ATE186736T1 - Aza-zyklohexapeptide - Google Patents

Aza-zyklohexapeptide

Info

Publication number
ATE186736T1
ATE186736T1 AT94200604T AT94200604T ATE186736T1 AT E186736 T1 ATE186736 T1 AT E186736T1 AT 94200604 T AT94200604 T AT 94200604T AT 94200604 T AT94200604 T AT 94200604T AT E186736 T1 ATE186736 T1 AT E186736T1
Authority
AT
Austria
Prior art keywords
aza
cyclohexapeptides
ceretain
found
preparation
Prior art date
Application number
AT94200604T
Other languages
English (en)
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE186736(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE186736T1 publication Critical patent/ATE186736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94200604T 1993-03-16 1994-03-09 Aza-zyklohexapeptide ATE186736T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
ATE186736T1 true ATE186736T1 (de) 1999-12-15

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94200604T ATE186736T1 (de) 1993-03-16 1994-03-09 Aza-zyklohexapeptide

Country Status (32)

Country Link
US (3) US5378804A (de)
EP (1) EP0620232B1 (de)
JP (1) JP2568474B2 (de)
KR (1) KR100329693B1 (de)
CN (1) CN1098274C (de)
AT (1) ATE186736T1 (de)
AU (1) AU668804B2 (de)
BG (1) BG63047B1 (de)
BR (2) BR9406009A (de)
CA (1) CA2118757C (de)
CZ (1) CZ286235B6 (de)
DE (2) DE69421639T2 (de)
DK (1) DK0620232T3 (de)
ES (1) ES2139043T3 (de)
FI (1) FI109542B (de)
GR (1) GR3031872T3 (de)
HR (1) HRP940161B1 (de)
HU (2) HU217614B (de)
IL (1) IL108892A (de)
LU (1) LU90875I2 (de)
LV (1) LV12574B (de)
NL (1) NL300076I2 (de)
NO (2) NO318372B1 (de)
NZ (1) NZ263360A (de)
PL (1) PL179261B1 (de)
RO (1) RO113246B1 (de)
RU (1) RU2122548C1 (de)
SI (1) SI9420013B (de)
SK (1) SK282527B6 (de)
UA (1) UA59329C2 (de)
WO (1) WO1994021677A1 (de)
ZA (1) ZA941807B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
ATE186737T1 (de) * 1994-08-23 1999-12-15 Merck & Co Inc Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl- lipopeptiden
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
DE69528065T2 (de) * 1994-09-16 2003-04-10 Merck & Co., Inc. Azazyklohexapeptid-verbindungen
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2211138A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
DK0925070T3 (da) * 1996-09-12 2003-12-01 Merck & Co Inc Antifungal kombinationsterapi
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
US7166572B1 (en) * 1999-07-27 2007-01-23 Aventis Pharma Deutschland Gmbh Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
JP2005531486A (ja) * 2001-08-06 2005-10-20 キュービスト ファーマシューティカルズ， インコーポレイテッド 新規のデプシペプチドおよびこれを調製するためのプロセス
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
ES2298821T3 (es) * 2003-07-22 2008-05-16 Theravance, Inc. Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico.
EP1730180A4 (de) * 2004-02-24 2008-06-18 Commw Scient Ind Res Org Gegen pilze wirkende peptide
EP1785432A1 (de) * 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
US8232245B2 (en) * 2006-07-26 2012-07-31 Sandoz Ag Caspofungin formulations
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
EP2170362B1 (de) 2007-06-26 2015-11-04 Merck Sharp & Dohme Corp. Lyophilisierte antipilzzusammensetzung
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
WO2010008493A2 (en) * 2008-06-25 2010-01-21 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (de) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptid bzw. sein pharmazeutisch akzeptables salz, herstellungsverfahren und verwendung
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
RU2013114993A (ru) 2010-09-20 2014-10-27 Кселлия Фармасьютикалз Апс Композиция каспофунгина
RU2535489C1 (ru) * 2010-09-29 2014-12-10 Шанхай Техвелл Биофармасьютикал Ко., Лтд. Способ очистки циклолипопептидных соединений или их солей
CA2813335A1 (en) * 2010-09-30 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or salts thereof
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
PT2680873T (pt) 2011-03-03 2017-11-01 Cidara Therapeutics Inc Agentes antifúngicos e suas utilizações
