ATE183855T1 - Durch blitzlampe angeregter farbstofflaser mit ultralangem puls fuer therapie - Google Patents
Durch blitzlampe angeregter farbstofflaser mit ultralangem puls fuer therapieInfo
- Publication number
- ATE183855T1 ATE183855T1 AT96916932T AT96916932T ATE183855T1 AT E183855 T1 ATE183855 T1 AT E183855T1 AT 96916932 T AT96916932 T AT 96916932T AT 96916932 T AT96916932 T AT 96916932T AT E183855 T1 ATE183855 T1 AT E183855T1
- Authority
- AT
- Austria
- Prior art keywords
- pulse
- laser light
- ultralong
- therapy
- laser
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000037303 wrinkles Effects 0.000 abstract 3
- 210000004204 blood vessel Anatomy 0.000 abstract 2
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 230000036561 sun exposure Effects 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/10—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/02—Constructional details
- H01S3/022—Constructional details of liquid lasers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/09—Processes or apparatus for excitation, e.g. pumping
- H01S3/091—Processes or apparatus for excitation, e.g. pumping using optical pumping
- H01S3/0915—Processes or apparatus for excitation, e.g. pumping using optical pumping by incoherent light
- H01S3/092—Processes or apparatus for excitation, e.g. pumping using optical pumping by incoherent light of flash lamp
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/10—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
- H01S3/13—Stabilisation of laser output parameters, e.g. frequency or amplitude
- H01S3/131—Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling the active medium, e.g. by controlling the processes or apparatus for excitation
- H01S3/1312—Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling the active medium, e.g. by controlling the processes or apparatus for excitation by controlling the optical pumping
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/14—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range characterised by the material used as the active medium
- H01S3/20—Liquids
- H01S3/213—Liquids including an organic dye
Landscapes
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Plasma & Fusion (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Lasers (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/461,952 US5624435A (en) | 1995-06-05 | 1995-06-05 | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE183855T1 true ATE183855T1 (de) | 1999-09-15 |
Family
ID=23834596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96916932T ATE183855T1 (de) | 1995-06-05 | 1996-06-03 | Durch blitzlampe angeregter farbstofflaser mit ultralangem puls fuer therapie |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5624435A (de) |
| EP (1) | EP0830719B1 (de) |
| JP (1) | JPH11507180A (de) |
| KR (1) | KR100416449B1 (de) |
| AT (1) | ATE183855T1 (de) |
| CA (1) | CA2222990A1 (de) |
| DE (1) | DE69603960T2 (de) |
| ES (1) | ES2137699T3 (de) |
| IL (1) | IL122382A (de) |
| TW (1) | TW342339B (de) |
| WO (1) | WO1996039734A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141049B2 (en) * | 1999-03-09 | 2006-11-28 | Thermage, Inc. | Handpiece for treatment of tissue |
| US7115123B2 (en) * | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
| US7473251B2 (en) * | 1996-01-05 | 2009-01-06 | Thermage, Inc. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
| US20040000316A1 (en) * | 1996-01-05 | 2004-01-01 | Knowlton Edward W. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
| US7267675B2 (en) | 1996-01-05 | 2007-09-11 | Thermage, Inc. | RF device with thermo-electric cooler |
| US7229436B2 (en) * | 1996-01-05 | 2007-06-12 | Thermage, Inc. | Method and kit for treatment of tissue |
| US7452358B2 (en) * | 1996-01-05 | 2008-11-18 | Thermage, Inc. | RF electrode assembly for handpiece |
| US7189230B2 (en) | 1996-01-05 | 2007-03-13 | Thermage, Inc. | Method for treating skin and underlying tissue |
| US7006874B2 (en) | 1996-01-05 | 2006-02-28 | Thermage, Inc. | Treatment apparatus with electromagnetic energy delivery device and non-volatile memory |
| US7022121B2 (en) | 1999-03-09 | 2006-04-04 | Thermage, Inc. | Handpiece for treatment of tissue |
| US6547781B1 (en) * | 1996-04-09 | 2003-04-15 | Cynsure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
| US5871479A (en) | 1996-11-07 | 1999-02-16 | Cynosure, Inc. | Alexandrite laser system for hair removal and method therefor |
| GB9618051D0 (en) * | 1996-08-29 | 1996-10-09 | Sls Wales Ltd | Wrinkle removal |
