ATE182368T1 - Enzymatische racemat-spaltung von 2-piperidin- alkyl-carboxylaten - Google Patents

Enzymatische racemat-spaltung von 2-piperidin- alkyl-carboxylaten

Info

Publication number
ATE182368T1
ATE182368T1 AT94400381T AT94400381T ATE182368T1 AT E182368 T1 ATE182368 T1 AT E182368T1 AT 94400381 T AT94400381 T AT 94400381T AT 94400381 T AT94400381 T AT 94400381T AT E182368 T1 ATE182368 T1 AT E182368T1
Authority
AT
Austria
Prior art keywords
racemat
cleavage
enzymatic
piperidine
alkyl carboxylates
Prior art date
Application number
AT94400381T
Other languages
English (en)
Inventor
Serge Perard
Lydia Zard
Guy Rossey
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE182368T1 publication Critical patent/ATE182368T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94400381T 1993-03-03 1994-02-23 Enzymatische racemat-spaltung von 2-piperidin- alkyl-carboxylaten ATE182368T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9302434A FR2702220B1 (fr) 1993-03-03 1993-03-03 Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.

Publications (1)

Publication Number Publication Date
ATE182368T1 true ATE182368T1 (de) 1999-08-15

Family

ID=9444600

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94400381T ATE182368T1 (de) 1993-03-03 1994-02-23 Enzymatische racemat-spaltung von 2-piperidin- alkyl-carboxylaten

Country Status (10)

Country Link
EP (1) EP0614986B1 (de)
JP (1) JPH06296498A (de)
KR (1) KR940021737A (de)
CN (1) CN1100143A (de)
AT (1) ATE182368T1 (de)
CA (1) CA2116833A1 (de)
DE (1) DE69419547D1 (de)
FI (1) FI940999L (de)
FR (1) FR2702220B1 (de)
IL (1) IL108829A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2718439B3 (fr) * 1994-04-12 1996-02-09 Synthelabo Dérivés de l'acide pipécolique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
FR2804682B1 (fr) * 2000-02-09 2002-05-03 Rhodia Chimie Sa Procede de preparation diastereoselective de piperidines fonctionnalisees en positions 2 et 4 utilisables comme intermediaires de synthese
WO2002053536A1 (en) * 2000-12-29 2002-07-11 Chirotech Technology Ltd. Chiral scaffolds and their preparation
CN101712645B (zh) * 2009-11-20 2013-08-28 重庆威尔德·浩瑞医药化工有限公司 一种(2r,4r)-4-甲基-2-哌啶甲酸的制备方法
CN102952065A (zh) * 2011-08-24 2013-03-06 重庆华邦胜凯制药有限公司 一种拆分顺式2,3-吡啶二甲酸酯的方法
CN102719512B (zh) * 2012-06-21 2014-06-11 浙江工业大学 一种r-2-（4-羟基苯氧基）丙酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS60502054A (ja) * 1983-08-01 1985-11-28 アストラ・レケメデル・アクチボラグ Ｌ―Ｎ―ｎ―プロピルピペコリン酸―２，６―キシリダイドおよびその製造方法
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
FR2702220A1 (fr) 1994-09-09
CA2116833A1 (fr) 1994-09-04
CN1100143A (zh) 1995-03-15
FR2702220B1 (fr) 1995-05-12
FI940999A7 (fi) 1994-09-04
EP0614986B1 (de) 1999-07-21
EP0614986A1 (de) 1994-09-14
IL108829A (en) 1999-03-12
FI940999L (fi) 1994-09-04
JPH06296498A (ja) 1994-10-25
DE69419547D1 (de) 1999-08-26
FI940999A0 (fi) 1994-03-02
IL108829A0 (en) 1994-06-24
KR940021737A (ko) 1994-10-19

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