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
WO2012146099A1 (zh) 2011-04-28 2012-11-01 上海源力生物技术有限公司 用于合成卡帕芬净的中间体及其制备方法
MX387450B (es) 2012-03-19 2025-03-04 Cidara Therapeutics Inc Regimenes de dosificacion para compuestos de la clase de las equinocandinas.
HRP20161703T1 (hr) * 2012-11-20 2017-03-10 Fresenius Kabi Usa, Llc Formulacije kaspofungin acetata
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
US9675659B2 (en) 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
EP3399995A4 (de) 2016-01-08 2019-08-21 Cidara Therapeutics, Inc. Verfahren zur vorbeugung und behandlung von pneumocystis-infektionen
US11712459B2 (en) 2016-03-16 2023-08-01 Cidara Therapeutics, Inc. Dosing regimens for treatment of fungal infections
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
US11197909B2 (en) 2017-07-12 2021-12-14 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2019157453A1 (en) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Caspofungin compositions for inhalation
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
GB2065130A (en) * 1979-12-13 1981-06-24 Lilly Co Eli Recovery process for a-30912 antibiotics
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
DE3030554A1 (de) * 1980-08-13 1982-03-25 Chemische Werke Hüls AG, 4370 Marl Einbrennlacke
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
NZ234225A (en) * 1989-06-30 1993-09-27 Merck & Co Inc Antibiotic from zalerion arboricola and its use as an antifungal agent and antipneumocystis agent
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
US5219985A (en) * 1990-10-31 1993-06-15 Merck & Co., Inc. Antifungal agent
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
BR1100273A (pt) 1999-10-13
IL108892A0 (en) 1994-06-24
DE69421639T2 (de) 2000-06-08
NL300076I1 (nl) 2002-03-01
ZA941807B (en) 1994-10-13
FI109542B (fi) 2002-08-30
HU217614B (hu) 2000-03-28
KR960701092A (ko) 1996-02-24
NO953648D0 (no) 1995-09-15
CZ286235B6 (cs) 2000-02-16
AU5783294A (en) 1994-09-22
NO953648L (no) 1995-11-15
DK0620232T3 (da) 2000-03-13
LV12574A (en) 2000-11-20
HRP940161A2 (en) 1996-08-31
RO113246B1 (ro) 1998-05-29
EP0620232A1 (de) 1994-10-19
FI954327L (fi) 1995-09-14
UA59329C2 (uk) 2003-09-15
HU211890A9 (en) 1995-12-28
DE69421639D1 (de) 1999-12-23
CN1098274C (zh) 2003-01-08
CN1119441A (zh) 1996-03-27
SI9420013B (sl) 2002-12-31
CZ235895A3 (en) 1996-02-14
KR100329693B1 (ko) 2002-08-14
NZ263360A (en) 1997-08-22
WO1994021677A1 (en) 1994-09-29
RU2122548C1 (ru) 1998-11-27
HK1008674A1 (en) 1999-05-14
SK113695A3 (en) 1996-02-07
AU668804B2 (en) 1996-05-16
DE10299013I2 (de) 2009-11-19
HRP940161B1 (en) 2001-04-30
IL108892A (en) 1998-07-15
GR3031872T3 (en) 2000-02-29
LU90875I2 (en) 2002-03-04
FI954327A0 (fi) 1995-09-14
LV12574B (en) 2001-04-20
NO318372B1 (no) 2005-03-14
JP2568474B2 (ja) 1997-01-08
US5378804A (en) 1995-01-03
HUT73496A (en) 1996-08-28
PL179261B1 (pl) 2000-08-31
US5514650A (en) 1996-05-07
BG99999A (bg) 1996-04-30
CA2118757C (en) 2002-05-14
EP0620232B1 (de) 1999-11-17
ES2139043T3 (es) 2000-02-01
PL310634A1 (en) 1995-12-27
NO2005020I1 (no) 2005-09-13
SI9420013A (en) 1996-08-31
US5792746A (en) 1998-08-11
BG63047B1 (bg) 2001-02-28
NL300076I2 (nl) 2002-04-02
BR9406009A (pt) 1995-12-26
HU9502703D0 (en) 1995-11-28
JPH06321986A (ja) 1994-11-22
NO2005020I2 (no) 2008-12-01
CA2118757A1 (en) 1994-09-17
DE10299013I1 (de) 2003-01-23
SK282527B6 (sk) 2002-10-08

Similar Documents

Publication Publication Date Title
DK0620232T3 (da) Azacyclohexapeptid-forbindelser
PL300066A1 (en) Novel 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxy-tyetracyclines, methods of obtaining them and pharmaceutical composition
AU4461393A (en) Novel 7-(substituted)-8-(substituted-9-{(substituted glycyl) amido}-6-demethyl-6-deoxytetracyclines
SG47559A1 (en) 7-(substituted)-9-[(substituted glycl) amido]-6-demethyl-6-deoxytetracyclines
DK0618190T3 (da) 9-(Substitueret glycyl)amido-6-(substitueret)-5-hydroxy-6-deoxy-tetracycliner
PH30006A (en) 9-¬(Substituted glycol)amido¾-6.demethyl-6-deoxytetra-cyclines