ATE183776T1 - Regulator-gen für clavulansäure biosynthese - Google Patents

Regulator-gen für clavulansäure biosynthese

Info

Publication number: ATE183776T1
Authority: AT; Austria
Prior art keywords: clavulanic acid; acid biosynthesis; regulator gene; dna; gene
Prior art date: 1993-02-02

Application number

AT94904734T

Other languages

English (en)

Inventor

Nicola Jane Walters

Barry Barton

Alison Jane Earl

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-02

Filing date

1994-01-28

Publication date

1999-09-15

1994-01-28 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183776T1 publication Critical patent/ATE183776T1/de

Links

HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 3
HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 3
229960003324 clavulanic acid Drugs 0.000 title abstract 3
108700005075 Regulator Genes Proteins 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
239000012634 fragment Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94904734T 1993-02-02 1994-01-28 Regulator-gen für clavulansäure biosynthese ATE183776T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939302041A GB9302041D0 (en)	1993-02-02	1993-02-02	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE183776T1 true ATE183776T1 (de)	1999-09-15

Family

ID=10729724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94904734T ATE183776T1 (de)	1993-02-02	1994-01-28	Regulator-gen für clavulansäure biosynthese

Country Status (8)

Country	Link
US (1)	US6361982B1 (de)
EP (1)	EP0682706B1 (de)
JP (1)	JPH08506021A (de)
AT (1)	ATE183776T1 (de)
DE (1)	DE69420253T2 (de)
ES (1)	ES2134927T3 (de)
GB (1)	GB9302041D0 (de)
WO (1)	WO1994018326A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9511679D0 (en)	1995-06-09	1995-08-02	Smithkline Beecham Plc	Novel process
ES2131001B1 (es) *	1997-06-16	2000-04-01	Antibioticos Sau	Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.
CN100355895C (zh) *	2004-12-17	2007-12-19	天津科技大学	棒状链霉菌lat基因缺失的质粒、衍生物及其构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8813055D0 (en)	1988-06-02	1988-07-06	Beecham Group Plc	Novel substance
FI104984B (fi)	1988-08-11	2000-05-15	Dsm Nv	Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi

1993
- 1993-02-02 GB GB939302041A patent/GB9302041D0/en active Pending
1994
- 1994-01-28 ES ES94904734T patent/ES2134927T3/es not_active Expired - Lifetime
- 1994-01-28 EP EP94904734A patent/EP0682706B1/de not_active Expired - Lifetime
- 1994-01-28 WO PCT/GB1994/000173 patent/WO1994018326A2/en not_active Ceased
- 1994-01-28 DE DE69420253T patent/DE69420253T2/de not_active Expired - Lifetime
- 1994-01-28 US US08/491,944 patent/US6361982B1/en not_active Expired - Fee Related
- 1994-01-28 JP JP6517764A patent/JPH08506021A/ja active Pending
- 1994-01-28 AT AT94904734T patent/ATE183776T1/de active

Also Published As

Publication number	Publication date
WO1994018326A2 (en)	1994-08-18
WO1994018326A3 (en)	1995-01-12
EP0682706A1 (de)	1995-11-22
DE69420253T2 (de)	2000-05-11
DE69420253D1 (en)	1999-09-30
ES2134927T3 (es)	1999-10-16
EP0682706B1 (de)	1999-08-25
GB9302041D0 (en)	1993-03-17
JPH08506021A (ja)	1996-07-02
US6361982B1 (en)	2002-03-26

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