| EP1018955A4 (de) * | 1997-06-24 | 2001-06-20 | Laser Aesthetics Inc | Pulsierend betätigte glühlampe zur hautbehandlung |
| US5885274A (en) * | 1997-06-24 | 1999-03-23 | New Star Lasers, Inc. | Filament lamp for dermatological treatment |
| US7232456B2 (en) * | 1997-10-17 | 2007-06-19 | Chernoff W Gregory | Tissue treatment method |
| US6077294A (en) * | 1998-06-11 | 2000-06-20 | Cynosure, Inc. | Method for non-invasive wrinkle removal and skin treatment |
| US20070099170A1 (en) * | 1998-07-21 | 2007-05-03 | Navigant Biotechnologies, Inc. | Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate |
| US7498156B2 (en) | 1998-07-21 | 2009-03-03 | Caridianbct Biotechnologies, Llc | Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components |
| US6258577B1 (en) | 1998-07-21 | 2001-07-10 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers |
| US7049110B2 (en) * | 1998-07-21 | 2006-05-23 | Gambro, Inc. | Inactivation of West Nile virus and malaria using photosensitizers |
| US6101207A (en) * | 1998-08-25 | 2000-08-08 | Ilorinne; Toni | Dye laser |
| US6059820A (en) | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
| US7220747B2 (en) | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| US7094378B1 (en) | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6451007B1 (en) * | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
| US6268120B1 (en) | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
| US6364872B1 (en) | 1999-12-06 | 2002-04-02 | Candela Corporation | Multipulse dye laser |
| US6552301B2 (en) * | 2000-01-25 | 2003-04-22 | Peter R. Herman | Burst-ultrafast laser machining method |
| US6436094B1 (en) | 2000-03-16 | 2002-08-20 | Laserscope, Inc. | Electromagnetic and laser treatment and cooling device |
| US6554825B1 (en) | 2000-05-09 | 2003-04-29 | Laserscope | Variable pulse duration, adjustable wavelength medical laser system |
| US7985588B2 (en) * | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
| US7648699B2 (en) * | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
| TW590780B (en) * | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
| US6843961B2 (en) * | 2000-06-15 | 2005-01-18 | Gambro, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| GB2368020A (en) * | 2000-10-18 | 2002-04-24 | Icn Photonics Ltd | Treatment of acne vulgaris skin condition by irradiation with light of specific wavelengths to target specific chromophores & stimulate collagen production |
| EP1337849B1 (de) * | 2000-11-30 | 2009-11-18 | Boston Probes, Inc. | Verfahren und zusammensetzungen zum aussortieren und/oder nachweis von mikroorganismen |
| GB2370229A (en) * | 2000-12-22 | 2002-06-26 | Icn Photonics Ltd | Light delivery system for improving the appearance of skin |
| AU2003245573A1 (en) | 2002-06-19 | 2004-01-06 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
| US7250045B2 (en) | 2003-02-25 | 2007-07-31 | Spectragenics, Inc. | Self-contained, eye-safe hair-regrowth-inhibition apparatus and method |
| JP4361081B2 (ja) * | 2003-02-25 | 2009-11-11 | トリア ビューティ インコーポレイテッド | 目に安全な皮膚病学的処置装置 |
| ES2570987T3 (es) * | 2003-02-25 | 2016-05-23 | Tria Beauty Inc | Aparato de tratamiento dermatológico, basado en láser de diodo y autónomo |
| JP2006518614A (ja) * | 2003-02-25 | 2006-08-17 | スペクトラジェニクス インコーポレイテッド | ニキビ処置装置および方法 |
| US8709003B2 (en) * | 2003-02-25 | 2014-04-29 | Tria Beauty, Inc. | Capacitive sensing method and device for detecting skin |
| WO2004077020A2 (en) * | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Skin sensing method and apparatus |
| EP2604215B1 (de) | 2003-02-25 | 2017-10-11 | Tria Beauty, Inc. | Vorrichtung und Verfahren für augensichere, dermatologische Behandlung |
| US20100069898A1 (en) * | 2003-02-25 | 2010-03-18 | Tria Beauty, Inc. | Acne Treatment Method, System and Device |
| WO2004075976A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Method and apparatus for the treatment of benign pigmented lesions |
| WO2004078034A2 (en) * | 2003-03-04 | 2004-09-16 | Spectragenics, Inc. | Method and apparatus for the repigmentation of human skin |
| WO2004080279A2 (en) * | 2003-03-06 | 2004-09-23 | Spectragenics, Inc. | In the patent cooperation treaty application for patent |
| US8777935B2 (en) * | 2004-02-25 | 2014-07-15 | Tria Beauty, Inc. | Optical sensor and method for identifying the presence of skin |
| WO2006000873A2 (en) * | 2004-06-21 | 2006-01-05 | Kilolambda Technologies Ltd. | Dermatological laser system |
| US7427289B2 (en) * | 2005-01-14 | 2008-09-23 | Cynosure, Inc. | Multiple wavelength laser workstation |
| US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
| US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
| US8613741B1 (en) | 2006-10-11 | 2013-12-24 | Candela Corporation | Voltage bucking circuit for driving flashlamp-pumped lasers for treating skin |
| US20090088822A1 (en) * | 2007-09-27 | 2009-04-02 | Led Healing Light, Llc | Therapeutic pulse laser methods and apparatus |
| JP5628792B2 (ja) * | 2008-04-25 | 2014-11-19 | トリア ビューティ インコーポレイテッド | 皮膚の存在および皮膚の色素沈着を識別するための光学センサおよびその方法 |
| US20090275928A1 (en) * | 2008-05-01 | 2009-11-05 | Solomon Mark P | Suture-less laser blepharoplasty with skin tightening |
| US8717194B2 (en) | 2010-12-21 | 2014-05-06 | GE Lighting Solutions, LLC | LED traffic signal compensation and protection methods |
| WO2013158299A1 (en) | 2012-04-18 | 2013-10-24 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
| EP2973894A2 (de) | 2013-03-15 | 2016-01-20 | Cynosure, Inc. | Optische picosekunden-strahlungssysteme und verfahren zur verwendung |
| CN112042066A (zh) | 2018-02-26 | 2020-12-04 | 赛诺秀股份有限公司 | 调q倾腔亚纳秒激光器 |
| US20250087967A1 (en) * | 2022-05-13 | 2025-03-13 | Cold Laser Therapeutics, Llc | Switchable low pulse rate and high pulse rate laser driver |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766488A (en) * | 1971-06-17 | 1973-10-16 | Bell Telephone Labor Inc | Dye laser with pump cavity mode matched to laser resonator |
| US4292601A (en) * | 1977-06-29 | 1981-09-29 | Jersey Nuclear-Avco Isotopes, Inc. | Flashlamp excited fluid laser amplifier |
| DE3577026D1 (de) * | 1984-10-25 | 1990-05-10 | Candela Laser Corp | Abstimmbarer langpulsfarbstofflaser. |
| US4862886A (en) * | 1985-05-08 | 1989-09-05 | Summit Technology Inc. | Laser angioplasty |
| US5092865A (en) * | 1987-02-27 | 1992-03-03 | Xintec Corporation | Optical fiber fault detector |
| US5057099A (en) * | 1987-02-27 | 1991-10-15 | Xintec Corporation | Method for laser surgery |
| US4822600A (en) * | 1987-05-27 | 1989-04-18 | Neutrogena Corporation | Infrared blocker |
| US4977571A (en) * | 1988-03-29 | 1990-12-11 | Candela Laser Corporation | Dye laser solution circulation system |
| US5180378A (en) * | 1989-04-24 | 1993-01-19 | Abiomed, Inc. | Laser surgery system |
| US5109387A (en) * | 1990-12-26 | 1992-04-28 | Garden Jerome M | Dye laser system and method |
| US5287380A (en) * | 1993-02-19 | 1994-02-15 | Candela Laser Corporation | Method and apparatus for generating long output pulses from flashlamp-excited lasers |
| US5387211B1 (en) * | 1993-03-10 | 1996-12-31 | Trimedyne Inc | Multi-head laser assembly |
| US5668824A (en) * | 1993-07-28 | 1997-09-16 | Cynosure, Inc. | Method and apparatus for replenishing dye solution in a dye laser |
| FR2729854A1 (fr) * | 1995-01-26 | 1996-08-02 | Oreal | Utilisation du sulfate de dehydroepi-androsterone dans une composition cosmetique ou dermatologique |
-
1995
- 1995-06-05 US US08/461,952 patent/US5624435A/en not_active Expired - Lifetime
-
1996
- 1996-06-01 TW TW085106589A patent/TW342339B/zh active
- 1996-06-03 KR KR1019970708751A patent/KR100416449B1/ko not_active Expired - Fee Related
- 1996-06-03 EP EP96916932A patent/EP0830719B1/de not_active Expired - Lifetime
- 1996-06-03 AT AT96916932T patent/ATE183855T1/de not_active IP Right Cessation
- 1996-06-03 IL IL12238296A patent/IL122382A/en not_active IP Right Cessation
- 1996-06-03 DE DE69603960T patent/DE69603960T2/de not_active Expired - Lifetime
- 1996-06-03 WO PCT/US1996/008301 patent/WO1996039734A1/en not_active Ceased
- 1996-06-03 JP JP9500946A patent/JPH11507180A/ja not_active Ceased
- 1996-06-03 ES ES96916932T patent/ES2137699T3/es not_active Expired - Lifetime
- 1996-06-03 CA CA002222990A patent/CA2222990A1/en not_active Abandoned
-
2001
- 2001-03-01 US US09/797,124 patent/US20010009998A1/en not_active Abandoned
- 2001-12-07 US US10/010,872 patent/US20020049433A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5624435A (en) | 1997-04-29 |
| KR19990022272A (ko) | 1999-03-25 |
| WO1996039734A1 (en) | 1996-12-12 |
| DE69603960D1 (de) | 1999-09-30 |
| IL122382A0 (en) | 1998-06-15 |
| ES2137699T3 (es) | 1999-12-16 |
| EP0830719A1 (de) | 1998-03-25 |
| DE69603960T2 (de) | 2000-01-27 |
| US20010009998A1 (en) | 2001-07-26 |
| JPH11507180A (ja) | 1999-06-22 |
| US20020049433A1 (en) | 2002-04-25 |
| TW342339B (en) | 1998-10-11 |
| KR100416449B1 (ko) | 2004-03-19 |
| CA2222990A1 (en) | 1996-12-12 |
| IL122382A (en) | 2002-03-10 |
| EP0830719B1 (de) | 1999-08-25 |
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