927T1/de not_active IP Right Cessation
- 1997-04-08 EP EP97302416A patent/EP0801075B1/de not_active Expired - Lifetime
- 1997-04-08 DE DE69700308T patent/DE69700308T2/de not_active Expired - Fee Related
-
1999
- 1999-09-22 GR GR990402402T patent/GR3031302T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0801075T3 (da) | 1999-11-22 |
| WO1997038702A1 (en) | 1997-10-23 |
| DE69700308T2 (de) | 1999-11-18 |
| AU2441697A (en) | 1997-11-07 |
| EP0801075B1 (de) | 1999-07-07 |
| DE69700308D1 (de) | 1999-08-12 |
| GR3031302T3 (en) | 1999-12-31 |
| EP0801075A1 (de) | 1997-10-15 |
| ES2136457T3 (es) | 1999-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |