PT691128E - Metodos de administracao de antagonistas de crf - Google Patents

Metodos de administracao de antagonistas de crf

Info

Publication number: PT691128E
Authority: PT; Portugal
Prior art keywords: chem; formula; administration; methods; crf antagonists
Prior art date: 1994-06-15

Application number

PT95201475T

Other languages

English (en)

Inventor

Gene M Bright

Willard M Welch

Yuhpyng L Chen

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-15

Filing date

1995-06-06

Publication date

2003-02-28

1995-06-06 Application filed by Pfizer filed Critical Pfizer

2003-02-28 Publication of PT691128E publication Critical patent/PT691128E/pt

Links

239000005557 antagonist Substances 0.000 title 1
229940122010 Corticotropin releasing factor antagonist Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002769 corticotropin releasing factor antagonist Substances 0.000 abstract 1
150000003217 pyrazoles Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

PT95201475T 1994-06-15 1995-06-06 Metodos de administracao de antagonistas de crf PT691128E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/259,835 US5646152A (en)	1994-06-15	1994-06-15	Methods of administering CRF antagonists

Publications (1)

Publication Number	Publication Date
PT691128E true PT691128E (pt)	2003-02-28

Family

ID=22986605

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95201475T PT691128E (pt)	1994-06-15	1995-06-06	Metodos de administracao de antagonistas de crf

Country Status (17)

Country	Link
US (2)	US5646152A (pt)
EP (1)	EP0691128B1 (pt)
JP (1)	JPH083041A (pt)
KR (1)	KR960000221A (pt)
AT (1)	ATE229334T1 (pt)
AU (1)	AU701963B2 (pt)
CA (1)	CA2151674C (pt)
CZ (1)	CZ294696B6 (pt)
DE (1)	DE69529121T2 (pt)
DK (1)	DK0691128T3 (pt)
ES (1)	ES2186704T3 (pt)
HU (1)	HUT71602A (pt)
IL (1)	IL114061A0 (pt)
MY (1)	MY115960A (pt)
NZ (1)	NZ272357A (pt)
PT (1)	PT691128E (pt)
ZA (1)	ZA954921B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005109A (en) *	1997-10-30	1999-12-21	Pflizer Inc.	Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
US6103900A (en) *	1992-12-17	2000-08-15	Pfizer Inc	Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
DE59500788D1 (de) *	1994-05-03	1997-11-20	Ciba Geigy Ag	Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
KR100263429B1 (ko) *	1994-06-06	2000-08-01	디. 제이. 우드	코르티코트로핀-방출 인자(crf) 길항 활성을 갖는 치환된 피라졸
EP0729758A3 (en) *	1995-03-02	1997-10-29	Pfizer	Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases
US6403599B1 (en) *	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
US6664261B2 (en)	1996-02-07	2003-12-16	Neurocrine Biosciences, Inc.	Pyrazolopyrimidines as CRF receptor antagonists
US6051578A (en) *	1996-02-12	2000-04-18	Pfizer Inc.	Pyrazolopyrimidines for treatment of CNS disorders
US6022978A (en) *	1996-06-11	2000-02-08	Pfizer Inc.	Benzimidazole derivatives
CA2263907A1 (en) *	1996-08-30	1998-03-05	Christopher Leighon Jordan	Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
US6472402B1 (en)	1998-04-02	2002-10-29	Neurogen Corporation	Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
EP1068205A1 (en)	1998-04-02	2001-01-17	Neurogen Corporation	Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino 2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino 4,5-b]indole derivatives: crf1 specific ligands
CA2326383A1 (en)	1998-04-02	1999-10-14	Neurogen Corporation	Aminoalkyl substituted pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d]pyrimidine derivatives: modulators of crf1 receptors
KR100505394B1 (ko) *	1998-10-17	2005-10-26	주식회사 하이닉스반도체	웨이퍼수준 칩크기 반도체 패키지와 그 제조방법
US6432989B1 (en) *	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
CO5271670A1 (es) *	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
KR20030016222A (ko) *	2000-02-14	2003-02-26	니뽄 다바코 산교 가부시키가이샤	수술후 스트레스 예방ㆍ치료제
GB0016787D0 (en) *	2000-07-07	2000-08-30	Pfizer Ltd	Compounds useful in therapy
DE60213851T2 (de) *	2001-12-04	2007-09-13	F. Hoffmann-La Roche Ag	Ringannelierte pyrazolderivate
MXPA05005794A (es) *	2002-12-02	2005-08-16	Hoffmann La Roche	Derivados de indazol como antagonistas del factor de liberacion de corticotropina.
TWI270549B (en)	2002-12-26	2007-01-11	Taisho Pharmaceutical Co Ltd	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
ES2393950T3 (es)	2003-06-26	2013-01-02	Novartis Ag	Inhibidores de la quinasa P38 con base en heterociclos de 5 miembros
CA2555287A1 (en) *	2004-02-18	2005-08-25	David Garrett Loughhead	Heterocyclic gaba-a subtype selective receptor modulators
DE102006029074A1 (de)	2006-06-22	2007-12-27	Friedrich-Schiller-Universität Jena	4-Amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidin-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung als antivirale Wirkstoffe
JP5670113B2 (ja)	2010-08-02	2015-02-18	株式会社やまびこ	反転掃気式２サイクルエンジン
PT2766367T (pt)	2011-10-14	2022-08-12	Scandion Oncology As	Derivados de 4-amino-3-fenilamino-6-fenilpirazolo[3,4-d]pirimidina para o tratamento de infeções virais, em particular infeções por picornavírus
DE102012004736A1 (de)	2011-10-20	2013-04-25	Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg	4-Amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidin-Derivate und deren Verwendung als antivirale Wirkstoffe

