ATE184008T1 - Pyrrolopyridinderivate als dopaminrezeptor liganden - Google Patents

Pyrrolopyridinderivate als dopaminrezeptor liganden

Info

Publication number: ATE184008T1
Authority: AT; Austria
Prior art keywords: pct; dopamine receptor; image; receptor ligands; pyrrolopyridine derivatives
Prior art date: 1993-03-01

Application number

AT94906978T

Other languages

English (en)

Inventor

Raymond Baker

Neil Roy Curtis

Janusz Jozef Kulagowski

Paul David Leeson

Adrian Leonard Smith

Mark Peter Ridgill

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-01

Filing date

1994-02-25

Publication date

1999-09-15

1993-03-01 Priority claimed from GB939304110A external-priority patent/GB9304110D0/en

1993-08-05 Priority claimed from GB939316260A external-priority patent/GB9316260D0/en

1994-02-25 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE184008T1 publication Critical patent/ATE184008T1/de

Links

102000015554 Dopamine receptor Human genes 0.000 title abstract 2
108050004812 Dopamine receptor Proteins 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
150000005255 pyrrolopyridines Chemical class 0.000 title 1
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT94906978T 1993-03-01 1994-02-25 Pyrrolopyridinderivate als dopaminrezeptor liganden ATE184008T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939304110A GB9304110D0 (en)	1993-03-01	1993-03-01	Therapeutic agents
GB939316260A GB9316260D0 (en)	1993-08-05	1993-08-05	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE184008T1 true ATE184008T1 (de)	1999-09-15

Family

ID=26302518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94906978T ATE184008T1 (de)	1993-03-01	1994-02-25	Pyrrolopyridinderivate als dopaminrezeptor liganden

Country Status (4)

Country	Link
US (1)	US5700809A (de)
AT (1)	ATE184008T1 (de)
DE (1)	DE69420394T2 (de)
ES (1)	ES2134929T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9605065D0 (en) *	1996-03-11	1996-05-08	Merck Sharp & Dohme	Therapeutic agents
US20070066641A1 (en) *	2003-12-19	2007-03-22	Prabha Ibrahim	Compounds and methods for development of RET modulators
PL1696920T3 (pl) *	2003-12-19	2015-03-31	Plexxikon Inc	Związki i sposoby opracowywania modulatorów Ret
US7498342B2 (en) *	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
JP2008503473A (ja) *	2004-06-17	2008-02-07	プレキシコン，インコーポレーテッド	Ｃ−ｋｉｔ活性を調節する化合物
DE102004060659A1 (de) *	2004-12-15	2006-07-06	Lanxess Deutschland Gmbh	Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung
CA2608733A1 (en) *	2005-05-17	2007-02-01	Plexxikon, Inc.	Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
WO2006135650A1 (en) *	2005-06-09	2006-12-21	Mallinckrodt Inc.	Method for separation and purification of naltrexone by preparative chromatography
DK2395004T3 (en)	2005-06-22	2016-03-21	Plexxikon Inc	Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en)	2006-12-21	2008-07-03	Plexxikon, Inc.	Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) *	2006-12-21	2008-11-12	Plexxikon Inc	COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008080015A2 (en)	2006-12-21	2008-07-03	Plexxikon, Inc.	Compounds and methods for kinase modulation, and indications therefor
US20100190777A1 (en)	2007-07-17	2010-07-29	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
HUE027598T2 (en)	2009-04-03	2016-10-28	Hoffmann La Roche	Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es)	2009-11-06	2017-09-20	Plexxikon, Inc.	Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
MA34948B1 (fr)	2011-02-07	2014-03-01	Plexxikon Inc	Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
US11992535B2 (en)	2019-12-18	2024-05-28	Chdi Foundation, Inc.	Compounds and probes for imaging huntingtin protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2044254B (en) *	1979-01-26	1983-01-26	Wyeth John & Brother Ltd	Piperidine derivatives
US5124335A (en) *	1991-01-30	1992-06-23	Merck & Co., Inc.	Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists
US5622950A (en) *	1993-03-01	1997-04-22	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
US5576319A (en) *	1993-03-01	1996-11-19	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
PL310443A1 (en) *	1993-03-01	1995-12-11	Merck Sharp & Dohme	Derivatives of pyrolo-pyridine
GB9416189D0 (en) *	1994-08-10	1994-09-28	Merck Sharp & Dohme	Therapeutic agents
GB9416162D0 (en) *	1994-08-10	1994-09-28	Merck Sharp & Dohme	Therapeutic agents
WO1996005200A1 (en) *	1994-08-10	1996-02-22	Merck Sharp & Dohme Limited	TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO[2,3-b]PYRIDINE

1994
- 1994-02-25 DE DE69420394T patent/DE69420394T2/de not_active Expired - Fee Related
- 1994-02-25 AT AT94906978T patent/ATE184008T1/de not_active IP Right Cessation
- 1994-02-25 ES ES94906978T patent/ES2134929T3/es not_active Expired - Lifetime
- 1994-02-25 US US08/513,828 patent/US5700809A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5700809A (en)	1997-12-23
DE69420394D1 (de)	1999-10-07
ES2134929T3 (es)	1999-10-16
DE69420394T2 (de)	2000-04-13

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Legal Events

Date	Code	Title	Description
2000-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties