IL108829A - Enzymatic process for the preparation of optically pure (2R-trans)-alkyl-2-piperidinecarboxylates and use of the compounds obtained as synthesis intermediates - Google Patents

Enzymatic process for the preparation of optically pure (2R-trans)-alkyl-2-piperidinecarboxylates and use of the compounds obtained as synthesis intermediates

Info

Publication number
IL108829A
IL108829A IL10882994A IL10882994A IL108829A IL 108829 A IL108829 A IL 108829A IL 10882994 A IL10882994 A IL 10882994A IL 10882994 A IL10882994 A IL 10882994A IL 108829 A IL108829 A IL 108829A
Authority
IL
Israel
Prior art keywords
group
trans
alkyl
methyl
mmol
Prior art date
Application number
IL10882994A
Other languages
English (en)
Other versions
IL108829A0 (en
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of IL108829A0 publication Critical patent/IL108829A0/xx
Publication of IL108829A publication Critical patent/IL108829A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10882994A 1993-03-03 1994-03-02 Enzymatic process for the preparation of optically pure (2R-trans)-alkyl-2-piperidinecarboxylates and use of the compounds obtained as synthesis intermediates IL108829A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9302434A FR2702220B1 (fr) 1993-03-03 1993-03-03 Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.

Publications (2)

Publication Number Publication Date
IL108829A0 IL108829A0 (en) 1994-06-24
IL108829A true IL108829A (en) 1999-03-12

Family

ID=9444600

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10882994A IL108829A (en) 1993-03-03 1994-03-02 Enzymatic process for the preparation of optically pure (2R-trans)-alkyl-2-piperidinecarboxylates and use of the compounds obtained as synthesis intermediates

Country Status (10)

Country Link
EP (1) EP0614986B1 (de)
JP (1) JPH06296498A (de)
KR (1) KR940021737A (de)
CN (1) CN1100143A (de)
AT (1) ATE182368T1 (de)
CA (1) CA2116833A1 (de)
DE (1) DE69419547D1 (de)
FI (1) FI940999A7 (de)
FR (1) FR2702220B1 (de)
IL (1) IL108829A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2718439B3 (fr) * 1994-04-12 1996-02-09 Synthelabo Dérivés de l'acide pipécolique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
FR2804682B1 (fr) * 2000-02-09 2002-05-03 Rhodia Chimie Sa Procede de preparation diastereoselective de piperidines fonctionnalisees en positions 2 et 4 utilisables comme intermediaires de synthese
EP1355882B1 (de) 2000-12-29 2006-05-17 Chirotech Technology Limited Chirale gerüste und deren herstellung
CN101712645B (zh) * 2009-11-20 2013-08-28 重庆威尔德·浩瑞医药化工有限公司 一种(2r,4r)-4-甲基-2-哌啶甲酸的制备方法
CN102952065A (zh) * 2011-08-24 2013-03-06 重庆华邦胜凯制药有限公司 一种拆分顺式2,3-吡啶二甲酸酯的方法
CN102719512B (zh) * 2012-06-21 2014-06-11 浙江工业大学 一种r-2-（4-羟基苯氧基）丙酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
AU560367B2 (en) * 1983-08-01 1987-04-02 Astra Lakemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
DE69419547D1 (de) 1999-08-26
CA2116833A1 (fr) 1994-09-04
EP0614986B1 (de) 1999-07-21
JPH06296498A (ja) 1994-10-25
FR2702220B1 (fr) 1995-05-12
ATE182368T1 (de) 1999-08-15
FR2702220A1 (fr) 1994-09-09
FI940999A0 (fi) 1994-03-02
EP0614986A1 (de) 1994-09-14
IL108829A0 (en) 1994-06-24
FI940999L (fi) 1994-09-04
KR940021737A (ko) 1994-10-19
FI940999A7 (fi) 1994-09-04
CN1100143A (zh) 1995-03-15

Similar Documents

Publication Publication Date Title
JP7001597B2 (ja) 新規なプロセスおよび中間体
JP2010529187A (ja) ベポタスチンの製造方法及びそれに用いられる中間体
JPH06199807A (ja) イミダゾール誘導体類の合成中間体
EP0215335A2 (de) Verfahren zur Herstellung von N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline
WO2002050056A1 (en) Benzylamine derivatives and their use as thrombin inhibitors
EP0270234A2 (de) Renin-Inhibitoren
CA2266514A1 (en) Novel (alpha-aminophosphino) peptide derivatives, method for making same and therapeutic applications thereof
JPH0637496B2 (ja) 第４級カルバペネム誘導体の製造方法
EP0614986B1 (de) Enzymatische Racemat-Spaltung von 2-Piperidin-alkyl-carboxylaten
JP4197741B2 (ja) ３―ピロリン―２―カルボン酸誘導体の製法
Hamilton et al. Asymmetric synthesis of a potent and selective competitive NMDA antagonist
EP1031575B1 (de) Verfahren zur Herstellung von Substanzen zur Förderung der Sekretion des Wachstumsharmones
EP2200981B1 (de) Neue carbamoylglycinderivate
US5476942A (en) 1-[2-amino-5-[1-(triphenylmethyl)-1H-imidazol-4-YL]-1-oxopentyl] piperidine derivatives, their preparation and their use as synthetic intermediates
WO2009098251A1 (en) NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
US20080003652A1 (en) Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
US4847384A (en) Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
US5552410A (en) 1,2,3,4,-tetrahydroquinoline-8-sulphonic acid chlorides and acids, their preparation and their use as synthetic intermediates
DE69533002T2 (de) Verfahren zur Herstellung von Zwischenprodukten von Inhibitoren Von Enkephalinase und Angiotensin konvertierendem Enzym und Zwischenprodukte davon
EP0882138B1 (de) Stereoselektive herstellung von 2-substituierten succinatderivaten
JPH0649005A (ja) ビニルグリシン（２−アミノ−３−ブテン酸）の簡単な製造方法および誘導体の簡便な分割
US4876343A (en) Process for statine and statine analogs
FR2777780A1 (fr) Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
US5061808A (en) 2-oxo-1-pyrrolidine carboxylic acid esters
US5585498A (en) Imidazole derivatives useful as synthetic intermediates

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed