ES2138993T3 - Halicondrinas: macrolidos de polieter citotoxicos. - Google Patents

Halicondrinas: macrolidos de polieter citotoxicos.

Info

Publication number
ES2138993T3
ES2138993T3 ES93302148T ES93302148T ES2138993T3 ES 2138993 T3 ES2138993 T3 ES 2138993T3 ES 93302148 T ES93302148 T ES 93302148T ES 93302148 T ES93302148 T ES 93302148T ES 2138993 T3 ES2138993 T3 ES 2138993T3
Authority
ES
Spain
Prior art keywords
halicondrinas
citotoxicos
polyeter
macrolides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93302148T
Other languages
English (en)
Inventor
Dolores Garcia Gravalos
Robin John Lake
John Wilson Blunt
Murray Herbert Gibson Munro
Marc Stephane Philibe Litaudon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of ES2138993T3 publication Critical patent/ES2138993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Dental Preparations (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE HALICONDRINAS, ISOESTABLES DE UNA ESPONJA MARINA DE LA LISSODENDIX SP., QUE TIENE PREPARACIONES CITOTOXICAS Y SON DE FORMULA : EN LA QUE R1 Y R2 JUNTOS REPRESENTAN UN GRUPO DE LA FORMULA:
ES93302148T 1992-03-23 1993-03-22 Halicondrinas: macrolidos de polieter citotoxicos. Expired - Lifetime ES2138993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206244A GB9206244D0 (en) 1992-03-23 1992-03-23 Cytotoxic compound from a marine sponge

Publications (1)

Publication Number Publication Date
ES2138993T3 true ES2138993T3 (es) 2000-02-01

Family

ID=10712627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93302148T Expired - Lifetime ES2138993T3 (es) 1992-03-23 1993-03-22 Halicondrinas: macrolidos de polieter citotoxicos.

Country Status (12)

Country Link
US (1) US5786492A (es)
EP (1) EP0572109B1 (es)
JP (1) JP3168098B2 (es)
AT (1) ATE184009T1 (es)
AU (1) AU671818B2 (es)
CA (1) CA2092108A1 (es)
DE (1) DE69326192T2 (es)
DK (1) DK0572109T3 (es)
ES (1) ES2138993T3 (es)
GB (1) GB9206244D0 (es)
GR (1) GR3031981T3 (es)
ZA (1) ZA932061B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
HU227912B1 (en) * 1998-06-17 2012-05-29 Eisai R & D Man Co Halichondrin analogs and methods of their use and preparation
PL2522663T3 (pl) 2004-06-03 2015-08-31 Eisai R&D Man Co Ltd Produkty pośrednie do otrzymywania halichondryny B
CN108948039B (zh) 2007-10-03 2021-12-31 卫材R&D管理有限公司 用于合成软海绵素b类似物的中间体和方法
CN105801599A (zh) 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
JP2011528361A (ja) * 2008-07-15 2011-11-17 ビーエーエスエフ、カタリスツ、エルエルシー 二酸化塩素の投与のための方法、システムおよび機器
CN102803254B (zh) 2010-01-26 2016-09-14 卫材R&D管理有限公司 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
CN105683198B (zh) 2013-11-04 2019-03-12 卫材R&D管理有限公司 软海绵素b的类似物合成中有用的大环化反应和中间体
HUE043088T2 (hu) 2013-12-06 2019-08-28 Eisai R&D Man Co Ltd Halikondrin B analógok szintézisében alkalmazható eljárások
EP3160970A4 (en) 2014-06-30 2017-12-27 President and Fellows of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
RU2020141025A (ru) 2015-05-07 2020-12-28 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов
US10676481B2 (en) 2016-02-12 2020-06-09 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
SG11201811671XA (en) 2016-06-30 2019-01-30 Eisai R&D Man Co Ltd Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
KR102836514B1 (ko) 2017-04-05 2025-07-22 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 마크로시클릭 화합물 및 그의 용도
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
ES2974243T3 (es) 2017-11-15 2024-06-26 Harvard College Compuestos macrocíclicos y usos de los mismos
EP3713565A1 (en) 2017-11-20 2020-09-30 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
KR20250057138A (ko) 2018-01-03 2025-04-28 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물

Also Published As

Publication number Publication date
JPH06122687A (ja) 1994-05-06
EP0572109A1 (en) 1993-12-01
CA2092108A1 (en) 1993-09-24
AU671818B2 (en) 1996-09-12
ATE184009T1 (de) 1999-09-15
GB9206244D0 (en) 1992-05-06
DE69326192D1 (de) 1999-10-07
JP3168098B2 (ja) 2001-05-21
US5786492A (en) 1998-07-28
EP0572109B1 (en) 1999-09-01
AU3543393A (en) 1993-09-30
DK0572109T3 (da) 2000-03-27
GR3031981T3 (en) 2000-03-31
ZA932061B (en) 1993-10-19
DE69326192T2 (de) 2000-05-04

Similar Documents

Publication Publication Date Title
DE10399022I1 (de) Androstenderivate.
ES2195970T3 (es) L-ribavirina y usos de la misma.
DE69111555D1 (de) Düse.
DE69103283D1 (de) Beschützte dichtung.
DE68909846D1 (de) Abdichtung.
FI923378L (fi) Stabiliserade mikroorganismkulturer.
DE68908679D1 (de) Sicherheitssiegel.
DE69326192D1 (de) Halichondrine: zytotoxische Polyäther-Makrolide
NO900607L (no) Enzymatisk oppvaskmiddel.
FR2694357B1 (fr) Différentiel.
DE59300631D1 (de) Biologisch abbaubare, wässrige Dispersionen.
FI911308L (fi) Lipopeptidderivat.
DE68911164D1 (de) Filmformende Polysiloxanmikroemulsion.
DE68902546D1 (de) Abdichtungen.
DE69023975D1 (de) Tandem-montierte, stirnseitige Dichtungen.
DE69103442D1 (de) Ausgrabungswerkzeug.
EP0664779A4 (en) ANTIBIOTIC AGENTS.
FR2705239B1 (fr) Aiguille clivable.
DE69108539D1 (de) Abdichtung.
TR27956A (tr) Hidroksietil-azolil türevleri.
ITTO941089A0 (it) Struttura di tenuta.
NO962931L (no) N,N-dietyl-8,8-dipropyl-2-azaspiro£4,5|decan-2-propanamindimaleat
EP0617000A3 (en) 4-Fluorobiphenyl derivatives.
FI922527A0 (fi) Vaeggkonstruktion foer anordning i byggnader.
ES1021779Y (es) Un precinto mejorado.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 572109

Country of ref document: ES