ATE183498T1 - Substituierte indenoylguanidines mit antiarrhythmischer und cardioprotektiver wirkung - Google Patents

Substituierte indenoylguanidines mit antiarrhythmischer und cardioprotektiver wirkung

Info

Publication number: ATE183498T1
Authority: AT; Austria
Prior art keywords: indenoylguanidines; antiarrhythmic; substituted; cardioprotective effects; useful
Prior art date: 1995-04-18

Application number

AT96105873T

Other languages

English (en)

Inventor

Nirogi Ramakrishna

Tulsidas Sitaram More

Soc Housing

Anagha Suhas Kulkarni

Bansi Lal

Roa Vadlamudi

A Sector

Anil Vatantrao Ghate

Wolfgang Dr Scholz

Hans-Jochen Dr Lang

Ravindra Dattatraya Gupte

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-18

Filing date

1996-04-15

Publication date

1999-09-15

1996-04-15 Application filed by Hoechst Ag filed Critical Hoechst Ag

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183498T1 publication Critical patent/ATE183498T1/de

Links

230000003288 anthiarrhythmic effect Effects 0.000 title 1
239000003416 antiarrhythmic agent Substances 0.000 title 1
230000003293 cardioprotective effect Effects 0.000 title 1
239000003814 drug Substances 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010003119 arrhythmia Diseases 0.000 abstract 1
229940045200 cardioprotective agent Drugs 0.000 abstract 1
239000012659 cardioprotective agent Substances 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
WBCXYMNAMCHKSU-UHFFFAOYSA-N n-(diaminomethylidene)-1h-indene-1-carboxamide Chemical class C1=CC=C2C(C(=O)NC(=N)N)C=CC2=C1 WBCXYMNAMCHKSU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Surgery (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Optical Record Carriers And Manufacture Thereof (AREA)

AT96105873T 1995-04-18 1996-04-15 Substituierte indenoylguanidines mit antiarrhythmischer und cardioprotektiver wirkung ATE183498T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95105724		1995-04-18
US08/633,223 US5733934A (en)	1995-04-18	1996-04-16	Antiarrythmic and cardioprotective substituted indenoylguanidines

Publications (1)

Publication Number	Publication Date
ATE183498T1 true ATE183498T1 (de)	1999-09-15

Family

ID=26138562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96105873T ATE183498T1 (de)	1995-04-18	1996-04-15	Substituierte indenoylguanidines mit antiarrhythmischer und cardioprotektiver wirkung

Country Status (23)

Country	Link
US (1)	US5733934A (de)
EP (1)	EP0738712B1 (de)
JP (1)	JPH08291131A (de)
CN (1)	CN1061648C (de)
AT (1)	ATE183498T1 (de)
AU (1)	AU706055B2 (de)
BR (1)	BR9601989A (de)
CA (1)	CA2174406A1 (de)
CZ (1)	CZ291538B6 (de)
DE (1)	DE69603771T2 (de)
DK (1)	DK0738712T3 (de)
ES (1)	ES2135811T3 (de)
GR (1)	GR3031540T3 (de)
HU (1)	HUP9600998A3 (de)
IL (1)	IL117927A (de)
NO (1)	NO305655B1 (de)
NZ (1)	NZ286380A (de)
PL (1)	PL182566B1 (de)
RU (1)	RU2182902C2 (de)
SI (1)	SI0738712T1 (de)
SK (1)	SK282011B6 (de)
TR (1)	TR199600316A1 (de)
ZA (1)	ZA963046B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0837055A1 (de) *	1996-07-30	1998-04-22	Hoechst Aktiengesellschaft	Substituierte Indanylidinacetylguanidine als Natrium-Protonen-Antiporter, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika und sie enthaltende Medikamente
JP2002502414A (ja) *	1997-06-02	2002-01-22	藤沢薬品工業株式会社	細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体
US6011059A (en) *	1997-12-24	2000-01-04	Bristol-Myers Squibb Company	Acyl guanidine sodium/proton exchange inhibitors and method
US6160134A (en) *	1997-12-24	2000-12-12	Bristol-Myers Squibb Co.	Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
TW462964B (en)	1998-05-26	2001-11-11	Sumitomo Pharma	Guanidine derivatives for the treatment and prevention of disorders caused by inhibiting hyperactivity of Na/H exchange transport system and process for producing the same
DE19859727A1 (de) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
WO2000064445A1 (en)	1999-04-23	2000-11-02	Bristol-Myers Squibb Company	Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
BRPI0411900B8 (pt) *	2003-06-26	2021-05-25	Biotron Ltd	compostos e composições farmacêuticas compreendendo os mesmos
US20070099968A1 (en) *	2004-06-26	2007-05-03	Biotron Limited	Antiviral compounds and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2734904A (en) *		1956-02-14		Xcxnhxc-nh
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
US4544670A (en) *	1982-08-24	1985-10-01	William H. Rorer, Inc.	Method of treating coccidiosis with acyl guanidines
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DK0556673T3 (da) *	1992-02-15	1998-04-14	Hoechst Ag	o-Substituerede benzoylguanidiner til behandling og profylakse af hjerterytmeforstyrrelser og iskæmisk inducerede skader samt til inhiberering af celleproliferation
DE4326005A1 (de) *	1993-08-03	1995-02-09	Hoechst Ag	Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
EP0639573A1 (de) *	1993-08-03	1995-02-22	Hoechst Aktiengesellschaft	Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
DE4327244A1 (de) *	1993-08-13	1995-02-16	Hoechst Ag	Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

1996
- 1996-04-15 DK DK96105873T patent/DK0738712T3/da active
- 1996-04-15 EP EP96105873A patent/EP0738712B1/de not_active Expired - Lifetime
- 1996-04-15 ES ES96105873T patent/ES2135811T3/es not_active Expired - Lifetime
- 1996-04-15 SI SI9630097T patent/SI0738712T1/xx not_active IP Right Cessation
- 1996-04-15 AT AT96105873T patent/ATE183498T1/de not_active IP Right Cessation
- 1996-04-15 DE DE69603771T patent/DE69603771T2/de not_active Expired - Fee Related
- 1996-04-16 AU AU50676/96A patent/AU706055B2/en not_active Ceased
- 1996-04-16 CZ CZ19961096A patent/CZ291538B6/cs not_active IP Right Cessation
- 1996-04-16 CN CN96104990A patent/CN1061648C/zh not_active Expired - Fee Related
- 1996-04-16 NZ NZ286380A patent/NZ286380A/en unknown
- 1996-04-16 US US08/633,223 patent/US5733934A/en not_active Expired - Fee Related
- 1996-04-16 SK SK483-96A patent/SK282011B6/sk unknown
- 1996-04-16 IL IL11792796A patent/IL117927A/en not_active IP Right Cessation
- 1996-04-16 TR TR96/00316A patent/TR199600316A1/xx unknown
- 1996-04-17 PL PL96313809A patent/PL182566B1/pl unknown
- 1996-04-17 NO NO961521A patent/NO305655B1/no not_active IP Right Cessation
- 1996-04-17 ZA ZA963046A patent/ZA963046B/xx unknown
- 1996-04-17 RU RU96107258/04A patent/RU2182902C2/ru not_active IP Right Cessation
- 1996-04-17 HU HU9600998A patent/HUP9600998A3/hu unknown
- 1996-04-17 JP JP8094952A patent/JPH08291131A/ja active Pending
- 1996-04-17 CA CA002174406A patent/CA2174406A1/en not_active Abandoned
- 1996-04-18 BR BR9601989A patent/BR9601989A/pt active Search and Examination
1999
- 1999-10-15 GR GR990402627T patent/GR3031540T3/el unknown

Also Published As

Publication number	Publication date
GR3031540T3 (en)	2000-01-31
NZ286380A (en)	1997-09-22
EP0738712A1 (de)	1996-10-23
NO961521L (no)	1996-10-21
IL117927A0 (en)	1996-08-04
DE69603771T2 (de)	2000-09-07
CA2174406A1 (en)	1996-10-19
HU9600998D0 (en)	1996-06-28
CZ291538B6 (cs)	2003-03-12
CZ109696A3 (en)	1996-11-13
TR199600316A1 (tr)	1997-03-21
MX9601424A (es)	1997-07-31
SK282011B6 (sk)	2001-10-08
SI0738712T1 (en)	1999-12-31
AU706055B2 (en)	1999-06-10
IL117927A (en)	2001-12-23
HUP9600998A3 (en)	1997-11-28
PL182566B1 (pl)	2002-01-31
HUP9600998A2 (en)	1997-01-28
AU5067696A (en)	1996-10-31
CN1061648C (zh)	2001-02-07
US5733934A (en)	1998-03-31
ES2135811T3 (es)	1999-11-01
DE69603771D1 (de)	1999-09-23
JPH08291131A (ja)	1996-11-05
CN1140164A (zh)	1997-01-15
NO305655B1 (no)	1999-07-05
ZA963046B (en)	1996-10-22
SK48396A3 (en)	1996-12-04
NO961521D0 (no)	1996-04-17
BR9601989A (pt)	1998-04-07
RU2182902C2 (ru)	2002-05-27
DK0738712T3 (da)	2000-03-06
EP0738712B1 (de)	1999-08-18

Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2005-01-15	REN	Ceased due to non-payment of the annual fee

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GR3033020T3 (en)	2000-08-31	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses.
IT1229570B (it)	1991-09-04	Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
FI920023A0 (fi)	1992-01-03	Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
DE68906609D1 (de)	1993-06-24	Dopamin-vorlaeufer.
ES2051479T3 (es)	1994-06-16	Uso de imidazoles substituidos en 4 para disminuir la presion intraocular.
DE69603771D1 (de)	1999-09-23	Substituierte Indenoylguanidines mit antiarrhythmischer und cardioprotektiver Wirkung
ES2045189T3 (es)	1994-01-16	Nuevos agentes anti-arritmicos i.
ES2111352T3 (es)	1998-03-01	Uso de diester fosfato para el tratamiento de enfermedades retinianas.
ATE110721T1 (de)	1994-09-15	2-alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische zusammensetzungen.
HUT49283A (en)	1989-09-28	Process for production of medical compositions applicable for treatment of peptical ulcer
MX15697A (es)	1993-12-01	Derivados heterotetraciclicos de lactama y procesopara su preparacion
IT1241927B (it)	1994-02-01	3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
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ATE21908T1 (de)	1986-09-15	Derivate von 1,4-diaminocyclitol, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
AR004481A1 (es)	1998-12-16	Indenoilguanidinas sustituidas antiarritmicas y cardioprotectoras
ATE79259T1 (de)	1992-08-15	Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung.
MX9606397A (es)	1997-10-31	Cromanilsulfonil(tio)ureas sustituidas, procedimientos para prepararlas, y su utilizacion en preparados farmaceuticos, asi como preparados farmaceuticos que las contienen.