ATE184009T1 - Halichondrine: zytotoxische polyäther-makrolide - Google Patents

Halichondrine: zytotoxische polyäther-makrolide

Info

Publication number
ATE184009T1
ATE184009T1 AT93302148T AT93302148T ATE184009T1 AT E184009 T1 ATE184009 T1 AT E184009T1 AT 93302148 T AT93302148 T AT 93302148T AT 93302148 T AT93302148 T AT 93302148T AT E184009 T1 ATE184009 T1 AT E184009T1
Authority
AT
Austria
Prior art keywords
cytotoxic
halichondrine
macrolids
polyether
chem
Prior art date
Application number
AT93302148T
Other languages
English (en)
Inventor
Dolores Garcia Gravalos
Tres Cantos Industrial
Robin John Lake
John Wilson Blunt
Murray Herbert Gibson Munro
Marc Stephane Philibe Litaudon
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE184009T1 publication Critical patent/ATE184009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Dental Preparations (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT93302148T 1992-03-23 1993-03-22 Halichondrine: zytotoxische polyäther-makrolide ATE184009T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206244A GB9206244D0 (en) 1992-03-23 1992-03-23 Cytotoxic compound from a marine sponge

Publications (1)

Publication Number Publication Date
ATE184009T1 true ATE184009T1 (de) 1999-09-15

Family

ID=10712627

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93302148T ATE184009T1 (de) 1992-03-23 1993-03-22 Halichondrine: zytotoxische polyäther-makrolide

Country Status (12)

Country Link
US (1) US5786492A (de)
EP (1) EP0572109B1 (de)
JP (1) JP3168098B2 (de)
AT (1) ATE184009T1 (de)
AU (1) AU671818B2 (de)
CA (1) CA2092108A1 (de)
DE (1) DE69326192T2 (de)
DK (1) DK0572109T3 (de)
ES (1) ES2138993T3 (de)
GB (1) GB9206244D0 (de)
GR (1) GR3031981T3 (de)
ZA (1) ZA932061B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
AU762998B2 (en) * 1998-06-17 2003-07-10 Eisai R&D Management Co., Ltd. Macrocyclic analogs and methods of their use and preparation
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
CN104876896A (zh) 2004-06-03 2015-09-02 卫材R&D管理有限公司 用于制备软海绵素b的类似物的中间体
CN108948039B (zh) 2007-10-03 2021-12-31 卫材R&D管理有限公司 用于合成软海绵素b类似物的中间体和方法
RU2517167C2 (ru) 2008-04-04 2014-05-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Аналоги галихондрина в
US20100112059A1 (en) * 2008-07-15 2010-05-06 Basf Catalysts Llc Methods, Systems and Devices for Administration of Chlorine Dioxide
WO2011094339A1 (en) 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
BR112016009452B1 (pt) 2013-11-04 2022-06-07 Eisai R&D Management Co., Ltd Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários
MX376869B (es) 2013-12-06 2025-03-07 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
WO2016003975A1 (en) 2014-06-30 2016-01-07 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
WO2016179607A1 (en) 2015-05-07 2016-11-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
EP3413887B1 (de) 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Zwischenprodukte bei der synthese von eribulin und zugehörige syntheseverfahren
KR102404629B1 (ko) 2016-06-30 2022-06-02 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
SG11201908603PA (en) 2017-04-05 2019-10-30 Harvard College Macrocyclic compound and uses thereof
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
SI4101855T1 (sl) 2017-04-27 2024-03-29 Pharma Mar S.A. Protitumorske spojine
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
JP7370313B2 (ja) 2017-07-06 2023-10-27 プレジデント アンド フェローズ オブ ハーバード カレッジ ハリコンドリンの合成
EP3710454B1 (de) 2017-11-15 2024-01-03 President And Fellows Of Harvard College Makrozyklische verbindungen und verwendungen davon
EP3713565A1 (de) 2017-11-20 2020-09-30 Basilea Pharmaceutica International AG Pharmazeutische kombinationen zur verwendung in der behandlung von neoplastischen erkrankungen
IL275729B2 (en) 2018-01-03 2023-09-01 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs

Also Published As

Publication number Publication date
DE69326192T2 (de) 2000-05-04
DE69326192D1 (de) 1999-10-07
GR3031981T3 (en) 2000-03-31
EP0572109B1 (de) 1999-09-01
ES2138993T3 (es) 2000-02-01
JPH06122687A (ja) 1994-05-06
AU671818B2 (en) 1996-09-12
AU3543393A (en) 1993-09-30
EP0572109A1 (de) 1993-12-01
DK0572109T3 (da) 2000-03-27
ZA932061B (en) 1993-10-19
GB9206244D0 (en) 1992-05-06
JP3168098B2 (ja) 2001-05-21
CA2092108A1 (en) 1993-09-24
US5786492A (en) 1998-07-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee