ATE184601T1 - Bicyclische heterocyclen als neurokinin a antagonisten - Google Patents

Bicyclische heterocyclen als neurokinin a antagonisten

Info

Publication number: ATE184601T1
Authority: AT; Austria
Prior art keywords: antagonists; neurokin; bicyclic heterocycles; compounds; formula
Prior art date: 1993-12-07

Application number

AT95902223T

Other languages

English (en)

Inventor

Scott Carson Miller

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-07

Filing date

1994-12-02

Publication date

1999-10-15

1994-12-02 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1999-10-15 Application granted granted Critical

1999-10-15 Publication of ATE184601T1 publication Critical patent/ATE184601T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 1
HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 abstract 1
102400000097 Neurokinin A Human genes 0.000 abstract 1
101800000399 Neurokinin A Proteins 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT95902223T 1993-12-07 1994-12-02 Bicyclische heterocyclen als neurokinin a antagonisten ATE184601T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939325074A GB9325074D0 (en)	1993-12-07	1993-12-07	Bicyclic heterocycles

Publications (1)

Publication Number	Publication Date
ATE184601T1 true ATE184601T1 (de)	1999-10-15

Family

ID=10746267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95902223T ATE184601T1 (de)	1993-12-07	1994-12-02	Bicyclische heterocyclen als neurokinin a antagonisten

Country Status (12)

Country	Link
US (2)	US5602138A (de)
EP (1)	EP0733051B1 (de)
JP (1)	JP3498849B2 (de)
AT (1)	ATE184601T1 (de)
AU (1)	AU1115895A (de)
CA (1)	CA2175701A1 (de)
DE (1)	DE69420738T2 (de)
DK (1)	DK0733051T3 (de)
ES (1)	ES2138181T3 (de)
GB (1)	GB9325074D0 (de)
GR (1)	GR3031215T3 (de)
WO (1)	WO1995015961A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9317104D0 (en)	1993-08-17	1993-09-29	Zeneca Ltd	Therapeutic heterocycles
GB9322643D0 (en) *	1993-11-03	1993-12-22	Zeneca Ltd	Lactam derivatives
GB9325074D0 (en) *	1993-12-07	1994-02-02	Zeneca Ltd	Bicyclic heterocycles
GB9408872D0 (en) *	1994-05-03	1994-06-22	Zeneca Ltd	Heterocyclic compounds
DE69534213T2 (de) *	1994-10-25	2006-01-12	Astrazeneca Ab	Therapeutisch wirksame Heterocyclen
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
GB9421709D0 (en) *	1994-10-27	1994-12-14	Zeneca Ltd	Therapeutic compounds
GB9508786D0 (en) *	1995-04-29	1995-06-21	Zeneca Ltd	Substituted heterocycles
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
IL158484A0 (en)	2001-04-18	2004-05-12	Euro Celtique Sa	Nociceptin analogs
US20100189797A1 (en)	2002-06-10	2010-07-29	Julien Mendlewicz	Oral antidepressant formulation
MY141978A (en)	2002-09-04	2010-08-16	Schering Corp	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7205308B2 (en) *	2002-09-04	2007-04-17	Schering Corporation	Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
CA2497539A1 (en) *	2002-09-04	2004-03-18	Schering Corporation	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
AR057828A1 (es)	2005-09-29	2007-12-19	Astrazeneca Ab	Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US8106208B2 (en)	2006-05-18	2012-01-31	Albireo Ab	Benzamide compounds that act as NK receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) *	1991-05-03	1993-08-27	Sanofi Elf	Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) *	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) *	1992-11-03	1993-12-08	Zeneca Ltd	Carboxamide derivatives
GB9310066D0 (en) *	1993-05-17	1993-06-30	Zeneca Ltd	Alkyl substituted heterocycles
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
GB9322643D0 (en) *	1993-11-03	1993-12-22	Zeneca Ltd	Lactam derivatives
GB9325074D0 (en) *	1993-12-07	1994-02-02	Zeneca Ltd	Bicyclic heterocycles
US5589489A (en) *	1993-12-15	1996-12-31	Zeneca Limited	Cyclic amide derivatives for treating asthma

1993
- 1993-12-07 GB GB939325074A patent/GB9325074D0/en active Pending
1994
- 1994-12-02 AU AU11158/95A patent/AU1115895A/en not_active Abandoned
- 1994-12-02 EP EP95902223A patent/EP0733051B1/de not_active Expired - Lifetime
- 1994-12-02 DK DK95902223T patent/DK0733051T3/da active
- 1994-12-02 US US08/349,117 patent/US5602138A/en not_active Expired - Fee Related
- 1994-12-02 JP JP51602895A patent/JP3498849B2/ja not_active Expired - Fee Related
- 1994-12-02 DE DE69420738T patent/DE69420738T2/de not_active Expired - Fee Related
- 1994-12-02 AT AT95902223T patent/ATE184601T1/de not_active IP Right Cessation
- 1994-12-02 WO PCT/GB1994/002646 patent/WO1995015961A1/en not_active Ceased
- 1994-12-02 ES ES95902223T patent/ES2138181T3/es not_active Expired - Lifetime
- 1994-12-02 CA CA002175701A patent/CA2175701A1/en not_active Abandoned
1998
- 1998-06-02 US US09/089,019 patent/US5977135A/en not_active Expired - Fee Related
1999
- 1999-09-16 GR GR990402287T patent/GR3031215T3/el unknown

Also Published As

Publication number	Publication date
AU1115895A (en)	1995-06-27
DE69420738T2 (de)	2000-01-13
DE69420738D1 (de)	1999-10-21
ES2138181T3 (es)	2000-01-01
EP0733051A1 (de)	1996-09-25
CA2175701A1 (en)	1995-06-15
WO1995015961A1 (en)	1995-06-15
JPH09506103A (ja)	1997-06-17
DK0733051T3 (da)	2000-04-03
GB9325074D0 (en)	1994-02-02
US5977135A (en)	1999-11-02
GR3031215T3 (en)	1999-12-31
EP0733051B1 (de)	1999-09-15
JP3498849B2 (ja)	2004-02-23
US5602138A (en)	1997-02-11

Legal Events

Date	Code	Title
2000-03-15	UEP	Publication of translation of european patent specification
2005-05-15	EEIH	Change in the person of patent owner
2009-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
MY112102A (en)	2001-04-30	Therapeutic heterocycles.
ATE221064T1 (de)	2002-08-15	Cyclische amidderivate als neurokinin a antagonisten
ATE184601T1 (de)	1999-10-15	Bicyclische heterocyclen als neurokinin a antagonisten
GB9322643D0 (en)	1993-12-22	Lactam derivatives
GB9523526D0 (en)	1996-01-17	Therapeutic compounds
PT1029853E (pt)	2004-05-31	Derivados biciclicos heteroaromaticos uteis como agentes anticancerigenos
YU30902A (sh)	2005-07-19	Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju
MX9705801A (es)	1997-10-31	Derivados de acido 5-(4-piperidinil-1-sustituido)-3-arilpentaoico como antagonistas del receptor de taquicinina.
WO2001010860A3 (en)	2001-08-23	Quinazolinone and azaquinazolinone derivatives
WO1998031704A3 (en)	1998-09-11	Tachykinin antagonists
PT896822E (pt)	2003-07-31	4-aminopirrolo (3,2-d)pirimidinas como antagonistas do receptor de neuropeptideo y
EP0739891A3 (de)	2000-04-26	Substituierte Heterocyclen
CA2180660A1 (en)	1996-05-17	Novel piperidine derivatives with paf antagonist activity