ATE183751T1 - Zytotoxische zyklische depsipeptide des manteltierchen trididemnum solidum - Google Patents

Zytotoxische zyklische depsipeptide des manteltierchen trididemnum solidum

Info

Publication number: ATE183751T1
Authority: AT; Austria
Prior art keywords: muscalate; cyclic depsipeptides; trididemnum solidum; cytotoxic cyclic; solidum
Prior art date: 1989-04-10

Application number

AT90303672T

Other languages

English (en)

Inventor

Kenneth L Rinehart Jr

Ryuichi Sakai

Justin G Stroh

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-10

Filing date

1990-04-05

Publication date

1999-09-15

1990-04-05 Application filed by Univ Illinois filed Critical Univ Illinois

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183751T1 publication Critical patent/ATE183751T1/de

Links

241000804473 Trididemnum solidum Species 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
108010002156 Depsipeptides Proteins 0.000 title 1
231100000433 cytotoxic Toxicity 0.000 title 1
KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
GXKAOWYTJPGGBI-BHTIDRDUSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20- Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C GXKAOWYTJPGGBI-BHTIDRDUSA-N 0.000 abstract 1
BUHGEDVBBOQECR-HGESRAKOSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trime Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C BUHGEDVBBOQECR-HGESRAKOSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90303672T 1989-04-10 1990-04-05 Zytotoxische zyklische depsipeptide des manteltierchen trididemnum solidum ATE183751T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/335,903 US4948791A (en)	1989-04-10	1989-04-10	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum

Publications (1)

Publication Number	Publication Date
ATE183751T1 true ATE183751T1 (de)	1999-09-15

Family

ID=23313708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90303672T ATE183751T1 (de)	1989-04-10	1990-04-05	Zytotoxische zyklische depsipeptide des manteltierchen trididemnum solidum

Country Status (10)

Country	Link
US (1)	US4948791A (de)
EP (1)	EP0393883B1 (de)
JP (1)	JP3431920B2 (de)
AT (1)	ATE183751T1 (de)
AU (1)	AU640130B2 (de)
CA (1)	CA2012867C (de)
DE (1)	DE69033257T2 (de)
DK (1)	DK0393883T3 (de)
ES (1)	ES2140373T3 (de)
GR (1)	GR3031846T3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
DE4120327A1 (de) *	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
US5830996A (en) *	1996-09-27	1998-11-03	University Of Utah Research Foundation	Cyclic peptide antitumor agent from an ascidian
DE69735583T2 (de)	1996-10-24	2007-04-05	The Board Of Trustees Of The University Of Illinois, Urbana	Semisynthetisches verfahren zur herstellung von didemninanalogen
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
IL155273A0 (en)	2000-10-12	2003-11-23	Pharma Mar Sa	Pharmaceutical compositions comprising an aplidine compound
EP1620117A4 (de)	2003-03-12	2009-07-29	Pharma Mar Sa	Verbesserte antitumorale behandlungen
AU2004218883B2 (en)	2003-03-12	2009-10-01	Dana-Farber Cancer Institute, Inc.	Aplidine for multiple myeloma treatment
WO2007101235A2 (en)	2006-02-28	2007-09-07	Pharma Mar, S.A.	Improved antitumoral treatments
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2576022B1 (fr) *	1985-01-11	1987-09-11	Rhone Poulenc Sante	Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent

1989
- 1989-04-10 US US07/335,903 patent/US4948791A/en not_active Expired - Lifetime
1990
- 1990-03-22 CA CA002012867A patent/CA2012867C/en not_active Expired - Fee Related
- 1990-04-05 DE DE69033257T patent/DE69033257T2/de not_active Expired - Fee Related
- 1990-04-05 AT AT90303672T patent/ATE183751T1/de not_active IP Right Cessation
- 1990-04-05 ES ES90303672T patent/ES2140373T3/es not_active Expired - Lifetime
- 1990-04-05 EP EP90303672A patent/EP0393883B1/de not_active Expired - Lifetime
- 1990-04-05 DK DK90303672T patent/DK0393883T3/da active
- 1990-04-09 AU AU53053/90A patent/AU640130B2/en not_active Ceased
- 1990-04-10 JP JP09327490A patent/JP3431920B2/ja not_active Expired - Fee Related
1999
- 1999-11-16 GR GR990402940T patent/GR3031846T3/el unknown

Also Published As

Publication number	Publication date
AU5305390A (en)	1990-10-11
DE69033257D1 (de)	1999-09-30
EP0393883B1 (de)	1999-08-25
US4948791A (en)	1990-08-14
DK0393883T3 (da)	2000-03-20
CA2012867A1 (en)	1990-10-10
ES2140373T3 (es)	2000-03-01
DE69033257T2 (de)	2000-04-13
CA2012867C (en)	1999-09-21
JP3431920B2 (ja)	2003-07-28
EP0393883A1 (de)	1990-10-24
JPH03135999A (ja)	1991-06-10
GR3031846T3 (en)	2000-02-29
AU640130B2 (en)	1993-08-19

Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2008-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
GB8922026D0 (en)	1989-11-15	Novel anti-viral and cytotoxic agent
DE69033257D1 (de)	1999-09-30	Zytotoxische zyklische Depsipeptide des Manteltierchen Trididemnum Solidum
DK366889A (da)	1990-01-27	Peptidderivat
FR2757521B1 (fr)	1999-01-29	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
ES2063278T3 (es)	1995-01-01	Proteina morfogenetica de hueso.
IL99912A0 (en)	1992-08-18	Cyclosporins,their preparation and pharmaceutical compositions containing them
ES2142953T3 (es)	2000-05-01	Factor de crecimiento y diferenciacion de la familia del tgf-beta.
EP1449921A3 (de)	2006-01-11	Neuartige, biologisch aktive Polypeptide, ihre Herstellung und diese Polypeptide enthaltende pharmazeutische Zusammensetzung
ATE210988T1 (de)	2002-01-15	Zytotoxischer aminozucker und verwandte zuckerderivate von indolopyrrolocarbazolen
ES2056180T3 (es)	1994-10-01	Nuevos derivados de 2'-halometiliden, 2'-eteniliden y 2'-etinil citidina.
ATE109779T1 (de)	1994-08-15	Ester des hexahydro-8-hydroxy-2,6-methano-2h- chinolizin-3(4h)-ons und verwandte verbindungen.
EP0353678A3 (de)	1991-03-20	FR-901154- und FR-901155-Derivate, Verfahren zu ihrer Herstellung
DE68927759D1 (de)	1997-03-27	Cyclische Peptide mit Substance P-und Substance K-antagonistischer Aktivität
DE59001121D1 (en)	1993-05-06	Antacidatabletten.
DE69418353D1 (de)	1999-06-17	Cyclische Pentapeptide mit Beta-Turn und Gamma-Turn
ES2126580T3 (es)	1999-04-01	Proteina condromodulina-ii.
DK0579939T3 (da)	1999-09-20	Phospholipidderivater
DE3869939D1 (de)	1992-05-14	Biologisch wirksame peptide.
DE3782199D1 (de)	1992-11-19	Biologisch aktive peptide tan-866.
IT8622051A1 (it)	1988-04-17	Composizioni farmaceutiche ad attivita' cicatrizzante
AU5141190A (en)	1990-09-20	Improvements in chemical compounds
ATE81531T1 (de)	1992-10-15	Biologisch aktive peptide tan-866.
ITMI922332A1 (it)	1994-04-09	Composizioni farmaceutiche per la somministrazione di paratormone, suoi frammenti biologicamente attivi o peptidi correlati per via rettale.