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DE2430454A1 (de) *	1974-06-25	1976-01-15	Thomae Gmbh Dr K	Neue pyrazolo eckige klammer auf 3,4d eckige klammer zu pyrimidine
US4139705A (en) *	1977-05-20	1979-02-13	The Dow Chemical Company	Pyrazolopyrimidines
DE2818676A1 (de) *	1978-04-27	1979-11-08	Troponwerke Gmbh & Co Kg	Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2460299A1 (fr) *	1979-07-05	1981-01-23	Bellon Labor Sa Roger	Nouveaux derives du pyrazole et leur application therapeutique
DE3145287A1 (de) *	1981-11-14	1983-05-19	Troponwerke GmbH & Co KG, 5000 Köln	Pyrrolo (2.3-d)pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
GB8432073D0 (en) *	1984-12-19	1985-01-30	Roussel Lab Ltd	Chemical compounds
DE3712735A1 (de) *	1987-04-15	1988-11-10	Boehringer Mannheim Gmbh	Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel
US4885300A (en) *	1988-03-03	1989-12-05	Ortho Pharmaceutical Corporation	4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
US5063245A (en) *	1990-03-28	1991-11-05	Nova Pharmaceutical Corporation	Corticotropin-releasing factor antagonism compounds
JPH05196008A (ja) *	1991-11-20	1993-08-06	Myotoku Kk	空気圧動作装置とその制御装置
WO1993010715A2 (en) *	1991-12-03	1993-06-10	Vesitec Medical, Inc.	Surgical treatment of stress urinary incontinence
IT222061Z2 (it) *	1991-12-03	1994-12-29	Hydro Aluminium Systems Spa	Complesso di profilati metallici per serramenti muniti di squadrette di rinforzo
JPH0669494B2 (ja) *	1991-12-04	1994-09-07	南雄河野	医療用窓付断熱カテーテル
FR2692893B1 (fr) *	1992-06-24	1994-09-02	Sanofi Elf	Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
ES2128544T3 (es) *	1992-12-17	1999-05-16	Pfizer	Pirrolopirimidinas como antagonistas del crf.
US5712303A (en) *	1992-12-17	1998-01-27	Pfizer Inc.	Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
TW336932B (en) *	1992-12-17	1998-07-21	Pfizer	Amino-substituted pyrazoles

1994
- 1994-06-15 US US08/259,835 patent/US5646152A/en not_active Expired - Fee Related
1995
- 1995-06-06 AT AT95201475T patent/ATE229334T1/de not_active IP Right Cessation
- 1995-06-06 EP EP95201475A patent/EP0691128B1/en not_active Expired - Lifetime
- 1995-06-06 DE DE69529121T patent/DE69529121T2/de not_active Expired - Fee Related
- 1995-06-06 DK DK95201475T patent/DK0691128T3/da active
- 1995-06-06 ES ES95201475T patent/ES2186704T3/es not_active Expired - Lifetime
- 1995-06-06 PT PT95201475T patent/PT691128E/pt unknown
- 1995-06-07 MY MYPI95001500A patent/MY115960A/en unknown
- 1995-06-08 IL IL11406195A patent/IL114061A0/xx unknown
- 1995-06-13 CA CA002151674A patent/CA2151674C/en not_active Expired - Fee Related
- 1995-06-14 KR KR1019950015661A patent/KR960000221A/ko not_active Ceased
- 1995-06-14 CZ CZ19951537A patent/CZ294696B6/cs not_active IP Right Cessation
- 1995-06-14 NZ NZ272357A patent/NZ272357A/en unknown
- 1995-06-14 AU AU21691/95A patent/AU701963B2/en not_active Ceased
- 1995-06-14 JP JP7170453A patent/JPH083041A/ja active Pending
- 1995-06-14 HU HU9501738A patent/HUT71602A/hu unknown
- 1995-06-14 ZA ZA954921A patent/ZA954921B/xx unknown
1997
- 1997-02-05 US US08/796,096 patent/US6200979B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ272357A (en)	1997-06-24
ZA954921B (en)	1996-12-17
CA2151674C (en)	1999-06-22
ATE229334T1 (de)	2002-12-15
MY115960A (en)	2003-10-31
JPH083041A (ja)	1996-01-09
EP0691128A1 (en)	1996-01-10
CZ294696B6 (cs)	2005-02-16
AU2169195A (en)	1995-12-21
EP0691128B1 (en)	2002-12-11
KR960000221A (ko)	1996-01-25
DK0691128T3 (da)	2003-03-31
ES2186704T3 (es)	2003-05-16
CZ153795A3 (en)	1996-01-17
HU9501738D0 (en)	1995-08-28
CA2151674A1 (en)	1995-12-16
DE69529121D1 (de)	2003-01-23
US6200979B1 (en)	2001-03-13
US5646152A (en)	1997-07-08
AU701963B2 (en)	1999-02-11
IL114061A0 (en)	1995-10-31
HUT71602A (en)	1996-01-29
DE69529121T2 (de)	2003-04-24

Publication	Publication Date	Title
IL114061A0 (en)	1995-10-31	Methods of administering crf antagonists
FI935585A0 (fi)	1993-12-13	Pyrrolopyrimidiner
GR3032461T3 (en)	2000-05-31	Substituted pyrazoles as crf antagonists.
NO952396D0 (no)	1995-06-16	Amino-substituerte pyrazoler med CRF antagonistisk virkning
EA200100554A1 (ru)	2001-12-24	Замещенные пиразолы как ингибиторы p38 киназы
NO965209D0 (no)	1996-12-05	Substituerte pyrazoler med corticotropin-frigjörende faktor (CRF) antagonist-aktivitet
GR3034329T3 (en)	2000-12-29	Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists.
DE69332898D1 (de)	2003-05-22	4-Carboxamidopiperidinderivate und ihre Verwendung als Neurokinin Antagonisten
DE69628804D1 (de)	2003-07-31	Substitutierte heterozyclische Derivate als CRF Antagonisten
FI960727L (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
DE69715097D1 (de)	2002-10-10	Benzimidazol-derivate und ihre Verwendung als Corticotropin freisetzenden Faktor Antagonisten
ATE181071T1 (de)	1999-06-15	Piperidinessigsäurederivate und ihre verwendung als fibrinogenantagonistmittel
GR1001405B (el)	1993-11-30	Ενώσεις 2-πιπεραζινόνης και η παραγωγή και η χρησιμοποίηση αυτών.